Gene SRGN - ENSG00000122862 | NCBI Gene ID: 5552

Details for: SRGN

Gene ID: 5552

Symbol: SRGN

Ensembl ID: ENSG00000122862

Description: serglycin

Associated with

Hemostasis
(R-HSA-109582)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Platelet degranulation
(R-HSA-114608)
Response to elevated platelet cytosolic ca2+
(R-HSA-76005)
Apoptotic process
(GO:0006915)
Biomineral tissue development
(GO:0031214)
Cytolytic granule
(GO:0044194)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Golgi apparatus
(GO:0005794)
Granzyme-mediated programmed cell death signaling pathway
(GO:0140507)
Maintenance of granzyme b location in t cell secretory granule
(GO:0033382)
Maintenance of protease location in mast cell secretory granule
(GO:0033373)
Mast cell granule
(GO:0042629)
Mast cell secretory granule organization
(GO:0033364)
Negative regulation of bone mineralization
(GO:0030502)
Negative regulation of cytokine production
(GO:0001818)
Platelet alpha granule lumen
(GO:0031093)
Protein binding
(GO:0005515)
Protein processing
(GO:0016485)
Secretory granule
(GO:0030141)
Secretory granule organization
(GO:0033363)
T cell secretory granule organization
(GO:0033371)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 5.36
Marker Score: 15632
Cell Name: mature T cell (CL0002419)
Fold Change: 5.11
Marker Score: 50651
Cell Name: early promyelocyte (CL0002154)
Fold Change: 4.97
Marker Score: 3979
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 4.75
Marker Score: 3446
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 4.57
Marker Score: 2348
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 4.5
Marker Score: 14198
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 4.48
Marker Score: 250381.5
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 4.45
Marker Score: 12299.5
Cell Name: intraepithelial lymphocyte (CL0002496)
Fold Change: 4.3
Marker Score: 4773
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 4.23
Marker Score: 11873
Cell Name: memory T cell (CL0000813)
Fold Change: 4.13
Marker Score: 1777
Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 4.02
Marker Score: 10216
Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
Fold Change: 4
Marker Score: 1299
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 3.9
Marker Score: 3326
Cell Name: lung macrophage (CL1001603)
Fold Change: 3.88
Marker Score: 4434
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 3.83
Marker Score: 3298
Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: 3.82
Marker Score: 1970.5
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 3.74
Marker Score: 2194
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 3.74
Marker Score: 3149
Cell Name: blood cell (CL0000081)
Fold Change: 3.72
Marker Score: 43220
Cell Name: naive T cell (CL0000898)
Fold Change: 3.6
Marker Score: 2316
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 3.57
Marker Score: 8622
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 3.52
Marker Score: 3405
Cell Name: basophil (CL0000767)
Fold Change: 3.5
Marker Score: 1662
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 3.49
Marker Score: 6801.5
Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: 3.46
Marker Score: 1908
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 3.42
Marker Score: 5040
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 3.31
Marker Score: 1654
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 3.31
Marker Score: 4564
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 3.28
Marker Score: 14082
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 3.19
Marker Score: 1375
Cell Name: type I NK T cell (CL0000921)
Fold Change: 3.13
Marker Score: 2459
Cell Name: exhausted T cell (CL0011025)
Fold Change: 3.12
Marker Score: 1796.5
Cell Name: myelocyte (CL0002193)
Fold Change: 3.12
Marker Score: 1347
Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
Fold Change: 3.08
Marker Score: 818
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 3.06
Marker Score: 6103
Cell Name: Kupffer cell (CL0000091)
Fold Change: 3.06
Marker Score: 3056
Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 3.05
Marker Score: 2857
Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: 3.05
Marker Score: 2205
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 3.05
Marker Score: 161189
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 3.05
Marker Score: 7590.5
Cell Name: late promyelocyte (CL0002151)
Fold Change: 3.02
Marker Score: 758
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 3.01
Marker Score: 2680
Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
Fold Change: 2.99
Marker Score: 984.5
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 2.97
Marker Score: 7707
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 2.96
Marker Score: 918
Cell Name: regulatory T cell (CL0000815)
Fold Change: 2.95
Marker Score: 3258
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 2.94
Marker Score: 4267
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 2.92
Marker Score: 4136
Cell Name: eurydendroid cell (CL0000253)
Fold Change: 2.92
Marker Score: 1193
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: 2.91
Marker Score: 6550
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 2.87
Marker Score: 73410
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 2.84
Marker Score: 2359
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 2.82
Marker Score: 18031.5
Cell Name: granulocyte (CL0000094)
Fold Change: 2.8
Marker Score: 1255
Cell Name: microglial cell (CL0000129)
Fold Change: 2.79
Marker Score: 5087
Cell Name: ILC1, human (CL0001077)
Fold Change: 2.78
Marker Score: 705
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 2.72
Marker Score: 976
Cell Name: elicited macrophage (CL0000861)
Fold Change: 2.66
Marker Score: 16140
Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 2.61
Marker Score: 1089
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: 2.6
Marker Score: 4238
Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
Fold Change: 2.53
Marker Score: 556
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 2.51
Marker Score: 4910
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 2.47
Marker Score: 1812
Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 2.47
Marker Score: 3572.5
Cell Name: memory regulatory T cell (CL0002678)
Fold Change: 2.47
Marker Score: 861
Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 2.47
Marker Score: 1786
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: 2.47
Marker Score: 2661
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 2.43
Marker Score: 946
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 2.4
Marker Score: 2893
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 2.39
Marker Score: 1472
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 2.39
Marker Score: 735
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 2.39
Marker Score: 1605
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 2.38
Marker Score: 1804
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 2.37
Marker Score: 4059
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 2.37
Marker Score: 1412
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 2.31
Marker Score: 966
Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
Fold Change: 2.31
Marker Score: 522
Cell Name: dendritic cell (CL0000451)
Fold Change: 2.27
Marker Score: 1554
Cell Name: endothelial cell (CL0000115)
Fold Change: 2.27
Marker Score: 2031
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 2.26
Marker Score: 3817
Cell Name: promyelocyte (CL0000836)
Fold Change: 2.25
Marker Score: 1114
Cell Name: classical monocyte (CL0000860)
Fold Change: 2.23
Marker Score: 9267
Cell Name: mature microglial cell (CL0002629)
Fold Change: 2.2
Marker Score: 795
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 2.15
Marker Score: 1897
Cell Name: endothelial cell of artery (CL1000413)
Fold Change: 2.15
Marker Score: 890
Cell Name: naive regulatory T cell (CL0002677)
Fold Change: 2.13
Marker Score: 647
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 2.12
Marker Score: 1033
Cell Name: natural killer cell (CL0000623)
Fold Change: 2.11
Marker Score: 2731
Cell Name: erythroid progenitor cell, mammalian (CL0001066)
Fold Change: 2.1
Marker Score: 674
Cell Name: Unknown (CL0000548)
Fold Change: 2.1
Marker Score: 1527
Cell Name: IgG plasmablast (CL0000982)
Fold Change: 2.06
Marker Score: 568
Cell Name: IgA plasmablast (CL0000984)
Fold Change: 2.05
Marker Score: 539
Cell Name: macrophage (CL0000235)
Fold Change: 2.05
Marker Score: 2280
Cell Name: endocardial cell (CL0002350)
Fold Change: 2.05
Marker Score: 1157
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 2.04
Marker Score: 3642
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 2.02
Marker Score: 1111
Cell Name: plasmablast (CL0000980)
Fold Change: 2.01
Marker Score: 2671
Cell Name: vein endothelial cell (CL0002543)
Fold Change: 2.01
Marker Score: 1814
Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 2
Marker Score: 391

Hover over a box to see details here...

**Key Characteristics:** Serglycin is a 28-kDa protein with a unique structure, consisting of four C-type lectin-like domains and a serine-rich region. This structure allows it to interact with various proteins and lipids, influencing cellular processes. Serglycin is predominantly expressed in immune cells, including natural killer cells, T cells, and monocytes, which highlights its role in immune regulation. **Pathways and Functions:** Serglycin is involved in multiple cellular pathways, including: 1. **Apoptotic Process:** Serglycin has been shown to regulate apoptosis in immune cells, influencing the balance between cell survival and death. 2. **Biomineralization:** Serglycin plays a crucial role in the biomineralization of bone and platelets, highlighting its involvement in tissue development and repair. 3. **Cytolytic Granule:** Serglycin is essential for the formation and function of cytolytic granules in immune cells, such as natural killer cells and T cells. 4. **Protein Processing:** Serglycin is involved in the processing and maturation of proteins, including granzyme B and proteases, which are essential for immune cell function. 5. **Signaling and Aggregation:** Serglycin interacts with platelet receptors, influencing platelet activation and aggregation. **Clinical Significance:** Serglycin's dysregulation has been implicated in various immune-related disorders, including: 1. **Immune-Mediated Diseases:** Alterations in srglycin expression have been linked to autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer:** Serglycin's involvement in apoptosis and protein processing suggests its potential as a biomarker for cancer diagnosis and treatment. 3. **Platelet Disorders:** Abnormalities in srglycin expression have been associated with bleeding disorders, such as thrombocytopenia. 4. **Infectious Diseases:** Serglycin's role in immune cell function suggests its potential as a target for the treatment of infectious diseases. In conclusion, srglycin is a multifaceted protein with a wide range of functions in immune regulation and cellular processes. Its dysregulation has been implicated in various immune-related disorders, highlighting the importance of further research into its role in human health and disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Serglycin

Genular Protein ID: 3533950957

Symbol: SRGN_HUMAN

Name: Serglycin

UniProtKB Accession Codes:

P10124 B2R4L7 Q5VW06

Database IDs:

Citations:

PubMed ID: 2835370

Title: Isolation and characterization of a cDNA that encodes the peptide core of the secretory granule proteoglycan of human promyelocytic leukemia HL-60 cells.

PubMed ID: 2835370

DOI: 10.1016/s0021-9258(18)68639-9

PubMed ID: 2798108

Title: Nucleotide sequence of a cDNA encoding a hemopoietic proteoglycan core protein.

PubMed ID: 2798108

DOI: 10.1093/nar/17.18.7523

PubMed ID: 2180935

Title: Characterization of the human gene that encodes the peptide core of secretory granule proteoglycans in promyelocytic leukemia HL-60 cells and analysis of the translated product.

PubMed ID: 2180935

DOI: 10.1016/s0021-9258(19)39446-3

PubMed ID: 1377686

Title: The human serglycin gene. Nucleotide sequence and methylation pattern in human promyelocytic leukemia HL-60 cells and T-lymphoblast Molt-4 cells.

PubMed ID: 1377686

DOI: 10.1016/s0021-9258(18)42248-x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3402609

Title: Complete amino acid sequence of a human platelet proteoglycan.

PubMed ID: 3402609

DOI: 10.1016/0014-5793(88)80298-9

PubMed ID: 3214420

Title: Characterization and N-terminal sequence of human platelet proteoglycan.

PubMed ID: 3214420

DOI: 10.1042/bj2551007

PubMed ID: 11154222

Title: Synthesis, secretion, and subcellular localization of serglycin proteoglycan in human endothelial cells.

PubMed ID: 11154222

DOI: 10.1182/blood.v97.2.449

PubMed ID: 11911826

Title: Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation.

PubMed ID: 11911826

DOI: 10.1016/s1074-7613(02)00286-8

PubMed ID: 12388539

Title: Cytotoxic cell granule-mediated apoptosis. Characterization of the macromolecular complex of granzyme B with serglycin.

PubMed ID: 12388539

DOI: 10.1074/jbc.m209607200

PubMed ID: 15136585

Title: Localization of serglycin in human neutrophil granulocytes and their precursors.

PubMed ID: 15136585

DOI: 10.1189/jlb.1003502

PubMed ID: 16420477

Title: Secretion of proteases in serglycin transfected Madin-Darby canine kidney cells.

PubMed ID: 16420477

DOI: 10.1111/j.1742-4658.2005.05085.x

PubMed ID: 16870619

Title: Serglycin constitutively secreted by myeloma plasma cells is a potent inhibitor of bone mineralization in vitro.

PubMed ID: 16870619

DOI: 10.1074/jbc.m601061200

Sequence Information:

Length: 158
Mass: 17652
Checksum: BD7767F39FFBC477
Sequence:

MMQKLLKCSR LVLALALILV LESSVQGYPT RRARYQWVRC NPDSNSANCL EEKGPMFELL 
PGESNKIPRL RTDLFPKTRI QDLNRIFPLS EDYSGSGFGS GSGSGSGSGS GFLTEMEQDY 
QLVDESDAFH DNLRSLDRNL PSDSQDLGQH GLEEDFML

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: SRGN

Associated with

Cells (max top 100)

Other Information

Isolation and characterization of a cDNA that encodes the peptide core of the secretory granule proteoglycan of human promyelocytic leukemia HL-60 cells. PubMed ID: 2835370

Nucleotide sequence of a cDNA encoding a hemopoietic proteoglycan core protein. PubMed ID: 2798108

Characterization of the human gene that encodes the peptide core of secretory granule proteoglycans in promyelocytic leukemia HL-60 cells and analysis of the translated product. PubMed ID: 2180935

The human serglycin gene. Nucleotide sequence and methylation pattern in human promyelocytic leukemia HL-60 cells and T-lymphoblast Molt-4 cells. PubMed ID: 1377686

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and comparative analysis of human chromosome 10. PubMed ID: 15164054

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Complete amino acid sequence of a human platelet proteoglycan. PubMed ID: 3402609

Characterization and N-terminal sequence of human platelet proteoglycan. PubMed ID: 3214420

Synthesis, secretion, and subcellular localization of serglycin proteoglycan in human endothelial cells. PubMed ID: 11154222

Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation. PubMed ID: 11911826

Cytotoxic cell granule-mediated apoptosis. Characterization of the macromolecular complex of granzyme B with serglycin. PubMed ID: 12388539

Localization of serglycin in human neutrophil granulocytes and their precursors. PubMed ID: 15136585

Secretion of proteases in serglycin transfected Madin-Darby canine kidney cells. PubMed ID: 16420477

Serglycin constitutively secreted by myeloma plasma cells is a potent inhibitor of bone mineralization in vitro. PubMed ID: 16870619