Details for: NR4A1

Gene ID: 3164

Symbol: NR4A1

Ensembl ID: ENSG00000123358

Description: nuclear receptor subfamily 4 group A member 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.78
    Marker Score: 94470.5
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.78
    Marker Score: 2965
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.65
    Marker Score: 2256
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 2.61
    Marker Score: 1064
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.53
    Marker Score: 5758.5
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.49
    Marker Score: 943
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 2.43
    Marker Score: 3160
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.41
    Marker Score: 4206
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.2
    Marker Score: 3234
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 2.18
    Marker Score: 1872
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.08
    Marker Score: 656
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 2.07
    Marker Score: 966
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.07
    Marker Score: 2366
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.02
    Marker Score: 4585.5
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.02
    Marker Score: 1932
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.01
    Marker Score: 1438
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.99
    Marker Score: 675
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 1.97
    Marker Score: 1677
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.96
    Marker Score: 7255
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.96
    Marker Score: 486
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.95
    Marker Score: 611
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1.94
    Marker Score: 835
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.94
    Marker Score: 8367
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.93
    Marker Score: 558
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.92
    Marker Score: 1915
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.91
    Marker Score: 5289
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.9
    Marker Score: 7931.5
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.89
    Marker Score: 788.5
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.88
    Marker Score: 1471.5
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.88
    Marker Score: 4117.5
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.86
    Marker Score: 2954
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.83
    Marker Score: 1770
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 1.83
    Marker Score: 420.5
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.82
    Marker Score: 2989.5
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.81
    Marker Score: 661
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.77
    Marker Score: 1162
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.75
    Marker Score: 2050
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.75
    Marker Score: 4222
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.75
    Marker Score: 10365
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 1.71
    Marker Score: 771
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.67
    Marker Score: 3144
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.67
    Marker Score: 4367
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.66
    Marker Score: 10806
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.64
    Marker Score: 1642
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.64
    Marker Score: 470
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.61
    Marker Score: 1696
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.6
    Marker Score: 4151
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 1.6
    Marker Score: 453
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.59
    Marker Score: 1861
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.59
    Marker Score: 8377
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 1.56
    Marker Score: 646
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.56
    Marker Score: 537
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.54
    Marker Score: 1188
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.53
    Marker Score: 3884
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.52
    Marker Score: 752
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.51
    Marker Score: 486
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.5
    Marker Score: 381.5
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.48
    Marker Score: 4027
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 1.47
    Marker Score: 342
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 1.47
    Marker Score: 1023
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.46
    Marker Score: 588
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.45
    Marker Score: 753
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.45
    Marker Score: 166160
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.44
    Marker Score: 332
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.44
    Marker Score: 2086
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.43
    Marker Score: 2849
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.42
    Marker Score: 827
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.42
    Marker Score: 349.5
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.41
    Marker Score: 525
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.4
    Marker Score: 15734
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.39
    Marker Score: 24741
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.39
    Marker Score: 13941
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.38
    Marker Score: 2527
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 1.38
    Marker Score: 864
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.38
    Marker Score: 709
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.37
    Marker Score: 1226
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.37
    Marker Score: 1230
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 1.35
    Marker Score: 569
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.35
    Marker Score: 2079
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.35
    Marker Score: 1871.5
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.34
    Marker Score: 333
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.34
    Marker Score: 943
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 1.34
    Marker Score: 613
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 1.33
    Marker Score: 1011
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.33
    Marker Score: 333
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.32
    Marker Score: 1635.5
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.31
    Marker Score: 334
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.31
    Marker Score: 760
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.3
    Marker Score: 1243
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 1.3
    Marker Score: 891
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 1.3
    Marker Score: 745
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.3
    Marker Score: 20280
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.28
    Marker Score: 1411
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.27
    Marker Score: 724
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.27
    Marker Score: 1795
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 1.26
    Marker Score: 287
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.26
    Marker Score: 7684
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.26
    Marker Score: 8206
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 1.26
    Marker Score: 273
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.25
    Marker Score: 2939

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Other Information

**Key characteristics:** * NR4A1 is a transcription factor that is highly expressed in the nucleus. * It is a key regulator of cell growth, differentiation, and survival. * NR4A1 is involved in the regulation of a variety of cellular processes, including cell cycle progression, apoptosis, and inflammation. * It is a key regulator of tumor growth and metastasis. **Pathways and functions:** * NR4A1 is a key regulator of cell growth and differentiation. * It is involved in the regulation of epithelial-mesenchymal transition (EMT), a process that allows epithelial cells to lose their epithelial characteristics and acquire mesenchymal characteristics. * NR4A1 is also involved in the regulation of cell survival, proliferation, and apoptosis. * It is a key regulator of tumor growth and metastasis. **Clinical significance:** * NR4A1 is a potential target for cancer therapy. * Inhibition of NR4A1 has been shown to inhibit tumor growth and metastasis in preclinical models. * NR4A1 is a promising target for the treatment of cancer. **Additional information:** * NR4A1 is a member of the NR4A family of nuclear receptors, which are a large family of transcription factors that are involved in a variety of cellular processes. * NR4A1 is a highly conserved protein that is found in mammals. * NR4A1 is a well-studied protein that has been extensively characterized in both animal models and humans.

Genular Protein ID: 3090185347

Symbol: NR4A1_HUMAN

Name: Nuclear receptor subfamily 4immunitygroup A member 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2283997

Title: A human early response gene homologous to murine nur77 and rat NGFI-B, and related to the nuclear receptor superfamily.

PubMed ID: 2283997

DOI: 10.1210/mend-4-10-1438

PubMed ID: 2626032

Title: Isolation and characterization of human TR3 receptor: a member of steroid receptor superfamily.

PubMed ID: 2626032

DOI: 10.1016/0022-4731(89)90114-3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1651101

Title: Phorbol ester, forskolin, and serum induction of a human colon nuclear hormone receptor gene related to the NUR 77/NGFI-B genes.

PubMed ID: 1651101

PubMed ID: 8121493

Title: Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomas.

PubMed ID: 8121493

DOI: 10.1038/367277a0

PubMed ID: 9315652

Title: Novel dimeric Nur77 signaling mechanism in endocrine and lymphoid cells.

PubMed ID: 9315652

DOI: 10.1128/mcb.17.10.5946

PubMed ID: 15509776

Title: Retinoid X receptor regulates Nur77/TR3-dependent apoptosis [corrected] by modulating its nuclear export and mitochondrial targeting.

PubMed ID: 15509776

DOI: 10.1128/mcb.24.22.9705-9725.2004

PubMed ID: 15466594

Title: Negative cross-talk between the human orphan nuclear receptor Nur77/NAK-1/TR3 and nuclear factor-kappaB.

PubMed ID: 15466594

DOI: 10.1093/nar/gkh856

PubMed ID: 15459248

Title: CR6-interacting factor 1 interacts with orphan nuclear receptor Nur77 and inhibits its transactivation.

PubMed ID: 15459248

DOI: 10.1210/me.2004-0107

PubMed ID: 17360704

Title: RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation.

PubMed ID: 17360704

DOI: 10.1074/jbc.m700906200

PubMed ID: 17761950

Title: Orphan receptor TR3 attenuates the p300-induced acetylation of retinoid X receptor-alpha.

PubMed ID: 17761950

DOI: 10.1210/me.2007-0107

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18690216

Title: Cytosporone B is an agonist for nuclear orphan receptor Nur77.

PubMed ID: 18690216

DOI: 10.1038/nchembio.106

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20438716

Title: Regulation of Nur77 protein turnover through acetylation and deacetylation induced by p300 and HDAC1.

PubMed ID: 20438716

DOI: 10.1016/j.bcp.2010.04.026

PubMed ID: 22427340

Title: The interferon stimulated gene 12 inactivates vasculoprotective functions of NR4A nuclear receptors.

PubMed ID: 22427340

DOI: 10.1161/circresaha.111.258814

PubMed ID: 37001519

Title: The orphan receptor Nur77 binds cytoplasmic LPS to activate the non-canonical NLRP3 inflammasome.

PubMed ID: 37001519

DOI: 10.1016/j.immuni.2023.03.003

PubMed ID: 22983157

Title: The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK.

PubMed ID: 22983157

DOI: 10.1038/nchembio.1069

Sequence Information:

  • Length: 598
  • Mass: 64463
  • Checksum: 41DAAEA7C25FDA22
  • Sequence:
  • MPCIQAQYGT PAPSPGPRDH LASDPLTPEF IKPTMDLASP EAAPAAPTAL PSFSTFMDGY 
    TGEFDTFLYQ LPGTVQPCSS ASSSASSTSS SSATSPASAS FKFEDFQVYG CYPGPLSGPV 
    DEALSSSGSD YYGSPCSAPS PSTPSFQPPQ LSPWDGSFGH FSPSQTYEGL RAWTEQLPKA 
    SGPPQPPAFF SFSPPTGPSP SLAQSPLKLF PSQATHQLGE GESYSMPTAF PGLAPTSPHL 
    EGSGILDTPV TSTKARSGAP GGSEGRCAVC GDNASCQHYG VRTCEGCKGF FKRTVQKNAK 
    YICLANKDCP VDKRRRNRCQ FCRFQKCLAV GMVKEVVRTD SLKGRRGRLP SKPKQPPDAS 
    PANLLTSLVR AHLDSGPSTA KLDYSKFQEL VLPHFGKEDA GDVQQFYDLL SGSLEVIRKW 
    AEKIPGFAEL SPADQDLLLE SAFLELFILR LAYRSKPGEG KLIFCSGLVL HRLQCARGFG 
    DWIDSILAFS RSLHSLLVDV PAFACLSALV LITDRHGLQE PRRVEELQNR IASCLKEHVA 
    AVAGEPQPAS CLSRLLGKLP ELRTLCTQGL QRIFYLKLED LVPPPPIIDK IFMDTLPF

Genular Protein ID: 499753470

Symbol: Q6ZMM6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 652
  • Mass: 70421
  • Checksum: 0FA4496BD672D73C
  • Sequence:
  • MTSAQYKIKI LIEGLHHGQR PGPAPPRQPG SFCWALKADG IMWLAKACWS IQSEMPCIQA 
    QYGTPAPSPG PRDHLASDPL TPEFIKPTMD LASPEAAPAA PTALPSFSTF MDGYTGEFDT 
    FLYQLPGTVQ PCSSASSSAS STSSSSATSP ASASFKFEDF QVYGCYPGPL SGPVDEALSS 
    SGSDYYGSPC SAPSPSTPSF QPPQLSPWDG SFGHFSPSQT YEGLRAWTEQ LPKASGPPQP 
    PAFFSFSPPT GPSPSLAQSP LKLFPSQATH QLGEGESYSM PTAFPGLAPT SPHLEGSGIL 
    DTPVTSTKAR SGAPGGSEGR CAVCGDNASC QHYGVRTCEG CKGFFKRTVQ KNAKYICLAN 
    KDCPVDKRRR NRCQFCRFQK CLAVGMVKEV VRTDSLKGRR GRLPSKPKQP PDASPANLLT 
    SLVRAHLDSG PSTAKLDYSK FQELVLPHFG KEDAGDVQQF YDLLSGSLEV IRKWAEKIPG 
    FAELSPADQD LLLESAFLEL FILRLAYRSK PGEGKLIFCS GLVLHRLQCA RGFGDRIDSI 
    LAFSRSLHSL LVDVPAFACL SALVLITDRH GLQEPRRVEE LQNRIASCLK EHVAAVAGEP 
    QPASCLSRLL GKLPELRTLC TQGLQRIFYL KLEDLVPPPP IIDKIFMDTL PF

Genular Protein ID: 1707725433

Symbol: F5GXF0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

Sequence Information:

  • Length: 652
  • Mass: 70451
  • Checksum: FFA44C6BD5A9BC51
  • Sequence:
  • MTSAQYKIKI LIEGLHHGQR PGPAPPRQPG SFCWALKADG IMWLAKACWS IQSEMPCIQA 
    QYGTPAPSPG PRDHLASDPL TPEFIKPTMD LASPEAAPAA PTALPSFSTF MDGYTGEFDT 
    FLYQLPGTVQ PCSSASSSAS STSSSSATSP ASASFKFEDF QVYGCYPGPL SGPVDEALSS 
    SGSDYYGSPC SAPSPSTPSF QPPQLSPWDG SFGHFSPSQT YEGLRAWTEQ LPKASGPPQP 
    PAFFSFSPPT GPSPSLAQSP LKLFPSQATH QLGEGESYSM PTAFPGLAPT SPHLEGSGIL 
    DTPVTSTKAR SGAPGGSEGR CAVCGDNASC QHYGVRTCEG CKGFFKRTVQ KNAKYICLAN 
    KDCPVDKRRR NRCQFCRFQK CLAVGMVKEV VRTDSLKGRR GRLPSKPKQP PDASPANLLT 
    SLVRAHLDSG PSTAKLDYSK FQELVLPHFG KEDAGDVQQF YDLLSGSLEV IRKWAEKIPG 
    FAELSPADQD LLLESAFLEL FILRLAYRSK PGEGKLIFCS GLVLHRLQCA RGFGDWIDSI 
    LAFSRSLHSL LVDVPAFACL SALVLITDRH GLQEPRRVEE LQNRIASCLK EHVAAVAGEP 
    QPASCLSRLL GKLPELRTLC TQGLQRIFYL KLEDLVPPPP IIDKIFMDTL PF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.