Details for: HSPA1A

Gene ID: 3303

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: HSPA1A

Ensembl ID: ENSG00000204389

Description: heat shock protein family A (Hsp70) member 1A

Cell Significance Landscape

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • immature B cell CL0000816
    CSI 56.27
    rCSI 41.81%
    PRS 16.85
  • fraction A pre-pro B cell CL0002045
    CSI 40.39
    rCSI 46.24%
    PRS 23.34
  • bronchus fibroblast of lung CL2000093
    CSI 37
    rCSI 30.06%
    PRS 12.06
  • mature T cell CL0002419
    CSI 36.78
    rCSI 28.61%
    PRS 16.38
  • granulocyte monocyte progenitor cell CL0000557
    CSI 33.92
    rCSI 29.37%
    PRS 12.66
  • CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203
    CSI 32.14
    rCSI 38.95%
    PRS 15.24
  • group 3 innate lymphoid cell CL0001071
    CSI 30.87
    rCSI 23.2%
    PRS 11.77
  • memory B cell CL0000787
    CSI 30.58
    rCSI 30.2%
    PRS 43.53
  • activated CD8-positive, alpha-beta T cell, human CL0001049
    CSI 28.72
    rCSI 49.14%
    PRS 22.99
  • CD4-positive helper T cell CL0000492
    CSI 27.48
    rCSI 20.79%
    PRS 15.71
  • activated type II NK T cell CL0000931
    CSI 25.72
    rCSI 28.95%
    PRS 18.16
  • promyelocyte CL0000836
    CSI 25.27
    rCSI 36.45%
    PRS 15.82
  • skin fibroblast CL0002620
    CSI 23.73
    rCSI 20.46%
    PRS 18.51
  • promonocyte CL0000559
    CSI 23.44
    rCSI 40.16%
    PRS 15.21
  • conventional dendritic cell CL0000990
    CSI 22.96
    rCSI 19.16%
    PRS 33.54
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 22.62
    rCSI 26.12%
    PRS 10.04
  • pro-B cell CL0000826
    CSI 22.19
    rCSI 18.37%
    PRS 11.36
  • double-positive, alpha-beta thymocyte CL0000809
    CSI 21.66
    rCSI 22.07%
    PRS 16.21
  • late pro-B cell CL0002048
    CSI 21.46
    rCSI 53.77%
    PRS 33.92
  • CD8-positive, alpha-beta cytotoxic T cell CL0000794
    CSI 21.2
    rCSI 25.31%
    PRS 19.67
  • IgA plasma cell CL0000987
    CSI 20.78
    rCSI 21.28%
    PRS 21.22
  • retinal blood vessel endothelial cell CL0002585
    CSI 19.77
    rCSI 31.57%
    PRS 12.43
  • respiratory suprabasal cell CL4033048
    CSI 19.59
    rCSI 25.13%
    PRS 13.13
  • central memory CD8-positive, alpha-beta T cell CL0000907
    CSI 19.38
    rCSI 13.06%
    PRS 13.61
  • CD14-positive, CD16-positive monocyte CL0002397
    CSI 19.35
    rCSI 25.35%
    PRS 15.91
  • T-helper 17 cell CL0000899
    CSI 19.1
    rCSI 15.16%
    PRS 19.98
  • glioblast CL0000030
    CSI 17.87
    rCSI 28.5%
    PRS 9.81
  • fallopian tube secretory epithelial cell CL4030006
    CSI 17.46
    rCSI 16.81%
    PRS 11.76
  • basal cell of prostate epithelium CL0002341
    CSI 15.74
    rCSI 45.54%
    PRS 25.38
  • early lymphoid progenitor CL0000936
    CSI 14.36
    rCSI 12.61%
    PRS 12.76
  • activated CD8-positive, alpha-beta T cell CL0000906
    CSI 14.32
    rCSI 14.07%
    PRS 32.56
  • plasma cell CL0000786
    CSI 13.86
    rCSI 18.17%
    PRS 49.73
  • mucous neck cell CL0000651
    CSI 13.81
    rCSI 19.9%
    PRS 18.35
  • radial glial cell CL0000681
    CSI 13.57
    rCSI 18.86%
    PRS 11.75
  • neural crest cell CL0011012
    CSI 13.56
    rCSI 10.72%
    PRS 7.84
  • type EC enteroendocrine cell CL0000577
    CSI 13.09
    rCSI 46.46%
    PRS 18.63
  • neuroblast (sensu Vertebrata) CL0000031
    CSI 12.99
    rCSI 16.67%
    PRS 11.09
  • myofibroblast cell CL0000186
    CSI 12.71
    rCSI 17.61%
    PRS 16.38
  • multi-ciliated epithelial cell CL0005012
    CSI 12.57
    rCSI 12.54%
    PRS 9.75
  • enteroglial cell CL4040002
    CSI 12.33
    rCSI 64.82%
    PRS 21.63
  • macroglial cell CL0000126
    CSI 12.16
    rCSI 31.25%
    PRS 16.75
  • capillary endothelial cell CL0002144
    CSI 12.12
    rCSI 22.21%
    PRS 48.55
  • dendritic cell CL0000451
    CSI 12
    rCSI 14.78%
    PRS 36.25
  • CD8-positive, alpha-beta memory T cell CL0000909
    CSI 12
    rCSI 12.53%
    PRS 34.51
  • nasal mucosa goblet cell CL0002480
    CSI 11.74
    rCSI 13.62%
    PRS 16.85
  • CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792
    CSI 11.7
    rCSI 11.49%
    PRS 17.88
  • ciliated columnar cell of tracheobronchial tree CL0002145
    CSI 11.59
    rCSI 26.41%
    PRS 11.92
  • deuterosomal cell CL4033044
    CSI 11.43
    rCSI 38.65%
    PRS 19.22
  • keratinocyte CL0000312
    CSI 11.34
    rCSI 9.5%
    PRS 13.63
  • mature B cell CL0000785
    CSI 11.07
    rCSI 9.62%
    PRS 14.01
  • retina horizontal cell CL0000745
    CSI 11
    rCSI 16.77%
    PRS 10.63
  • blood vessel endothelial cell CL0000071
    CSI 10.72
    rCSI 22.24%
    PRS 11.36
  • endothelial cell of artery CL1000413
    CSI 10.64
    rCSI 15.59%
    PRS 53.84
  • alpha-beta T cell CL0000789
    CSI 10.62
    rCSI 12.44%
    PRS 15.46
  • macrophage CL0000235
    CSI 10.61
    rCSI 19.29%
    PRS 44.92
  • ciliated cell CL0000064
    CSI 10.55
    rCSI 17.09%
    PRS 11.63
  • enteric smooth muscle cell CL0002504
    CSI 10.51
    rCSI 15%
    PRS 12.82
  • IgG plasma cell CL0000985
    CSI 10.51
    rCSI 12.59%
    PRS 19.51
  • pulmonary artery endothelial cell CL1001568
    CSI 10.46
    rCSI 14.23%
    PRS 17.43
  • renal alpha-intercalated cell CL0005011
    CSI 10.26
    rCSI 13.72%
    PRS 15.18
  • precursor B cell CL0000817
    CSI 10.23
    rCSI 8.96%
    PRS 15.09
  • intrahepatic cholangiocyte CL0002538
    CSI 10.19
    rCSI 24.44%
    PRS 20.95
  • megakaryocyte-erythroid progenitor cell CL0000050
    CSI 10.06
    rCSI 9.09%
    PRS 10.04
  • CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell CL0000915
    CSI 10.06
    rCSI 45.71%
    PRS 39.67
  • fibroblast of lung CL0002553
    CSI 10.02
    rCSI 9.33%
    PRS 11.44
  • differentiation-committed oligodendrocyte precursor CL4023059
    CSI 9.9
    rCSI 17.99%
    PRS 9.41
  • serous secreting cell of bronchus submucosal gland CL4033005
    CSI 9.88
    rCSI 56.22%
    PRS 43.89
  • epithelial cell CL0000066
    CSI 9.54
    rCSI 14.66%
    PRS 16.26
  • activated CD4-positive, alpha-beta T cell CL0000896
    CSI 9.52
    rCSI 8.8%
    PRS 20.7
  • keratocyte CL0002363
    CSI 9.36
    rCSI 22.49%
    PRS 17.19
  • ependymal cell CL0000065
    CSI 9.26
    rCSI 18.79%
    PRS 4.82
  • large pre-B-II cell CL0000957
    CSI 9.23
    rCSI 26.35%
    PRS 19.69
  • common dendritic progenitor CL0001029
    CSI 9.2
    rCSI 11.55%
    PRS 14.48
  • mammary gland epithelial cell CL0002327
    CSI 9.19
    rCSI 32.24%
    PRS 20.59
  • common lymphoid progenitor CL0000051
    CSI 9.15
    rCSI 12.22%
    PRS 21.69
  • vein endothelial cell of respiratory system CL4033008
    CSI 9.14
    rCSI 62.76%
    PRS 22.37
  • Hofbauer cell CL3000001
    CSI 9.13
    rCSI 17.23%
    PRS 14.13
  • vascular associated smooth muscle cell CL0000359
    CSI 9.02
    rCSI 29.27%
    PRS 13.93
  • follicular B cell CL0000843
    CSI 8.91
    rCSI 32.4%
    PRS 44.13
  • common myeloid progenitor CL0000049
    CSI 8.85
    rCSI 7.16%
    PRS 11.21
  • melanocyte CL0000148
    CSI 8.79
    rCSI 6.51%
    PRS 10.17
  • alveolar macrophage CL0000583
    CSI 8.77
    rCSI 14.44%
    PRS 13.25
  • CD1c-positive myeloid dendritic cell CL0002399
    CSI 8.42
    rCSI 10.17%
    PRS 13.34
  • colon macrophage CL0009038
    CSI 8.38
    rCSI 38.71%
    PRS 23.87
  • microcirculation associated smooth muscle cell CL0008035
    CSI 8.23
    rCSI 23.82%
    PRS 12.89
  • tracheobronchial serous cell CL0019001
    CSI 8.16
    rCSI 35.24%
    PRS 21.84
  • Kupffer cell CL0000091
    CSI 8.11
    rCSI 18.55%
    PRS 11.01
  • adventitial cell CL0002503
    CSI 8.08
    rCSI 19.3%
    PRS 17.83
  • granulocyte CL0000094
    CSI 7.92
    rCSI 12.1%
    PRS 14.35
  • collagen secreting cell CL0000667
    CSI 7.73
    rCSI 44.36%
    PRS 42.36
  • intestinal tuft cell CL0019032
    CSI 7.73
    rCSI 11.81%
    PRS 13.1
  • myeloid leukocyte CL0000766
    CSI 7.68
    rCSI 7.09%
    PRS 11.55
  • lung resident memory CD8-positive, alpha-beta T cell CL4033039
    CSI 7.67
    rCSI 19.84%
    PRS 30.85
  • hepatic stellate cell CL0000632
    CSI 7.62
    rCSI 28.56%
    PRS 9.71
  • CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920
    CSI 7.56
    rCSI 15.08%
    PRS 18.99
  • secretory cell CL0000151
    CSI 7.53
    rCSI 7.85%
    PRS 11.68
  • memory T cell CL0000813
    CSI 7.38
    rCSI 14.22%
    PRS 25.48
  • central nervous system macrophage CL0000878
    CSI 7.11
    rCSI 23.57%
    PRS 9.91
  • type L enteroendocrine cell CL0002279
    CSI 7.07
    rCSI 13.27%
    PRS 22.54
  • mononuclear phagocyte CL0000113
    CSI 7.01
    rCSI 15.42%
    PRS 12.52
  • extravillous trophoblast CL0008036
    CSI -12.4
    rCSI -15.3%
    PRS 10.0%
  • pancreatic A cell CL0000171
    CSI -12.3
    rCSI -12.9%
    PRS 12.1%
  • cerebral cortex neuron CL0010012
    CSI -3.4
    rCSI -13.7%
    PRS 11.9%
  • periportal region hepatocyte CL0019026
    CSI -2.9
    rCSI -11.4%
    PRS 16.3%
  • peripheral nervous system neuron CL2000032
    CSI -2.9
    rCSI -3.9%
    PRS 10.2%
  • VIP GABAergic cortical interneuron CL4023016
    CSI -2.6
    rCSI -3.1%
    PRS 6.5%
  • regular ventricular cardiac myocyte CL0002131
    CSI -2.4
    rCSI -15.1%
    PRS 9.0%
  • neuroendocrine cell CL0000165
    CSI -2.1
    rCSI -7.9%
    PRS 23.7%
  • pancreatic epsilon cell CL0005019
    CSI -1.6
    rCSI -7.6%
    PRS 27.5%
  • mesenchymal stem cell of adipose tissue CL0002570
    CSI -1.5
    rCSI -8.4%
    PRS 34.1%
  • enteroendocrine cell of colon CL0009042
    CSI -1.5
    rCSI -6.9%
    PRS 30.6%
  • pancreatic stellate cell CL0002410
    CSI -0.2
    rCSI -1.0%
    PRS 17.1%
  • intestinal crypt stem cell of colon CL0009043
    CSI 0.0
    rCSI 0.2%
    PRS 21.0%
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 0.1
    rCSI 0.2%
    PRS 7.7%
  • enterocyte of epithelium of large intestine CL0002071
    CSI 0.2
    rCSI 0.8%
    PRS 20.7%
  • central nervous system neuron CL2000029
    CSI 0.2
    rCSI 1.2%
    PRS 5.7%
  • hepatic pit cell CL2000054
    CSI 0.2
    rCSI 2.6%
    PRS 60.0%
  • cytotoxic T cell CL0000910
    CSI 0.2
    rCSI 1.4%
    PRS 16.6%
  • enteroendocrine cell of small intestine CL0009006
    CSI 0.3
    rCSI 0.6%
    PRS 17.5%
  • ON-bipolar cell CL0000749
    CSI 0.3
    rCSI 0.4%
    PRS 14.0%
  • retinal ganglion cell CL0000740
    CSI 0.3
    rCSI 0.7%
    PRS 8.2%
  • corneal epithelial cell CL0000575
    CSI 0.3
    rCSI 1.0%
    PRS 20.6%
  • tissue-resident macrophage CL0000864
    CSI 0.4
    rCSI 1.6%
    PRS 24.6%
  • retinal bipolar neuron CL0000748
    CSI 0.4
    rCSI 0.8%
    PRS 8.3%
  • epithelial cell of esophagus CL0002252
    CSI 0.4
    rCSI 4.1%
    PRS 40.6%
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 0.4
    rCSI 0.6%
    PRS 6.2%
  • myeloid lineage restricted progenitor cell CL0000839
    CSI 0.5
    rCSI 2.3%
    PRS 22.4%
  • colonocyte CL1000347
    CSI 0.5
    rCSI 0.7%
    PRS 15.6%
  • kidney connecting tubule principal cell CL4030018
    CSI 0.5
    rCSI 3.6%
    PRS 65.1%
  • BEST4+ enteroycte CL4030026
    CSI 0.5
    rCSI 0.7%
    PRS 12.0%
  • pre-conventional dendritic cell CL0002010
    CSI 0.6
    rCSI 7.4%
    PRS 37.1%
  • basal cell of epidermis CL0002187
    CSI 0.6
    rCSI 1.1%
    PRS 11.5%
  • mature alpha-beta T cell CL0000791
    CSI 0.6
    rCSI 2.2%
    PRS 19.4%
  • glandular epithelial cell CL0000150
    CSI 0.6
    rCSI 1.7%
    PRS 22.3%
  • basophil CL0000767
    CSI 0.6
    rCSI 1.4%
    PRS 23.5%
  • lung neuroendocrine cell CL1000223
    CSI 0.7
    rCSI 1.0%
    PRS 13.1%
  • intestinal epithelial cell CL0002563
    CSI 0.7
    rCSI 0.7%
    PRS 12.0%
  • pancreatic PP cell CL0002275
    CSI 0.7
    rCSI 2.7%
    PRS 20.0%
  • epithelial cell of nephron CL1000449
    CSI 0.7
    rCSI 6.5%
    PRS 47.5%
  • CD14-positive, CD16-negative classical monocyte CL0002057
    CSI 0.7
    rCSI 4.3%
    PRS 25.5%
  • H1 horizontal cell CL0004217
    CSI 0.7
    rCSI 2.9%
    PRS 16.7%
  • rod bipolar cell CL0000751
    CSI 0.8
    rCSI 1.4%
    PRS 9.5%
  • kidney interstitial fibroblast CL1000692
    CSI 0.8
    rCSI 4.2%
    PRS 28.2%
  • renal intercalated cell CL0005010
    CSI 0.8
    rCSI 7.1%
    PRS 71.3%
  • Merkel cell CL0000242
    CSI 0.8
    rCSI 18.7%
    PRS 67.4%
  • helper T cell CL0000912
    CSI 0.8
    rCSI 1.2%
    PRS 16.0%
  • endothelial cell of pericentral hepatic sinusoid CL0019022
    CSI 0.8
    rCSI 2.5%
    PRS 18.2%
  • lung macrophage CL1001603
    CSI 0.8
    rCSI 1.9%
    PRS 12.9%
  • class switched memory B cell CL0000972
    CSI 0.8
    rCSI 0.6%
    PRS 19.1%
  • sst GABAergic cortical interneuron CL4023017
    CSI 0.8
    rCSI 1.1%
    PRS 7.0%
  • regular atrial cardiac myocyte CL0002129
    CSI 0.8
    rCSI 2.7%
    PRS 12.5%
  • lung goblet cell CL1000143
    CSI 0.9
    rCSI 9.5%
    PRS 37.1%
  • parietal cell CL0000162
    CSI 0.9
    rCSI 7.6%
    PRS 57.5%
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 0.9
    rCSI 1.3%
    PRS 10.7%
  • placental villous trophoblast CL2000060
    CSI 1.0
    rCSI 1.5%
    PRS 10.7%
  • intraepithelial lymphocyte CL0002496
    CSI 1.0
    rCSI 2.7%
    PRS 46.2%
  • basal cell of epithelium of trachea CL1000348
    CSI 1.0
    rCSI 7.1%
    PRS 35.1%
  • eosinophil CL0000771
    CSI 1.0
    rCSI 6.7%
    PRS 29.6%
  • OFF-bipolar cell CL0000750
    CSI 1.0
    rCSI 1.4%
    PRS 18.9%
  • M cell of gut CL0000682
    CSI 1.0
    rCSI 1.1%
    PRS 20.3%
  • neural progenitor cell CL0011020
    CSI 1.1
    rCSI 4.6%
    PRS 11.2%
  • neuroplacodal cell CL0000032
    CSI 1.1
    rCSI 9.9%
    PRS 34.9%
  • pulmonary ionocyte CL0017000
    CSI 1.1
    rCSI 1.3%
    PRS 14.4%
  • inhibitory interneuron CL0000498
    CSI 1.2
    rCSI 2.7%
    PRS 9.4%
  • interstitial cell of Cajal CL0002088
    CSI 1.2
    rCSI 1.5%
    PRS 13.2%
  • muscle cell CL0000187
    CSI 1.2
    rCSI 2.4%
    PRS 26.8%
  • Langerhans cell CL0000453
    CSI 1.2
    rCSI 1.9%
    PRS 19.9%
  • intestinal crypt stem cell of small intestine CL0009017
    CSI 1.2
    rCSI 3.3%
    PRS 14.7%
  • endothelial cell of uterus CL0009095
    CSI 1.2
    rCSI 9.0%
    PRS 31.2%
  • renal interstitial pericyte CL1001318
    CSI 1.3
    rCSI 3.5%
    PRS 10.9%
  • paneth cell of colon CL0009009
    CSI 1.3
    rCSI 12.5%
    PRS 32.7%
  • kidney resident macrophage CL1000698
    CSI 1.3
    rCSI 25.8%
    PRS 80.8%
  • basophil mast progenitor cell CL0002028
    CSI 1.3
    rCSI 7.0%
    PRS 41.4%
  • acinar cell of salivary gland CL0002623
    CSI 1.3
    rCSI 30.9%
    PRS 20.2%
  • parietal epithelial cell CL1000452
    CSI 1.3
    rCSI 3.6%
    PRS 10.0%
  • CD4-positive, alpha-beta memory T cell CL0000897
    CSI 1.3
    rCSI 1.0%
    PRS 15.4%
  • blood vessel smooth muscle cell CL0019018
    CSI 1.4
    rCSI 11.1%
    PRS 11.9%
  • erythroid progenitor cell CL0000038
    CSI 1.4
    rCSI 8.1%
    PRS 17.6%
  • epithelial cell of urethra CL1000296
    CSI 1.4
    rCSI 35.4%
    PRS 36.8%
  • epicardial adipocyte CL1000309
    CSI 1.4
    rCSI 4.6%
    PRS 14.3%
  • effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062
    CSI 1.4
    rCSI 7.2%
    PRS 14.8%
  • skeletal muscle satellite stem cell CL0008011
    CSI 1.5
    rCSI 6.5%
    PRS 33.5%
  • endothelial cell of placenta CL0009092
    CSI 1.5
    rCSI 7.3%
    PRS 15.5%
  • transit amplifying cell of colon CL0009011
    CSI 1.5
    rCSI 1.7%
    PRS 13.5%
  • plasmacytoid dendritic cell, human CL0001058
    CSI 1.5
    rCSI 1.1%
    PRS 11.9%
  • mesodermal cell CL0000222
    CSI 1.6
    rCSI 1.9%
    PRS 11.3%
  • lung secretory cell CL1000272
    CSI 1.6
    rCSI 3.9%
    PRS 10.5%
  • H2 horizontal cell CL0004218
    CSI 1.6
    rCSI 8.0%
    PRS 12.8%
  • erythroblast CL0000765
    CSI 1.6
    rCSI 4.3%
    PRS 19.0%
  • small intestine goblet cell CL1000495
    CSI 1.6
    rCSI 3.6%
    PRS 15.3%
  • perivascular cell CL4033054
    CSI 1.6
    rCSI 2.2%
    PRS 12.9%
  • respiratory basal cell CL0002633
    CSI 1.7
    rCSI 1.8%
    PRS 13.4%
  • conjunctival epithelial cell CL1000432
    CSI 1.7
    rCSI 2.6%
    PRS 11.4%
  • myeloid dendritic cell, human CL0001057
    CSI 1.7
    rCSI 9.6%
    PRS 36.0%
  • paneth cell of epithelium of small intestine CL1000343
    CSI 1.7
    rCSI 4.9%
    PRS 17.6%
  • respiratory epithelial cell CL0002368
    CSI 1.7
    rCSI 10.7%
    PRS 36.7%
  • lymphoid lineage restricted progenitor cell CL0000838
    CSI 1.7
    rCSI 6.8%
    PRS 18.7%
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 1.8
    rCSI 3.1%
    PRS 6.7%
  • kidney distal convoluted tubule epithelial cell CL1000849
    CSI 1.8
    rCSI 18.8%
    PRS 16.4%
  • mesenchymal cell CL0008019
    CSI 1.8
    rCSI 4.6%
    PRS 11.6%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.

Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [HSPA1A](/details-gene/3303) encodes Heat Shock Protein Family A (Hsp70) Member 1A, a canonical member of the Hsp70 family of molecular chaperones. This protein plays a crucial role in maintaining cellular homeostasis by facilitating the folding of newly synthesized proteins, refolding of misfolded or aggregated proteins, and assisting in protein transport across membranes. Its expression is strongly induced by various cellular stressors, including heat shock, oxidative stress, and exposure to toxins. Functionally, [HSPA1A](/details-gene/3303) is a key component of the cell's proteostasis network and is deeply involved in processes such as signal transduction, apoptosis regulation, and immune responses. Its gene is located within the Major Histocompatibility Complex (MHC) class III region on chromosome 6 ([Link](https://pubmed.ncbi.nlm.nih.gov/2538825/)). Expression data indicates a significant role for [HSPA1A](/details-gene/3303) within the hematopoietic system, with particularly high significance in developing and mature B and T lymphocytes. Clinically, it is associated with OMIM entry [140550](https://omim.org/entry/140550). ## Cellular Roles and Expression Landscape **Overall**, the expression profile of [HSPA1A](/details-gene/3303) highlights its profound importance within the immune system, particularly during lymphocyte development and maturation, as well as in stromal cells like fibroblasts. The highest significance scores are observed in early B cell progenitors and mature T cell populations, suggesting a critical function in managing the high protein synthesis demands of these cell types. **Top Expressed Cell Types:** * **B Cell Lineage:** [immature B cell](/details-cell/CL0000816) (CSI: 56.27), [fraction A pre-pro B cell](/details-cell/CL0002045) (CSI: 40.39), and [memory B cell](/details-cell/CL0000787) (CSI: 30.58). * **T Cell and ILC Lineage:** [mature T cell](/details-cell/CL0002419) (CSI: 36.78), [CD8-positive, alpha-beta memory T cell, CD45RO-positive](/details-cell/CL0001203) (CSI: 32.14), [group 3 innate lymphoid cell](/details-cell/CL0001071) (CSI: 30.87), [activated CD8-positive, alpha-beta T cell, human](/details-cell/CL0001049) (CSI: 28.72), and [CD4-positive helper T cell](/details-cell/CL0000492) (CSI: 27.48). * **Myeloid Progenitors:** [granulocyte monocyte progenitor cell](/details-cell/CL0000557) (CSI: 33.92), [promyelocyte](/details-cell/CL0000836) (CSI: 25.27), and [promonocyte](/details-cell/CL0000559) (CSI: 23.44). * **Fibroblasts:** [bronchus fibroblast of lung](/details-cell/CL2000093) (CSI: 37.00) and [skin fibroblast](/details-cell/CL0002620) (CSI: 23.73). Conversely, its expression is notably low in several terminally differentiated cell types, underscoring its specialized role. This includes low significance in [pancreatic A cell](/details-cell/CL0000171) (CSI: -12.32), [extravillous trophoblast](/details-cell/CL0008036) (CSI: -12.38), and various neuronal populations such as [cerebral cortex neuron](/details-cell/CL0010012) (CSI: -3.35). This pattern suggests that while [HSPA1A](/details-gene/3303) is a ubiquitous stress protein, its basal significance is highest in cells with high metabolic activity, active proliferation, or complex protein secretion functions, such as those found in the immune system. ## Pathways and Molecular Function The functional annotations for [HSPA1A](/details-gene/3303) confirm its identity as a central player in cellular stress response and protein quality control. * **Stress Response and Proteostasis:** As a canonical heat shock protein, it is integral to pathways like '[Cellular response to heat stress](/details-reactome/R-HSA-3371556)' and '[Response to unfolded protein](/details-go/GO:0006986)'. Its molecular functions, including '[Atp binding](/details-go/GO:0005524)', '[Unfolded protein binding](/details-go/GO:0051082)', and '[Protein refolding](/details-go/GO:0042026)', define its core chaperone activity. It actively manages protein aggregates through its '[Atp-dependent protein disaggregase activity](/details-go/GO:0140545)' and by preventing the formation of inclusion bodies ([Negative regulation of inclusion body assembly](/details-go/GO:0090084)). * **Immune System Modulation:** Consistent with its high expression in immune cells, [HSPA1A](/details-gene/3303) is involved in numerous immune-related pathways. These include the broad '[Immune system](/details-reactome/R-HSA-168256)' and '[Innate immune system](/details-reactome/R-HSA-168249)' pathways, as well as more specific processes like '[Neutrophil degranulation](/details-reactome/R-HSA-6798695)' and '[Cytokine signaling in immune system](/details-reactome/R-HSA-1280215)'. It also participates in antiviral responses through pathways like '[Antiviral mechanism by ifn-stimulated genes](/details-reactome/R-HSA-1169410)'. * **Regulation of Cell Fate:** A key role of [HSPA1A](/details-gene/3303) is the regulation of apoptosis. It acts as a pro-survival factor through its involvement in the '[Negative regulation of apoptotic process](/details-go/GO:0043066)', which helps protect cells from stress-induced death. This function is critical for the survival and expansion of lymphocytes during an immune response. ## Research Directions The data provides a strong foundation for investigating the specific roles of [HSPA1A](/details-gene/3303) in immune cell biology and pathology. **Proposed Hypotheses:** 1. Given its high significance in progenitor cells like [fraction A pre-pro B cell](/details-cell/CL0002045) and [granulocyte monocyte progenitor cell](/details-cell/CL0000557), [HSPA1A](/details-gene/3303) is likely indispensable for managing proteotoxic stress during the rapid proliferation and differentiation stages of hematopoiesis. Its functional inhibition may therefore lead to defects in immune lineage commitment and maturation. 2. The high CSI score in [activated CD8-positive, alpha-beta T cell, human](/details-cell/CL0001049) suggests that [HSPA1A](/details-gene/3303) is essential for supporting the massive increase in protein synthesis (e.g., cytokines, cytotoxic granules) required for effector T cell function. It may act as a crucial bottleneck regulating the magnitude and sustainability of an adaptive immune response. **Experimental Approach to Test Hypothesis 2:** To investigate the role of [HSPA1A](/details-gene/3303) in T cell activation and effector function, one could utilize a targeted gene knockdown approach. Primary human CD8+ T cells could be isolated and treated with shRNA or CRISPR-Cas9 constructs targeting [HSPA1A](/details-gene/3303). These modified cells, along with control cells, would then be activated *in vitro* using anti-CD3/CD28 antibodies. The functional consequences could be assessed by measuring key parameters of T cell activation, including proliferation (via CFSE dilution), cytokine production (IFN-gamma and TNF-alpha levels via ELISA), and cytotoxic potential (Granzyme B expression and target cell lysis assays). A parallel RNA-seq analysis could reveal the global transcriptomic impact of [HSPA1A](/details-gene/3303) loss on T cell activation programs. It is predicted that knockdown of [HSPA1A](/details-gene/3303) would result in impaired effector function and increased activation-induced cell death. **Therapeutic Potential:** As a key pro-survival and proteostasis factor, [HSPA1A](/details-gene/3303) represents a compelling therapeutic target. Many cancer cells, particularly those of hematopoietic origin like lymphomas and leukemias, are highly dependent on chaperone proteins to cope with oncogenic stress. Therefore, pharmacological **inhibition** of [HSPA1A](/details-gene/3303) could selectively induce apoptosis in malignant cells, making it a promising strategy for anti-cancer therapy. Furthermore, in the context of autoimmune diseases, transient inhibition of [HSPA1A](/details-gene/3303) could be explored as a method to dampen the function of overactive T cells, thereby providing a novel immunomodulatory approach.

Genular Protein ID: 515514565

Symbol: HS71A_HUMAN

Name: Heat shock 70 kDa protein 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 3931075

Title: Conserved features of eukaryotic hsp70 genes revealed by comparison with the nucleotide sequence of human hsp70.

PubMed ID: 3931075

DOI: 10.1073/pnas.82.19.6455

PubMed ID: 1700760

Title: Structure and expression of the three MHC-linked HSP70 genes.

PubMed ID: 1700760

DOI: 10.1007/bf00187095

PubMed ID: 14656967

Title: Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.

PubMed ID: 14656967

DOI: 10.1101/gr.1736803

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2538825

Title: Human major histocompatibility complex contains genes for the major heat shock protein HSP70.

PubMed ID: 2538825

DOI: 10.1073/pnas.86.6.1968

PubMed ID: 3786141

Title: In vitro transcription of a human hsp 70 heat shock gene by extracts prepared from heat-shocked and non-heat-shocked human cells.

PubMed ID: 3786141

DOI: 10.1093/nar/14.22.8933

PubMed ID: 23349634

Title: A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity.

PubMed ID: 23349634

DOI: 10.1371/journal.pgen.1003210

PubMed ID: 7935376

Title: Interaction between heat shock factor and hsp70 is insufficient to suppress induction of DNA-binding activity in vivo.

PubMed ID: 7935376

DOI: 10.1128/mcb.14.10.6552-6560.1994

PubMed ID: 9499401

Title: Molecular chaperones as HSF1-specific transcriptional repressors.

PubMed ID: 9499401

DOI: 10.1101/gad.12.5.654

PubMed ID: 11274138

Title: Stable association of hsp90 and p23, but Not hsp70, with active human telomerase.

PubMed ID: 11274138

DOI: 10.1074/jbc.c100055200

PubMed ID: 12853476

Title: Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system.

PubMed ID: 12853476

DOI: 10.1093/emboj/cdg362

PubMed ID: 15963462

Title: Phosphorylation and binding partner analysis of the TSC1-TSC2 complex.

PubMed ID: 15963462

DOI: 10.1016/j.bbrc.2005.05.175

PubMed ID: 15383005

Title: Human protein phosphatase 5 dissociates from heat-shock proteins and is proteolytically activated in response to arachidonic acid and the microtubule-depolymerizing drug nocodazole.

PubMed ID: 15383005

DOI: 10.1042/bj20040690

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17233114

Title: The disordered amino-terminus of SIMPL interacts with members of the 70-kDa heat-shock protein family.

PubMed ID: 17233114

DOI: 10.1089/dna.2006.25.704

PubMed ID: 16537599

Title: The peptide-binding and ATPase domains of recombinant hsc70 are required to interact with rotavirus and reduce its infectivity.

PubMed ID: 16537599

DOI: 10.1128/jvi.80.7.3322-3331.2006

PubMed ID: 17182002

Title: HDJC9, a novel human type C DnaJ/HSP40 member interacts with and cochaperones HSP70 through the J domain.

PubMed ID: 17182002

DOI: 10.1016/j.bbrc.2006.12.013

PubMed ID: 17289661

Title: Molecular composition of IMP1 ribonucleoprotein granules.

PubMed ID: 17289661

DOI: 10.1074/mcp.m600346-mcp200

PubMed ID: 17947705

Title: Heat shock protein 90 associates with monarch-1 and regulates its ability to promote degradation of NF-kappaB-inducing kinase.

PubMed ID: 17947705

DOI: 10.4049/jimmunol.179.9.6291

PubMed ID: 18620420

Title: Role of the cochaperone Tpr2 in Hsp90 chaperoning.

PubMed ID: 18620420

DOI: 10.1021/bi800770g

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20053985

Title: Hsp70 interacts with the retroviral restriction factor TRIM5alpha and assists the folding of TRIM5alpha.

PubMed ID: 20053985

DOI: 10.1074/jbc.m109.040618

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21081504

Title: ChChd3, an inner mitochondrial membrane protein, is essential for maintaining crista integrity and mitochondrial function.

PubMed ID: 21081504

DOI: 10.1074/jbc.m110.171975

PubMed ID: 22528486

Title: Nucleophosmin (NPM1/B23) interacts with activating transcription factor 5 (ATF5) protein and promotes proteasome- and caspase-dependent ATF5 degradation in hepatocellular carcinoma cells.

PubMed ID: 22528486

DOI: 10.1074/jbc.m112.363622

PubMed ID: 22905912

Title: Resveratrol-induced changes of the human adipocyte secretion profile.

PubMed ID: 22905912

DOI: 10.1021/pr300539b

PubMed ID: 23973223

Title: The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3.

PubMed ID: 23973223

DOI: 10.1016/j.immuni.2013.08.006

PubMed ID: 23921388

Title: Identification and characterization of a novel human methyltransferase modulating Hsp70 function through lysine methylation.

PubMed ID: 23921388

DOI: 10.1074/jbc.m113.483248

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24270810

Title: High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy.

PubMed ID: 24270810

DOI: 10.1038/nature12748

PubMed ID: 24012426

Title: Hsp70 chaperone dynamics and molecular mechanism.

PubMed ID: 24012426

DOI: 10.1016/j.tibs.2013.08.001

PubMed ID: 24613385

Title: Hsp70 and Hsp90 oppositely regulate TGF-beta signaling through CHIP/Stub1.

PubMed ID: 24613385

DOI: 10.1016/j.bbrc.2014.02.124

PubMed ID: 24318877

Title: Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro.

PubMed ID: 24318877

DOI: 10.1074/jbc.m113.521997

PubMed ID: 24790089

Title: The molecular chaperone HSP70 binds to and stabilizes NOD2, an important protein involved in Crohn disease.

PubMed ID: 24790089

DOI: 10.1074/jbc.m114.557686

PubMed ID: 25281747

Title: RING finger protein RNF207, a novel regulator of cardiac excitation.

PubMed ID: 25281747

DOI: 10.1074/jbc.m114.592295

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27133716

Title: A novel nuclear DnaJ protein, DNAJC8, can suppress the formation of spinocerebellar ataxia 3 polyglutamine aggregation in a J-domain independent manner.

PubMed ID: 27133716

DOI: 10.1016/j.bbrc.2016.03.152

PubMed ID: 26865365

Title: The human HSP70 family of chaperones: where do we stand?

PubMed ID: 26865365

DOI: 10.1007/s12192-016-0676-6

PubMed ID: 27137183

Title: HSP70 regulates the function of mitotic centrosomes.

PubMed ID: 27137183

DOI: 10.1007/s00018-016-2236-8

PubMed ID: 27708256

Title: ARD1-mediated Hsp70 acetylation balances stress-induced protein refolding and degradation.

PubMed ID: 27708256

DOI: 10.1038/ncomms12882

PubMed ID: 28842558

Title: HSP70-Hrd1 axis precludes the oncorepressor potential of N-terminal misfolded Blimp-1s in lymphoma cells.

PubMed ID: 28842558

DOI: 10.1038/s41467-017-00476-w

PubMed ID: 10216320

Title: Structure of a new crystal form of human hsp70 ATPase domain.

PubMed ID: 10216320

DOI: 10.1107/s0907444999002103

PubMed ID: 20179333

Title: Direct inter-subdomain interactions switch between the closed and open forms of the Hsp70 nucleotide-binding domain in the nucleotide-free state.

PubMed ID: 20179333

DOI: 10.1107/s0907444909053979

PubMed ID: 20072699

Title: Crystal structures of the ATPase domains of four human Hsp70 isoforms: HSPA1L/Hsp70-hom, HSPA2/Hsp70-2, HSPA6/Hsp70B', and HSPA5/BiP/GRP78.

PubMed ID: 20072699

DOI: 10.1371/journal.pone.0008625

PubMed ID: 20223214

Title: The C-terminal BAG domain of BAG5 induces conformational changes of the Hsp70 nucleotide-binding domain for ADP-ATP exchange.

PubMed ID: 20223214

DOI: 10.1016/j.str.2010.01.004

PubMed ID: 21608060

Title: Biochemical and structural studies on the high affinity of Hsp70 for ADP.

PubMed ID: 21608060

DOI: 10.1002/pro.663

Sequence Information:

  • Length: 641
  • Mass: 70052
  • Checksum: 78F513118C96DE66
  • Sequence:
  • MAKAAAIGID LGTTYSCVGV FQHGKVEIIA NDQGNRTTPS YVAFTDTERL IGDAAKNQVA 
    LNPQNTVFDA KRLIGRKFGD PVVQSDMKHW PFQVINDGDK PKVQVSYKGE TKAFYPEEIS 
    SMVLTKMKEI AEAYLGYPVT NAVITVPAYF NDSQRQATKD AGVIAGLNVL RIINEPTAAA 
    IAYGLDRTGK GERNVLIFDL GGGTFDVSIL TIDDGIFEVK ATAGDTHLGG EDFDNRLVNH 
    FVEEFKRKHK KDISQNKRAV RRLRTACERA KRTLSSSTQA SLEIDSLFEG IDFYTSITRA 
    RFEELCSDLF RSTLEPVEKA LRDAKLDKAQ IHDLVLVGGS TRIPKVQKLL QDFFNGRDLN 
    KSINPDEAVA YGAAVQAAIL MGDKSENVQD LLLLDVAPLS LGLETAGGVM TALIKRNSTI 
    PTKQTQIFTT YSDNQPGVLI QVYEGERAMT KDNNLLGRFE LSGIPPAPRG VPQIEVTFDI 
    DANGILNVTA TDKSTGKANK ITITNDKGRL SKEEIERMVQ EAEKYKAEDE VQRERVSAKN 
    ALESYAFNMK SAVEDEGLKG KISEADKKKV LDKCQEVISW LDANTLAEKD EFEHKRKELE 
    QVCNPIISGL YQGAGGPGPG GFGAQGPKGG SGSGPTIEEV D

Genular Protein ID: 690584237

Symbol: B3KTT5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 476
  • Mass: 51917
  • Checksum: 24C7844D48228F36
  • Sequence:
  • MAKAAAIGID LGTTYSCVGV FQHGKGERNV LIFDLGGGTF DVSILTIDDG IFEVKATAGD 
    THLGGEDFDN RLVNHFVEEF KRKHKKDISQ NKRAVRRLRT ACERAKRTLS SSTQASLEID 
    SLFEGIDFYT SITRARFEEL CSDLFRSTLE PVEKALRDAK LDKAQIHDLV LVGGSTRIPK 
    VQKLLQDFFN GRDLNKSINP DEAVAYGAAV QAAILMGDKS ENVQDLLLLD VAPLSLGLET 
    AGGVMTALIK RNSTIPTKQT QIFTTYSDNQ PGVLIQVYEG ERAMTKDNNL LGRFELSGIP 
    PAPRGVPQIE VTFDIDANGI LNVTATDKSA GKANKITITN DKGRLSKEEI ERMVQEAEKY 
    KAEDEVQRER VSAKNALESY AFNMKSAVED EGLKGKISEA DKKKVLDKCQ EVISWLDANT 
    LAEKDEFEHK RKELEQVCNP IISGLYQGAG GPGPGGFGAQ GPKGGSGSGP TIEEVD