Details for: PRR16

Gene ID: 51334

Symbol: PRR16

Ensembl ID: ENSG00000184838

Description: proline rich 16

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 216.3036
    Cell Significance Index: -33.6500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 130.5376
    Cell Significance Index: -33.1100
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 6.3092
    Cell Significance Index: 56.0100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 4.3651
    Cell Significance Index: 1565.6800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 3.2655
    Cell Significance Index: 144.4400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.9553
    Cell Significance Index: 111.9100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.3421
    Cell Significance Index: 469.8200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.1271
    Cell Significance Index: 119.3600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 2.0142
    Cell Significance Index: 28.9300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.9979
    Cell Significance Index: 153.3200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.9236
    Cell Significance Index: 1330.4300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.3741
    Cell Significance Index: 9.3100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.3373
    Cell Significance Index: 89.9200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.2896
    Cell Significance Index: 16.0000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.8967
    Cell Significance Index: 25.5900
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.8039
    Cell Significance Index: 4.9600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.3848
    Cell Significance Index: 9.8900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2982
    Cell Significance Index: 5.1100
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.2830
    Cell Significance Index: 3.6700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2219
    Cell Significance Index: 13.6400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0144
    Cell Significance Index: 26.5000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0136
    Cell Significance Index: 25.6100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0130
    Cell Significance Index: 1.7800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0072
    Cell Significance Index: 0.1400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.0040
    Cell Significance Index: 0.0800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0021
    Cell Significance Index: 0.0500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0017
    Cell Significance Index: -2.5600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0066
    Cell Significance Index: -4.2100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0165
    Cell Significance Index: -22.4200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0176
    Cell Significance Index: -3.1800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0319
    Cell Significance Index: -23.6300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0478
    Cell Significance Index: -36.1700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0523
    Cell Significance Index: -23.7200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0538
    Cell Significance Index: -33.6100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0544
    Cell Significance Index: -30.6600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0571
    Cell Significance Index: -31.1800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0854
    Cell Significance Index: -0.9300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0941
    Cell Significance Index: -27.0800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1422
    Cell Significance Index: -2.1000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1484
    Cell Significance Index: -31.2700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1499
    Cell Significance Index: -19.2200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1539
    Cell Significance Index: -30.5500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1596
    Cell Significance Index: -3.9800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1706
    Cell Significance Index: -29.1300
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.1822
    Cell Significance Index: -2.4300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1844
    Cell Significance Index: -26.8000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1852
    Cell Significance Index: -22.7700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1936
    Cell Significance Index: -4.1100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2002
    Cell Significance Index: -25.8600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2044
    Cell Significance Index: -3.4200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2086
    Cell Significance Index: -6.8300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2113
    Cell Significance Index: -6.7300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2725
    Cell Significance Index: -32.1400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2762
    Cell Significance Index: -31.6400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2919
    Cell Significance Index: -29.8200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2939
    Cell Significance Index: -34.2500
  • Cell Name: flat midget bipolar cell (CL4033033)
    Fold Change: -0.3041
    Cell Significance Index: -3.7800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3108
    Cell Significance Index: -32.3700
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.3190
    Cell Significance Index: -3.5200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3277
    Cell Significance Index: -7.0800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3609
    Cell Significance Index: -10.0900
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.3621
    Cell Significance Index: -4.5200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3785
    Cell Significance Index: -13.2600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4083
    Cell Significance Index: -21.2700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4106
    Cell Significance Index: -19.3000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4107
    Cell Significance Index: -30.6100
  • Cell Name: L5/6 near-projecting glutamatergic neuron of the primary motor cortex (CL4023043)
    Fold Change: -0.4107
    Cell Significance Index: -4.1500
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.4141
    Cell Significance Index: -5.3100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.4217
    Cell Significance Index: -8.3000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.4463
    Cell Significance Index: -10.8900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4466
    Cell Significance Index: -23.4500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4605
    Cell Significance Index: -9.6400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.4672
    Cell Significance Index: -6.6900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4868
    Cell Significance Index: -25.2900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.4905
    Cell Significance Index: -4.6500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.5050
    Cell Significance Index: -10.5400
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.5203
    Cell Significance Index: -6.0700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5242
    Cell Significance Index: -33.0400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.5314
    Cell Significance Index: -23.1000
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.5482
    Cell Significance Index: -8.3400
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.5666
    Cell Significance Index: -7.1500
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.5899
    Cell Significance Index: -7.0600
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.5910
    Cell Significance Index: -7.3700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5988
    Cell Significance Index: -27.9200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.6023
    Cell Significance Index: -12.0100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.7030
    Cell Significance Index: -13.9000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7126
    Cell Significance Index: -26.1600
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.7317
    Cell Significance Index: -8.8700
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.7622
    Cell Significance Index: -10.1600
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.7699
    Cell Significance Index: -7.3300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.7860
    Cell Significance Index: -27.6200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.8116
    Cell Significance Index: -22.0900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.8128
    Cell Significance Index: -12.5800
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.8486
    Cell Significance Index: -10.3300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.8861
    Cell Significance Index: -30.7900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.8884
    Cell Significance Index: -18.9900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.9111
    Cell Significance Index: -10.3500
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.9551
    Cell Significance Index: -4.4100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.9583
    Cell Significance Index: -27.4700
  • Cell Name: diffuse bipolar 2 cell (CL4033028)
    Fold Change: -0.9590
    Cell Significance Index: -11.7800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PRR16 is a proline-rich protein that exhibits high expression in specific cell types, such as polychromatophilic erythroblasts, hematopoietic oligopotent progenitor cells, and basal epithelial cells of the prostatic duct. The protein is known to interact with other proteins and influence cellular processes, including cell size regulation and translation. PRR16 is also involved in the regulation of protein binding, which can have significant consequences for cellular function and disease. **Pathways and Functions:** PRR16 is involved in several key pathways, including: 1. **Positive Regulation of Cell Size:** PRR16 interacts with other proteins to regulate cell size, which is essential for cell growth, differentiation, and survival. Dysregulation of this pathway can lead to abnormal cell growth and cancer. 2. **Positive Regulation of Translation:** PRR16 is involved in the regulation of protein translation, which is critical for cellular function and homeostasis. Dysregulation of this pathway can lead to impaired protein synthesis and disease. 3. **Protein Binding:** PRR16 interacts with other proteins to regulate protein binding, which can have significant consequences for cellular function and disease. **Functions:** The functions of PRR16 include: 1. **Regulation of Cell Size:** PRR16 interacts with other proteins to regulate cell size, which is essential for cell growth, differentiation, and survival. 2. **Regulation of Translation:** PRR16 is involved in the regulation of protein translation, which is critical for cellular function and homeostasis. 3. **Protein Binding:** PRR16 interacts with other proteins to regulate protein binding, which can have significant consequences for cellular function and disease. **Clinical Significance:** Dysregulation of PRR16 has been implicated in various diseases, including cancer, cardiovascular disease, and neurological disorders. For example: 1. **Cancer:** PRR16 dysregulation has been associated with cancer, including lymphoma and leukemia, where it can contribute to abnormal cell growth and tumor progression. 2. **Cardiovascular Disease:** PRR16 dysregulation has been implicated in cardiovascular disease, including atherosclerosis and cardiac hypertrophy, where it can contribute to abnormal cell growth and vascular dysfunction. 3. **Neurological Disorders:** PRR16 dysregulation has been associated with neurological disorders, including Alzheimer's disease and Parkinson's disease, where it can contribute to abnormal protein aggregation and neuronal dysfunction. In conclusion, PRR16 is a multifunctional protein that plays a crucial role in various cellular processes, including cell size regulation, translation, and protein binding. Its dysregulation can contribute to various diseases, including cancer, cardiovascular disease, and neurological disorders. Further research is needed to fully understand the role of PRR16 in human disease and to develop effective therapeutic strategies to target this protein.

Genular Protein ID: 111890467

Symbol: LARGN_HUMAN

Name: Protein Largen

UniProtKB Accession Codes:

Q569H4 D3DSZ0 Q8IXY1 Q9NYI5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 3 ExpressionAtlas 1 GO 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 RefSeq 5 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 24656129

Title: Largen: a molecular regulator of mammalian cell size control.

PubMed ID: 24656129

DOI: 10.1016/j.molcel.2014.02.028

Sequence Information:

  • Length: 304
  • Mass: 32812
  • Checksum: 42FF6EFF0AE2D2BF
  • Sequence:
    • MSAKSKGNPS SSCPAEGPPA ASKTKVKEQI KIIVEDLELV LGDLKDVAKE LKEVVDQIDT 
LTSDLQLEDE MTDSSKTDTL NSSSSGTTAS SLEKIKVQAN APLIKPPAHP SAILTVLRKP 
NPPPPPPRLT PVKCEDPKRV VPTANPVKTN GTLLRNGGLP GGPNKIPNGD ICCIPNSNLD 
KAPVQLLMHR PEKDRCPQAG PRERVRFNEK VQYHGYCPDC DTRYNIKNRE VHLHSEPVHP 
PGKIPHQGPP LPPTPHLPPF PLENGGMGIS HSNSFPPIRP ATVPPPTAPK PQKTILRKST 
TTTV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.