Details for: CL0002138

Cell ID: CL0002138

Cell Name: endothelial cell of lymphatic vessel

Marker Score Threshold: 624
(Derived using integrated single-cell and genomic data)

Description: A endothelial cell of a lymphatic vessel. The border of the oak leaf-shaped endothelial cell of initial lymphatics are joined by specialized buttons. The discontinuous feature of buttons distinguishes them from zippers in collecting lymphatics, but both types of junctions are composed of proteins typical of adherens junctions and tight junctions found in the endothelium of blood vessels. Buttons seal the sides of flaps of the oak leaf-shaped endothelial cell, leaving open the tips of flaps as routes for fluid entry without disassembly and reformation of intercellular junctions.

Synonyms: LEC, lymphatic endothelial cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.56
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.4
    Ensembl ID: ENSG00000075624
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 3.19
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.11
    Ensembl ID: ENSG00000184009
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.93
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.8
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.67
    Ensembl ID: ENSG00000135390
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.61
    Ensembl ID: ENSG00000142192
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.58
    Ensembl ID: ENSG00000143933
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 2.53
    Ensembl ID: ENSG00000135404
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.53
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.48
    Ensembl ID: ENSG00000179218
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.33
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.2
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.19
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.19
    Ensembl ID: ENSG00000143761
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.18
    Ensembl ID: ENSG00000134825
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.16
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.14
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 2.11
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.05
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.05
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 2.03
    Ensembl ID: ENSG00000148700
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 2.01
    Ensembl ID: ENSG00000084234
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.97
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.97
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.92
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.92
    Ensembl ID: ENSG00000124172
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.9
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.89
    Ensembl ID: ENSG00000154518
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.88
    Ensembl ID: ENSG00000153113
  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 1.81
    Ensembl ID: ENSG00000122786
  • Gene Symbol: CD59 (ENSG00000085063)
    Fold Change: 1.8
    Ensembl ID: ENSG00000085063
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.78
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.75
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.74
    Ensembl ID: ENSG00000085224
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.74
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.73
    Ensembl ID: ENSG00000152234
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.71
    Ensembl ID: ENSG00000100300
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.7
    Ensembl ID: ENSG00000198931
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 1.64
    Ensembl ID: ENSG00000151914
  • Gene Symbol: CD9 (ENSG00000010278)
    Fold Change: 1.62
    Ensembl ID: ENSG00000010278
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.62
    Ensembl ID: ENSG00000196776
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.61
    Ensembl ID: ENSG00000149925
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.6
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.59
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.58
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.58
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.57
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.54
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.53
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.51
    Ensembl ID: ENSG00000137845
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.51
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.49
    Ensembl ID: ENSG00000177556
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.47
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.47
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.45
    Ensembl ID: ENSG00000072110
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.44
    Ensembl ID: ENSG00000146731
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.44
    Ensembl ID: ENSG00000087274
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.43
    Ensembl ID: ENSG00000116489
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.42
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.41
    Ensembl ID: ENSG00000159199
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.4
    Ensembl ID: ENSG00000126247
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.39
    Ensembl ID: ENSG00000155366
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.38
    Ensembl ID: ENSG00000108561
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.37
    Ensembl ID: ENSG00000104765
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.37
    Ensembl ID: ENSG00000183255
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.36
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.35
    Ensembl ID: ENSG00000138279
  • Gene Symbol: SCARB2 (ENSG00000138760)
    Fold Change: 1.33
    Ensembl ID: ENSG00000138760
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.32
    Ensembl ID: ENSG00000104964
  • Gene Symbol: CD36 (ENSG00000135218)
    Fold Change: 1.3
    Ensembl ID: ENSG00000135218
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.29
    Ensembl ID: ENSG00000142599
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.29
    Ensembl ID: ENSG00000115307
  • Gene Symbol: SERPING1 (ENSG00000149131)
    Fold Change: 1.29
    Ensembl ID: ENSG00000149131
  • Gene Symbol: CALU (ENSG00000128595)
    Fold Change: 1.28
    Ensembl ID: ENSG00000128595
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.27
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.27
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 1.25
    Ensembl ID: ENSG00000213465
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 1.25
    Ensembl ID: ENSG00000162909
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.25
    Ensembl ID: ENSG00000087088
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.23
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.22
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.21
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.19
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.15
    Ensembl ID: ENSG00000143727
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.15
    Ensembl ID: ENSG00000164615
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.14
    Ensembl ID: ENSG00000107262
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.13
    Ensembl ID: ENSG00000123505
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.12
    Ensembl ID: ENSG00000112576
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.11
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.09
    Ensembl ID: ENSG00000131100
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.08
    Ensembl ID: ENSG00000070961
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.06
    Ensembl ID: ENSG00000140299
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.05
    Ensembl ID: ENSG00000004455
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.05
    Ensembl ID: ENSG00000111275
  • Gene Symbol: CASP4 (ENSG00000196954)
    Fold Change: 1.04
    Ensembl ID: ENSG00000196954
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.03
    Ensembl ID: ENSG00000006125
  • Gene Symbol: AP2A2 (ENSG00000183020)
    Fold Change: 1.02
    Ensembl ID: ENSG00000183020
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.02
    Ensembl ID: ENSG00000196975
Hovered Details

Hover over a box to see details here...

Hovered Details

Hover over a box to see details here...

**Key Characteristics** 1. **Morphology**: LECs have a unique oak leaf-shaped morphology with specialized buttons that seal the sides of the cells. 2. **Specialized junctions**: LECs have adherens junctions and tight junctions, similar to those found in blood vessels. 3. **Button structure**: The buttons on the surface of LECs allow for selective passage of molecules. 4. **B2M gene**: The LEC is encoded by the B2M gene, which is involved in various cellular processes. 5. **Antigen presentation**: LECs are involved in the presentation of antigens to T cells. 6. **Iron ion homeostasis**: LECs play a role in regulating iron ion homeostasis in the body. 7. **Interaction with MHC molecules**: LECs interact with MHC class I and II molecules to regulate the immune response. **Clinical Significance** 1. **Immunodeficiency disorders**: Abnormalities in LEC function or structure have been implicated in immunodeficiency disorders, such as HIV-1 infection. 2. **Cancer**: LECs have been shown to play a role in cancer development and progression, particularly in the context of metastasis. 3. **Infectious diseases**: LECs are involved in the pathogenesis of infectious diseases, such as Leishmania infection. 4. **Autoimmune diseases**: Abnormalities in LEC function or structure have been implicated in autoimmune diseases, such as multiple sclerosis. 5. **Regulatory T cell function**: LECs play a role in regulating T cell function and the immune response. **Diseases Associated with LEC Abnormalities** 1. **HIV-1 infection**: Abnormalities in LEC function or structure have been implicated in HIV-1 infection. 2. **Leishmania infection**: LECs play a role in the pathogenesis of Leishmania infection. 3. **Multiple sclerosis**: Abnormalities in LEC function or structure have been implicated in multiple sclerosis. 4. **Cancer**: LECs have been shown to play a role in cancer development and progression, particularly in the context of metastasis. 5. **Autoimmune diseases**: Abnormalities in LEC function or structure have been implicated in autoimmune diseases, such as rheumatoid arthritis. In conclusion, endothelial cells of lymphatic vessels play a crucial role in the immune system and are involved in various cellular processes, including antigen presentation, immune response, and iron ion homeostasis. Abnormalities in LEC function or structure have been implicated in various diseases, including immunodeficiency disorders, cancer, infectious diseases, autoimmune diseases, and regulatory T cell dysfunction. Further research is needed to fully understand the role of LECs in the immune system and their involvement in disease.