Details for: CL0000706

Cell ID: CL0000706

Cell Name: choroid plexus epithelial cell

Marker Score Threshold: 919
(Derived using integrated single-cell and genomic data)

Description: A specialized ependymal cell that is part of the choroid plexus epithelium, responsible for producing cerebrospinal fluid (CSF) by selectively filtering and modifying blood plasma components before secreting it into the brain and spinal cord. This cell is characterized by a brush border on its apical surface, which enhances the secretion of CSF.

Synonyms: choroid plexus cell, epithelial cell of choroid plexus

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: COX2 (ENSG00000198712)
    Fold Change: 3.75
    Ensembl ID: ENSG00000198712
  • Gene Symbol: COX1 (ENSG00000198804)
    Fold Change: 3.6
    Ensembl ID: ENSG00000198804
  • Gene Symbol: COX3 (ENSG00000198938)
    Fold Change: 3.5
    Ensembl ID: ENSG00000198938
  • Gene Symbol: ND4 (ENSG00000198886)
    Fold Change: 3.24
    Ensembl ID: ENSG00000198886
  • Gene Symbol: DDX5 (ENSG00000108654)
    Fold Change: 3.07
    Ensembl ID: ENSG00000108654
  • Gene Symbol: HNRNPA2B1 (ENSG00000122566)
    Fold Change: 3.02
    Ensembl ID: ENSG00000122566
  • Gene Symbol: CYTB (ENSG00000198727)
    Fold Change: 2.99
    Ensembl ID: ENSG00000198727
  • Gene Symbol: RNR2 (ENSG00000210082)
    Fold Change: 2.95
    Ensembl ID: ENSG00000210082
  • Gene Symbol: HSP90AA1 (ENSG00000080824)
    Fold Change: 2.88
    Ensembl ID: ENSG00000080824
  • Gene Symbol: ND1 (ENSG00000198888)
    Fold Change: 2.87
    Ensembl ID: ENSG00000198888
  • Gene Symbol: ND2 (ENSG00000198763)
    Fold Change: 2.86
    Ensembl ID: ENSG00000198763
  • Gene Symbol: ATP6 (ENSG00000198899)
    Fold Change: 2.8
    Ensembl ID: ENSG00000198899
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.75
    Ensembl ID: ENSG00000198668
  • Gene Symbol: HCK (ENSG00000101336)
    Fold Change: 2.75
    Ensembl ID: ENSG00000101336
  • Gene Symbol: HNRNPC (ENSG00000092199)
    Fold Change: 2.73
    Ensembl ID: ENSG00000092199
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 2.71
    Ensembl ID: ENSG00000122545
  • Gene Symbol: ND3 (ENSG00000198840)
    Fold Change: 2.68
    Ensembl ID: ENSG00000198840
  • Gene Symbol: GNAS (ENSG00000087460)
    Fold Change: 2.61
    Ensembl ID: ENSG00000087460
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 2.6
    Ensembl ID: ENSG00000099622
  • Gene Symbol: RNR1 (ENSG00000211459)
    Fold Change: 2.6
    Ensembl ID: ENSG00000211459
  • Gene Symbol: HNRNPU (ENSG00000153187)
    Fold Change: 2.56
    Ensembl ID: ENSG00000153187
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 2.48
    Ensembl ID: ENSG00000165629
  • Gene Symbol: BORCS8 MEF2B (ENSG00000213999)
    Fold Change: 2.43
    Ensembl ID: ENSG00000213999
  • Gene Symbol: FUS (ENSG00000089280)
    Fold Change: 2.43
    Ensembl ID: ENSG00000089280
  • Gene Symbol: HMGB1 (ENSG00000189403)
    Fold Change: 2.43
    Ensembl ID: ENSG00000189403
  • Gene Symbol: KTN1 (ENSG00000126777)
    Fold Change: 2.41
    Ensembl ID: ENSG00000126777
  • Gene Symbol: EEF1D (ENSG00000104529)
    Fold Change: 2.41
    Ensembl ID: ENSG00000104529
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.4
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ND5 (ENSG00000198786)
    Fold Change: 2.39
    Ensembl ID: ENSG00000198786
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 2.38
    Ensembl ID: ENSG00000152234
  • Gene Symbol: FTH1 (ENSG00000167996)
    Fold Change: 2.37
    Ensembl ID: ENSG00000167996
  • Gene Symbol: MBNL1 (ENSG00000152601)
    Fold Change: 2.36
    Ensembl ID: ENSG00000152601
  • Gene Symbol: GAPDH (ENSG00000111640)
    Fold Change: 2.34
    Ensembl ID: ENSG00000111640
  • Gene Symbol: EIF3E (ENSG00000104408)
    Fold Change: 2.32
    Ensembl ID: ENSG00000104408
  • Gene Symbol: LLGL2 (ENSG00000073350)
    Fold Change: 2.29
    Ensembl ID: ENSG00000073350
  • Gene Symbol: HNRNPH1 (ENSG00000169045)
    Fold Change: 2.29
    Ensembl ID: ENSG00000169045
  • Gene Symbol: HNRNPK (ENSG00000165119)
    Fold Change: 2.27
    Ensembl ID: ENSG00000165119
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.25
    Ensembl ID: ENSG00000075624
  • Gene Symbol: JAK1 (ENSG00000162434)
    Fold Change: 2.25
    Ensembl ID: ENSG00000162434
  • Gene Symbol: CSNK1A1 (ENSG00000113712)
    Fold Change: 2.25
    Ensembl ID: ENSG00000113712
  • Gene Symbol: EIF4A2 (ENSG00000156976)
    Fold Change: 2.23
    Ensembl ID: ENSG00000156976
  • Gene Symbol: AK4 (ENSG00000162433)
    Fold Change: 2.23
    Ensembl ID: ENSG00000162433
  • Gene Symbol: EEF2 (ENSG00000167658)
    Fold Change: 2.22
    Ensembl ID: ENSG00000167658
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.16
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ND4L (ENSG00000212907)
    Fold Change: 2.14
    Ensembl ID: ENSG00000212907
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 2.14
    Ensembl ID: ENSG00000172270
  • Gene Symbol: HSP90AB1 (ENSG00000096384)
    Fold Change: 2.13
    Ensembl ID: ENSG00000096384
  • Gene Symbol: ECI1 (ENSG00000167969)
    Fold Change: 2.12
    Ensembl ID: ENSG00000167969
  • Gene Symbol: ENO1 (ENSG00000074800)
    Fold Change: 2.11
    Ensembl ID: ENSG00000074800
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 2.1
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ELF1 (ENSG00000120690)
    Fold Change: 2.08
    Ensembl ID: ENSG00000120690
  • Gene Symbol: GPX4 (ENSG00000167468)
    Fold Change: 2.07
    Ensembl ID: ENSG00000167468
  • Gene Symbol: EEF1B2 (ENSG00000114942)
    Fold Change: 2.05
    Ensembl ID: ENSG00000114942
  • Gene Symbol: ENSA (ENSG00000143420)
    Fold Change: 2.05
    Ensembl ID: ENSG00000143420
  • Gene Symbol: EIF4G2 (ENSG00000110321)
    Fold Change: 2.04
    Ensembl ID: ENSG00000110321
  • Gene Symbol: GOLGA4 (ENSG00000144674)
    Fold Change: 2.04
    Ensembl ID: ENSG00000144674
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.03
    Ensembl ID: ENSG00000067560
  • Gene Symbol: MYO9B (ENSG00000099331)
    Fold Change: 2.03
    Ensembl ID: ENSG00000099331
  • Gene Symbol: PDIA3 (ENSG00000167004)
    Fold Change: 2.02
    Ensembl ID: ENSG00000167004
  • Gene Symbol: GSTP1 (ENSG00000084207)
    Fold Change: 2.01
    Ensembl ID: ENSG00000084207
  • Gene Symbol: HNRNPD (ENSG00000138668)
    Fold Change: 2
    Ensembl ID: ENSG00000138668
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.98
    Ensembl ID: ENSG00000085224
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.97
    Ensembl ID: ENSG00000127022
  • Gene Symbol: CST3 (ENSG00000101439)
    Fold Change: 1.96
    Ensembl ID: ENSG00000101439
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.95
    Ensembl ID: ENSG00000185650
  • Gene Symbol: EWSR1 (ENSG00000182944)
    Fold Change: 1.92
    Ensembl ID: ENSG00000182944
  • Gene Symbol: KIF5B (ENSG00000170759)
    Fold Change: 1.92
    Ensembl ID: ENSG00000170759
  • Gene Symbol: COX6C (ENSG00000164919)
    Fold Change: 1.91
    Ensembl ID: ENSG00000164919
  • Gene Symbol: EIF4B (ENSG00000063046)
    Fold Change: 1.91
    Ensembl ID: ENSG00000063046
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 1.9
    Ensembl ID: ENSG00000131143
  • Gene Symbol: DARS1 (ENSG00000115866)
    Fold Change: 1.89
    Ensembl ID: ENSG00000115866
  • Gene Symbol: CLCN5 (ENSG00000171365)
    Fold Change: 1.89
    Ensembl ID: ENSG00000171365
  • Gene Symbol: LMNA (ENSG00000160789)
    Fold Change: 1.88
    Ensembl ID: ENSG00000160789
  • Gene Symbol: HNF4A (ENSG00000101076)
    Fold Change: 1.87
    Ensembl ID: ENSG00000101076
  • Gene Symbol: FTL (ENSG00000087086)
    Fold Change: 1.87
    Ensembl ID: ENSG00000087086
  • Gene Symbol: JUND (ENSG00000130522)
    Fold Change: 1.86
    Ensembl ID: ENSG00000130522
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1.86
    Ensembl ID: ENSG00000135390
  • Gene Symbol: NIPSNAP2 (ENSG00000146729)
    Fold Change: 1.86
    Ensembl ID: ENSG00000146729
  • Gene Symbol: DLG3 (ENSG00000082458)
    Fold Change: 1.85
    Ensembl ID: ENSG00000082458
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.85
    Ensembl ID: ENSG00000130402
  • Gene Symbol: BPTF (ENSG00000171634)
    Fold Change: 1.84
    Ensembl ID: ENSG00000171634
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.83
    Ensembl ID: ENSG00000084234
  • Gene Symbol: EEF1A1 (ENSG00000156508)
    Fold Change: 1.83
    Ensembl ID: ENSG00000156508
  • Gene Symbol: MGST3 (ENSG00000143198)
    Fold Change: 1.82
    Ensembl ID: ENSG00000143198
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 1.82
    Ensembl ID: ENSG00000070831
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 1.81
    Ensembl ID: ENSG00000166710
  • Gene Symbol: XRCC6 (ENSG00000196419)
    Fold Change: 1.79
    Ensembl ID: ENSG00000196419
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.79
    Ensembl ID: ENSG00000143761
  • Gene Symbol: NR3C1 (ENSG00000113580)
    Fold Change: 1.79
    Ensembl ID: ENSG00000113580
  • Gene Symbol: DBT (ENSG00000137992)
    Fold Change: 1.78
    Ensembl ID: ENSG00000137992
  • Gene Symbol: HNRNPF (ENSG00000169813)
    Fold Change: 1.78
    Ensembl ID: ENSG00000169813
  • Gene Symbol: GAD1 (ENSG00000128683)
    Fold Change: 1.77
    Ensembl ID: ENSG00000128683
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.76
    Ensembl ID: ENSG00000182718
  • Gene Symbol: HSPD1 (ENSG00000144381)
    Fold Change: 1.76
    Ensembl ID: ENSG00000144381
  • Gene Symbol: LDHB (ENSG00000111716)
    Fold Change: 1.76
    Ensembl ID: ENSG00000111716
  • Gene Symbol: CTNNB1 (ENSG00000168036)
    Fold Change: 1.76
    Ensembl ID: ENSG00000168036
  • Gene Symbol: GNB1 (ENSG00000078369)
    Fold Change: 1.76
    Ensembl ID: ENSG00000078369
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.76
    Ensembl ID: ENSG00000142192
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.75
    Ensembl ID: ENSG00000173575
  • Gene Symbol: TMEM50B (ENSG00000142188)
    Fold Change: 1.75
    Ensembl ID: ENSG00000142188

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in choroid plexus epithelial cell cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in choroid plexus epithelial cell cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.
**Key Characteristics** 1. **Specialized ependymal cell**: The CPE is a type of ependymal cell, which is a type of glial cell that lines the ventricles and central canal of the spinal cord. 2. **Brush border**: The CPE has a brush border on its apical surface, which enhances the secretion of CSF. 3. **CSF production**: The CPE is responsible for producing CSF by selectively filtering and modifying blood plasma components. 4. **Energy production**: The CPE is involved in energy production through the mitochondrial electron transport chain. 5. **Stress response**: The CPE is involved in the cellular response to stress, including hypoxia and oxidative stress. 6. **Gene expression regulation**: The CPE regulates gene expression through various signaling pathways, including the TP53 pathway. **Clinical Significance** 1. **Cerebrospinal fluid disorders**: Abnormalities in CSF production can lead to various disorders, including hydrocephalus, meningitis, and encephalitis. 2. **Brain injury**: CPE damage can lead to brain injury, including traumatic brain injury and stroke. 3. **Neurodegenerative diseases**: Abnormalities in CSF production have been linked to various neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. 4. **Cancer**: CPEs have been implicated in cancer development and progression, particularly in glioblastoma and medulloblastoma. 5. **Infection**: CPEs can be infected by various pathogens, including bacteria, viruses, and fungi, leading to infections such as meningitis and encephalitis. In conclusion, the choroid plexus epithelial cell plays a critical role in CSF production and is involved in various cellular processes, including energy production, stress response, and gene expression regulation. Understanding the characteristics and clinical significance of CPEs is essential for the diagnosis and treatment of various neurological disorders.