Details for: WNT9A

Gene ID: 7483

Symbol: WNT9A

Ensembl ID: ENSG00000143816

Description: Wnt family member 9A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 34.0094
    Cell Significance Index: -5.2900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 4.9961
    Cell Significance Index: -4.7700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 2.7382
    Cell Significance Index: 167.8800
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 1.8779
    Cell Significance Index: 30.3000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.7408
    Cell Significance Index: -3.8100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.5808
    Cell Significance Index: 38.2900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.1463
    Cell Significance Index: 15.6400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.1216
    Cell Significance Index: 18.0000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.1185
    Cell Significance Index: 27.2900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 1.0136
    Cell Significance Index: 35.6200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7802
    Cell Significance Index: 148.4800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.7301
    Cell Significance Index: 18.2500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.7225
    Cell Significance Index: 15.8200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.4700
    Cell Significance Index: 6.6900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4406
    Cell Significance Index: 22.8900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4333
    Cell Significance Index: 42.8700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3991
    Cell Significance Index: 360.4000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.3168
    Cell Significance Index: 46.0500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.3119
    Cell Significance Index: 8.9400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2886
    Cell Significance Index: 31.4000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2876
    Cell Significance Index: 6.2300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2639
    Cell Significance Index: 11.9600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2616
    Cell Significance Index: 42.5400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2606
    Cell Significance Index: 2.4000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2492
    Cell Significance Index: 14.9600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2260
    Cell Significance Index: 17.3400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.2239
    Cell Significance Index: 4.3700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2190
    Cell Significance Index: 6.3100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2183
    Cell Significance Index: 6.1000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.2085
    Cell Significance Index: 5.3600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1672
    Cell Significance Index: 8.4500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1641
    Cell Significance Index: 11.3500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1041
    Cell Significance Index: 18.7700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0908
    Cell Significance Index: 11.1600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0709
    Cell Significance Index: 1.0200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0633
    Cell Significance Index: 22.7200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0585
    Cell Significance Index: 8.0300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0420
    Cell Significance Index: 3.1300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0163
    Cell Significance Index: 2.7900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0113
    Cell Significance Index: 2.2700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0048
    Cell Significance Index: 7.4300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0045
    Cell Significance Index: 6.0800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0014
    Cell Significance Index: 0.7600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0011
    Cell Significance Index: 0.0700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0009
    Cell Significance Index: 0.4200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0002
    Cell Significance Index: -0.2800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0003
    Cell Significance Index: -0.2100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0011
    Cell Significance Index: -2.0300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0031
    Cell Significance Index: -0.4000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0044
    Cell Significance Index: -3.2500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0058
    Cell Significance Index: -3.2600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0065
    Cell Significance Index: -4.9500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0080
    Cell Significance Index: -0.1700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0084
    Cell Significance Index: -5.2500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0100
    Cell Significance Index: -1.2800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0102
    Cell Significance Index: -4.6200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0128
    Cell Significance Index: -3.6900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0134
    Cell Significance Index: -0.4300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0158
    Cell Significance Index: -0.2500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0183
    Cell Significance Index: -0.3800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0207
    Cell Significance Index: -4.1200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0221
    Cell Significance Index: -1.0300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0235
    Cell Significance Index: -4.9400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0300
    Cell Significance Index: -3.5000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0339
    Cell Significance Index: -1.9000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0340
    Cell Significance Index: -3.8900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0384
    Cell Significance Index: -1.0500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0406
    Cell Significance Index: -0.6000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0421
    Cell Significance Index: -4.3000
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0422
    Cell Significance Index: -0.2800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0477
    Cell Significance Index: -2.2400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0487
    Cell Significance Index: -0.7000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0513
    Cell Significance Index: -5.3400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0736
    Cell Significance Index: -4.9500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0760
    Cell Significance Index: -3.9600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0829
    Cell Significance Index: -1.4200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0851
    Cell Significance Index: -1.4600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0860
    Cell Significance Index: -1.4400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0860
    Cell Significance Index: -5.5500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0886
    Cell Significance Index: -2.9000
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0893
    Cell Significance Index: -1.1500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0909
    Cell Significance Index: -3.9500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0989
    Cell Significance Index: -1.4900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1008
    Cell Significance Index: -5.2900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1065
    Cell Significance Index: -3.9100
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.1070
    Cell Significance Index: -1.1600
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.1139
    Cell Significance Index: -1.2700
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.1143
    Cell Significance Index: -1.7100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1205
    Cell Significance Index: -4.2200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1221
    Cell Significance Index: -5.4000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1318
    Cell Significance Index: -3.1600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1356
    Cell Significance Index: -4.3200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1369
    Cell Significance Index: -3.4200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1400
    Cell Significance Index: -2.9300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1421
    Cell Significance Index: -3.0700
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1427
    Cell Significance Index: -2.0800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1433
    Cell Significance Index: -4.0900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1448
    Cell Significance Index: -5.4900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1497
    Cell Significance Index: -4.0100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1506
    Cell Significance Index: -4.0200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Wnt family member:** WNT9A is a member of the Wnt family, a group of secreted proteins that play a pivotal role in regulating cell fate commitment, development, and disease pathogenesis. 2. **Canonical Wnt signaling pathway:** WNT9A is involved in the canonical Wnt signaling pathway, a well-characterized signaling cascade that regulates various biological processes, including cell proliferation, differentiation, and survival. 3. **Cellular localization:** WNT9A is primarily expressed in hematopoietic stem cells, corneal epithelial cells, and cardiac muscle myoblasts, highlighting its role in specific cell types and developmental processes. 4. **Signaling mechanisms:** WNT9A interacts with Frizzled receptors and co-receptors, such as LRP5/6, to regulate Wnt signaling, which involves the activation of transcription factors, including β-catenin and TCF/LEF. **Pathways and Functions:** 1. **Canonical Wnt signaling pathway:** WNT9A is involved in the canonical Wnt signaling pathway, which regulates cell fate commitment, proliferation, differentiation, and survival. 2. **Cellular response to retinoic acid:** WNT9A is also involved in the cellular response to retinoic acid, a key regulator of embryonic development and tissue patterning. 3. **Embryonic skeletal joint development:** WNT9A plays a crucial role in embryonic skeletal joint development, highlighting its importance in regulating bone formation and patterning. 4. **Corneal development:** WNT9A is involved in corneal development, a complex process that requires precise regulation of cell fate commitment and tissue patterning. 5. **Iris morphogenesis:** WNT9A is also involved in iris morphogenesis, a critical process that regulates the development of the eye. **Clinical Significance:** 1. **Cancer:** Aberrant Wnt signaling, including WNT9A, has been implicated in various cancers, including colorectal, breast, and ovarian cancer, highlighting the potential for targeting Wnt signaling in cancer therapy. 2. **Bone disorders:** WNT9A is involved in regulating bone formation and patterning, making it a potential target for the treatment of bone disorders, such as osteoporosis and bone cancer. 3. **Eye diseases:** WNT9A is involved in corneal development and iris morphogenesis, highlighting its potential role in the pathogenesis of eye diseases, such as corneal dystrophy and iris coloboma. 4. **Neurological disorders:** WNT9A is also involved in regulating neuronal development and function, making it a potential target for the treatment of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, WNT9A is a unique member of the Wnt family with distinct roles in development, cell fate commitment, and disease pathogenesis. Further research is needed to fully elucidate the mechanisms by which WNT9A regulates biological processes and to explore its potential therapeutic applications.

Genular Protein ID: 4073835374

Symbol: WNT9A_HUMAN

Name: Protein Wnt-9a

UniProtKB Accession Codes:

O14904 A6NLW2 Q2M2J3 Q5VWU0 Q96S50

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 4 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11414706

Title: Molecular cloning and characterization of WNT3a and WNT14 clustered in human chromosome 1q42 region.

PubMed ID: 11414706

DOI: 10.1006/bbrc.2001.5105

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9441749

Title: Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21.

PubMed ID: 9441749

DOI: 10.1006/geno.1997.5041

PubMed ID: 26902720

Title: Active and water-soluble form of lipidated Wnt protein is maintained by a serum glycoprotein afamin/alpha-albumin.

PubMed ID: 26902720

DOI: 10.7554/elife.11621

Sequence Information:

  • Length: 365
  • Mass: 40320
  • Checksum: 1E1284D744C6A9B2
  • Sequence:
    • MLDGSPLARW LAAAFGLTLL LAALRPSAAY FGLTGSEPLT ILPLTLEPEA AAQAHYKACD 
RLKLERKQRR MCRRDPGVAE TLVEAVSMSA LECQFQFRFE RWNCTLEGRY RASLLKRGFK 
ETAFLYAISS AGLTHALAKA CSAGRMERCT CDEAPDLENR EAWQWGGCGD NLKYSSKFVK 
EFLGRRSSKD LRARVDFHNN LVGVKVIKAG VETTCKCHGV SGSCTVRTCW RQLAPFHEVG 
KHLKHKYETA LKVGSTTNEA AGEAGAISPP RGRASGAGGS DPLPRTPELV HLDDSPSFCL 
AGRFSPGTAG RRCHREKNCE SICCGRGHNT QSRVVTRPCQ CQVRWCCYVE CRQCTQREEV 
YTCKG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.