Details for: SCGB2A2

Gene ID: 4250

Symbol: SCGB2A2

Ensembl ID: ENSG00000110484

Description: secretoglobin family 2A member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 49.0191
    Cell Significance Index: 35.0300
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 3.7844
    Cell Significance Index: 23.2900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.6987
    Cell Significance Index: 348.6500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.5590
    Cell Significance Index: 120.2700
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.4014
    Cell Significance Index: 30.9300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.2761
    Cell Significance Index: 22.5500
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.2036
    Cell Significance Index: 12.8900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.0786
    Cell Significance Index: 80.3900
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.6138
    Cell Significance Index: 3.8600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.5433
    Cell Significance Index: 8.8000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.1977
    Cell Significance Index: 3.3800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0892
    Cell Significance Index: 12.2500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0323
    Cell Significance Index: 17.6400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0299
    Cell Significance Index: 13.2300
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.0160
    Cell Significance Index: 0.0400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0008
    Cell Significance Index: 0.0300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0173
    Cell Significance Index: -1.2200
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0188
    Cell Significance Index: -0.2000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0217
    Cell Significance Index: -16.0400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0283
    Cell Significance Index: -15.9600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0330
    Cell Significance Index: -0.5600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0623
    Cell Significance Index: -0.8500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0632
    Cell Significance Index: -1.6100
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0653
    Cell Significance Index: -0.7800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0693
    Cell Significance Index: -12.5000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0778
    Cell Significance Index: -11.3100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0779
    Cell Significance Index: -15.6300
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.0905
    Cell Significance Index: -0.7200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0946
    Cell Significance Index: -16.1600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0949
    Cell Significance Index: -9.6900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0998
    Cell Significance Index: -45.2800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1176
    Cell Significance Index: -1.3400
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.1258
    Cell Significance Index: -1.3200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1260
    Cell Significance Index: -2.4600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1369
    Cell Significance Index: -15.6900
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: -0.1389
    Cell Significance Index: -1.0600
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.1568
    Cell Significance Index: -1.2700
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.1590
    Cell Significance Index: -1.5100
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: -0.1671
    Cell Significance Index: -1.4400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1686
    Cell Significance Index: -12.9400
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.1716
    Cell Significance Index: -1.3900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2030
    Cell Significance Index: -5.8200
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.2195
    Cell Significance Index: -1.1800
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.2289
    Cell Significance Index: -2.8800
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.2367
    Cell Significance Index: -3.0300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2681
    Cell Significance Index: -12.5000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2928
    Cell Significance Index: -10.7500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.3303
    Cell Significance Index: -4.5300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3363
    Cell Significance Index: -9.0100
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.3426
    Cell Significance Index: -3.1000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3517
    Cell Significance Index: -8.9600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.3542
    Cell Significance Index: -5.4800
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.3547
    Cell Significance Index: -3.8400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3655
    Cell Significance Index: -10.4300
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.3902
    Cell Significance Index: -4.4900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4016
    Cell Significance Index: -12.7900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4160
    Cell Significance Index: -9.1100
  • Cell Name: immature alpha-beta T cell (CL0000790)
    Fold Change: -0.4213
    Cell Significance Index: -3.1400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.4500
    Cell Significance Index: -11.2400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.5127
    Cell Significance Index: -12.7900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.5295
    Cell Significance Index: -8.9200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.5324
    Cell Significance Index: -10.4100
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.5417
    Cell Significance Index: -7.0100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.5429
    Cell Significance Index: -10.9000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5446
    Cell Significance Index: -28.2900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.5597
    Cell Significance Index: -8.8800
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.5688
    Cell Significance Index: -9.6600
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.5787
    Cell Significance Index: -7.0400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.6021
    Cell Significance Index: -14.6900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.6026
    Cell Significance Index: -13.0200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.6109
    Cell Significance Index: -8.8700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.6133
    Cell Significance Index: -14.1700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.6211
    Cell Significance Index: -11.4800
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.6248
    Cell Significance Index: -7.6000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.6348
    Cell Significance Index: -9.3700
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.6410
    Cell Significance Index: -8.8900
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.6638
    Cell Significance Index: -9.2100
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.6761
    Cell Significance Index: -14.1000
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.6953
    Cell Significance Index: -9.2400
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: -0.7156
    Cell Significance Index: -6.6400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.7214
    Cell Significance Index: -15.3100
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: -0.7406
    Cell Significance Index: -3.4100
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.7459
    Cell Significance Index: -10.4300
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: -0.7470
    Cell Significance Index: -0.9700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.7509
    Cell Significance Index: -12.9800
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.7531
    Cell Significance Index: -9.0300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.7544
    Cell Significance Index: -9.5200
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.7574
    Cell Significance Index: -4.1300
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.7651
    Cell Significance Index: -9.6100
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.7653
    Cell Significance Index: -9.5600
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: -0.7705
    Cell Significance Index: -5.9200
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.7724
    Cell Significance Index: -9.1700
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.7939
    Cell Significance Index: -9.2200
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.8000
    Cell Significance Index: -9.6500
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.8035
    Cell Significance Index: -10.4200
  • Cell Name: podocyte (CL0000653)
    Fold Change: -0.8073
    Cell Significance Index: -9.2600
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.8084
    Cell Significance Index: -9.1800
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.8179
    Cell Significance Index: -9.4200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.8211
    Cell Significance Index: -8.5000
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.8372
    Cell Significance Index: -7.7700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** SCGB2A2 is significantly expressed in a wide array of cell types, including oligodendrocyte precursor cells, progenitor cells, microglial cells, T cells, mammary gland epithelial cells, plasma cells, blood vessel endothelial cells, and glandular cells of the esophagus and stomach. 2. **Protein Structure:** The protein product of SCGB2A2, SG2A2_HUMAN (Mammaglobin-A), consists of a single chain of 129 amino acids, with a molecular weight of approximately 14.5 kDa. 3. **Cellular Localization:** SG2A2_HUMAN is primarily localized to the extracellular space, where it may interact with other proteins, lipids, or carbohydrates. **Pathways and Functions:** 1. **Androgen Receptor Signaling Pathway:** SCGB2A2 is implicated in the androgen receptor signaling pathway, which plays a crucial role in regulating gene expression in response to androgen hormones. This interaction suggests that SCGB2A2 may modulate the androgen receptor's activity, influencing cellular processes such as proliferation, differentiation, and survival. 2. **Cellular Homeostasis:** SCGB2A2's expression in various cell types suggests that it may play a role in maintaining cellular homeostasis, particularly in the context of immune regulation. Its presence in T cells, microglial cells, and plasma cells implies that it may influence immune cell function, development, or survival. 3. **Extracellular Matrix Interaction:** SG2A2_HUMAN's extracellular localization and potential interactions with other proteins, lipids, or carbohydrates suggest that it may participate in modulating the extracellular matrix, influencing cellular adhesion, migration, or signaling. **Clinical Significance:** 1. **Cancer Association:** SCGB2A2's overexpression has been linked to various types of cancer, including breast, prostate, and esophageal cancer. Its role in cancer progression and metastasis remains an area of active research. 2. **Immune Regulation:** SCGB2A2's involvement in immune cell function and regulation suggests that it may be a potential therapeutic target for immune-related disorders, such as autoimmune diseases or immunodeficiency conditions. 3. **Diagnostic Biomarkers:** The expression of SCGB2A2 in specific cell types or tissues may serve as a diagnostic biomarker for various diseases, including cancer or immune-related disorders. In conclusion, SCGB2A2, or mammaglobin-A, is a multifaceted gene with diverse expression patterns and potential roles in immune regulation, cellular homeostasis, and extracellular matrix interaction. Further research is necessary to elucidate the functional significance of SCGB2A2 and its potential applications in cancer, immune-related disorders, and diagnostics.

Genular Protein ID: 1776726370

Symbol: SG2A2_HUMAN

Name: Mammaglobin-A

UniProtKB Accession Codes:

Q13296 A1A522 Q86WH8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8631025

Title: Mammaglobin, a mammary-specific member of the uteroglobin gene family, is overexpressed in human breast cancer.

PubMed ID: 8631025

PubMed ID: 9488047

Title: Structure and transcriptional regulation of the human mammaglobin gene, a breast cancer associated member of the uteroglobin gene family localized to chromosome 11q13.

PubMed ID: 9488047

DOI: 10.1038/sj.onc.1201597

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 93
  • Mass: 10499
  • Checksum: 2896E8C43BF053E2
  • Sequence:
    • MKLLMVLMLA ALSQHCYAGS GCPLLENVIS KTINPQVSKT EYKELLQEFI DDNATTNAID 
ELKECFLNQT DETLSNVEVF MQLIYDSSLC DLF

Genular Protein ID: 4233539909

Symbol: Q6NX70_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6NX70

Database IDs:

ARBA 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 GO 1 GeneTree 1 HGNC 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

Sequence Information:

  • Length: 120
  • Mass: 13289
  • Checksum: 4A37A6296CE9039B
  • Sequence:
    • MKLLMVLMLA ALSQHCYAGS GCPLLENVIS KTINPQVSKT EYKELLQEFI DDNATTNAID 
ELKECFLNQT DETLSNVEVF MVISFSSYKL FKSPDQGQVG SSFLTDNAKA TSEQAFSYIG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.