Details for: HSPA1A

Gene ID: 3303

Symbol: HSPA1A

Ensembl ID: ENSG00000204389

Description: heat shock protein family A (Hsp70) member 1A

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 4.33
    Marker Score: 5646
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.3
    Marker Score: 146132
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 4.03
    Marker Score: 3437
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 3.77
    Marker Score: 2953
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.67
    Marker Score: 4432.5
  • Cell Name: theca cell (CL0000503)
    Fold Change: 3.65
    Marker Score: 2614
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.54
    Marker Score: 3782
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 3.53
    Marker Score: 2362
  • Cell Name: germ cell (CL0000586)
    Fold Change: 3.4
    Marker Score: 5941
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.37
    Marker Score: 6336
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 3.27
    Marker Score: 3080.5
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.18
    Marker Score: 7756
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 3.1
    Marker Score: 6198
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 2.95
    Marker Score: 1647
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.8
    Marker Score: 4318
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.78
    Marker Score: 4558.5
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.77
    Marker Score: 1049
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 2.77
    Marker Score: 1840
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 2.75
    Marker Score: 639
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.74
    Marker Score: 8601.5
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 2.73
    Marker Score: 800
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 2.69
    Marker Score: 1155.5
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.67
    Marker Score: 26432.5
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.63
    Marker Score: 2635
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.59
    Marker Score: 16829
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.57
    Marker Score: 33960
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.56
    Marker Score: 5204
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.55
    Marker Score: 6438
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.55
    Marker Score: 2913
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.54
    Marker Score: 1057
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 2.52
    Marker Score: 920
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.52
    Marker Score: 1985
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 2.49
    Marker Score: 1663
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.47
    Marker Score: 5150
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 2.46
    Marker Score: 1861
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.44
    Marker Score: 4049
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 2.42
    Marker Score: 3016
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.41
    Marker Score: 2541
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.41
    Marker Score: 8923
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 2.38
    Marker Score: 1182
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 2.29
    Marker Score: 30466
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 2.29
    Marker Score: 2697
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.28
    Marker Score: 810
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 2.27
    Marker Score: 1305
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.26
    Marker Score: 5913
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 2.26
    Marker Score: 2354
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.25
    Marker Score: 14354
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 2.25
    Marker Score: 1478
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 2.23
    Marker Score: 998
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.22
    Marker Score: 3773.5
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.19
    Marker Score: 24700
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.17
    Marker Score: 16178
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.17
    Marker Score: 1829
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 2.14
    Marker Score: 1911
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.14
    Marker Score: 10496
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.14
    Marker Score: 11230
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.13
    Marker Score: 18472
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 2.11
    Marker Score: 670
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 2.1
    Marker Score: 1787
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.1
    Marker Score: 4783
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.1
    Marker Score: 1399
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 2.09
    Marker Score: 8680
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 2.07
    Marker Score: 896
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 2.07
    Marker Score: 770
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.06
    Marker Score: 1060
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.06
    Marker Score: 5122
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 2.05
    Marker Score: 1711
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.04
    Marker Score: 3457
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.04
    Marker Score: 3242
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.02
    Marker Score: 1268.5
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 2.02
    Marker Score: 1230
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.01
    Marker Score: 51528
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.01
    Marker Score: 4561
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2
    Marker Score: 2750
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.99
    Marker Score: 1877
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.99
    Marker Score: 2925
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.97
    Marker Score: 2738
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.97
    Marker Score: 489
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.97
    Marker Score: 1340
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.96
    Marker Score: 583
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.94
    Marker Score: 2059
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.94
    Marker Score: 670
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.93
    Marker Score: 443
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.92
    Marker Score: 3355
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.9
    Marker Score: 16400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.89
    Marker Score: 14796
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.89
    Marker Score: 1103
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 1.89
    Marker Score: 1373
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.89
    Marker Score: 2215
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.89
    Marker Score: 1341
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.88
    Marker Score: 680
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.87
    Marker Score: 2652
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 1.87
    Marker Score: 926
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.87
    Marker Score: 1944
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 1.87
    Marker Score: 1072
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.87
    Marker Score: 725
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.87
    Marker Score: 885
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 1.85
    Marker Score: 420
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.85
    Marker Score: 1592
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.85
    Marker Score: 626

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Other Information

**Key characteristics:** * HSPA1A is a large protein (120 kDa) that is expressed in multiple isoforms. * The full-length protein is encoded by a gene that is located on chromosome 17. * HSPA1A is a member of the HSP70 family of heat shock proteins. * It is involved in a variety of cellular processes, including stress response, immune response, and metabolism. **Pathways and functions:** * HSPA1A is involved in the antiviral mechanism by ifn-stimulated genes. * It binds to and destabilizes mRNA, preventing it from being translated. * It is involved in cellular responses to stimuli, cellular responses to stress, and cellular response to heat stress. * It is also involved in cytokine signaling in the immune system. * It is involved in disease, hsf1 activation, and hsf1-dependent transactivation. * It is a key regulator of the heat shock response. * It is also involved in the regulation of mrna stability by proteins that bind au-rich elements. **Clinical significance:** * Mutations in the HSPA1A gene have been linked to a number of human diseases, including heat stress, autoimmune diseases, and cancer. * HSPA1A inhibitors are being investigated as a treatment for these diseases.

Genular Protein ID: 515514565

Symbol: HS71A_HUMAN

Name: Heat shock 70 kDa protein 1

UniProtKB Accession Codes:

P0DMV8 B4E3B6 P08107 P19790 Q5JQI4 Q5SP17 Q9UQL9 Q9UQM0

Database IDs:

ABCD 1 AGR 2 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID-ORCS 2 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 2 CarbonylDB 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 2 DrugCentral 1 EMBL 11 EMDB 1 Ensembl 5 ExpressionAtlas 1 GO 79 Gene3D 3 GeneCards 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 2 MANE-Select 1 MIM 2 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 2 OrthoDB 1 PANTHER 2 PDB 56 PDBsum 44 PIR 4 PRIDE 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 8 RefSeq 2 SAM 1 SASBDB 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3931075

Title: Conserved features of eukaryotic hsp70 genes revealed by comparison with the nucleotide sequence of human hsp70.

PubMed ID: 3931075

DOI: 10.1073/pnas.82.19.6455

PubMed ID: 1700760

Title: Structure and expression of the three MHC-linked HSP70 genes.

PubMed ID: 1700760

DOI: 10.1007/bf00187095

PubMed ID: 14656967

Title: Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.

PubMed ID: 14656967

DOI: 10.1101/gr.1736803

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2538825

Title: Human major histocompatibility complex contains genes for the major heat shock protein HSP70.

PubMed ID: 2538825

DOI: 10.1073/pnas.86.6.1968

PubMed ID: 3786141

Title: In vitro transcription of a human hsp 70 heat shock gene by extracts prepared from heat-shocked and non-heat-shocked human cells.

PubMed ID: 3786141

DOI: 10.1093/nar/14.22.8933

PubMed ID: 23349634

Title: A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity.

PubMed ID: 23349634

DOI: 10.1371/journal.pgen.1003210

PubMed ID: 7935376

Title: Interaction between heat shock factor and hsp70 is insufficient to suppress induction of DNA-binding activity in vivo.

PubMed ID: 7935376

DOI: 10.1128/mcb.14.10.6552-6560.1994

PubMed ID: 9499401

Title: Molecular chaperones as HSF1-specific transcriptional repressors.

PubMed ID: 9499401

DOI: 10.1101/gad.12.5.654

PubMed ID: 11274138

Title: Stable association of hsp90 and p23, but Not hsp70, with active human telomerase.

PubMed ID: 11274138

DOI: 10.1074/jbc.c100055200

PubMed ID: 12853476

Title: Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system.

PubMed ID: 12853476

DOI: 10.1093/emboj/cdg362

PubMed ID: 15963462

Title: Phosphorylation and binding partner analysis of the TSC1-TSC2 complex.

PubMed ID: 15963462

DOI: 10.1016/j.bbrc.2005.05.175

PubMed ID: 15383005

Title: Human protein phosphatase 5 dissociates from heat-shock proteins and is proteolytically activated in response to arachidonic acid and the microtubule-depolymerizing drug nocodazole.

PubMed ID: 15383005

DOI: 10.1042/bj20040690

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17233114

Title: The disordered amino-terminus of SIMPL interacts with members of the 70-kDa heat-shock protein family.

PubMed ID: 17233114

DOI: 10.1089/dna.2006.25.704

PubMed ID: 16537599

Title: The peptide-binding and ATPase domains of recombinant hsc70 are required to interact with rotavirus and reduce its infectivity.

PubMed ID: 16537599

DOI: 10.1128/jvi.80.7.3322-3331.2006

PubMed ID: 17182002

Title: HDJC9, a novel human type C DnaJ/HSP40 member interacts with and cochaperones HSP70 through the J domain.

PubMed ID: 17182002

DOI: 10.1016/j.bbrc.2006.12.013

PubMed ID: 17289661

Title: Molecular composition of IMP1 ribonucleoprotein granules.

PubMed ID: 17289661

DOI: 10.1074/mcp.m600346-mcp200

PubMed ID: 17947705

Title: Heat shock protein 90 associates with monarch-1 and regulates its ability to promote degradation of NF-kappaB-inducing kinase.

PubMed ID: 17947705

DOI: 10.4049/jimmunol.179.9.6291

PubMed ID: 18620420

Title: Role of the cochaperone Tpr2 in Hsp90 chaperoning.

PubMed ID: 18620420

DOI: 10.1021/bi800770g

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20053985

Title: Hsp70 interacts with the retroviral restriction factor TRIM5alpha and assists the folding of TRIM5alpha.

PubMed ID: 20053985

DOI: 10.1074/jbc.m109.040618

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21081504

Title: ChChd3, an inner mitochondrial membrane protein, is essential for maintaining crista integrity and mitochondrial function.

PubMed ID: 21081504

DOI: 10.1074/jbc.m110.171975

PubMed ID: 22528486

Title: Nucleophosmin (NPM1/B23) interacts with activating transcription factor 5 (ATF5) protein and promotes proteasome- and caspase-dependent ATF5 degradation in hepatocellular carcinoma cells.

PubMed ID: 22528486

DOI: 10.1074/jbc.m112.363622

PubMed ID: 22905912

Title: Resveratrol-induced changes of the human adipocyte secretion profile.

PubMed ID: 22905912

DOI: 10.1021/pr300539b

PubMed ID: 23973223

Title: The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3.

PubMed ID: 23973223

DOI: 10.1016/j.immuni.2013.08.006

PubMed ID: 23921388

Title: Identification and characterization of a novel human methyltransferase modulating Hsp70 function through lysine methylation.

PubMed ID: 23921388

DOI: 10.1074/jbc.m113.483248

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24270810

Title: High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy.

PubMed ID: 24270810

DOI: 10.1038/nature12748

PubMed ID: 24012426

Title: Hsp70 chaperone dynamics and molecular mechanism.

PubMed ID: 24012426

DOI: 10.1016/j.tibs.2013.08.001

PubMed ID: 24613385

Title: Hsp70 and Hsp90 oppositely regulate TGF-beta signaling through CHIP/Stub1.

PubMed ID: 24613385

DOI: 10.1016/j.bbrc.2014.02.124

PubMed ID: 24318877

Title: Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro.

PubMed ID: 24318877

DOI: 10.1074/jbc.m113.521997

PubMed ID: 24790089

Title: The molecular chaperone HSP70 binds to and stabilizes NOD2, an important protein involved in Crohn disease.

PubMed ID: 24790089

DOI: 10.1074/jbc.m114.557686

PubMed ID: 25281747

Title: RING finger protein RNF207, a novel regulator of cardiac excitation.

PubMed ID: 25281747

DOI: 10.1074/jbc.m114.592295

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27133716

Title: A novel nuclear DnaJ protein, DNAJC8, can suppress the formation of spinocerebellar ataxia 3 polyglutamine aggregation in a J-domain independent manner.

PubMed ID: 27133716

DOI: 10.1016/j.bbrc.2016.03.152

PubMed ID: 26865365

Title: The human HSP70 family of chaperones: where do we stand?

PubMed ID: 26865365

DOI: 10.1007/s12192-016-0676-6

PubMed ID: 27137183

Title: HSP70 regulates the function of mitotic centrosomes.

PubMed ID: 27137183

DOI: 10.1007/s00018-016-2236-8

PubMed ID: 27708256

Title: ARD1-mediated Hsp70 acetylation balances stress-induced protein refolding and degradation.

PubMed ID: 27708256

DOI: 10.1038/ncomms12882

PubMed ID: 28842558

Title: HSP70-Hrd1 axis precludes the oncorepressor potential of N-terminal misfolded Blimp-1s in lymphoma cells.

PubMed ID: 28842558

DOI: 10.1038/s41467-017-00476-w

PubMed ID: 10216320

Title: Structure of a new crystal form of human hsp70 ATPase domain.

PubMed ID: 10216320

DOI: 10.1107/s0907444999002103

PubMed ID: 20179333

Title: Direct inter-subdomain interactions switch between the closed and open forms of the Hsp70 nucleotide-binding domain in the nucleotide-free state.

PubMed ID: 20179333

DOI: 10.1107/s0907444909053979

PubMed ID: 20072699

Title: Crystal structures of the ATPase domains of four human Hsp70 isoforms: HSPA1L/Hsp70-hom, HSPA2/Hsp70-2, HSPA6/Hsp70B', and HSPA5/BiP/GRP78.

PubMed ID: 20072699

DOI: 10.1371/journal.pone.0008625

PubMed ID: 20223214

Title: The C-terminal BAG domain of BAG5 induces conformational changes of the Hsp70 nucleotide-binding domain for ADP-ATP exchange.

PubMed ID: 20223214

DOI: 10.1016/j.str.2010.01.004

PubMed ID: 21608060

Title: Biochemical and structural studies on the high affinity of Hsp70 for ADP.

PubMed ID: 21608060

DOI: 10.1002/pro.663

Sequence Information:

  • Length: 641
  • Mass: 70052
  • Checksum: 78F513118C96DE66
  • Sequence:
    • MAKAAAIGID LGTTYSCVGV FQHGKVEIIA NDQGNRTTPS YVAFTDTERL IGDAAKNQVA 
LNPQNTVFDA KRLIGRKFGD PVVQSDMKHW PFQVINDGDK PKVQVSYKGE TKAFYPEEIS 
SMVLTKMKEI AEAYLGYPVT NAVITVPAYF NDSQRQATKD AGVIAGLNVL RIINEPTAAA 
IAYGLDRTGK GERNVLIFDL GGGTFDVSIL TIDDGIFEVK ATAGDTHLGG EDFDNRLVNH 
FVEEFKRKHK KDISQNKRAV RRLRTACERA KRTLSSSTQA SLEIDSLFEG IDFYTSITRA 
RFEELCSDLF RSTLEPVEKA LRDAKLDKAQ IHDLVLVGGS TRIPKVQKLL QDFFNGRDLN 
KSINPDEAVA YGAAVQAAIL MGDKSENVQD LLLLDVAPLS LGLETAGGVM TALIKRNSTI 
PTKQTQIFTT YSDNQPGVLI QVYEGERAMT KDNNLLGRFE LSGIPPAPRG VPQIEVTFDI 
DANGILNVTA TDKSTGKANK ITITNDKGRL SKEEIERMVQ EAEKYKAEDE VQRERVSAKN 
ALESYAFNMK SAVEDEGLKG KISEADKKKV LDKCQEVISW LDANTLAEKD EFEHKRKELE 
QVCNPIISGL YQGAGGPGPG GFGAQGPKGG SGSGPTIEEV D

Genular Protein ID: 690584237

Symbol: B3KTT5_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KTT5

Database IDs:

ARBA 8 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 2 Gene3D 2 Genevisible 1 GenomeRNAi 1 IntAct 1 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 SAM 1 SUPFAM 3

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 476
  • Mass: 51917
  • Checksum: 24C7844D48228F36
  • Sequence:
    • MAKAAAIGID LGTTYSCVGV FQHGKGERNV LIFDLGGGTF DVSILTIDDG IFEVKATAGD 
THLGGEDFDN RLVNHFVEEF KRKHKKDISQ NKRAVRRLRT ACERAKRTLS SSTQASLEID 
SLFEGIDFYT SITRARFEEL CSDLFRSTLE PVEKALRDAK LDKAQIHDLV LVGGSTRIPK 
VQKLLQDFFN GRDLNKSINP DEAVAYGAAV QAAILMGDKS ENVQDLLLLD VAPLSLGLET 
AGGVMTALIK RNSTIPTKQT QIFTTYSDNQ PGVLIQVYEG ERAMTKDNNL LGRFELSGIP 
PAPRGVPQIE VTFDIDANGI LNVTATDKSA GKANKITITN DKGRLSKEEI ERMVQEAEKY 
KAEDEVQRER VSAKNALESY AFNMKSAVED EGLKGKISEA DKKKVLDKCQ EVISWLDANT 
LAEKDEFEHK RKELEQVCNP IISGLYQGAG GPGPGGFGAQ GPKGGSGSGP TIEEVD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.