Details for: CL1000692

Cell ID: CL1000692

Cell Name: kidney interstitial fibroblast

Marker Score Threshold: 1924
(Derived using integrated single-cell and genomic data)

Description: A fibroblast that is part of an interstitial compartment of a kidney.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 4.07
    Ensembl ID: ENSG00000163697
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 3.97
    Ensembl ID: ENSG00000151914
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 3.63
    Ensembl ID: ENSG00000142599
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 3.06
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3
    Ensembl ID: ENSG00000075624
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 2.94
    Ensembl ID: ENSG00000204217
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 2.85
    Ensembl ID: ENSG00000085224
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.77
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 2.76
    Ensembl ID: ENSG00000130402
  • Gene Symbol: BRAF (ENSG00000157764)
    Fold Change: 2.54
    Ensembl ID: ENSG00000157764
  • Gene Symbol: A2M (ENSG00000175899)
    Fold Change: 2.52
    Ensembl ID: ENSG00000175899
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 2.51
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 2.51
    Ensembl ID: ENSG00000143153
  • Gene Symbol: ACACA (ENSG00000278540)
    Fold Change: 2.46
    Ensembl ID: ENSG00000278540
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 2.45
    Ensembl ID: ENSG00000170634
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 2.45
    Ensembl ID: ENSG00000100852
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.38
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 2.34
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 2.34
    Ensembl ID: ENSG00000151150
  • Gene Symbol: BMPR1B (ENSG00000138696)
    Fold Change: 2.27
    Ensembl ID: ENSG00000138696
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 2.23
    Ensembl ID: ENSG00000072110
  • Gene Symbol: BMPR1A (ENSG00000107779)
    Fold Change: 2.21
    Ensembl ID: ENSG00000107779
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 2.14
    Ensembl ID: ENSG00000156110
  • Gene Symbol: ANGPT1 (ENSG00000154188)
    Fold Change: 2.13
    Ensembl ID: ENSG00000154188
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 2.09
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.07
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 2.05
    Ensembl ID: ENSG00000140836
  • Gene Symbol: ABL1 (ENSG00000097007)
    Fold Change: 1.97
    Ensembl ID: ENSG00000097007
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.92
    Ensembl ID: ENSG00000149311
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.92
    Ensembl ID: ENSG00000137845
  • Gene Symbol: C1S (ENSG00000182326)
    Fold Change: 1.9
    Ensembl ID: ENSG00000182326
  • Gene Symbol: ARHGAP6 (ENSG00000047648)
    Fold Change: 1.88
    Ensembl ID: ENSG00000047648
  • Gene Symbol: BICD1 (ENSG00000151746)
    Fold Change: 1.82
    Ensembl ID: ENSG00000151746
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.78
    Ensembl ID: ENSG00000174437
  • Gene Symbol: BACH1 (ENSG00000156273)
    Fold Change: 1.77
    Ensembl ID: ENSG00000156273
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.76
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ADH1B (ENSG00000196616)
    Fold Change: 1.74
    Ensembl ID: ENSG00000196616
  • Gene Symbol: KLF9 (ENSG00000119138)
    Fold Change: 1.73
    Ensembl ID: ENSG00000119138
  • Gene Symbol: ACACB (ENSG00000076555)
    Fold Change: 1.71
    Ensembl ID: ENSG00000076555
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.7
    Ensembl ID: ENSG00000198363
  • Gene Symbol: AUH (ENSG00000148090)
    Fold Change: 1.65
    Ensembl ID: ENSG00000148090
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.62
    Ensembl ID: ENSG00000196975
  • Gene Symbol: JAG1 (ENSG00000101384)
    Fold Change: 1.61
    Ensembl ID: ENSG00000101384
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.58
    Ensembl ID: ENSG00000070961
  • Gene Symbol: AEBP1 (ENSG00000106624)
    Fold Change: 1.58
    Ensembl ID: ENSG00000106624
  • Gene Symbol: ABL2 (ENSG00000143322)
    Fold Change: 1.58
    Ensembl ID: ENSG00000143322
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.57
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ABCA1 (ENSG00000165029)
    Fold Change: 1.56
    Ensembl ID: ENSG00000165029
  • Gene Symbol: ADARB1 (ENSG00000197381)
    Fold Change: 1.53
    Ensembl ID: ENSG00000197381
  • Gene Symbol: AQP2 (ENSG00000167580)
    Fold Change: 1.53
    Ensembl ID: ENSG00000167580
  • Gene Symbol: ATR (ENSG00000175054)
    Fold Change: 1.52
    Ensembl ID: ENSG00000175054
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.52
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ADCY9 (ENSG00000162104)
    Fold Change: 1.52
    Ensembl ID: ENSG00000162104
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.5
    Ensembl ID: ENSG00000182718
  • Gene Symbol: BGN (ENSG00000182492)
    Fold Change: 1.5
    Ensembl ID: ENSG00000182492
  • Gene Symbol: BCL6 (ENSG00000113916)
    Fold Change: 1.49
    Ensembl ID: ENSG00000113916
  • Gene Symbol: ACTA2 (ENSG00000107796)
    Fold Change: 1.46
    Ensembl ID: ENSG00000107796
  • Gene Symbol: ALDH7A1 (ENSG00000164904)
    Fold Change: 1.44
    Ensembl ID: ENSG00000164904
  • Gene Symbol: GRK3 (ENSG00000100077)
    Fold Change: 1.43
    Ensembl ID: ENSG00000100077
  • Gene Symbol: ACVR2A (ENSG00000121989)
    Fold Change: 1.42
    Ensembl ID: ENSG00000121989
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.42
    Ensembl ID: ENSG00000006125
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.41
    Ensembl ID: ENSG00000152518
  • Gene Symbol: BCKDHB (ENSG00000083123)
    Fold Change: 1.41
    Ensembl ID: ENSG00000083123
  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 1.37
    Ensembl ID: ENSG00000145362
  • Gene Symbol: C1R (ENSG00000159403)
    Fold Change: 1.35
    Ensembl ID: ENSG00000159403
  • Gene Symbol: XIAP (ENSG00000101966)
    Fold Change: 1.35
    Ensembl ID: ENSG00000101966
  • Gene Symbol: BCL2L1 (ENSG00000171552)
    Fold Change: 1.33
    Ensembl ID: ENSG00000171552
  • Gene Symbol: ARRB1 (ENSG00000137486)
    Fold Change: 1.31
    Ensembl ID: ENSG00000137486
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.31
    Ensembl ID: ENSG00000104964
  • Gene Symbol: BCL2 (ENSG00000171791)
    Fold Change: 1.31
    Ensembl ID: ENSG00000171791
  • Gene Symbol: AP1G1 (ENSG00000166747)
    Fold Change: 1.3
    Ensembl ID: ENSG00000166747
  • Gene Symbol: AP2A2 (ENSG00000183020)
    Fold Change: 1.3
    Ensembl ID: ENSG00000183020
  • Gene Symbol: ARNT (ENSG00000143437)
    Fold Change: 1.29
    Ensembl ID: ENSG00000143437
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.28
    Ensembl ID: ENSG00000122359
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.27
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.25
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.25
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ACVR1 (ENSG00000115170)
    Fold Change: 1.23
    Ensembl ID: ENSG00000115170
  • Gene Symbol: AKR1B1 (ENSG00000085662)
    Fold Change: 1.22
    Ensembl ID: ENSG00000085662
  • Gene Symbol: ADCY3 (ENSG00000138031)
    Fold Change: 1.2
    Ensembl ID: ENSG00000138031
  • Gene Symbol: APBA1 (ENSG00000107282)
    Fold Change: 1.19
    Ensembl ID: ENSG00000107282
  • Gene Symbol: SERPING1 (ENSG00000149131)
    Fold Change: 1.19
    Ensembl ID: ENSG00000149131
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.18
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ACO1 (ENSG00000122729)
    Fold Change: 1.18
    Ensembl ID: ENSG00000122729
  • Gene Symbol: ALDH1A1 (ENSG00000165092)
    Fold Change: 1.17
    Ensembl ID: ENSG00000165092
  • Gene Symbol: ADCY5 (ENSG00000173175)
    Fold Change: 1.17
    Ensembl ID: ENSG00000173175
  • Gene Symbol: APC (ENSG00000134982)
    Fold Change: 1.16
    Ensembl ID: ENSG00000134982
  • Gene Symbol: ATP6V0A1 (ENSG00000033627)
    Fold Change: 1.16
    Ensembl ID: ENSG00000033627
  • Gene Symbol: AXL (ENSG00000167601)
    Fold Change: 1.12
    Ensembl ID: ENSG00000167601
  • Gene Symbol: ATP6V1A (ENSG00000114573)
    Fold Change: 1.12
    Ensembl ID: ENSG00000114573
  • Gene Symbol: SHROOM2 (ENSG00000146950)
    Fold Change: 1.1
    Ensembl ID: ENSG00000146950
  • Gene Symbol: ABR (ENSG00000159842)
    Fold Change: 1.1
    Ensembl ID: ENSG00000159842
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.09
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ATP2B4 (ENSG00000058668)
    Fold Change: 1.06
    Ensembl ID: ENSG00000058668
  • Gene Symbol: ACVR1B (ENSG00000135503)
    Fold Change: 1.05
    Ensembl ID: ENSG00000135503
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1.04
    Ensembl ID: ENSG00000135390
  • Gene Symbol: PARP4 (ENSG00000102699)
    Fold Change: 1.02
    Ensembl ID: ENSG00000102699
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.01
    Ensembl ID: ENSG00000197043
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.01
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ADGRB3 (ENSG00000135298)
    Fold Change: 1
    Ensembl ID: ENSG00000135298
Hovered Details

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Hovered Details

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**Key Characteristics** * **Cell Type**: Kidney interstitial fibroblast * **Location**: Interstitial compartment of the kidney * **Gene Expression Profile**: Complex, with multiple genes involved in different pathways, including: + Amyloid-beta binding (APBB2) + Axon guidance (DST) + Regulation of transcription by RNA polymerase II (RERE) + Other genes involved in cell signaling, growth cone formation, and extracellular matrix organization * **Cellular Processes**: Involvement in various cellular processes, including: + Cell signaling + Growth cone formation + Regulation of extracellular matrix organization + Pathogenesis of various diseases, including those related to kidney function and neurodegenerative disorders **Clinical Significance** The kidney interstitial fibroblast plays a crucial role in maintaining kidney function and regulating extracellular matrix organization. Dysregulation of this cell type has been implicated in various kidney diseases, including chronic kidney disease, fibrosis, and amyloidosis. Additionally, the cell's involvement in neurodegenerative disorders, such as Alzheimer's disease, highlights its potential role in the pathogenesis of these conditions. Further research is needed to fully understand the role of the kidney interstitial fibroblast in disease and to develop targeted therapies. **Pathways and Ontologies** The kidney interstitial fibroblast is involved in various pathways, including: * Amyloid-beta binding (APBB2) * Axon guidance (DST) * Regulation of transcription by RNA polymerase II (RERE) * Cell signaling * Growth cone formation * Regulation of extracellular matrix organization * Neurodegenerative diseases (APP) * Kidney function and disease ( DST, RERE, APBB2) The cell's ontology includes: * Actin binding * Assembly of collagen fibrils and other multimeric structures * Basal plasma membrane * Basement membrane * Calcium ion binding * Cell-cell communication * Cell adhesion * Cell cortex * Cell junction organization * Cell leading edge * Cell motility * Collagen formation * Cytoplasm * Cytoplasmic vesicle * Cytoskeleton organization * Cytosol * Endoplasmic reticulum membrane * Extracellular matrix organization * Focal adhesion * Hemidesmosome * Hemidesmosome assembly * H zone * Integrin-mediated signaling pathway * Integrin binding * Intermediate filament * Intermediate filament cytoskeleton organization * Maintenance of cell polarity * Membrane * Microtubule binding * Microtubule cytoskeleton * Microtubule plus-end * Microtubule plus-end binding * Nuclear envelope * Nucleoplasm * Nucleus * Protein binding * Response to wounding * Retrograde axonal transport * Rho GTPase cycle * Rhou GTPase cycle * Rnd1 GTPase cycle * Rnd2 GTPase cycle * Rnd3 GTPase cycle * Signaling by rho GTPases * Signaling by rho GTPases, miro GTPases, and rhobtb3 * Signal transduction * Stress fiber * Structural molecule activity * Type I hemidesmosome assembly * Wound healing * Z disc