Details for: CL0000706

Cell ID: CL0000706

Cell Name: choroid plexus epithelial cell

Marker Score Threshold: 919
(Derived using integrated single-cell and genomic data)

Description: A specialized ependymal cell that is part of the choroid plexus epithelium, responsible for producing cerebrospinal fluid (CSF) by selectively filtering and modifying blood plasma components before secreting it into the brain and spinal cord. This cell is characterized by a brush border on its apical surface, which enhances the secretion of CSF.

Synonyms: choroid plexus cell, epithelial cell of choroid plexus

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 2.48
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 2.38
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.25
    Ensembl ID: ENSG00000075624
  • Gene Symbol: AK4 (ENSG00000162433)
    Fold Change: 2.23
    Ensembl ID: ENSG00000162433
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.16
    Ensembl ID: ENSG00000110955
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 2.14
    Ensembl ID: ENSG00000172270
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.03
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.98
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.95
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1.86
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.85
    Ensembl ID: ENSG00000130402
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.83
    Ensembl ID: ENSG00000084234
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 1.81
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.79
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.76
    Ensembl ID: ENSG00000182718
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.76
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.72
    Ensembl ID: ENSG00000154723
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.71
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 1.71
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.7
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.67
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.67
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.67
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.67
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.65
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.64
    Ensembl ID: ENSG00000163399
  • Gene Symbol: CRYBG1 (ENSG00000112297)
    Fold Change: 1.62
    Ensembl ID: ENSG00000112297
  • Gene Symbol: CCND1 (ENSG00000110092)
    Fold Change: 1.62
    Ensembl ID: ENSG00000110092
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.59
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.55
    Ensembl ID: ENSG00000164111
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.54
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.54
    Ensembl ID: ENSG00000087274
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.51
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.51
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.51
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.51
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.46
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.45
    Ensembl ID: ENSG00000137845
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.45
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.43
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.42
    Ensembl ID: ENSG00000149311
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.42
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ACVR1B (ENSG00000135503)
    Fold Change: 1.39
    Ensembl ID: ENSG00000135503
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.38
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ALDH1A3 (ENSG00000184254)
    Fold Change: 1.37
    Ensembl ID: ENSG00000184254
  • Gene Symbol: ALCAM (ENSG00000170017)
    Fold Change: 1.32
    Ensembl ID: ENSG00000170017
  • Gene Symbol: ADSL (ENSG00000239900)
    Fold Change: 1.32
    Ensembl ID: ENSG00000239900
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.31
    Ensembl ID: ENSG00000197043
  • Gene Symbol: ACYP1 (ENSG00000119640)
    Fold Change: 1.31
    Ensembl ID: ENSG00000119640
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.3
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.3
    Ensembl ID: ENSG00000198363
  • Gene Symbol: ALDH9A1 (ENSG00000143149)
    Fold Change: 1.3
    Ensembl ID: ENSG00000143149
  • Gene Symbol: ATP7B (ENSG00000123191)
    Fold Change: 1.29
    Ensembl ID: ENSG00000123191
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.29
    Ensembl ID: ENSG00000174437
  • Gene Symbol: ADSS2 (ENSG00000035687)
    Fold Change: 1.29
    Ensembl ID: ENSG00000035687
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 1.28
    Ensembl ID: ENSG00000151914
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.28
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.27
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ARCN1 (ENSG00000095139)
    Fold Change: 1.27
    Ensembl ID: ENSG00000095139
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.26
    Ensembl ID: ENSG00000006125
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.26
    Ensembl ID: ENSG00000156110
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.26
    Ensembl ID: ENSG00000196975
  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 1.25
    Ensembl ID: ENSG00000145362
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.24
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.23
    Ensembl ID: ENSG00000100412
  • Gene Symbol: XIAP (ENSG00000101966)
    Fold Change: 1.23
    Ensembl ID: ENSG00000101966
  • Gene Symbol: AP1B1 (ENSG00000100280)
    Fold Change: 1.21
    Ensembl ID: ENSG00000100280
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.19
    Ensembl ID: ENSG00000100852
  • Gene Symbol: AP2A1 (ENSG00000196961)
    Fold Change: 1.18
    Ensembl ID: ENSG00000196961
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 1.18
    Ensembl ID: ENSG00000143153
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.17
    Ensembl ID: ENSG00000131100
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 1.15
    Ensembl ID: ENSG00000140836
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 1.15
    Ensembl ID: ENSG00000185883
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.14
    Ensembl ID: ENSG00000197894
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.13
    Ensembl ID: ENSG00000004455
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 1.12
    Ensembl ID: ENSG00000170634
  • Gene Symbol: ASL (ENSG00000126522)
    Fold Change: 1.12
    Ensembl ID: ENSG00000126522
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.11
    Ensembl ID: ENSG00000177556
  • Gene Symbol: BIRC2 (ENSG00000110330)
    Fold Change: 1.11
    Ensembl ID: ENSG00000110330
  • Gene Symbol: BLVRB (ENSG00000090013)
    Fold Change: 1.1
    Ensembl ID: ENSG00000090013
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: 1.1
    Ensembl ID: ENSG00000117054
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.1
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ATP2B4 (ENSG00000058668)
    Fold Change: 1.1
    Ensembl ID: ENSG00000058668
  • Gene Symbol: BRAF (ENSG00000157764)
    Fold Change: 1.09
    Ensembl ID: ENSG00000157764
  • Gene Symbol: ACAT1 (ENSG00000075239)
    Fold Change: 1.08
    Ensembl ID: ENSG00000075239
  • Gene Symbol: ATP2A3 (ENSG00000074370)
    Fold Change: 1.08
    Ensembl ID: ENSG00000074370
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.07
    Ensembl ID: ENSG00000111275
  • Gene Symbol: AARS1 (ENSG00000090861)
    Fold Change: 1.06
    Ensembl ID: ENSG00000090861
  • Gene Symbol: BCL2L1 (ENSG00000171552)
    Fold Change: 1.06
    Ensembl ID: ENSG00000171552
  • Gene Symbol: ARL3 (ENSG00000138175)
    Fold Change: 1.05
    Ensembl ID: ENSG00000138175
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 1.05
    Ensembl ID: ENSG00000204217
  • Gene Symbol: AP1G1 (ENSG00000166747)
    Fold Change: 1.04
    Ensembl ID: ENSG00000166747
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 1.03
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.03
    Ensembl ID: ENSG00000128272
  • Gene Symbol: BMI1 (ENSG00000168283)
    Fold Change: 1.03
    Ensembl ID: ENSG00000168283
  • Gene Symbol: ABCF1 (ENSG00000204574)
    Fold Change: 1.02
    Ensembl ID: ENSG00000204574
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.02
    Ensembl ID: ENSG00000143799
  • Gene Symbol: ACVR2B (ENSG00000114739)
    Fold Change: 1.02
    Ensembl ID: ENSG00000114739
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.01
    Ensembl ID: ENSG00000072110
  • Gene Symbol: AP2A2 (ENSG00000183020)
    Fold Change: 1.01
    Ensembl ID: ENSG00000183020
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Cellular location**: The CPEC is located in the choroid plexus, a specialized structure in the ventricles of the brain. 2. **Cellular structure**: The CPEC has a characteristic brush border on its apical surface, which is composed of microvilli that enhance the secretion of CSF. 3. **Function**: The CPEC is responsible for producing CSF by selectively filtering and modifying blood plasma components. 4. **Gene expression**: The CPEC expresses genes involved in energy metabolism, such as ATP5F1C, which encodes a subunit of the ATP synthase complex. 5. **Cellular interactions**: The CPEC interacts with other cells and molecules in the CNS, including astrocytes, microglia, and various growth factors and cytokines. **Clinical Significance** 1. **CSF production**: The CPEC is essential for the production of CSF, which is necessary for maintaining the health and function of the CNS. 2. **Dysregulation of CSF production**: Dysregulation of CSF production has been implicated in various neurological disorders, including hydrocephalus, meningitis, and multiple sclerosis. 3. **Neurodegenerative diseases**: The CPEC has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where abnormal CSF production and clearance have been observed. 4. **Cancer**: The CPEC has been shown to be involved in the pathogenesis of certain types of cancer, including glioblastoma and medulloblastoma, where abnormal CSF production and clearance have been observed. 5. **Therapeutic targeting**: The CPEC has been identified as a potential target for therapeutic interventions aimed at modulating CSF production and clearance, which may be beneficial for the treatment of various neurological disorders. In conclusion, the choroid plexus epithelial cell is a specialized ependymal cell that plays a crucial role in the production of cerebrospinal fluid in the brain. Its dysregulation has been implicated in various neurological disorders, and it has been identified as a potential target for therapeutic interventions. Further research is needed to fully understand the function and pathophysiology of the CPEC and its role in the CNS.