Details for: HSPA2

Gene ID: 3306

Symbol: HSPA2

Ensembl ID: ENSG00000126803

Description: heat shock protein family A (Hsp70) member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 152.6887
    Cell Significance Index: -23.7500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 95.9615
    Cell Significance Index: -24.3400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 47.4241
    Cell Significance Index: -22.3900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 33.6949
    Cell Significance Index: -22.6100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 19.5952
    Cell Significance Index: -24.1600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.4663
    Cell Significance Index: -22.6800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.1555
    Cell Significance Index: -24.2900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.5609
    Cell Significance Index: -17.0800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.9530
    Cell Significance Index: 133.8500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.6666
    Cell Significance Index: 341.8400
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 2.1036
    Cell Significance Index: 22.3500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.7562
    Cell Significance Index: 50.6000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.6903
    Cell Significance Index: 25.3300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2810
    Cell Significance Index: 1156.6900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.1544
    Cell Significance Index: 25.0100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8946
    Cell Significance Index: 97.3100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.8610
    Cell Significance Index: 15.2200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8291
    Cell Significance Index: 134.8500
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.8219
    Cell Significance Index: 4.3300
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.8035
    Cell Significance Index: 6.6500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8019
    Cell Significance Index: 48.1400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7244
    Cell Significance Index: 395.6300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6834
    Cell Significance Index: 35.5000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.6083
    Cell Significance Index: 6.9100
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.5841
    Cell Significance Index: 6.3300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.5616
    Cell Significance Index: 19.7400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4884
    Cell Significance Index: 48.3100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.4220
    Cell Significance Index: 33.4200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3655
    Cell Significance Index: 17.0400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3354
    Cell Significance Index: 60.4700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.3332
    Cell Significance Index: 244.2800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.3269
    Cell Significance Index: 3.0100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3058
    Cell Significance Index: 135.2200
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.2975
    Cell Significance Index: 4.8000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2875
    Cell Significance Index: 19.8900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2669
    Cell Significance Index: 7.2700
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.2253
    Cell Significance Index: 1.4000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1943
    Cell Significance Index: 10.2000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1932
    Cell Significance Index: 23.7500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1690
    Cell Significance Index: 3.5100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1480
    Cell Significance Index: 20.3300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1414
    Cell Significance Index: 2.9600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1275
    Cell Significance Index: 1.7400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.1153
    Cell Significance Index: 33.1700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.1139
    Cell Significance Index: 2.7800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1080
    Cell Significance Index: 2.7000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0950
    Cell Significance Index: 18.0800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0912
    Cell Significance Index: 2.9200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0513
    Cell Significance Index: 0.3100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0480
    Cell Significance Index: 3.5800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0291
    Cell Significance Index: 0.6200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0268
    Cell Significance Index: 0.7500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0184
    Cell Significance Index: 0.4900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0063
    Cell Significance Index: 0.2200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.0024
    Cell Significance Index: 0.0200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0086
    Cell Significance Index: -15.8000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0104
    Cell Significance Index: -19.5200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0119
    Cell Significance Index: -18.3900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0135
    Cell Significance Index: -18.3900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0156
    Cell Significance Index: -9.8900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0169
    Cell Significance Index: -6.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0260
    Cell Significance Index: -19.2700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0291
    Cell Significance Index: -13.2200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0303
    Cell Significance Index: -22.9400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0383
    Cell Significance Index: -23.9100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0399
    Cell Significance Index: -22.5000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0409
    Cell Significance Index: -1.9200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0433
    Cell Significance Index: -5.6000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0442
    Cell Significance Index: -0.4800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0540
    Cell Significance Index: -9.2200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0575
    Cell Significance Index: -11.4200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0581
    Cell Significance Index: -6.8500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0655
    Cell Significance Index: -13.1400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0776
    Cell Significance Index: -7.9300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1135
    Cell Significance Index: -23.9000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1322
    Cell Significance Index: -19.2200
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: -0.1358
    Cell Significance Index: -0.8500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1383
    Cell Significance Index: -16.1200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1447
    Cell Significance Index: -16.5800
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.1595
    Cell Significance Index: -1.7100
  • Cell Name: theca cell (CL0000503)
    Fold Change: -0.1923
    Cell Significance Index: -1.1300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1967
    Cell Significance Index: -13.9100
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.2036
    Cell Significance Index: -2.8300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2243
    Cell Significance Index: -9.1900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2278
    Cell Significance Index: -6.5300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2280
    Cell Significance Index: -23.7400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2396
    Cell Significance Index: -6.3000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.2452
    Cell Significance Index: -4.0400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2637
    Cell Significance Index: -16.2100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2668
    Cell Significance Index: -17.2100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2750
    Cell Significance Index: -16.8600
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2767
    Cell Significance Index: -4.3900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2805
    Cell Significance Index: -6.4800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2907
    Cell Significance Index: -19.5500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2944
    Cell Significance Index: -22.6000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3242
    Cell Significance Index: -5.4300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3278
    Cell Significance Index: -16.5700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3358
    Cell Significance Index: -21.1700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4143
    Cell Significance Index: -23.2500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4457
    Cell Significance Index: -16.3600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The HSPA2 gene is characterized by its ability to encode a protein that is highly conserved across species, suggesting its importance in maintaining cellular function. The protein HSP72 has a unique structure, consisting of an N-terminal domain, a central domain, and a C-terminal domain. The central domain is the most conserved region, and it is responsible for the protein's chaperone activity. HSP72 is a member of the Hsp70 family, which includes other chaperones such as HSP70, HSP90, and GRP78. These proteins share a common structure and function, but they also exhibit distinct differences in their substrate specificity and regulatory mechanisms. **Pathways and Functions** HSPA2, through the production of HSP72, is involved in various cellular processes, including: 1. **Protein folding and refolding**: HSP72 acts as a molecular chaperone to assist in the proper folding of proteins, preventing the formation of misfolded proteins that can lead to protein aggregation and cell death. 2. **Cellular responses to stress**: HSP72 is activated in response to various forms of stress, including heat shock, oxidative stress, and viral infections. It helps to protect cells against these stresses by preventing protein misfolding and aggregation. 3. **Immune system regulation**: HSP72 has been shown to regulate the immune response by modulating the activity of immune cells, such as T cells and macrophages. 4. **Cell cycle regulation**: HSP72 has been implicated in the regulation of the cell cycle, particularly in the G2/M transition phase, where it helps to ensure proper cell division. 5. **Viral inhibition**: HSP72 has been shown to inhibit viral replication and expression, suggesting its potential as a therapeutic target in the treatment of viral infections. **Clinical Significance** HSPA2 and its encoded protein HSP72 have been implicated in various diseases and disorders, including: 1. **Neurodegenerative diseases**: HSP72 has been shown to accumulate in the brains of patients with neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, suggesting its potential as a therapeutic target. 2. **Cancer**: HSP72 has been found to be overexpressed in various types of cancer, including breast cancer and colon cancer, suggesting its potential as a diagnostic and therapeutic target. 3. **Infectious diseases**: HSPA2 has been shown to inhibit viral replication and expression, suggesting its potential as a therapeutic target in the treatment of viral infections. 4. **Spermatogenesis**: HSPA2 has been implicated in the regulation of spermatogenesis, a process that is essential for fertility. In conclusion, HSPA2 is a gene that encodes a protein that plays a crucial role in maintaining protein homeostasis and protecting cells against various forms of stress. Its dysregulation has been implicated in various diseases and disorders, highlighting its potential as a therapeutic target in the treatment of these conditions.

Genular Protein ID: 2397150490

Symbol: HSP72_HUMAN

Name: Heat shock-related 70 kDa protein 2

UniProtKB Accession Codes:

P54652 Q15508 Q53XM3 Q9UE78

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 ELM 1 EMBL 7 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 36 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIR 2 PRIDE 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 5 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7829106

Title: Cloning, sequencing, and mapping of the human chromosome 14 heat shock protein gene (HSPA2).

PubMed ID: 7829106

DOI: 10.1006/geno.1994.1462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7849706

Title: A heat shock gene at 14q22: mapping and expression.

PubMed ID: 7849706

DOI: 10.1093/hmg/3.10.1819

PubMed ID: 18529014

Title: FKBP36 forms complexes with clathrin and Hsp72 in spermatocytes.

PubMed ID: 18529014

DOI: 10.1021/bi8001506

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23921388

Title: Identification and characterization of a novel human methyltransferase modulating Hsp70 function through lysine methylation.

PubMed ID: 23921388

DOI: 10.1074/jbc.m113.483248

PubMed ID: 26865365

Title: The human HSP70 family of chaperones: where do we stand?

PubMed ID: 26865365

DOI: 10.1007/s12192-016-0676-6

PubMed ID: 20072699

Title: Crystal structures of the ATPase domains of four human Hsp70 isoforms: HSPA1L/Hsp70-hom, HSPA2/Hsp70-2, HSPA6/Hsp70B', and HSPA5/BiP/GRP78.

PubMed ID: 20072699

DOI: 10.1371/journal.pone.0008625

Sequence Information:

  • Length: 639
  • Mass: 70021
  • Checksum: 3851755494E7B729
  • Sequence:
    • MSARGPAIGI DLGTTYSCVG VFQHGKVEII ANDQGNRTTP SYVAFTDTER LIGDAAKNQV 
AMNPTNTIFD AKRLIGRKFE DATVQSDMKH WPFRVVSEGG KPKVQVEYKG ETKTFFPEEI 
SSMVLTKMKE IAEAYLGGKV HSAVITVPAY FNDSQRQATK DAGTITGLNV LRIINEPTAA 
AIAYGLDKKG CAGGEKNVLI FDLGGGTFDV SILTIEDGIF EVKSTAGDTH LGGEDFDNRM 
VSHLAEEFKR KHKKDIGPNK RAVRRLRTAC ERAKRTLSSS TQASIEIDSL YEGVDFYTSI 
TRARFEELNA DLFRGTLEPV EKALRDAKLD KGQIQEIVLV GGSTRIPKIQ KLLQDFFNGK 
ELNKSINPDE AVAYGAAVQA AILIGDKSEN VQDLLLLDVT PLSLGIETAG GVMTPLIKRN 
TTIPTKQTQT FTTYSDNQSS VLVQVYEGER AMTKDNNLLG KFDLTGIPPA PRGVPQIEVT 
FDIDANGILN VTAADKSTGK ENKITITNDK GRLSKDDIDR MVQEAERYKS EDEANRDRVA 
AKNALESYTY NIKQTVEDEK LRGKISEQDK NKILDKCQEV INWLDRNQMA EKDEYEHKQK 
ELERVCNPII SKLYQGGPGG GSGGGGSGAS GGPTIEEVD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.