Details for: CL0002586

Cell ID: CL0002586

Cell Name: retinal pigment epithelial cell

Marker Score Threshold: 294
(Derived using integrated single-cell and genomic data)

Description: An epithelial cell of the retinal pigmented epithelium.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.49
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.39
    Ensembl ID: ENSG00000166710
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 2.88
    Ensembl ID: ENSG00000172757
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.85
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.76
    Ensembl ID: ENSG00000184009
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.65
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.53
    Ensembl ID: ENSG00000143933
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.49
    Ensembl ID: ENSG00000198668
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.46
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.36
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.32
    Ensembl ID: ENSG00000135390
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 2.32
    Ensembl ID: ENSG00000070831
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.26
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 2.07
    Ensembl ID: ENSG00000085224
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.07
    Ensembl ID: ENSG00000179218
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.05
    Ensembl ID: ENSG00000077549
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 2.03
    Ensembl ID: ENSG00000122545
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.99
    Ensembl ID: ENSG00000143761
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.97
    Ensembl ID: ENSG00000135404
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.89
    Ensembl ID: ENSG00000019582
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.86
    Ensembl ID: ENSG00000185650
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.86
    Ensembl ID: ENSG00000134825
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.82
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.81
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.79
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.77
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.76
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.76
    Ensembl ID: ENSG00000152518
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.71
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.69
    Ensembl ID: ENSG00000110955
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.68
    Ensembl ID: ENSG00000116489
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.66
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.63
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.6
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.6
    Ensembl ID: ENSG00000128272
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.59
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.56
    Ensembl ID: ENSG00000152234
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.55
    Ensembl ID: ENSG00000196776
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.54
    Ensembl ID: ENSG00000117410
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.54
    Ensembl ID: ENSG00000172270
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.52
    Ensembl ID: ENSG00000198898
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.5
    Ensembl ID: ENSG00000084234
  • Gene Symbol: CHD1 (ENSG00000153922)
    Fold Change: 1.49
    Ensembl ID: ENSG00000153922
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.48
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.46
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.43
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.42
    Ensembl ID: ENSG00000111348
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.41
    Ensembl ID: ENSG00000026508
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.41
    Ensembl ID: ENSG00000164111
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.4
    Ensembl ID: ENSG00000104964
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.4
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.4
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.4
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.39
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.39
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.38
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.37
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.36
    Ensembl ID: ENSG00000163399
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.36
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.32
    Ensembl ID: ENSG00000149311
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.32
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.31
    Ensembl ID: ENSG00000087274
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.31
    Ensembl ID: ENSG00000112576
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.3
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.29
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.29
    Ensembl ID: ENSG00000138279
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.28
    Ensembl ID: ENSG00000104765
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.27
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.27
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.27
    Ensembl ID: ENSG00000149925
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.27
    Ensembl ID: ENSG00000146731
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.26
    Ensembl ID: ENSG00000104763
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.26
    Ensembl ID: ENSG00000110651
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.25
    Ensembl ID: ENSG00000070961
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.25
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.25
    Ensembl ID: ENSG00000165527
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.21
    Ensembl ID: ENSG00000115307
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.18
    Ensembl ID: ENSG00000108561
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.17
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.16
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.15
    Ensembl ID: ENSG00000004059
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.14
    Ensembl ID: ENSG00000006125
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.14
    Ensembl ID: ENSG00000134480
  • Gene Symbol: CTSC (ENSG00000109861)
    Fold Change: 1.13
    Ensembl ID: ENSG00000109861
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.11
    Ensembl ID: ENSG00000100823
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.09
    Ensembl ID: ENSG00000164615
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.08
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.08
    Ensembl ID: ENSG00000156110
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.08
    Ensembl ID: ENSG00000130303
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.07
    Ensembl ID: ENSG00000137845
  • Gene Symbol: CENPC (ENSG00000145241)
    Fold Change: 1.06
    Ensembl ID: ENSG00000145241
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.06
    Ensembl ID: ENSG00000143799
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.06
    Ensembl ID: ENSG00000107262
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.04
    Ensembl ID: ENSG00000177556
  • Gene Symbol: BRAF (ENSG00000157764)
    Fold Change: 1.02
    Ensembl ID: ENSG00000157764
  • Gene Symbol: CBLB (ENSG00000114423)
    Fold Change: 1.02
    Ensembl ID: ENSG00000114423
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.02
    Ensembl ID: ENSG00000126247
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.01
    Ensembl ID: ENSG00000177105
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.01
    Ensembl ID: ENSG00000196975
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: N/A
    Ensembl ID: ENSG00000183255
Hovered Details

Hover over a box to see details here...

Hovered Details

Hover over a box to see details here...

**Key Characteristics** The retinal pigment epithelial cell (RPE) has several key characteristics that enable it to perform its functions: 1. **Actin cytoskeleton**: The RPE cell has a dynamic actin cytoskeleton that allows for cell motility, shape changes, and the formation of phagocytic cups. 2. **Adherens junctions**: The RPE cell has adherens junctions that provide mechanical strength and maintain cell polarity. 3. **Apical junction complex**: The RPE cell has an apical junction complex that regulates the movement of ions and molecules across the cell membrane. 4. **Blood-retina barrier**: The RPE cell forms a blood-retina barrier that regulates the exchange of molecules between the bloodstream and the retina. 5. **Photoreceptor outer segment renewal**: The RPE cell is responsible for the renewal of photoreceptor outer segments, which is essential for visual function. **Clinical Significance** The retinal pigment epithelial cell plays a crucial role in maintaining visual function, and its dysfunction is associated with various clinical conditions, including: 1. **Age-related macular degeneration (AMD)**: AMD is a leading cause of vision loss in older adults, and the RPE cell is thought to play a key role in the development of the disease. 2. **Retinitis pigmentosa**: Retinitis pigmentosa is a group of genetic disorders that affect the RPE cell and lead to progressive vision loss. 3. **Diabetic retinopathy**: Diabetic retinopathy is a complication of diabetes that affects the RPE cell and can lead to vision loss. 4. **Stargardt disease**: Stargardt disease is a genetic disorder that affects the RPE cell and leads to progressive vision loss. Understanding the biology of the retinal pigment epithelial cell is essential for the development of new treatments for these clinical conditions.