Details for: ADAMTSL1

Gene ID: 92949

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: ADAMTSL1

Ensembl ID: ENSG00000178031

Description: ADAMTS like 1

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • Bergmann glial cell CL0000644
    CSI 37.15
    rCSI 50.83%
    PRS 89.89
  • keratocyte CL0002363
    CSI 14.15
    rCSI 34.03%
    PRS 95.39
  • L6b glutamatergic cortical neuron CL4023038
    CSI 12.88
    rCSI 40.24%
    PRS 87.86
  • endocardial cell CL0002350
    CSI 12.44
    rCSI 59.57%
    PRS 92.96
  • tracheobronchial smooth muscle cell CL0019019
    CSI 9.04
    rCSI 15.95%
    PRS 96.58
  • blood vessel endothelial cell CL0000071
    CSI 8.95
    rCSI 18.57%
    PRS 94.02
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 8.12
    rCSI 30.69%
    PRS 87.02
  • adipocyte CL0000136
    CSI 7.78
    rCSI 9.98%
    PRS 89.39
  • retinal pigment epithelial cell CL0002586
    CSI 7.43
    rCSI 14.76%
    PRS 92.68
  • L5/6 near-projecting glutamatergic neuron CL4030067
    CSI 7.19
    rCSI 23.63%
    PRS 86.69
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 7.11
    rCSI 8.21%
    PRS 89.62
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 6.82
    rCSI 40.17%
    PRS 87.32
  • astrocyte of the cerebral cortex CL0002605
    CSI 6.57
    rCSI 14.74%
    PRS 87.17
  • renal beta-intercalated cell CL0002201
    CSI 6.24
    rCSI 14.86%
    PRS 95.21
  • renal interstitial pericyte CL1001318
    CSI 5.91
    rCSI 16.29%
    PRS 93.9
  • neural crest cell CL0011012
    CSI 5.86
    rCSI 4.63%
    PRS 90.99
  • inhibitory interneuron CL0000498
    CSI 5.25
    rCSI 12.11%
    PRS 88.99
  • hepatic stellate cell CL0000632
    CSI 5.16
    rCSI 19.32%
    PRS 92.8
  • sst GABAergic cortical interneuron CL4023017
    CSI 4.91
    rCSI 6.33%
    PRS 87.85
  • L2/3 intratelencephalic projecting glutamatergic neuron CL4030059
    CSI 4.8
    rCSI 10.42%
    PRS 86.79
  • kidney interstitial fibroblast CL1000692
    CSI 4.72
    rCSI 25.07%
    PRS 91
  • neural cell CL0002319
    CSI 4.57
    rCSI 17.25%
    PRS 84.8
  • interneuron CL0000099
    CSI 4.5
    rCSI 9.04%
    PRS 91.64
  • interstitial cell of Cajal CL0002088
    CSI 4.37
    rCSI 5.57%
    PRS 97.03
  • cardiac endothelial cell CL0010008
    CSI 4.33
    rCSI 17.49%
    PRS 95.47
  • VIP GABAergic cortical interneuron CL4023016
    CSI 4.31
    rCSI 5.15%
    PRS 86.88
  • renal alpha-intercalated cell CL0005011
    CSI 4.3
    rCSI 5.75%
    PRS 96.59
  • L4 intratelencephalic projecting glutamatergic neuron CL4030063
    CSI 4.25
    rCSI 10.17%
    PRS 87.82
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 4.22
    rCSI 5.25%
    PRS 85
  • glioblast CL0000030
    CSI 3.54
    rCSI 5.65%
    PRS 89.64
  • epithelial cell of lower respiratory tract CL0002632
    CSI 3.5
    rCSI 2.71%
    PRS 96.55
  • sncg GABAergic cortical interneuron CL4023015
    CSI 3.27
    rCSI 5.25%
    PRS 87.82
  • epithelial cell of proximal tubule CL0002306
    CSI 3.26
    rCSI 7.95%
    PRS 90.5
  • cerebellar granule cell CL0001031
    CSI 3.23
    rCSI 4.75%
    PRS 91.76
  • differentiation-committed oligodendrocyte precursor CL4023059
    CSI 3.09
    rCSI 5.62%
    PRS 91.05
  • vascular leptomeningeal cell CL4023051
    CSI 3.05
    rCSI 5.34%
    PRS 93.29
  • endothelial cell of vascular tree CL0002139
    CSI 3.03
    rCSI 16.59%
    PRS 91.99
  • glutamatergic neuron CL0000679
    CSI 2.98
    rCSI 6.13%
    PRS 86.34
  • epicardial adipocyte CL1000309
    CSI 2.98
    rCSI 9.69%
    PRS 93.09
  • stromal cell CL0000499
    CSI 2.93
    rCSI 8.25%
    PRS 92.47
  • kidney collecting duct intercalated cell CL1001432
    CSI 2.83
    rCSI 20.18%
    PRS 91.9
  • adventitial cell CL0002503
    CSI 2.7
    rCSI 6.46%
    PRS 96.61
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 2.64
    rCSI 6.4%
    PRS 85.06
  • neural progenitor cell CL0011020
    CSI 2.54
    rCSI 11.2%
    PRS 86.67
  • conjunctival epithelial cell CL1000432
    CSI 2.52
    rCSI 3.86%
    PRS 94.19
  • chondrocyte CL0000138
    CSI 2.39
    rCSI 3.79%
    PRS 92
  • retinal blood vessel endothelial cell CL0002585
    CSI 2.33
    rCSI 3.72%
    PRS 96.39
  • alveolar adventitial fibroblast CL4028006
    CSI 2.1
    rCSI 3.31%
    PRS 95.86
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 2.05
    rCSI 3.62%
    PRS 86.44
  • GABAergic neuron CL0000617
    CSI 2
    rCSI 6.7%
    PRS 85.22
  • GABAergic amacrine cell CL4030027
    CSI 1.93
    rCSI 6.62%
    PRS 85.59
  • cardiac muscle cell CL0000746
    CSI 1.91
    rCSI 2.74%
    PRS 89.35
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 1.9
    rCSI 3.19%
    PRS 87.04
  • parietal epithelial cell CL1000452
    CSI 1.54
    rCSI 4.13%
    PRS 92.01
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 1.51
    rCSI 5.44%
    PRS 85.38
  • enteroglial cell CL4040002
    CSI 1.46
    rCSI 7.66%
    PRS 94.83
  • retinal cone cell CL0000573
    CSI 1.41
    rCSI 2.28%
    PRS 89.35
  • pulmonary alveolar type 1 cell CL0002062
    CSI 1.34
    rCSI 7.7%
    PRS 93.15
  • cardiac blood vessel endothelial cell CL0010006
    CSI 1.07
    rCSI 7.55%
    PRS 90.66
  • endothelial cell of uterus CL0009095
    CSI 0.95
    rCSI 6.94%
    PRS 97.95
  • direct pathway medium spiny neuron CL4023026
    CSI 0.52
    rCSI 12.55%
    PRS 84.7
  • blood vessel smooth muscle cell CL0019018
    CSI 0.49
    rCSI 3.95%
    PRS 94.14
  • central nervous system neuron CL2000029
    CSI 0.45
    rCSI 3.33%
    PRS 89.95
  • indirect pathway medium spiny neuron CL4023029
    CSI 0.26
    rCSI 6.24%
    PRS 84.51

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [ADAMTSL1](/details-gene/92949) (ADAMTS like 1) encodes a secreted protein that is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) superfamily, although it lacks a catalytic metalloproteinase domain. Its primary function is associated with the structural organization and maintenance of the extracellular matrix ([GO:0030198](https://www.ebi.ac.uk/QuickGO/term/GO:0030198)). Expression data indicates that [ADAMTSL1](/details-gene/92949) is a highly significant marker in a variety of structural and neuronal support cells, with exceptionally high significance observed in [Bergmann glial cells](/details-cell/CL0000644) of the cerebellum. Its role appears crucial for tissue architecture, a function regulated by extensive post-translational modifications such as glycosylation. ## Cellular Roles and Expression Landscape **Overall**, the expression profile of [ADAMTSL1](/details-gene/92949) highlights its importance in tissues requiring robust extracellular matrix (ECM) integrity and specialized cellular support. The gene's significance is most pronounced in the nervous system, particularly within glial populations. It is the top marker for [Bergmann glial cells](/details-cell/CL0000644) (CSI: 37.15), a specialized astrocyte in the cerebellum responsible for guiding neuronal development and maintaining synaptic function. Its high significance is also noted in other neural cells, including [L6b glutamatergic cortical neurons](/details-cell/CL4023038), [astrocytes of the cerebral cortex](/details-cell/CL0002605), and various other projection neurons, suggesting a widespread role in maintaining the neuronal microenvironment. Beyond the nervous system, [ADAMTSL1](/details-gene/92949) is a key marker for cells involved in forming connective and structural tissues. This includes high significance in [keratocytes](/details-cell/CL0002363), which maintain the corneal stroma, as well as in [endocardial cells](/details-cell/CL0002350), [tracheobronchial smooth muscle cells](/details-cell/CL0019019), and [adipocytes](/details-cell/CL0000136). This pattern suggests that [ADAMTSL1](/details-gene/92949) is a fundamental component of the ECM across diverse organ systems. Notably, its expression appears to be less significant in hematopoietic and immune cell lineages, underscoring its specialized role in structural and neuronal tissues. ## Pathways and Molecular Function The functions of [ADAMTSL1](/details-gene/92949) are tightly linked to the biology of the extracellular space ([GO:0005576](https://www.ebi.ac.uk/QuickGO/term/GO:0005576)). Its involvement in [Extracellular matrix organization](/details-ontology/GO:0030198) is consistent with its discovery as an ECM-associated protein named Punctin-1 ([Link](https://doi.org/10.1074/jbc.m109665200)). Reactome pathway analysis emphasizes the critical role of post-translational modifications in its function. [ADAMTSL1](/details-gene/92949) is implicated in pathways of [O-linked glycosylation](/details-pathway/R-HSA-5173105), specifically the [O-glycosylation of TSR domain-containing proteins](/details-pathway/R-HSA-5173214). This is further substantiated by research demonstrating that O-fucosylation is essential for the proper secretion of the protein ([Link](https://doi.org/10.1074/jbc.m701065200)), and that it also undergoes C-mannosylation ([Link](https://doi.org/10.1074/jbc.m109.038059)). These modifications are part of a broader theme of [Metabolism of proteins](/details-pathway/R-HSA-392499) and are often dysregulated in [Diseases of glycosylation](/details-pathway/R-HSA-3781865). This suggests that the synthesis and secretion of functional [ADAMTSL1](/details-gene/92949) is a tightly regulated process, and defects in this pathway could have pathological consequences. ## Research Directions The highly specific expression pattern and functional annotations of [ADAMTSL1](/details-gene/92949) suggest several avenues for future research into its role in health and disease. **Proposed Hypotheses:** 1. Given its exceptionally high significance in [Bergmann glial cells](/details-cell/CL0000644), [ADAMTSL1](/details-gene/92949) is hypothesized to be a critical factor for cerebellar development and function, potentially by organizing the ECM to guide Purkinje cell dendritic arborization and stabilize climbing fiber synapses. Its deficiency or dysregulation may be an underlying cause of certain hereditary cerebellar ataxias. 2. In the cornea, [ADAMTSL1](/details-gene/92949) secreted by [keratocytes](/details-cell/CL0002363) is proposed to be essential for the precise arrangement of collagen fibrils, which is necessary for corneal transparency. Pathogenic variants in [ADAMTSL1](/details-gene/92949) could therefore lead to corneal dystrophies or opacification. 3. The post-translational glycosylation state of [ADAMTSL1](/details-gene/92949) may function as a molecular switch, modulating its binding affinity for other key ECM proteins like fibrillin-1. This regulatory mechanism could be crucial for the dynamic assembly and remodeling of microfibrils in connective tissues during development and disease. **Experimental Approach:** To test the first hypothesis regarding the role of [ADAMTSL1](/details-gene/92949) in cerebellar function, a conditional knockout mouse model could be developed. By crossing a floxed-[ADAMTSL1](/details-gene/92949) mouse line with a line expressing Cre-recombinase under a [Bergmann glia](/details-cell/CL0000644)-specific promoter (e.g., GLAST-CreERT2), the gene can be selectively ablated in the target cell population. Subsequent analysis would involve detailed immunohistochemistry of cerebellar sections to examine Purkinje cell morphology and synaptic marker expression, coupled with behavioral tests (e.g., rotarod) to assess motor coordination. **Therapeutic Potential:** As a secreted, structural protein, [ADAMTSL1](/details-gene/92949) presents potential therapeutic opportunities. For conditions caused by its deficiency, a protein replacement strategy using a recombinant form of [ADAMTSL1](/details-gene/92949) could be explored, particularly for localized pathologies like corneal defects to avoid systemic effects. Conversely, in fibrotic diseases where ECM components may be pathologically overexpressed, targeting [ADAMTSL1](/details-gene/92949) with a neutralizing monoclonal antibody could be a viable strategy to disrupt aberrant matrix deposition. The specificity of its expression in certain cell types might be leveraged to limit off-target effects, but its broad role in structural integrity across multiple tissues warrants a cautious approach to systemic inhibition.

Genular Protein ID: 926236832

Symbol: ATL1_HUMAN

Name: ADAMTS-like protein 1

UniProtKB Accession Codes:

Q8N6G6 A6PVN1 A8K7E1 Q496M6 Q496M8 Q5T708 Q5VZT8 Q8NAI9 Q96RW4 Q9BXY3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 14 Ensembl 6 ExpressionAtlas 1 GO 4 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 13 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 7 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 6 RNAct 1 Reactome 2 RefSeq 2 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 2 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11805097

Title: Punctin, a novel ADAMTS-like molecule, ADAMTSL-1, in extracellular matrix.

PubMed ID: 11805097

DOI: 10.1074/jbc.m109665200

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17395588

Title: O-fucosylation of thrombospondin type 1 repeats in ADAMTS-like-1/punctin-1 regulates secretion: implications for the ADAMTS superfamily.

PubMed ID: 17395588

DOI: 10.1074/jbc.m701065200

PubMed ID: 19671700

Title: Post-translational modification of thrombospondin type-1 repeats in ADAMTS-like 1/punctin-1 by C-mannosylation of tryptophan.

PubMed ID: 19671700

DOI: 10.1074/jbc.m109.038059

Sequence Information:

  • Length: 1762
  • Mass: 193409
  • Checksum: 2822C0A367C2EF4E
  • Sequence:
    • MECCRRATPG TLLLFLAFLL LSSRTARSEE DRDGLWDAWG PWSECSRTCG GGASYSLRRC 
LSSKSCEGRN IRYRTCSNVD CPPEAGDFRA QQCSAHNDVK HHGQFYEWLP VSNDPDNPCS 
LKCQAKGTTL VVELAPKVLD GTRCYTESLD MCISGLCQIV GCDHQLGSTV KEDNCGVCNG 
DGSTCRLVRG QYKSQLSATK SDDTVVAIPY GSRHIRLVLK GPDHLYLETK TLQGTKGENS 
LSSTGTFLVD NSSVDFQKFP DKEILRMAGP LTADFIVKIR NSGSADSTVQ FIFYQPIIHR 
WRETDFFPCS ATCGGGYQLT SAECYDLRSN RVVADQYCHY YPENIKPKPK LQECNLDPCP 
ASDGYKQIMP YDLYHPLPRW EATPWTACSS SCGGGIQSRA VSCVEEDIQG HVTSVEEWKC 
MYTPKMPIAQ PCNIFDCPKW LAQEWSPCTV TCGQGLRYRV VLCIDHRGMH TGGCSPKTKP 
HIKEECIVPT PCYKPKEKLP VEAKLPWFKQ AQELEEGAAV SEEPSFIPEA WSACTVTCGV 
GTQVRIVRCQ VLLSFSQSVA DLPIDECEGP KPASQRACYA GPCSGEIPEF NPDETDGLFG 
GLQDFDELYD WEYEGFTKCS ESCGGGVQEA VVSCLNKQTR EPAEENLCVT SRRPPQLLKS 
CNLDPCPARW EIGKWSPCSL TCGVGLQTRD VFCSHLLSRE MNETVILADE LCRQPKPSTV 
QACNRFNCPP AWYPAQWQPC SRTCGGGVQK REVLCKQRMA DGSFLELPET FCSASKPACQ 
QACKKDDCPS EWLLSDWTEC STSCGEGTQT RSAICRKMLK TGLSTVVNST LCPPLPFSSS 
IRPCMLATCA RPGRPSTKHS PHIAAARKVY IQTRRQRKLH FVVGGFAYLL PKTAVVLRCP 
ARRVRKPLIT WEKDGQHLIS STHVTVAPFG YLKIHRLKPS DAGVYTCSAG PAREHFVIKL 
IGGNRKLVAR PLSPRSEEEV LAGRKGGPKE ALQTHKHQNG IFSNGSKAEK RGLAANPGSR 
YDDLVSRLLE QGGWPGELLA SWEAQDSAER NTTSEEDPGA EQVLLHLPFT MVTEQRRLDD 
ILGNLSQQPE ELRDLYSKHL VAQLAQEIFR SHLEHQDTLL KPSERRTSPV TLSPHKHVSG 
FSSSLRTSST GDAGGGSRRP HRKPTILRKI SAAQQLSASE VVTHLGQTVA LASGTLSVLL 
HCEAIGHPRP TISWARNGEE VQFSDRILLQ PDDSLQILAP VEADVGFYTC NATNALGYDS 
VSIAVTLAGK PLVKTSRMTV INTEKPAVTV DIGSTIKTVQ GVNVTINCQV AGVPEAEVTW 
FRNKSKLGSP HHLHEGSLLL TNVSSSDQGL YSCRAANLHG ELTESTQLLI LDPPQVPTQL 
EDIRALLAAT GPNLPSVLTS PLGTQLVLDP GNSALLGCPI KGHPVPNITW FHGGQPIVTA 
TGLTHHILAA GQILQVANLS GGSQGEFSCL AQNEAGVLMQ KASLVIQDYW WSVDRLATCS 
ASCGNRGVQQ PRLRCLLNST EVNPAHCAGK VRPAVQPIAC NRRDCPSRWM VTSWSACTRS 
CGGGVQTRRV TCQKLKASGI STPVSNDMCT QVAKRPVDTQ ACNQQLCVEW AFSSWGQCNG 
PCIGPHLAVQ HRQVFCQTRD GITLPSEQCS ALPRPVSTQN CWSEACSVHW RVSLWTLCTA 
TCGNYGFQSR RVECVHARTN KAVPEHLCSW GPRPANWQRC NITPCENMEC RDTTRYCEKV 
KQLKLCQLSQ FKSRCCGTCG KA

Genular Protein ID: 507587586

Symbol: Q6MZQ3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6MZQ3

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 2 InterPro 9 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 3 PharmGKB 1 RefSeq 1 SMART 3 SUPFAM 2

Sequence Information:

  • Length: 370
  • Mass: 39163
  • Checksum: 3D460FE3B3086FB2
  • Sequence:
    • PVEADVGFYT CNATNALGYD SVSIAVTLAG KPLVKTSRMT VINTEKPAVT VDIGSTIKTV 
QGVNVTINCQ VAGVPEAEVT WFRNKSKLGS PHHLHEGSLL LTNVSSSDQG LYSCRAANLH 
GELTESTQLL ILDPPQVPTQ LEDIRALLAA TGPNLPSVLT SPLGTQLVLG PGNSALLGCP 
IKGHPVPNIT WFHGGQPIVT ATGLTHHILA AGQILQVANL SGGSQGEFSC LAQNEAGVLM 
QKASLVIQDY WWSVDRLATC SASCGNRGVQ QPRLRCLLNS TEVNPAHCAG KVRPAVQPIA 
CNRRDCPSRW MVTSWSACTR SCGGGVQTRR VTCQKLKASG ISTPVSNDMC TQVAKRPVDT 
QACNQQLCVE