Details for: KCNJ13

Gene ID: 3769

Symbol: KCNJ13

Ensembl ID: ENSG00000115474

Description: potassium inwardly rectifying channel subfamily J member 13

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 4.86
    Marker Score: 2692.5
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 2.34
    Marker Score: 6715.5
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.33
    Marker Score: 3595.5
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 873
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.33
    Marker Score: 500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1
    Marker Score: 418
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71831
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48056
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 511
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 464
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.98
    Marker Score: 1856
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.92
    Marker Score: 14351
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 328
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5187
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5288
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.83
    Marker Score: 332
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.81
    Marker Score: 473
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.8
    Marker Score: 394
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 599
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1266
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 706
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.75
    Marker Score: 1526
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.75
    Marker Score: 496
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 464
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.67
    Marker Score: 812
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.66
    Marker Score: 2782
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.64
    Marker Score: 259
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.63
    Marker Score: 850
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 463
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.54
    Marker Score: 323
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.53
    Marker Score: 168
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.51
    Marker Score: 151
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.48
    Marker Score: 281
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.46
    Marker Score: 1941
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.45
    Marker Score: 2144
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.44
    Marker Score: 201
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.43
    Marker Score: 5696
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.42
    Marker Score: 124
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.42
    Marker Score: 408
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.42
    Marker Score: 122
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.42
    Marker Score: 2524
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.41
    Marker Score: 857
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.4
    Marker Score: 208
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.39
    Marker Score: 164
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.39
    Marker Score: 168
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.38
    Marker Score: 101
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.38
    Marker Score: 120
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.38
    Marker Score: 375.5
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.37
    Marker Score: 175
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.35
    Marker Score: 96
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.34
    Marker Score: 553
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.33
    Marker Score: 80
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.33
    Marker Score: 331
  • Cell Name: epithelial fate stem cell (CL0000036)
    Fold Change: 0.33
    Marker Score: 94
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.29
    Marker Score: 740
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.29
    Marker Score: 291
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.29
    Marker Score: 203
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.29
    Marker Score: 1201
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.29
    Marker Score: 475
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.28
    Marker Score: 614
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.28
    Marker Score: 157.5
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.26
    Marker Score: 628
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 90
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.25
    Marker Score: 600
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.24
    Marker Score: 83
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.24
    Marker Score: 216
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.23
    Marker Score: 80
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.23
    Marker Score: 153
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.21
    Marker Score: 106
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.2
    Marker Score: 1337
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.2
    Marker Score: 103
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.2
    Marker Score: 303
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.19
    Marker Score: 190
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.19
    Marker Score: 85
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.19
    Marker Score: 206
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.19
    Marker Score: 189
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.19
    Marker Score: 75
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.19
    Marker Score: 127
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.19
    Marker Score: 263
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.18
    Marker Score: 109
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.18
    Marker Score: 60
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.18
    Marker Score: 194
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.18
    Marker Score: 186
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.17
    Marker Score: 84
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 0.17
    Marker Score: 88
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.16
    Marker Score: 202
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.16
    Marker Score: 291
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.16
    Marker Score: 115
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.16
    Marker Score: 139
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 0.15
    Marker Score: 41
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.15
    Marker Score: 79
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.15
    Marker Score: 48
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.15
    Marker Score: 38

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Other Information

**Key characteristics:** - The KCNJ13 protein is a transmembrane protein with a molecular weight of approximately 130 kDa. - It is a member of the KCNJ family of potassium channels, which are responsible for maintaining the resting membrane potential of cells. - KCNJ13 is a ligand-gated potassium channel, which means that it opens when a specific ligand binds to it. - The ligand for KCNJ13 is not fully understood, but it is thought to be a protein called connexin. **Pathways and functions:** - KCNJ13 is involved in regulating monoatomic ion transmembrane transport across the plasma membrane. - It is expressed in cells that are involved in maintaining the resting membrane potential, such as erythrocytes, retinal cone cells, enterocytes, granulocyte monocyte progenitor cell, intestinal crypt stem cell, and cerebral cortex GABAergic interneuron. - KCNJ13 is also involved in regulating the function of the blood-brain barrier. **Clinical significance:** - Mutations in the KCNJ13 gene have been linked to several human diseases, including hypertension, stroke, and heart failure. - These mutations can disrupt the function of KCNJ13 protein, leading to changes in the membrane potential of cells and the transport of ions across the plasma membrane. - Understanding the role of KCNJ13 in health and disease could lead to the development of new treatments for these disorders.

Genular Protein ID: 4234868716

Symbol: KCJ13_HUMAN

Name: Inward rectifier potassium channel 13

UniProtKB Accession Codes:

O60928 A0PGH1 O76023 Q53SA1 Q8N3Y4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 3 ExpressionAtlas 1 GO 6 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9738472

Title: Cloning and characterization of a novel human inwardly rectifying potassium channel predominantly expressed in small intestine.

PubMed ID: 9738472

DOI: 10.1016/s0014-5793(98)00972-7

PubMed ID: 9620703

Title: A novel inward rectifier K+ channel with unique pore properties.

PubMed ID: 9620703

DOI: 10.1016/s0896-6273(00)80480-8

PubMed ID: 18035352

Title: Expression of Kir7.1 and a novel Kir7.1 splice variant in native human retinal pigment epithelium.

PubMed ID: 18035352

DOI: 10.1016/j.exer.2007.09.011

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9878260

Title: Partial gene structure and assignment to chromosome 2q37 of the human inwardly rectifying K+ channel (Kir7.1) gene (KCNJ13).

PubMed ID: 9878260

DOI: 10.1006/geno.1998.5598

PubMed ID: 18976636

Title: Dual regulation of renal Kir7.1 potassium channels by protein Kinase A and protein Kinase C.

PubMed ID: 18976636

DOI: 10.1016/j.bbrc.2008.10.110

PubMed ID: 18179896

Title: Mutations in KCNJ13 cause autosomal-dominant snowflake vitreoretinal degeneration.

PubMed ID: 18179896

DOI: 10.1016/j.ajhg.2007.08.002

PubMed ID: 21763485

Title: Recessive mutations in KCNJ13, encoding an inwardly rectifying potassium channel subunit, cause leber congenital amaurosis.

PubMed ID: 21763485

DOI: 10.1016/j.ajhg.2011.06.002

Sequence Information:

  • Length: 360
  • Mass: 40530
  • Checksum: 0C49D0DBC619BC50
  • Sequence:
    • MDSSNCKVIA PLLSQRYRRM VTKDGHSTLQ MDGAQRGLAY LRDAWGILMD MRWRWMMLVF 
SASFVVHWLV FAVLWYVLAE MNGDLELDHD APPENHTICV KYITSFTAAF SFSLETQLTI 
GYGTMFPSGD CPSAIALLAI QMLLGLMLEA FITGAFVAKI ARPKNRAFSI RFTDTAVVAH 
MDGKPNLIFQ VANTRPSPLT SVRVSAVLYQ ERENGKLYQT SVDFHLDGIS SDECPFFIFP 
LTYYHSITPS SPLATLLQHE NPSHFELVVF LSAMQEGTGE ICQRRTSYLP SEIMLHHCFA 
SLLTRGSKGE YQIKMENFDK TVPEFPTPLV SKSPNRTDLD IHINGQSIDN FQISETGLTE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.