Details for: GLUL
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 652.4790
Cell Significance Index: -101.4900 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 386.4481
Cell Significance Index: -98.0200 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 252.6535
Cell Significance Index: -104.0800 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 238.6033
Cell Significance Index: -112.6500 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 208.4624
Cell Significance Index: -107.2300 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 168.1316
Cell Significance Index: -112.8200 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 101.4095
Cell Significance Index: -96.8200 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 83.6607
Cell Significance Index: -103.1500 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 40.1925
Cell Significance Index: -107.6700 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 29.6727
Cell Significance Index: -117.0900 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 22.6128
Cell Significance Index: -49.4900 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 10.0450
Cell Significance Index: 68.0600 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.7209
Cell Significance Index: 74.0600 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.6892
Cell Significance Index: 200.4300 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 2.6872
Cell Significance Index: 77.0300 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 2.1025
Cell Significance Index: 38.8600 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 2.0973
Cell Significance Index: 135.3100 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.9640
Cell Significance Index: 103.1200 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.8032
Cell Significance Index: 357.8600 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.7982
Cell Significance Index: 221.1100 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.7720
Cell Significance Index: 319.4400 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 1.6264
Cell Significance Index: 719.0600 - Cell Name: odontoblast (CL0000060)
Fold Change: 1.5060
Cell Significance Index: 193.0600 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.4993
Cell Significance Index: 205.9000 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.3079
Cell Significance Index: 61.4700 - Cell Name: cell in vitro (CL0001034)
Fold Change: 1.1515
Cell Significance Index: 628.8800 - Cell Name: type I muscle cell (CL0002211)
Fold Change: 1.0689
Cell Significance Index: 26.0800 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.9864
Cell Significance Index: 97.5800 - Cell Name: type II muscle cell (CL0002212)
Fold Change: 0.9467
Cell Significance Index: 15.2800 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.9201
Cell Significance Index: 16.2600 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.8355
Cell Significance Index: 22.3500 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.6789
Cell Significance Index: 243.5000 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.6720
Cell Significance Index: 86.8200 - Cell Name: granulosa cell (CL0000501)
Fold Change: 0.5727
Cell Significance Index: 15.0600 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.4894
Cell Significance Index: 310.8300 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.4579
Cell Significance Index: 31.6700 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.4304
Cell Significance Index: 19.5100 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.3718
Cell Significance Index: 63.4900 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.3548
Cell Significance Index: 57.7100 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.2272
Cell Significance Index: 205.1700 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.1853
Cell Significance Index: 348.8100 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.1623
Cell Significance Index: 5.6400 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.1134
Cell Significance Index: 209.1900 - Cell Name: subcutaneous adipocyte (CL0002521)
Fold Change: 0.0965
Cell Significance Index: 0.4200 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0941
Cell Significance Index: 17.9100 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.0706
Cell Significance Index: 3.6700 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.0521
Cell Significance Index: 5.3200 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0085
Cell Significance Index: 13.0100 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0342
Cell Significance Index: -25.8800 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0538
Cell Significance Index: -39.8800 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0633
Cell Significance Index: -1.6900 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0638
Cell Significance Index: -39.8600 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0661
Cell Significance Index: -48.4900 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0927
Cell Significance Index: -125.9800 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.1020
Cell Significance Index: -46.3000 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1631
Cell Significance Index: -91.9600 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.3434
Cell Significance Index: -68.8800 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.3562
Cell Significance Index: -102.5000 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.3582
Cell Significance Index: -52.0700 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.3825
Cell Significance Index: -13.4400 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.3904
Cell Significance Index: -10.9100 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.4083
Cell Significance Index: -86.0000 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.4424
Cell Significance Index: -12.7500 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.4574
Cell Significance Index: -6.2400 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.4852
Cell Significance Index: -8.1200 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.4869
Cell Significance Index: -55.7800 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.5039
Cell Significance Index: -23.4900 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.5590
Cell Significance Index: -6.3500 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.5877
Cell Significance Index: -69.3100 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.6001
Cell Significance Index: -68.5000 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.6117
Cell Significance Index: -71.2900 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.6691
Cell Significance Index: -51.3500 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.7347
Cell Significance Index: -14.3400 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.7680
Cell Significance Index: -19.6200 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.8629
Cell Significance Index: -61.0300 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.9376
Cell Significance Index: -57.6300 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.9827
Cell Significance Index: -102.3200 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -1.1288
Cell Significance Index: -89.4000 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -1.3152
Cell Significance Index: -16.3100 - Cell Name: Mueller cell (CL0000636)
Fold Change: -1.3232
Cell Significance Index: -10.1800 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -1.3342
Cell Significance Index: -84.0900 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -1.3733
Cell Significance Index: -69.4000 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -1.3832
Cell Significance Index: -77.6200 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -1.4159
Cell Significance Index: -23.8500 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.4490
Cell Significance Index: -88.8400 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -1.5493
Cell Significance Index: -23.2200 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -1.5711
Cell Significance Index: -105.6400 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -1.6471
Cell Significance Index: -52.7600 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -1.7698
Cell Significance Index: -44.2400 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -1.7897
Cell Significance Index: -27.6900 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -1.8121
Cell Significance Index: -94.3900 - Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: -1.8322
Cell Significance Index: -25.6200 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -2.0524
Cell Significance Index: -43.7100 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -2.0627
Cell Significance Index: -60.5800 - Cell Name: peg cell (CL4033014)
Fold Change: -2.1309
Cell Significance Index: -49.2300 - Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: -2.2253
Cell Significance Index: -13.7000 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -2.3165
Cell Significance Index: -18.8900 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -2.3374
Cell Significance Index: -95.7700 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -2.3467
Cell Significance Index: -21.6100 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -2.3535
Cell Significance Index: -69.3200
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2717441795
Symbol: GLNA_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2888076
Title: Sequence of a human glutamine synthetase cDNA.
PubMed ID: 2888076
PubMed ID: 1681907
Title: cDNA sequence of the long mRNA for human glutamine synthase.
PubMed ID: 1681907
PubMed ID: 7909780
Title: Overexpression of glutamine synthetase in human primary liver cancer.
PubMed ID: 7909780
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12387715
Title: Glutamine synthetase isolated from human brain: octameric structure and homology of partial primary structure with human liver glutamine synthetase.
PubMed ID: 12387715
PubMed ID: 18662667
Title: Glutamine synthetase is essential for proliferation of fetal skin fibroblasts.
PubMed ID: 18662667
PubMed ID: 18555765
Title: Wnt and steroid pathways control glutamate signalling by regulating glutamine synthetase activity in osteoblastic cells.
PubMed ID: 18555765
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 26711351
Title: Genome-wide RNAi Screening Identifies Protein Modules Required for 40S Subunit Synthesis in Human Cells.
PubMed ID: 26711351
PubMed ID: 26990986
Title: Glutamine triggers acetylation-dependent degradation of glutamine synthetase via the thalidomide receptor cereblon.
PubMed ID: 26990986
PubMed ID: 30158707
Title: Role of glutamine synthetase in angiogenesis beyond glutamine synthesis.
PubMed ID: 30158707
PubMed ID: 36289327
Title: Bestrophin-2 and glutamine synthetase form a complex for glutamate release.
PubMed ID: 36289327
PubMed ID: 18005987
Title: Crystal structures of mammalian glutamine synthetases illustrate substrate-induced conformational changes and provide opportunities for drug and herbicide design.
PubMed ID: 18005987
PubMed ID: 16267323
Title: Congenital glutamine deficiency with glutamine synthetase mutations.
PubMed ID: 16267323
DOI: 10.1056/nejmoa050456
PubMed ID: 38579670
Title: Clustered de novo start-loss variants in GLUL result in a developmental and epileptic encephalopathy via stabilization of glutamine synthetase.
PubMed ID: 38579670
Sequence Information:
- Length: 373
- Mass: 42064
- Checksum: 45390C100924FAF3
- Sequence:
MTTSASSHLN KGIKQVYMSL PQGEKVQAMY IWIDGTGEGL RCKTRTLDSE PKCVEELPEW NFDGSSTLQS EGSNSDMYLV PAAMFRDPFR KDPNKLVLCE VFKYNRRPAE TNLRHTCKRI MDMVSNQHPW FGMEQEYTLM GTDGHPFGWP SNGFPGPQGP YYCGVGADRA YGRDIVEAHY RACLYAGVKI AGTNAEVMPA QWEFQIGPCE GISMGDHLWV ARFILHRVCE DFGVIATFDP KPIPGNWNGA GCHTNFSTKA MREENGLKYI EEAIEKLSKR HQYHIRAYDP KGGLDNARRL TGFHETSNIN DFSAGVANRS ASIRIPRTVG QEKKGYFEDR RPSANCDPFS VTEALIRTCL LNETGDEPFQ YKN
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.