Details for: EPHA8

Gene ID: 2046

Symbol: EPHA8

Ensembl ID: ENSG00000070886

Description: EPH receptor A8

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 3.9090
    Cell Significance Index: 125.2000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 3.0274
    Cell Significance Index: 66.2900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 2.4742
    Cell Significance Index: 151.6900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 1.5561
    Cell Significance Index: 23.4500
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.1335
    Cell Significance Index: 15.9200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7704
    Cell Significance Index: 146.6200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.6407
    Cell Significance Index: 9.1800
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.5437
    Cell Significance Index: 7.1400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5285
    Cell Significance Index: 11.2600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.4727
    Cell Significance Index: 6.8900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4463
    Cell Significance Index: 44.1500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3723
    Cell Significance Index: 336.1700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3582
    Cell Significance Index: 21.5100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3468
    Cell Significance Index: 37.7200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2690
    Cell Significance Index: 3.6700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2611
    Cell Significance Index: 42.4700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1869
    Cell Significance Index: 4.0500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1673
    Cell Significance Index: 11.5700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1309
    Cell Significance Index: 8.2500
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.0678
    Cell Significance Index: 0.7700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.0597
    Cell Significance Index: 0.7400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0555
    Cell Significance Index: 38.4100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0450
    Cell Significance Index: 0.6400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0180
    Cell Significance Index: 3.6100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0115
    Cell Significance Index: 0.3300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0063
    Cell Significance Index: 0.1300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0033
    Cell Significance Index: 1.1700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0004
    Cell Significance Index: -0.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0010
    Cell Significance Index: -1.9500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0011
    Cell Significance Index: -1.9800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0013
    Cell Significance Index: -1.9800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0016
    Cell Significance Index: -2.1500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0026
    Cell Significance Index: -1.4400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0031
    Cell Significance Index: -0.1100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0031
    Cell Significance Index: -2.3200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0044
    Cell Significance Index: -2.4000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0056
    Cell Significance Index: -3.5800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0064
    Cell Significance Index: -2.9100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0064
    Cell Significance Index: -0.1600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0075
    Cell Significance Index: -2.1700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0075
    Cell Significance Index: -0.0900
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0078
    Cell Significance Index: -0.0600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0091
    Cell Significance Index: -1.0600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0095
    Cell Significance Index: -0.4300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0116
    Cell Significance Index: -2.4400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0169
    Cell Significance Index: -0.1600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0170
    Cell Significance Index: -0.8900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0194
    Cell Significance Index: -3.8500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0202
    Cell Significance Index: -2.7700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0204
    Cell Significance Index: -3.6700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0204
    Cell Significance Index: -2.9600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0211
    Cell Significance Index: -2.4200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0233
    Cell Significance Index: -1.3100
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.0240
    Cell Significance Index: -0.2900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0287
    Cell Significance Index: -1.4900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0316
    Cell Significance Index: -3.2900
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0392
    Cell Significance Index: -0.4300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0397
    Cell Significance Index: -2.6700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0416
    Cell Significance Index: -1.8400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0422
    Cell Significance Index: -1.3800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0430
    Cell Significance Index: -2.6400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0442
    Cell Significance Index: -4.5100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0448
    Cell Significance Index: -1.2200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0455
    Cell Significance Index: -1.1700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0462
    Cell Significance Index: -1.2900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0501
    Cell Significance Index: -1.2500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0510
    Cell Significance Index: -1.9300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0532
    Cell Significance Index: -1.1300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0541
    Cell Significance Index: -0.5600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0548
    Cell Significance Index: -1.3700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0549
    Cell Significance Index: -4.2100
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0563
    Cell Significance Index: -0.6900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0585
    Cell Significance Index: -2.0500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0602
    Cell Significance Index: -1.2600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0604
    Cell Significance Index: -2.8400
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0617
    Cell Significance Index: -0.7200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0641
    Cell Significance Index: -2.0400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0653
    Cell Significance Index: -1.4100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0658
    Cell Significance Index: -3.3300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0664
    Cell Significance Index: -1.7500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0687
    Cell Significance Index: -1.3400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0723
    Cell Significance Index: -1.5100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0733
    Cell Significance Index: -2.1000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0747
    Cell Significance Index: -1.2800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0817
    Cell Significance Index: -1.6400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0873
    Cell Significance Index: -2.1300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0887
    Cell Significance Index: -2.5300
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.0906
    Cell Significance Index: -1.2400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0925
    Cell Significance Index: -1.8300
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.0978
    Cell Significance Index: -1.3300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0990
    Cell Significance Index: -3.1300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1021
    Cell Significance Index: -1.7600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1053
    Cell Significance Index: -1.6900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1063
    Cell Significance Index: -2.5500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1070
    Cell Significance Index: -2.8600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1098
    Cell Significance Index: -1.8500
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1110
    Cell Significance Index: -1.4800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1120
    Cell Significance Index: -4.5900
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.1160
    Cell Significance Index: -1.2000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1170
    Cell Significance Index: -3.1400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The EPHA8 gene exhibits several key characteristics that are worth noting: 1. **Receptor structure**: EPHA8 is a transmembrane receptor with an extracellular domain that interacts with ephrin ligands, triggering a signaling cascade that regulates various cellular processes. 2. **Cellular expression**: EPHA8 is expressed in a wide range of cell types, including blood vessel endothelial cells, plasma cells, and intestinal stem cells, suggesting its involvement in maintaining tissue homeostasis and immune responses. 3. **Signaling pathways**: EPHA8 is involved in multiple signaling pathways, including the MAPK cascade, PI3K/PKB signaling, and protein phosphorylation, which regulate cell adhesion, migration, and growth. 4. **Evolutionary conservation**: EPHA8 is conserved across species, indicating its essential role in maintaining cellular homeostasis and immune responses. **Pathways and Functions** The EPHA8 gene is involved in several key pathways and functions, including: 1. **Axon guidance**: EPHA8 plays a crucial role in axon guidance, regulating the extension and branching of axons during neuronal development. 2. **Cell adhesion**: EPHA8 interacts with ephrin ligands to regulate cell adhesion, which is essential for maintaining tissue homeostasis and immune responses. 3. **Neuronal development**: EPHA8 is involved in neuronal development, regulating the formation and maintenance of neural connections. 4. **Immune responses**: Although EPHA8 is not primarily known for its involvement in immune responses, its expression in plasma cells and other immune cells suggests its potential role in regulating immune cell function and tissue homeostasis. **Clinical Significance** While EPHA8 is not directly associated with immune-related disorders, its involvement in various cellular processes makes it an interesting candidate for further study. Potential clinical implications of EPHA8 dysregulation include: 1. **Neurodevelopmental disorders**: Abnormalities in EPHA8 signaling may contribute to neurodevelopmental disorders, such as autism spectrum disorder or schizophrenia. 2. **Cancer**: EPHA8 dysregulation may contribute to cancer development and progression, particularly in tissues with high ephrin expression. 3. **Immune-related disorders**: Further study is needed to determine the potential role of EPHA8 in regulating immune responses and its involvement in immune-related disorders, such as autoimmune diseases or immunodeficiency disorders. In conclusion, the EPHA8 gene plays a crucial role in various cellular processes, including cell adhesion, axon guidance, and neuronal development. While its primary association is with non-immune related pathways, its expression in immune cells suggests its potential role in regulating immune responses and tissue homeostasis. Further study is needed to fully elucidate the clinical significance of EPHA8 and its involvement in immune-related disorders.

Genular Protein ID: 1215046859

Symbol: EPHA8_HUMAN

Name: Ephrin type-A receptor 8

UniProtKB Accession Codes:

P29322 Q6IN80 Q8IUX6 Q9NUA9 Q9P269

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CPTAC 2 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 2 EMBL 5 Ensembl 2 EvolutionaryTrace 1 GO 20 Gene3D 6 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 17 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PIRSF 1 PRINTS 2 PRO 1 PROSITE 9 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 3 RefSeq 2 Rhea 3 SIGNOR 1 SMART 5 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10819331

Title: Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10819331

DOI: 10.1093/dnares/7.2.143

PubMed ID: 1648701

Title: eek and erk, new members of the eph subclass of receptor protein-tyrosine kinases.

PubMed ID: 1648701

PubMed ID: 9267020

Title: Unified nomenclature for Eph family receptors and their ligands, the ephrins.

PubMed ID: 9267020

DOI: 10.1016/s0092-8674(00)80500-0

PubMed ID: 10498895

Title: Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity.

PubMed ID: 10498895

DOI: 10.1038/sj.onc.1202917

PubMed ID: 11416136

Title: The EphA8 receptor regulates integrin activity through p110gamma phosphatidylinositol-3 kinase in a tyrosine kinase activity-independent manner.

PubMed ID: 11416136

DOI: 10.1128/mcb.21.14.4579-4597.2001

PubMed ID: 17875921

Title: Identification of phosphotyrosine binding domain-containing proteins as novel downstream targets of the EphA8 signaling function.

PubMed ID: 17875921

DOI: 10.1128/mcb.00794-07

PubMed ID: 20496116

Title: EphA8-ephrinA5 signaling and clathrin-mediated endocytosis is regulated by Tiam-1, a Rac-specific guanine nucleotide exchange factor.

PubMed ID: 20496116

DOI: 10.1007/s10059-010-0075-2

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 1005
  • Mass: 111003
  • Checksum: 6FBF85535E4212B3
  • Sequence:
    • MAPARGRLPP ALWVVTAAAA AATCVSAARG EVNLLDTSTI HGDWGWLTYP AHGWDSINEV 
DESFQPIHTY QVCNVMSPNQ NNWLRTSWVP RDGARRVYAE IKFTLRDCNS MPGVLGTCKE 
TFNLYYLESD RDLGASTQES QFLKIDTIAA DESFTGADLG VRRLKLNTEV RSVGPLSKRG 
FYLAFQDIGA CLAILSLRIY YKKCPAMVRN LAAFSEAVTG ADSSSLVEVR GQCVRHSEER 
DTPKMYCSAE GEWLVPIGKC VCSAGYEERR DACVACELGF YKSAPGDQLC ARCPPHSHSA 
APAAQACHCD LSYYRAALDP PSSACTRPPS APVNLISSVN GTSVTLEWAP PLDPGGRSDI 
TYNAVCRRCP WALSRCEACG SGTRFVPQQT SLVQASLLVA NLLAHMNYSF WIEAVNGVSD 
LSPEPRRAAV VNITTNQAAP SQVVVIRQER AGQTSVSLLW QEPEQPNGII LEYEIKYYEK 
DKEMQSYSTL KAVTTRATVS GLKPGTRYVF QVRARTSAGC GRFSQAMEVE TGKPRPRYDT 
RTIVWICLTL ITGLVVLLLL LICKKRHCGY SKAFQDSDEE KMHYQNGQAP PPVFLPLHHP 
PGKLPEPQFY AEPHTYEEPG RAGRSFTREI EASRIHIEKI IGSGDSGEVC YGRLRVPGQR 
DVPVAIKALK AGYTERQRRD FLSEASIMGQ FDHPNIIRLE GVVTRGRLAM IVTEYMENGS 
LDTFLRTHDG QFTIMQLVGM LRGVGAGMRY LSDLGYVHRD LAARNVLVDS NLVCKVSDFG 
LSRVLEDDPD AAYTTTGGKI PIRWTAPEAI AFRTFSSASD VWSFGVVMWE VLAYGERPYW 
NMTNRDVISS VEEGYRLPAP MGCPHALHQL MLDCWHKDRA QRPRFSQIVS VLDALIRSPE 
SLRATATVSR CPPPAFVRSC FDLRGGSGGG GGLTVGDWLD SIRMGRYRDH FAAGGYSSLG 
MVLRMNAQDV RALGITLMGH QKKILGSIQT MRAQLTSTQG PRRHL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.