Details for: HSPA2

Gene ID: 3306

Symbol: HSPA2

Ensembl ID: ENSG00000126803

Description: heat shock protein family A (Hsp70) member 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 16.84
    Marker Score: 24188
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 2.17
    Marker Score: 8392
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.1
    Marker Score: 5618
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.03
    Marker Score: 768
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.85
    Marker Score: 4418
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.77
    Marker Score: 6548
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.63
    Marker Score: 1358
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.62
    Marker Score: 3988
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.49
    Marker Score: 2609
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.47
    Marker Score: 3700
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.38
    Marker Score: 1402
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.35
    Marker Score: 1434
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.23
    Marker Score: 361
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.22
    Marker Score: 5256
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.2
    Marker Score: 10376
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.17
    Marker Score: 2668
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.14
    Marker Score: 1139
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.12
    Marker Score: 12579
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 1.11
    Marker Score: 1085.5
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.09
    Marker Score: 2174
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.07
    Marker Score: 36912
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251754
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.03
    Marker Score: 1939
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.03
    Marker Score: 1688
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.01
    Marker Score: 1432
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.01
    Marker Score: 7497
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71772
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47996
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30404
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.95
    Marker Score: 250
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 489
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2406
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 444
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2723
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 314
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4960
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5266
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.86
    Marker Score: 423
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.83
    Marker Score: 12993
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.81
    Marker Score: 255
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.81
    Marker Score: 1697
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.81
    Marker Score: 416
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.81
    Marker Score: 232
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.8
    Marker Score: 1157
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.8
    Marker Score: 3140
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.79
    Marker Score: 195
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.78
    Marker Score: 457
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1254
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.77
    Marker Score: 1003
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.77
    Marker Score: 1458
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.77
    Marker Score: 505
  • Cell Name: smooth muscle cell of small intestine (CL1000275)
    Fold Change: 0.75
    Marker Score: 196
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.75
    Marker Score: 240
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.74
    Marker Score: 1749
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 382
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.74
    Marker Score: 1083
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.73
    Marker Score: 575
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.72
    Marker Score: 580
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.72
    Marker Score: 547.5
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.71
    Marker Score: 1208
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.71
    Marker Score: 646
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.7
    Marker Score: 279
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.69
    Marker Score: 234
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.68
    Marker Score: 297
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.67
    Marker Score: 1580.5
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.67
    Marker Score: 724
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.66
    Marker Score: 176
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.66
    Marker Score: 815
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.66
    Marker Score: 2768
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.66
    Marker Score: 849
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.66
    Marker Score: 228
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.65
    Marker Score: 5065
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.65
    Marker Score: 183
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.64
    Marker Score: 409
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.63
    Marker Score: 452
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.63
    Marker Score: 1327
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.63
    Marker Score: 233
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.61
    Marker Score: 276
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.61
    Marker Score: 132
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.61
    Marker Score: 343
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.6
    Marker Score: 145
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.6
    Marker Score: 686
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.58
    Marker Score: 549
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.58
    Marker Score: 894
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.58
    Marker Score: 117
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.58
    Marker Score: 980.5
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.57
    Marker Score: 551
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.57
    Marker Score: 607
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.57
    Marker Score: 940
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.56
    Marker Score: 1526
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.56
    Marker Score: 179
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.55
    Marker Score: 520.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 429
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.54
    Marker Score: 494
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.54
    Marker Score: 105
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.53
    Marker Score: 139
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.51
    Marker Score: 127
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.51
    Marker Score: 212
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.51
    Marker Score: 313

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Other Information

**Key characteristics:** - HSPA2 is a large protein (110 kDa) that is expressed in all tissues tested. - It is a chaperone protein that binds to misfolded or damaged proteins and helps to refold them. - HSPA2 is also a regulator of the unfolded protein response (UPR). - It is involved in the regulation of inflammation and cell death. **Pathways and functions:** - HSPA2 is involved in the prevention of protein misfolding and aggregation. - It does this by binding to misfolded proteins and helping to refold them. - HSPA2 is also involved in the regulation of the UPR. - It is a key regulator of the heat shock response, and its overexpression can lead to the development of heat stress disorders. **Clinical significance:** - HSPA2 is a potential therapeutic target for a variety of diseases, including heat stress disorders, neurodegenerative diseases, and cancer. - Inhibitors of HSPA2 have been shown to be effective in protecting cells from damage and death. - HSPA2 is a promising target for the treatment of human diseases.

Genular Protein ID: 2397150490

Symbol: HSP72_HUMAN

Name: Heat shock-related 70 kDa protein 2

UniProtKB Accession Codes:

P54652 Q15508 Q53XM3 Q9UE78

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 ELM 1 EMBL 7 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 36 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 6 PIR 2 PRIDE 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 5 RefSeq 1 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7829106

Title: Cloning, sequencing, and mapping of the human chromosome 14 heat shock protein gene (HSPA2).

PubMed ID: 7829106

DOI: 10.1006/geno.1994.1462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7849706

Title: A heat shock gene at 14q22: mapping and expression.

PubMed ID: 7849706

DOI: 10.1093/hmg/3.10.1819

PubMed ID: 18529014

Title: FKBP36 forms complexes with clathrin and Hsp72 in spermatocytes.

PubMed ID: 18529014

DOI: 10.1021/bi8001506

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23921388

Title: Identification and characterization of a novel human methyltransferase modulating Hsp70 function through lysine methylation.

PubMed ID: 23921388

DOI: 10.1074/jbc.m113.483248

PubMed ID: 26865365

Title: The human HSP70 family of chaperones: where do we stand?

PubMed ID: 26865365

DOI: 10.1007/s12192-016-0676-6

PubMed ID: 20072699

Title: Crystal structures of the ATPase domains of four human Hsp70 isoforms: HSPA1L/Hsp70-hom, HSPA2/Hsp70-2, HSPA6/Hsp70B', and HSPA5/BiP/GRP78.

PubMed ID: 20072699

DOI: 10.1371/journal.pone.0008625

Sequence Information:

  • Length: 639
  • Mass: 70021
  • Checksum: 3851755494E7B729
  • Sequence:
    • MSARGPAIGI DLGTTYSCVG VFQHGKVEII ANDQGNRTTP SYVAFTDTER LIGDAAKNQV 
AMNPTNTIFD AKRLIGRKFE DATVQSDMKH WPFRVVSEGG KPKVQVEYKG ETKTFFPEEI 
SSMVLTKMKE IAEAYLGGKV HSAVITVPAY FNDSQRQATK DAGTITGLNV LRIINEPTAA 
AIAYGLDKKG CAGGEKNVLI FDLGGGTFDV SILTIEDGIF EVKSTAGDTH LGGEDFDNRM 
VSHLAEEFKR KHKKDIGPNK RAVRRLRTAC ERAKRTLSSS TQASIEIDSL YEGVDFYTSI 
TRARFEELNA DLFRGTLEPV EKALRDAKLD KGQIQEIVLV GGSTRIPKIQ KLLQDFFNGK 
ELNKSINPDE AVAYGAAVQA AILIGDKSEN VQDLLLLDVT PLSLGIETAG GVMTPLIKRN 
TTIPTKQTQT FTTYSDNQSS VLVQVYEGER AMTKDNNLLG KFDLTGIPPA PRGVPQIEVT 
FDIDANGILN VTAADKSTGK ENKITITNDK GRLSKDDIDR MVQEAERYKS EDEANRDRVA 
AKNALESYTY NIKQTVEDEK LRGKISEQDK NKILDKCQEV INWLDRNQMA EKDEYEHKQK 
ELERVCNPII SKLYQGGPGG GSGGGGSGAS GGPTIEEVD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.