Details for: EPHA8

Gene ID: 2046

Symbol: EPHA8

Ensembl ID: ENSG00000070886

Description: EPH receptor A8

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.36
    Marker Score: 2374.5
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.96
    Marker Score: 2191
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1170
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.54
    Marker Score: 1539.5
  • Cell Name: interneuron (CL0000099)
    Fold Change: 1.16
    Marker Score: 532
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7693
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4813
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.07
    Marker Score: 727
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.04
    Marker Score: 433
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 1.03
    Marker Score: 400
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71825
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48049
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.98
    Marker Score: 450.5
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 462
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5332
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 374
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.93
    Marker Score: 1759
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 327
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.88
    Marker Score: 1792
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5284
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.84
    Marker Score: 488
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.79
    Marker Score: 12401
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.77
    Marker Score: 704
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 462
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.72
    Marker Score: 24353
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.64
    Marker Score: 1026.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.61
    Marker Score: 486
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 175
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 278
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.42
    Marker Score: 315
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.42
    Marker Score: 250
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.39
    Marker Score: 375
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.39
    Marker Score: 227
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.37
    Marker Score: 130
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.33
    Marker Score: 1335
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.32
    Marker Score: 153
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.31
    Marker Score: 336
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.3
    Marker Score: 556.5
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.3
    Marker Score: 94
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.28
    Marker Score: 1505
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.27
    Marker Score: 87
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.27
    Marker Score: 2349
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.27
    Marker Score: 131
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.27
    Marker Score: 270
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.25
    Marker Score: 707
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.24
    Marker Score: 107
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.24
    Marker Score: 2238
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.23
    Marker Score: 122
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.23
    Marker Score: 957
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.21
    Marker Score: 82
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.21
    Marker Score: 235
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.2
    Marker Score: 64
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.2
    Marker Score: 256
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.19
    Marker Score: 97
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.19
    Marker Score: 105
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.18
    Marker Score: 45
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.18
    Marker Score: 1835
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.17
    Marker Score: 560
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.16
    Marker Score: 40
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.13
    Marker Score: 273
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.13
    Marker Score: 164
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.13
    Marker Score: 4794
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.13
    Marker Score: 97.5
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.13
    Marker Score: 113
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.13
    Marker Score: 120
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.12
    Marker Score: 189
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.12
    Marker Score: 39
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.12
    Marker Score: 336
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.12
    Marker Score: 489
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.11
    Marker Score: 196.5
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.11
    Marker Score: 49
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.11
    Marker Score: 97
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.11
    Marker Score: 24
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 0.11
    Marker Score: 27
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.11
    Marker Score: 498
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.11
    Marker Score: 109
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.11
    Marker Score: 53
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.1
    Marker Score: 129
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.1
    Marker Score: 26
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.1
    Marker Score: 37
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.1
    Marker Score: 157
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.1
    Marker Score: 177
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.1
    Marker Score: 63
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.1
    Marker Score: 26
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.1
    Marker Score: 26
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.1
    Marker Score: 22
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.1
    Marker Score: 25
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1
    Marker Score: 100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.09
    Marker Score: 27
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.09
    Marker Score: 88
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.09
    Marker Score: 26

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Other Information

**Key characteristics:** - EPHA8 is a type I transmembrane receptor that is expressed in a variety of cell types. - It is a cell surface receptor that is involved in cell adhesion and migration. - It is a key regulator of cell adhesion mediated by integrin. - It is also involved in the regulation of cell adhesion mediated by ephrins. **Pathways and functions:** - EPHA8 is a key regulator of cell adhesion. It is expressed in cells that are in contact with other cells, and it is responsible for the adhesion of these cells to each other. - It is also involved in the migration of cells. - It is involved in the regulation of cell adhesion mediated by integrin. - It is also involved in the regulation of cell adhesion mediated by ephrins. - It is also involved in the development of the nervous system. **Clinical significance:** - Mutations in EPHA8 have been linked to a number of human diseases, including cancer and cardiovascular disease. - EPHA8 is a potential target for the treatment of these diseases.

Genular Protein ID: 1215046859

Symbol: EPHA8_HUMAN

Name: Ephrin type-A receptor 8

UniProtKB Accession Codes:

P29322 Q6IN80 Q8IUX6 Q9NUA9 Q9P269

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CPTAC 2 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 2 EMBL 5 EPD 1 Ensembl 2 EvolutionaryTrace 1 GO 21 Gene3D 6 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 16 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 3 PIR 1 PIRSF 1 PRINTS 2 PRO 1 PROSITE 9 PROSITE-ProRule 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 3 RefSeq 2 Rhea 3 SIGNOR 1 SMART 5 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10819331

Title: Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10819331

DOI: 10.1093/dnares/7.2.143

PubMed ID: 1648701

Title: eek and erk, new members of the eph subclass of receptor protein-tyrosine kinases.

PubMed ID: 1648701

PubMed ID: 9267020

Title: Unified nomenclature for Eph family receptors and their ligands, the ephrins.

PubMed ID: 9267020

DOI: 10.1016/s0092-8674(00)80500-0

PubMed ID: 10498895

Title: Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity.

PubMed ID: 10498895

DOI: 10.1038/sj.onc.1202917

PubMed ID: 11416136

Title: The EphA8 receptor regulates integrin activity through p110gamma phosphatidylinositol-3 kinase in a tyrosine kinase activity-independent manner.

PubMed ID: 11416136

DOI: 10.1128/mcb.21.14.4579-4597.2001

PubMed ID: 17875921

Title: Identification of phosphotyrosine binding domain-containing proteins as novel downstream targets of the EphA8 signaling function.

PubMed ID: 17875921

DOI: 10.1128/mcb.00794-07

PubMed ID: 20496116

Title: EphA8-ephrinA5 signaling and clathrin-mediated endocytosis is regulated by Tiam-1, a Rac-specific guanine nucleotide exchange factor.

PubMed ID: 20496116

DOI: 10.1007/s10059-010-0075-2

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 1005
  • Mass: 111003
  • Checksum: 6FBF85535E4212B3
  • Sequence:
    • MAPARGRLPP ALWVVTAAAA AATCVSAARG EVNLLDTSTI HGDWGWLTYP AHGWDSINEV 
DESFQPIHTY QVCNVMSPNQ NNWLRTSWVP RDGARRVYAE IKFTLRDCNS MPGVLGTCKE 
TFNLYYLESD RDLGASTQES QFLKIDTIAA DESFTGADLG VRRLKLNTEV RSVGPLSKRG 
FYLAFQDIGA CLAILSLRIY YKKCPAMVRN LAAFSEAVTG ADSSSLVEVR GQCVRHSEER 
DTPKMYCSAE GEWLVPIGKC VCSAGYEERR DACVACELGF YKSAPGDQLC ARCPPHSHSA 
APAAQACHCD LSYYRAALDP PSSACTRPPS APVNLISSVN GTSVTLEWAP PLDPGGRSDI 
TYNAVCRRCP WALSRCEACG SGTRFVPQQT SLVQASLLVA NLLAHMNYSF WIEAVNGVSD 
LSPEPRRAAV VNITTNQAAP SQVVVIRQER AGQTSVSLLW QEPEQPNGII LEYEIKYYEK 
DKEMQSYSTL KAVTTRATVS GLKPGTRYVF QVRARTSAGC GRFSQAMEVE TGKPRPRYDT 
RTIVWICLTL ITGLVVLLLL LICKKRHCGY SKAFQDSDEE KMHYQNGQAP PPVFLPLHHP 
PGKLPEPQFY AEPHTYEEPG RAGRSFTREI EASRIHIEKI IGSGDSGEVC YGRLRVPGQR 
DVPVAIKALK AGYTERQRRD FLSEASIMGQ FDHPNIIRLE GVVTRGRLAM IVTEYMENGS 
LDTFLRTHDG QFTIMQLVGM LRGVGAGMRY LSDLGYVHRD LAARNVLVDS NLVCKVSDFG 
LSRVLEDDPD AAYTTTGGKI PIRWTAPEAI AFRTFSSASD VWSFGVVMWE VLAYGERPYW 
NMTNRDVISS VEEGYRLPAP MGCPHALHQL MLDCWHKDRA QRPRFSQIVS VLDALIRSPE 
SLRATATVSR CPPPAFVRSC FDLRGGSGGG GGLTVGDWLD SIRMGRYRDH FAAGGYSSLG 
MVLRMNAQDV RALGITLMGH QKKILGSIQT MRAQLTSTQG PRRHL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.