Details for: SRGN

Gene ID: 5552

Symbol: SRGN

Ensembl ID: ENSG00000122862

Description: serglycin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 440.3221
    Cell Significance Index: -68.4900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 218.1623
    Cell Significance Index: -88.6300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 210.3666
    Cell Significance Index: -86.6600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 175.4037
    Cell Significance Index: -44.4900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 175.2189
    Cell Significance Index: -90.1300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 171.5232
    Cell Significance Index: -80.9800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 121.1137
    Cell Significance Index: -81.2700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 94.3395
    Cell Significance Index: -90.0700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 57.1391
    Cell Significance Index: -70.4500
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 52.4566
    Cell Significance Index: 140.5300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 26.0398
    Cell Significance Index: -79.9800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 19.3763
    Cell Significance Index: -76.4600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 17.2010
    Cell Significance Index: 317.9200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 16.8897
    Cell Significance Index: 451.7900
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 12.0649
    Cell Significance Index: 80.0400
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 11.0236
    Cell Significance Index: 45.8800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 6.6649
    Cell Significance Index: 195.7400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 5.9488
    Cell Significance Index: 105.1200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 5.1760
    Cell Significance Index: 80.0800
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 4.7872
    Cell Significance Index: 30.5600
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 3.7372
    Cell Significance Index: 26.8400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 3.6394
    Cell Significance Index: 90.9800
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 2.9366
    Cell Significance Index: 50.4500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.1494
    Cell Significance Index: 59.8700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0331
    Cell Significance Index: 196.6100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.8975
    Cell Significance Index: 57.9000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6983
    Cell Significance Index: 630.5300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6627
    Cell Significance Index: 78.1500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.5519
    Cell Significance Index: 6.2700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5090
    Cell Significance Index: 50.3500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3162
    Cell Significance Index: 6.8500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2745
    Cell Significance Index: 35.1900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.2061
    Cell Significance Index: 1.2500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1623
    Cell Significance Index: 26.3900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0317
    Cell Significance Index: -23.9600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0360
    Cell Significance Index: -67.8000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0409
    Cell Significance Index: -62.9500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0477
    Cell Significance Index: -29.8000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0488
    Cell Significance Index: -90.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0507
    Cell Significance Index: -37.5500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0555
    Cell Significance Index: -1.9500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0669
    Cell Significance Index: -91.0100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0734
    Cell Significance Index: -7.5000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0849
    Cell Significance Index: -47.8900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1259
    Cell Significance Index: -79.9900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.1403
    Cell Significance Index: -76.6200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.1576
    Cell Significance Index: -69.6600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1725
    Cell Significance Index: -78.3100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1846
    Cell Significance Index: -36.6300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1962
    Cell Significance Index: -70.3900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1965
    Cell Significance Index: -35.4200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2218
    Cell Significance Index: -63.8100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2483
    Cell Significance Index: -12.5500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.2538
    Cell Significance Index: -27.6100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2637
    Cell Significance Index: -55.5400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.3001
    Cell Significance Index: -36.9000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.3588
    Cell Significance Index: -61.2700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.3588
    Cell Significance Index: -49.2800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.3695
    Cell Significance Index: -6.3700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.3765
    Cell Significance Index: -75.5200
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.3877
    Cell Significance Index: -2.7900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.4019
    Cell Significance Index: -11.5800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.4137
    Cell Significance Index: -18.7500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.5252
    Cell Significance Index: -76.3400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.5630
    Cell Significance Index: -72.7300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.5733
    Cell Significance Index: -23.4900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.5975
    Cell Significance Index: -28.0800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.6499
    Cell Significance Index: -75.7400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.6743
    Cell Significance Index: -76.9700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.7193
    Cell Significance Index: -49.7500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.7236
    Cell Significance Index: -75.3400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.7711
    Cell Significance Index: -88.3400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7784
    Cell Significance Index: -24.9300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8371
    Cell Significance Index: -51.3200
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.8451
    Cell Significance Index: -12.3600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.8646
    Cell Significance Index: -66.3500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -1.0042
    Cell Significance Index: -74.8400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -1.0163
    Cell Significance Index: -71.8800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -1.0377
    Cell Significance Index: -45.1200
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -1.0655
    Cell Significance Index: -5.8100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.1150
    Cell Significance Index: -28.4900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -1.1232
    Cell Significance Index: -67.4300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.1335
    Cell Significance Index: -89.7700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -1.1381
    Cell Significance Index: -30.3900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.1981
    Cell Significance Index: -80.5600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.2168
    Cell Significance Index: -74.7900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -1.3294
    Cell Significance Index: -19.1200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.4919
    Cell Significance Index: -83.7200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.4977
    Cell Significance Index: -77.8000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: -1.5604
    Cell Significance Index: 4.1800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.5805
    Cell Significance Index: -82.9800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.5874
    Cell Significance Index: -100.0500
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -1.6386
    Cell Significance Index: -27.8300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -1.7001
    Cell Significance Index: -33.2400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.7148
    Cell Significance Index: -79.9500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.8190
    Cell Significance Index: -80.4600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -1.9069
    Cell Significance Index: -15.5500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.9623
    Cell Significance Index: -56.2500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.9963
    Cell Significance Index: -55.7900
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: -2.0363
    Cell Significance Index: -12.7500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Serglycin is a 28-kDa protein with a unique structure, consisting of four C-type lectin-like domains and a serine-rich region. This structure allows it to interact with various proteins and lipids, influencing cellular processes. Serglycin is predominantly expressed in immune cells, including natural killer cells, T cells, and monocytes, which highlights its role in immune regulation. **Pathways and Functions:** Serglycin is involved in multiple cellular pathways, including: 1. **Apoptotic Process:** Serglycin has been shown to regulate apoptosis in immune cells, influencing the balance between cell survival and death. 2. **Biomineralization:** Serglycin plays a crucial role in the biomineralization of bone and platelets, highlighting its involvement in tissue development and repair. 3. **Cytolytic Granule:** Serglycin is essential for the formation and function of cytolytic granules in immune cells, such as natural killer cells and T cells. 4. **Protein Processing:** Serglycin is involved in the processing and maturation of proteins, including granzyme B and proteases, which are essential for immune cell function. 5. **Signaling and Aggregation:** Serglycin interacts with platelet receptors, influencing platelet activation and aggregation. **Clinical Significance:** Serglycin's dysregulation has been implicated in various immune-related disorders, including: 1. **Immune-Mediated Diseases:** Alterations in srglycin expression have been linked to autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer:** Serglycin's involvement in apoptosis and protein processing suggests its potential as a biomarker for cancer diagnosis and treatment. 3. **Platelet Disorders:** Abnormalities in srglycin expression have been associated with bleeding disorders, such as thrombocytopenia. 4. **Infectious Diseases:** Serglycin's role in immune cell function suggests its potential as a target for the treatment of infectious diseases. In conclusion, srglycin is a multifaceted protein with a wide range of functions in immune regulation and cellular processes. Its dysregulation has been implicated in various immune-related disorders, highlighting the importance of further research into its role in human health and disease.

Genular Protein ID: 3533950957

Symbol: SRGN_HUMAN

Name: Serglycin

UniProtKB Accession Codes:

P10124 B2R4L7 Q5VW06

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 Ensembl 1 GO 18 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 4 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2835370

Title: Isolation and characterization of a cDNA that encodes the peptide core of the secretory granule proteoglycan of human promyelocytic leukemia HL-60 cells.

PubMed ID: 2835370

DOI: 10.1016/s0021-9258(18)68639-9

PubMed ID: 2798108

Title: Nucleotide sequence of a cDNA encoding a hemopoietic proteoglycan core protein.

PubMed ID: 2798108

DOI: 10.1093/nar/17.18.7523

PubMed ID: 2180935

Title: Characterization of the human gene that encodes the peptide core of secretory granule proteoglycans in promyelocytic leukemia HL-60 cells and analysis of the translated product.

PubMed ID: 2180935

DOI: 10.1016/s0021-9258(19)39446-3

PubMed ID: 1377686

Title: The human serglycin gene. Nucleotide sequence and methylation pattern in human promyelocytic leukemia HL-60 cells and T-lymphoblast Molt-4 cells.

PubMed ID: 1377686

DOI: 10.1016/s0021-9258(18)42248-x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3402609

Title: Complete amino acid sequence of a human platelet proteoglycan.

PubMed ID: 3402609

DOI: 10.1016/0014-5793(88)80298-9

PubMed ID: 3214420

Title: Characterization and N-terminal sequence of human platelet proteoglycan.

PubMed ID: 3214420

DOI: 10.1042/bj2551007

PubMed ID: 11154222

Title: Synthesis, secretion, and subcellular localization of serglycin proteoglycan in human endothelial cells.

PubMed ID: 11154222

DOI: 10.1182/blood.v97.2.449

PubMed ID: 11911826

Title: Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation.

PubMed ID: 11911826

DOI: 10.1016/s1074-7613(02)00286-8

PubMed ID: 12388539

Title: Cytotoxic cell granule-mediated apoptosis. Characterization of the macromolecular complex of granzyme B with serglycin.

PubMed ID: 12388539

DOI: 10.1074/jbc.m209607200

PubMed ID: 15136585

Title: Localization of serglycin in human neutrophil granulocytes and their precursors.

PubMed ID: 15136585

DOI: 10.1189/jlb.1003502

PubMed ID: 16420477

Title: Secretion of proteases in serglycin transfected Madin-Darby canine kidney cells.

PubMed ID: 16420477

DOI: 10.1111/j.1742-4658.2005.05085.x

PubMed ID: 16870619

Title: Serglycin constitutively secreted by myeloma plasma cells is a potent inhibitor of bone mineralization in vitro.

PubMed ID: 16870619

DOI: 10.1074/jbc.m601061200

Sequence Information:

  • Length: 158
  • Mass: 17652
  • Checksum: BD7767F39FFBC477
  • Sequence:
    • MMQKLLKCSR LVLALALILV LESSVQGYPT RRARYQWVRC NPDSNSANCL EEKGPMFELL 
PGESNKIPRL RTDLFPKTRI QDLNRIFPLS EDYSGSGFGS GSGSGSGSGS GFLTEMEQDY 
QLVDESDAFH DNLRSLDRNL PSDSQDLGQH GLEEDFML

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.