Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 33.3655
Cell Significance Index: 4850.0700 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 18.0806
Cell Significance Index: 309.8500 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 6.9879
Cell Significance Index: 2506.4300 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 6.3849
Cell Significance Index: 12022.1000 - Cell Name: granule cell (CL0000120)
Fold Change: 6.2421
Cell Significance Index: 71.0700 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 4.8981
Cell Significance Index: -10.7200 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 3.7806
Cell Significance Index: 143.1600 - Cell Name: granulosa cell (CL0000501)
Fold Change: 3.7332
Cell Significance Index: 98.1700 - Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: 3.4077
Cell Significance Index: 37.8300 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 3.3881
Cell Significance Index: 672.3900 - Cell Name: stellate neuron (CL0000122)
Fold Change: 2.8191
Cell Significance Index: 32.0200 - Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 2.6543
Cell Significance Index: 20.9600 - Cell Name: proerythroblast (CL0000547)
Fold Change: 2.0586
Cell Significance Index: 29.5000 - Cell Name: hippocampal interneuron (CL1001569)
Fold Change: 1.8267
Cell Significance Index: 23.6900 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 1.3847
Cell Significance Index: 879.4600 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 1.1079
Cell Significance Index: 62.1700 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.7855
Cell Significance Index: 543.2800 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.5750
Cell Significance Index: 25.4400 - Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.5228
Cell Significance Index: 4.9700 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.3801
Cell Significance Index: 9.7700 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.3420
Cell Significance Index: 21.0200 - Cell Name: midget ganglion cell of retina (CL4023188)
Fold Change: 0.2957
Cell Significance Index: 3.0800 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.2742
Cell Significance Index: 505.7300 - Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 0.2244
Cell Significance Index: 1.4600 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.1856
Cell Significance Index: 4.5000 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 0.1828
Cell Significance Index: 19.0300 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.1585
Cell Significance Index: 3.4700 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.1520
Cell Significance Index: 233.9900 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.1183
Cell Significance Index: 23.7400 - Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.1047
Cell Significance Index: 2.5100 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.0996
Cell Significance Index: 1.9700 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.0318
Cell Significance Index: 19.8500 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0115
Cell Significance Index: 2.0700 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0021
Cell Significance Index: 0.9500 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0034
Cell Significance Index: -4.5700 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0090
Cell Significance Index: -6.6700 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0155
Cell Significance Index: -8.7500 - Cell Name: retinal ganglion cell (CL0000740)
Fold Change: -0.0260
Cell Significance Index: -0.2200 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0324
Cell Significance Index: -6.8300 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0335
Cell Significance Index: -0.4800 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0344
Cell Significance Index: -26.0400 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0432
Cell Significance Index: -23.5900 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.0574
Cell Significance Index: -1.1200 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0620
Cell Significance Index: -17.8500 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0693
Cell Significance Index: -11.8300 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0695
Cell Significance Index: -3.2400 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.1009
Cell Significance Index: -12.9300 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.1173
Cell Significance Index: -2.3600 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.1429
Cell Significance Index: -17.5700 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.1460
Cell Significance Index: -1.8200 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.1710
Cell Significance Index: -23.4800 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: -0.1712
Cell Significance Index: -1.7300 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.1787
Cell Significance Index: -23.0900 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.1972
Cell Significance Index: -22.5100 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.1982
Cell Significance Index: -8.6200 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.2146
Cell Significance Index: -21.9300 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2162
Cell Significance Index: -24.7700 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2216
Cell Significance Index: -25.8300 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.2473
Cell Significance Index: -18.9800 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.2643
Cell Significance Index: -5.7100 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.2946
Cell Significance Index: -4.0200 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.3065
Cell Significance Index: -20.6100 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.3099
Cell Significance Index: -23.1000 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.3342
Cell Significance Index: -9.3400 - Cell Name: invaginating midget bipolar cell (CL4033034)
Fold Change: -0.3593
Cell Significance Index: -4.4400 - Cell Name: GABAergic neuron (CL0000617)
Fold Change: -0.3598
Cell Significance Index: -4.5400 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.3695
Cell Significance Index: -17.3700 - Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -0.3866
Cell Significance Index: -7.7100 - Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: -0.3905
Cell Significance Index: -3.0100 - Cell Name: neural cell (CL0002319)
Fold Change: -0.3947
Cell Significance Index: -4.6100 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.4128
Cell Significance Index: -11.8300 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.4209
Cell Significance Index: -22.1000 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -0.4418
Cell Significance Index: -5.4800 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.4437
Cell Significance Index: -23.1100 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.4440
Cell Significance Index: -6.8700 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.4474
Cell Significance Index: -23.2400 - Cell Name: neuron (CL0000540)
Fold Change: -0.4515
Cell Significance Index: -4.2800 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -0.4669
Cell Significance Index: -9.1900 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.4727
Cell Significance Index: -16.5600 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: -0.4867
Cell Significance Index: -5.8200 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.5169
Cell Significance Index: -7.6300 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.5268
Cell Significance Index: -23.8800 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.5295
Cell Significance Index: -8.9200 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.5791
Cell Significance Index: -18.9600 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.6138
Cell Significance Index: -19.5500 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.6235
Cell Significance Index: -9.4700 - Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: -0.6262
Cell Significance Index: -7.5900 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.6340
Cell Significance Index: -13.2700 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.6435
Cell Significance Index: -22.3600 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.6928
Cell Significance Index: -20.4100 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.6957
Cell Significance Index: -25.5400 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.7117
Cell Significance Index: -20.3100 - Cell Name: neuronal brush cell (CL0000555)
Fold Change: -0.7243
Cell Significance Index: -7.8600 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.7243
Cell Significance Index: -25.4500 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.7460
Cell Significance Index: -10.6200 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.7550
Cell Significance Index: -23.8800 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: -0.7768
Cell Significance Index: -12.8000 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.7968
Cell Significance Index: -16.6300 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.8094
Cell Significance Index: -20.1900 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.8537
Cell Significance Index: -18.1200
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 492378053
Symbol: RELN_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9049633
Title: The human reelin gene: isolation, sequencing, and mapping on chromosome 7.
PubMed ID: 9049633
DOI: 10.1101/gr.7.2.157
PubMed ID: 12853948
PubMed ID: 12690205
Title: Human chromosome 7: DNA sequence and biology.
PubMed ID: 12690205
PubMed ID: 10328932
Title: Evolutionarily conserved, alternative splicing of reelin during brain development.
PubMed ID: 10328932
PubMed ID: 9861036
Title: A decrease of reelin expression as a putative vulnerability factor in schizophrenia.
PubMed ID: 9861036
PubMed ID: 10973257
Title: Autosomal recessive lissencephaly with cerebellar hypoplasia is associated with human RELN mutations.
PubMed ID: 10973257
DOI: 10.1038/79246
PubMed ID: 11317216
Title: Reelin gene alleles and haplotypes as a factor predisposing to autistic disorder.
PubMed ID: 11317216
PubMed ID: 19159218
Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
PubMed ID: 19159218
DOI: 10.1021/pr8008012
PubMed ID: 26046367
Title: Heterozygous reelin mutations cause autosomal-dominant lateral temporal epilepsy.
PubMed ID: 26046367
Sequence Information:
- Length: 3460
- Mass: 388388
- Checksum: 9A398EC17FA4EE1B
- Sequence:
MERSGWARQT FLLALLLGAT LRARAAAGYY PRFSPFFFLC THHGELEGDG EQGEVLISLH IAGNPTYYVP GQEYHVTIST STFFDGLLVT GLYTSTSVQA SQSIGGSSAF GFGIMSDHQF GNQFMCSVVA SHVSHLPTTN LSFIWIAPPA GTGCVNFMAT ATHRGQVIFK DALAQQLCEQ GAPTDVTVHP HLAEIHSDSI ILRDDFDSYH QLQLNPNIWV ECNNCETGEQ CGAIMHGNAV TFCEPYGPRE LITTGLNTTT ASVLQFSIGS GSCRFSYSDP SIIVLYAKNN SADWIQLEKI RAPSNVSTII HILYLPEDAK GENVQFQWKQ ENLRVGEVYE ACWALDNILI INSAHRQVVL EDSLDPVDTG NWLFFPGATV KHSCQSDGNS IYFHGNEGSE FNFATTRDVD LSTEDIQEQW SEEFESQPTG WDVLGAVIGT ECGTIESGLS MVFLKDGERK LCTPSMDTTG YGNLRFYFVM GGICDPGNSH ENDIILYAKI EGRKEHITLD TLSYSSYKVP SLVSVVINPE LQTPATKFCL RQKNHQGHNR NVWAVDFFHV LPVLPSTMSH MIQFSINLGC GTHQPGNSVS LEFSTNHGRS WSLLHTECLP EICAGPHLPH STVYSSENYS GWNRITIPLP NAALTRNTRI RWRQTGPILG NMWAIDNVYI GPSCLKFCSG RGQCTRHGCK CDPGFSGPAC EMASQTFPMF ISESFGSSRL SSYHNFYSIR GAEVSFGCGV LASGKALVFN KDGRRQLITS FLDSSQSRFL QFTLRLGSKS VLSTCRAPDQ PGEGVLLHYS YDNGITWKLL EHYSYLSYHE PRIISVELPG DAKQFGIQFR WWQPYHSSQR EDVWAIDEII MTSVLFNSIS LDFTNLVEVT QSLGFYLGNV QPYCGHDWTL CFTGDSKLAS SMRYVETQSM QIGASYMIQF SLVMGCGQKY TPHMDNQVKL EYSTNHGLTW HLVQEECLPS MPSCQEFTSA SIYHASEFTQ WRRVIVLLPQ KTWSSATRFR WSQSYYTAQD EWALDSIYIG QQCPNMCSGH GSCDHGICRC DQGYQGTECH PEAALPSTIM SDFENQNGWE SDWQEVIGGE IVKPEQGCGV ISSGSSLYFS KAGKRQLVSW DLDTSWVDFV QFYIQIGGES ASCNKPDSRE EGVLLQYSNN GGIQWHLLAE MYFSDFSKPR FVYLELPAAA KTPCTRFRWW QPVFSGEDYD QWAVDDIIIL SEKQKQIIPV INPTLPQNFY EKPAFDYPMN QMSVWLMLAN EGMVKNETFC AATPSAMIFG KSDGDRFAVT RDLTLKPGYV LQFKLNIGCA NQFSSTAPVL LQYSHDAGMS WFLVKEGCYP ASAGKGCEGN SRELSEPTMY HTGDFEEWTR ITIVIPRSLA SSKTRFRWIQ ESSSQKNVPP FGLDGVYISE PCPSYCSGHG DCISGVCFCD LGYTAAQGTC VSNVPNHNEM FDRFEGKLSP LWYKITGAQV GTGCGTLNDG KSLYFNGPGK REARTVPLDT RNIRLVQFYI QIGSKTSGIT CIKPRTRNEG LIVQYSNDNG ILWHLLRELD FMSFLEPQII SIDLPQDAKT PATAFRWWQP QHGKHSAQWA LDDVLIGMND SSQTGFQDKF DGSIDLQANW YRIQGGQVDI DCLSMDTALI FTENIGKPRY AETWDFHVSA STFLQFEMSM GCSKPFSNSH SVQLQYSLNN GKDWHLVTEE CVPPTIGCLH YTESSIYTSE RFQNWKRITV YLPLSTISPR TRFRWIQANY TVGADSWAID NVVLASGCPW MCSGRGICDA GRCVCDRGFG GPYCVPVVPL PSILKDDFNG NLHPDLWPEV YGAERGNLNG ETIKSGTSLI FKGEGLRMLI SRDLDCTNTM YVQFSLRFIA KSTPERSHSI LLQFSISGGI TWHLMDEFYF PQTTNILFIN VPLPYTAQTN ATRFRLWQPY NNGKKEEIWI VDDFIIDGNN VNNPVMLLDT FDFGPREDNW FFYPGGNIGL YCPYSSKGAP EEDSAMVFVS NEVGEHSITT RDLNVNENTI IQFEINVGCS TDSSSADPVR LEFSRDFGAT WHLLLPLCYH SSSHVSSLCS TEHHPSSTYY AGTMQGWRRE VVHFGKLHLC GSVRFRWYQG FYPAGSQPVT WAIDNVYIGP QCEEMCNGQG SCINGTKCIC DPGYSGPTCK ISTKNPDFLK DDFEGQLESD RFLLMSGGKP SRKCGILSSG NNLFFNEDGL RMLMTRDLDL SHARFVQFFM RLGCGKGVPD PRSQPVLLQY SLNGGLSWSL LQEFLFSNSS NVGRYIALEI PLKARSGSTR LRWWQPSENG HFYSPWVIDQ ILIGGNISGN TVLEDDFTTL DSRKWLLHPG GTKMPVCGST GDALVFIEKA STRYVVSTDV AVNEDSFLQI DFAASCSVTD SCYAIELEYS VDLGLSWHPL VRDCLPTNVE CSRYHLQRIL VSDTFNKWTR ITLPLPPYTR SQATRFRWHQ PAPFDKQQTW AIDNVYIGDG CIDMCSGHGR CIQGNCVCDE QWGGLYCDDP ETSLPTQLKD NFNRAPSSQN WLTVNGGKLS TVCGAVASGM ALHFSGGCSR LLVTVDLNLT NAEFIQFYFM YGCLITPNNR NQGVLLEYSV NGGITWNLLM EIFYDQYSKP GFVNILLPPD AKEIATRFRW WQPRHDGLDQ NDWAIDNVLI SGSADQRTVM LDTFSSAPVP QHERSPADAG PVGRIAFDMF MEDKTSVNEH WLFHDDCTVE RFCDSPDGVM LCGSHDGREV YAVTHDLTPT EGWIMQFKIS VGCKVSEKIA QNQIHVQYST DFGVSWNYLV PQCLPADPKC SGSVSQPSVF FPTKGWKRIT YPLPESLVGN PVRFRFYQKY SDMQWAIDNF YLGPGCLDNC RGHGDCLREQ CICDPGYSGP NCYLTHTLKT FLKERFDSEE IKPDLWMSLE GGSTCTECGI LAEDTALYFG GSTVRQAVTQ DLDLRGAKFL QYWGRIGSEN NMTSCHRPIC RKEGVLLDYS TDGGITWTLL HEMDYQKYIS VRHDYILLPE DALTNTTRLR WWQPFVISNG IVVSGVERAQ WALDNILIGG AEINPSQLVD TFDDEGTSHE ENWSFYPNAV RTAGFCGNPS FHLYWPNKKK DKTHNALSSR ELIIQPGYMM QFKIVVGCEA TSCGDLHSVM LEYTKDARSD SWQLVQTQCL PSSSNSIGCS PFQFHEATIY NSVNSSSWKR ITIQLPDHVS SSATQFRWIQ KGEETEKQSW AIDHVYIGEA CPKLCSGHGY CTTGAICICD ESFQGDDCSV FSHDLPSYIK DNFESARVTE ANWETIQGGV IGSGCGQLAP YAHGDSLYFN GCQIRQAATK PLDLTRASKI MFVLQIGSMS QTDSCNSDLS GPHAVDKAVL LQYSVNNGIT WHVIAQHQPK DFTQAQRVSY NVPLEARMKG VLLRWWQPRH NGTGHDQWAL DHVEVVLVST RKQNYMMNFS RQHGLRHFYN RRRRSLRRYP
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.