Details for: HSPA1A

Gene ID: 3303

Symbol: HSPA1A

Ensembl ID: ENSG00000204389

Description: heat shock protein family A (Hsp70) member 1A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 833.3268
    Cell Significance Index: -129.6200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 499.4414
    Cell Significance Index: -126.6800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 319.9193
    Cell Significance Index: -131.7900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 295.2411
    Cell Significance Index: -139.3900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 263.0908
    Cell Significance Index: -135.3300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 208.0110
    Cell Significance Index: -139.5800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 106.5569
    Cell Significance Index: -131.3800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 47.0368
    Cell Significance Index: -126.0100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 35.8202
    Cell Significance Index: -110.0200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 33.4005
    Cell Significance Index: -131.8000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 18.5371
    Cell Significance Index: -40.5700
  • Cell Name: theca cell (CL0000503)
    Fold Change: 18.3761
    Cell Significance Index: 107.9600
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 15.5259
    Cell Significance Index: 164.9600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 14.8686
    Cell Significance Index: 426.2200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 13.5718
    Cell Significance Index: 104.6100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 7.6505
    Cell Significance Index: 980.7500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 7.2046
    Cell Significance Index: 378.2700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 6.6030
    Cell Significance Index: 52.7200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 4.4152
    Cell Significance Index: 312.2600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.5056
    Cell Significance Index: 481.4200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 3.4009
    Cell Significance Index: 1503.6300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.2702
    Cell Significance Index: 41.8800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 3.2276
    Cell Significance Index: 84.8700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.9869
    Cell Significance Index: 140.3800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.7731
    Cell Significance Index: 96.3700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.3917
    Cell Significance Index: 294.0900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.7794
    Cell Significance Index: 31.4500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.7613
    Cell Significance Index: 317.5000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.6727
    Cell Significance Index: 45.5300
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.2531
    Cell Significance Index: 9.0000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.2186
    Cell Significance Index: 665.4800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7984
    Cell Significance Index: 158.4400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.7823
    Cell Significance Index: 92.2600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6697
    Cell Significance Index: 19.3000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4434
    Cell Significance Index: 30.6600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.2410
    Cell Significance Index: 6.0100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2098
    Cell Significance Index: 9.7800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1418
    Cell Significance Index: 107.3500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0546
    Cell Significance Index: 0.6200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0039
    Cell Significance Index: -0.7800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0052
    Cell Significance Index: -0.8800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0243
    Cell Significance Index: -17.8200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0368
    Cell Significance Index: -3.7600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0417
    Cell Significance Index: -2.1100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0602
    Cell Significance Index: -113.3500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0672
    Cell Significance Index: -12.8000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0841
    Cell Significance Index: -3.4400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0911
    Cell Significance Index: -167.9800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1082
    Cell Significance Index: -38.8000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1086
    Cell Significance Index: -167.1900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.1149
    Cell Significance Index: -156.1800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1297
    Cell Significance Index: -96.1000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1367
    Cell Significance Index: -17.6600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1515
    Cell Significance Index: -94.5900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1546
    Cell Significance Index: -70.1500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1746
    Cell Significance Index: -110.8600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1933
    Cell Significance Index: -109.0100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.3377
    Cell Significance Index: -33.4100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4035
    Cell Significance Index: -4.8100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4436
    Cell Significance Index: -50.6400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4524
    Cell Significance Index: -9.4700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.4566
    Cell Significance Index: -96.1700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5829
    Cell Significance Index: -30.2800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.6781
    Cell Significance Index: -77.6900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.7416
    Cell Significance Index: -86.4200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.7601
    Cell Significance Index: -26.7100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.8098
    Cell Significance Index: -117.7200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.8316
    Cell Significance Index: -20.2900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.8823
    Cell Significance Index: -65.7600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.9413
    Cell Significance Index: -59.3300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.0796
    Cell Significance Index: -30.1700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -1.1941
    Cell Significance Index: -18.4800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.2781
    Cell Significance Index: -133.0800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.2826
    Cell Significance Index: -17.5000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.3399
    Cell Significance Index: -102.8300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -1.4625
    Cell Significance Index: -39.0500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.4899
    Cell Significance Index: -118.0000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -1.8393
    Cell Significance Index: -118.6600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.9536
    Cell Significance Index: -32.7000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.9767
    Cell Significance Index: -110.9200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -2.0573
    Cell Significance Index: -44.5700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -2.0586
    Cell Significance Index: -126.2100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -2.1402
    Cell Significance Index: -97.0100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -2.4557
    Cell Significance Index: -42.4600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -2.5316
    Cell Significance Index: -67.7200
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -2.5531
    Cell Significance Index: -51.9500
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: -2.6051
    Cell Significance Index: -9.9700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -2.6203
    Cell Significance Index: -96.1900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -2.7135
    Cell Significance Index: -86.9100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -2.8452
    Cell Significance Index: -83.5600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -2.8479
    Cell Significance Index: -125.9700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -2.8524
    Cell Significance Index: -65.9000
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -2.9483
    Cell Significance Index: -30.7800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -3.1501
    Cell Significance Index: -78.7500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -3.1585
    Cell Significance Index: -93.0300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -3.1765
    Cell Significance Index: -58.7100
  • Cell Name: glioblast (CL0000030)
    Fold Change: -3.1817
    Cell Significance Index: -19.9800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -3.3207
    Cell Significance Index: -116.3300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -3.3303
    Cell Significance Index: -126.1100
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: -3.3915
    Cell Significance Index: -12.6400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Heat Shock Protein Function:** HSPA1A is a member of the Hsp70 family, which is known for its chaperone activity, protein folding, and degradation functions. 2. **Cellular Expression:** HSPA1A is widely expressed in various cell types, including immune cells, suggesting its role in immune system regulation. 3. **Stress Response:** HSPA1A is induced in response to heat shock, oxidative stress, and other cellular stresses, indicating its involvement in stress response pathways. 4. **Immune System Modulation:** HSPA1A plays a role in regulating immune system function, including cytokine signaling, immune cell activation, and regulation of inflammatory responses. **Pathways and Functions:** 1. **Antiviral Mechanism:** HSPA1A is involved in the regulation of antiviral genes, such as interferon-stimulated genes (ISGs), which are essential for viral defense. 2. **Cellular Heat Acclimation:** HSPA1A helps cells adapt to heat stress by regulating heat shock proteins, which are essential for maintaining cellular homeostasis. 3. **Protein Refolding and Degradation:** HSPA1A ensures proper protein folding and degradation, which is critical for maintaining protein homeostasis and preventing protein misfolding. 4. **Immune System Regulation:** HSPA1A regulates immune system function by modulating cytokine signaling, immune cell activation, and regulation of inflammatory responses. 5. **Stress Response:** HSPA1A is involved in regulating cellular stress responses, including heat shock, oxidative stress, and endoplasmic reticulum stress. **Clinical Significance:** 1. **Immune System Disorders:** Dysregulation of HSPA1A has been implicated in various immune system disorders, including autoimmune diseases, cancer, and infectious diseases. 2. **Heat Shock Response:** HSPA1A plays a crucial role in the heat shock response, which is essential for protecting cells from heat stress-induced damage. 3. **Oxidative Stress:** HSPA1A helps regulate oxidative stress responses, which is critical for maintaining cellular homeostasis and preventing oxidative damage. 4. **Cancer:** HSPA1A has been implicated in cancer development and progression, suggesting its potential as a therapeutic target. 5. **Infectious Diseases:** HSPA1A plays a role in regulating viral infections, including influenza and other viral diseases. In conclusion, HSPA1A is a multifaceted protein that plays a critical role in maintaining cellular homeostasis, immune system function, and stress response pathways. Its dysregulation has been implicated in various human diseases, highlighting the importance of understanding its mechanisms and potential therapeutic applications.

Genular Protein ID: 515514565

Symbol: HS71A_HUMAN

Name: Heat shock 70 kDa protein 1

UniProtKB Accession Codes:

P0DMV8 B4E3B6 P08107 P19790 Q5JQI4 Q5SP17 Q9UQL9 Q9UQM0

Database IDs:

ABCD 1 AGR 2 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID-ORCS 2 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 2 CarbonylDB 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 2 DrugCentral 1 EMBL 11 EMDB 1 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 79 Gene3D 3 GeneCards 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 2 MANE-Select 1 MIM 2 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 2 OrthoDB 1 PANTHER 2 PDB 44 PDBsum 44 PIR 4 PRIDE 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 8 RefSeq 2 SASBDB 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3931075

Title: Conserved features of eukaryotic hsp70 genes revealed by comparison with the nucleotide sequence of human hsp70.

PubMed ID: 3931075

DOI: 10.1073/pnas.82.19.6455

PubMed ID: 1700760

Title: Structure and expression of the three MHC-linked HSP70 genes.

PubMed ID: 1700760

DOI: 10.1007/bf00187095

PubMed ID: 14656967

Title: Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.

PubMed ID: 14656967

DOI: 10.1101/gr.1736803

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2538825

Title: Human major histocompatibility complex contains genes for the major heat shock protein HSP70.

PubMed ID: 2538825

DOI: 10.1073/pnas.86.6.1968

PubMed ID: 3786141

Title: In vitro transcription of a human hsp 70 heat shock gene by extracts prepared from heat-shocked and non-heat-shocked human cells.

PubMed ID: 3786141

DOI: 10.1093/nar/14.22.8933

PubMed ID: 23349634

Title: A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity.

PubMed ID: 23349634

DOI: 10.1371/journal.pgen.1003210

PubMed ID: 7935376

Title: Interaction between heat shock factor and hsp70 is insufficient to suppress induction of DNA-binding activity in vivo.

PubMed ID: 7935376

DOI: 10.1128/mcb.14.10.6552-6560.1994

PubMed ID: 9499401

Title: Molecular chaperones as HSF1-specific transcriptional repressors.

PubMed ID: 9499401

DOI: 10.1101/gad.12.5.654

PubMed ID: 11274138

Title: Stable association of hsp90 and p23, but Not hsp70, with active human telomerase.

PubMed ID: 11274138

DOI: 10.1074/jbc.c100055200

PubMed ID: 12853476

Title: Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system.

PubMed ID: 12853476

DOI: 10.1093/emboj/cdg362

PubMed ID: 15963462

Title: Phosphorylation and binding partner analysis of the TSC1-TSC2 complex.

PubMed ID: 15963462

DOI: 10.1016/j.bbrc.2005.05.175

PubMed ID: 15383005

Title: Human protein phosphatase 5 dissociates from heat-shock proteins and is proteolytically activated in response to arachidonic acid and the microtubule-depolymerizing drug nocodazole.

PubMed ID: 15383005

DOI: 10.1042/bj20040690

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17233114

Title: The disordered amino-terminus of SIMPL interacts with members of the 70-kDa heat-shock protein family.

PubMed ID: 17233114

DOI: 10.1089/dna.2006.25.704

PubMed ID: 16537599

Title: The peptide-binding and ATPase domains of recombinant hsc70 are required to interact with rotavirus and reduce its infectivity.

PubMed ID: 16537599

DOI: 10.1128/jvi.80.7.3322-3331.2006

PubMed ID: 17182002

Title: HDJC9, a novel human type C DnaJ/HSP40 member interacts with and cochaperones HSP70 through the J domain.

PubMed ID: 17182002

DOI: 10.1016/j.bbrc.2006.12.013

PubMed ID: 17289661

Title: Molecular composition of IMP1 ribonucleoprotein granules.

PubMed ID: 17289661

DOI: 10.1074/mcp.m600346-mcp200

PubMed ID: 17947705

Title: Heat shock protein 90 associates with monarch-1 and regulates its ability to promote degradation of NF-kappaB-inducing kinase.

PubMed ID: 17947705

DOI: 10.4049/jimmunol.179.9.6291

PubMed ID: 18620420

Title: Role of the cochaperone Tpr2 in Hsp90 chaperoning.

PubMed ID: 18620420

DOI: 10.1021/bi800770g

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20053985

Title: Hsp70 interacts with the retroviral restriction factor TRIM5alpha and assists the folding of TRIM5alpha.

PubMed ID: 20053985

DOI: 10.1074/jbc.m109.040618

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21081504

Title: ChChd3, an inner mitochondrial membrane protein, is essential for maintaining crista integrity and mitochondrial function.

PubMed ID: 21081504

DOI: 10.1074/jbc.m110.171975

PubMed ID: 22528486

Title: Nucleophosmin (NPM1/B23) interacts with activating transcription factor 5 (ATF5) protein and promotes proteasome- and caspase-dependent ATF5 degradation in hepatocellular carcinoma cells.

PubMed ID: 22528486

DOI: 10.1074/jbc.m112.363622

PubMed ID: 22905912

Title: Resveratrol-induced changes of the human adipocyte secretion profile.

PubMed ID: 22905912

DOI: 10.1021/pr300539b

PubMed ID: 23973223

Title: The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3.

PubMed ID: 23973223

DOI: 10.1016/j.immuni.2013.08.006

PubMed ID: 23921388

Title: Identification and characterization of a novel human methyltransferase modulating Hsp70 function through lysine methylation.

PubMed ID: 23921388

DOI: 10.1074/jbc.m113.483248

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24270810

Title: High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy.

PubMed ID: 24270810

DOI: 10.1038/nature12748

PubMed ID: 24012426

Title: Hsp70 chaperone dynamics and molecular mechanism.

PubMed ID: 24012426

DOI: 10.1016/j.tibs.2013.08.001

PubMed ID: 24613385

Title: Hsp70 and Hsp90 oppositely regulate TGF-beta signaling through CHIP/Stub1.

PubMed ID: 24613385

DOI: 10.1016/j.bbrc.2014.02.124

PubMed ID: 24318877

Title: Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro.

PubMed ID: 24318877

DOI: 10.1074/jbc.m113.521997

PubMed ID: 24790089

Title: The molecular chaperone HSP70 binds to and stabilizes NOD2, an important protein involved in Crohn disease.

PubMed ID: 24790089

DOI: 10.1074/jbc.m114.557686

PubMed ID: 25281747

Title: RING finger protein RNF207, a novel regulator of cardiac excitation.

PubMed ID: 25281747

DOI: 10.1074/jbc.m114.592295

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27133716

Title: A novel nuclear DnaJ protein, DNAJC8, can suppress the formation of spinocerebellar ataxia 3 polyglutamine aggregation in a J-domain independent manner.

PubMed ID: 27133716

DOI: 10.1016/j.bbrc.2016.03.152

PubMed ID: 26865365

Title: The human HSP70 family of chaperones: where do we stand?

PubMed ID: 26865365

DOI: 10.1007/s12192-016-0676-6

PubMed ID: 27137183

Title: HSP70 regulates the function of mitotic centrosomes.

PubMed ID: 27137183

DOI: 10.1007/s00018-016-2236-8

PubMed ID: 27708256

Title: ARD1-mediated Hsp70 acetylation balances stress-induced protein refolding and degradation.

PubMed ID: 27708256

DOI: 10.1038/ncomms12882

PubMed ID: 28842558

Title: HSP70-Hrd1 axis precludes the oncorepressor potential of N-terminal misfolded Blimp-1s in lymphoma cells.

PubMed ID: 28842558

DOI: 10.1038/s41467-017-00476-w

PubMed ID: 10216320

Title: Structure of a new crystal form of human hsp70 ATPase domain.

PubMed ID: 10216320

DOI: 10.1107/s0907444999002103

PubMed ID: 20179333

Title: Direct inter-subdomain interactions switch between the closed and open forms of the Hsp70 nucleotide-binding domain in the nucleotide-free state.

PubMed ID: 20179333

DOI: 10.1107/s0907444909053979

PubMed ID: 20072699

Title: Crystal structures of the ATPase domains of four human Hsp70 isoforms: HSPA1L/Hsp70-hom, HSPA2/Hsp70-2, HSPA6/Hsp70B', and HSPA5/BiP/GRP78.

PubMed ID: 20072699

DOI: 10.1371/journal.pone.0008625

PubMed ID: 20223214

Title: The C-terminal BAG domain of BAG5 induces conformational changes of the Hsp70 nucleotide-binding domain for ADP-ATP exchange.

PubMed ID: 20223214

DOI: 10.1016/j.str.2010.01.004

PubMed ID: 21608060

Title: Biochemical and structural studies on the high affinity of Hsp70 for ADP.

PubMed ID: 21608060

DOI: 10.1002/pro.663

Sequence Information:

  • Length: 641
  • Mass: 70052
  • Checksum: 78F513118C96DE66
  • Sequence:
    • MAKAAAIGID LGTTYSCVGV FQHGKVEIIA NDQGNRTTPS YVAFTDTERL IGDAAKNQVA 
LNPQNTVFDA KRLIGRKFGD PVVQSDMKHW PFQVINDGDK PKVQVSYKGE TKAFYPEEIS 
SMVLTKMKEI AEAYLGYPVT NAVITVPAYF NDSQRQATKD AGVIAGLNVL RIINEPTAAA 
IAYGLDRTGK GERNVLIFDL GGGTFDVSIL TIDDGIFEVK ATAGDTHLGG EDFDNRLVNH 
FVEEFKRKHK KDISQNKRAV RRLRTACERA KRTLSSSTQA SLEIDSLFEG IDFYTSITRA 
RFEELCSDLF RSTLEPVEKA LRDAKLDKAQ IHDLVLVGGS TRIPKVQKLL QDFFNGRDLN 
KSINPDEAVA YGAAVQAAIL MGDKSENVQD LLLLDVAPLS LGLETAGGVM TALIKRNSTI 
PTKQTQIFTT YSDNQPGVLI QVYEGERAMT KDNNLLGRFE LSGIPPAPRG VPQIEVTFDI 
DANGILNVTA TDKSTGKANK ITITNDKGRL SKEEIERMVQ EAEKYKAEDE VQRERVSAKN 
ALESYAFNMK SAVEDEGLKG KISEADKKKV LDKCQEVISW LDANTLAEKD EFEHKRKELE 
QVCNPIISGL YQGAGGPGPG GFGAQGPKGG SGSGPTIEEV D

Genular Protein ID: 690584237

Symbol: B3KTT5_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KTT5

Database IDs:

ARBA 8 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 11 Gene3D 2 IntAct 1 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 SAM 1 SUPFAM 3

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 476
  • Mass: 51917
  • Checksum: 24C7844D48228F36
  • Sequence:
    • MAKAAAIGID LGTTYSCVGV FQHGKGERNV LIFDLGGGTF DVSILTIDDG IFEVKATAGD 
THLGGEDFDN RLVNHFVEEF KRKHKKDISQ NKRAVRRLRT ACERAKRTLS SSTQASLEID 
SLFEGIDFYT SITRARFEEL CSDLFRSTLE PVEKALRDAK LDKAQIHDLV LVGGSTRIPK 
VQKLLQDFFN GRDLNKSINP DEAVAYGAAV QAAILMGDKS ENVQDLLLLD VAPLSLGLET 
AGGVMTALIK RNSTIPTKQT QIFTTYSDNQ PGVLIQVYEG ERAMTKDNNL LGRFELSGIP 
PAPRGVPQIE VTFDIDANGI LNVTATDKSA GKANKITITN DKGRLSKEEI ERMVQEAEKY 
KAEDEVQRER VSAKNALESY AFNMKSAVED EGLKGKISEA DKKKVLDKCQ EVISWLDANT 
LAEKDEFEHK RKELEQVCNP IISGLYQGAG GPGPGGFGAQ GPKGGSGSGP TIEEVD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.