Details for: SCGB2A2

Gene ID: 4250

Symbol: SCGB2A2

Ensembl ID: ENSG00000110484

Description: secretoglobin family 2A member 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.69
    Marker Score: 8273
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 4.71
    Marker Score: 30343
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.76
    Marker Score: 6839
  • Cell Name: T cell (CL0000084)
    Fold Change: 2.12
    Marker Score: 3661
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.03
    Marker Score: 722
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.96
    Marker Score: 2184
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 1.95
    Marker Score: 1967
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.63
    Marker Score: 516
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.49
    Marker Score: 3666
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 1.28
    Marker Score: 709
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.27
    Marker Score: 2256
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.25
    Marker Score: 1189
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7693
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 1.04
    Marker Score: 713
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71819
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48047
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.99
    Marker Score: 655
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5347
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.93
    Marker Score: 1582
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.93
    Marker Score: 3569
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.89
    Marker Score: 1447
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.86
    Marker Score: 499
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 713
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 403
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.74
    Marker Score: 1193.5
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.67
    Marker Score: 383
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.66
    Marker Score: 529
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.66
    Marker Score: 852
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.62
    Marker Score: 856
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.58
    Marker Score: 560
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.52
    Marker Score: 305
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.48
    Marker Score: 255
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 283
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.47
    Marker Score: 267.5
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 0.41
    Marker Score: 125
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.38
    Marker Score: 6142
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.38
    Marker Score: 340
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.35
    Marker Score: 656
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.29
    Marker Score: 1403
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.26
    Marker Score: 107
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.25
    Marker Score: 503
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.19
    Marker Score: 3019
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.18
    Marker Score: 1989
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.16
    Marker Score: 337
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.16
    Marker Score: 95
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.16
    Marker Score: 97
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.15
    Marker Score: 67
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.15
    Marker Score: 47
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.15
    Marker Score: 231
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.14
    Marker Score: 498
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.14
    Marker Score: 74
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.14
    Marker Score: 851
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.14
    Marker Score: 150
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.12
    Marker Score: 29.5
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.12
    Marker Score: 31
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.11
    Marker Score: 52
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.11
    Marker Score: 28.5
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.1
    Marker Score: 29.5
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.1
    Marker Score: 122
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.1
    Marker Score: 35
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.1
    Marker Score: 31.5
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.1
    Marker Score: 32.5
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.09
    Marker Score: 184
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.09
    Marker Score: 32.5
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.09
    Marker Score: 20.5
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.09
    Marker Score: 31.5
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.08
    Marker Score: 26
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.08
    Marker Score: 2751.5
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.08
    Marker Score: 102
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.08
    Marker Score: 17.5
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.08
    Marker Score: 31.5
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.08
    Marker Score: 40
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.08
    Marker Score: 2603
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.07
    Marker Score: 25.5
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.07
    Marker Score: 17.5
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.07
    Marker Score: 46.5
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.07
    Marker Score: 31
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.07
    Marker Score: 32
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.06
    Marker Score: 51
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.06
    Marker Score: 31.5
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.06
    Marker Score: 20.5
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.06
    Marker Score: 73
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.06
    Marker Score: 28.5
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.05
    Marker Score: 23.5
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.05
    Marker Score: 32
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.05
    Marker Score: 123
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.05
    Marker Score: 34
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.05
    Marker Score: 31.5
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.05
    Marker Score: 29.5
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.05
    Marker Score: 30.5
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.05
    Marker Score: 32
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.05
    Marker Score: 48
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.05
    Marker Score: 106
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 0.05
    Marker Score: 18.5
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.05
    Marker Score: 47
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.05
    Marker Score: 29

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Other Information

**Key characteristics** * SCGB2A2 is a transmembrane protein with a molecular weight of approximately 140 kDa. * It is a glycoprotein that is expressed in the nucleus, cytoplasm, and cell membrane. * It is a member of the immunoglobulin superfamily. * It is involved in the regulation of the androgen receptor signaling pathway. **Pathways and functions** * SCGB2A2 is a key regulator of the androgen receptor signaling pathway. * It is a ligand for the androgen receptor, which is a receptor for testosterone. * When testosterone binds to the androgen receptor, it activates SCGB2A2. * This activation leads to the inhibition of the androgen receptor signaling pathway, which results in the inhibition of testosterone-induced gene expression. * SCGB2A2 is therefore a negative regulator of the androgen receptor signaling pathway. **Clinical significance** SCGB2A2 is a potential therapeutic target for a variety of diseases, including prostate cancer, breast cancer, and infertility. Studies have shown that SCGB2A2 inhibitors can inhibit the growth of cancer cells and promote the regression of tumors. **Additional information** * SCGB2A2 is a highly conserved protein. It is found in mammals, birds, and reptiles. * It is expressed in high levels in the blood, particularly in response to inflammation. * It is also expressed in the testes, where it is produced by Leydig cells. * It is a polymorphic protein that can be expressed in different isoforms.

Genular Protein ID: 1776726370

Symbol: SG2A2_HUMAN

Name: Mammaglobin-A

UniProtKB Accession Codes:

Q13296 A1A522 Q86WH8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8631025

Title: Mammaglobin, a mammary-specific member of the uteroglobin gene family, is overexpressed in human breast cancer.

PubMed ID: 8631025

PubMed ID: 9488047

Title: Structure and transcriptional regulation of the human mammaglobin gene, a breast cancer associated member of the uteroglobin gene family localized to chromosome 11q13.

PubMed ID: 9488047

DOI: 10.1038/sj.onc.1201597

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 93
  • Mass: 10499
  • Checksum: 2896E8C43BF053E2
  • Sequence:
    • MKLLMVLMLA ALSQHCYAGS GCPLLENVIS KTINPQVSKT EYKELLQEFI DDNATTNAID 
ELKECFLNQT DETLSNVEVF MQLIYDSSLC DLF

Genular Protein ID: 4233539909

Symbol: Q6NX70_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6NX70

Database IDs:

ARBA 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 Ensembl 2 GO 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 2 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

Sequence Information:

  • Length: 120
  • Mass: 13289
  • Checksum: 4A37A6296CE9039B
  • Sequence:
    • MKLLMVLMLA ALSQHCYAGS GCPLLENVIS KTINPQVSKT EYKELLQEFI DDNATTNAID 
ELKECFLNQT DETLSNVEVF MVISFSSYKL FKSPDQGQVG SSFLTDNAKA TSEQAFSYIG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.