Details for: LINC00305

Gene ID: 221241

Symbol: LINC00305

Ensembl ID: ENSG00000179676

Description: long intergenic non-protein coding RNA 305

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 9.4492
    Cell Significance Index: 155.7100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.6484
    Cell Significance Index: 9.4500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.5661
    Cell Significance Index: 5.8600
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.3977
    Cell Significance Index: 4.4500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1285
    Cell Significance Index: 174.7300
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.1093
    Cell Significance Index: 0.9400
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0905
    Cell Significance Index: 1.1500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0825
    Cell Significance Index: 2.2100
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.0804
    Cell Significance Index: 1.0100
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 0.0739
    Cell Significance Index: 0.2000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0705
    Cell Significance Index: 1.0400
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.0654
    Cell Significance Index: 0.7900
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.0386
    Cell Significance Index: 1.2200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0340
    Cell Significance Index: 0.7500
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.0296
    Cell Significance Index: 0.3500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0266
    Cell Significance Index: 0.4600
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.0168
    Cell Significance Index: 0.2000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0155
    Cell Significance Index: 23.8100
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.0106
    Cell Significance Index: 0.1200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.0081
    Cell Significance Index: 0.2400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.0038
    Cell Significance Index: 0.0300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0030
    Cell Significance Index: 0.6100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0028
    Cell Significance Index: 0.5600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0023
    Cell Significance Index: 0.3900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0009
    Cell Significance Index: 0.2500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0004
    Cell Significance Index: 0.7100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0003
    Cell Significance Index: 0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0003
    Cell Significance Index: 0.5000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0003
    Cell Significance Index: -0.1000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0009
    Cell Significance Index: -0.5700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0010
    Cell Significance Index: -0.7300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0012
    Cell Significance Index: -0.5500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0012
    Cell Significance Index: -0.6300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0021
    Cell Significance Index: -0.3700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0021
    Cell Significance Index: -0.3000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0034
    Cell Significance Index: -0.7200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0040
    Cell Significance Index: -0.5500
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0048
    Cell Significance Index: -0.0700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0050
    Cell Significance Index: -0.6100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0056
    Cell Significance Index: -0.5800
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0057
    Cell Significance Index: -0.0500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0061
    Cell Significance Index: -0.1800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0073
    Cell Significance Index: -0.7500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0073
    Cell Significance Index: -0.4900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0087
    Cell Significance Index: -0.3300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0088
    Cell Significance Index: -0.5400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0091
    Cell Significance Index: -0.7000
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: -0.0097
    Cell Significance Index: -0.0700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0103
    Cell Significance Index: -0.2800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0104
    Cell Significance Index: -0.4600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0108
    Cell Significance Index: -0.3800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0109
    Cell Significance Index: -0.6100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0113
    Cell Significance Index: -0.3600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0115
    Cell Significance Index: -0.4000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0125
    Cell Significance Index: -0.4100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0133
    Cell Significance Index: -0.2600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0138
    Cell Significance Index: -0.6500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0172
    Cell Significance Index: -0.4300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0179
    Cell Significance Index: -0.3000
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: -0.0184
    Cell Significance Index: -0.1400
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.0190
    Cell Significance Index: -0.1800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0193
    Cell Significance Index: -0.2100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0193
    Cell Significance Index: -0.4100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0194
    Cell Significance Index: -0.3800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0201
    Cell Significance Index: -0.4900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0208
    Cell Significance Index: -0.5200
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0210
    Cell Significance Index: -0.2300
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0213
    Cell Significance Index: -0.2700
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: -0.0214
    Cell Significance Index: -0.1600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0214
    Cell Significance Index: -0.4300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0215
    Cell Significance Index: -0.4700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0215
    Cell Significance Index: -0.4300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0215
    Cell Significance Index: -0.5200
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.0217
    Cell Significance Index: -0.3100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0217
    Cell Significance Index: -0.6200
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0218
    Cell Significance Index: -0.3100
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0224
    Cell Significance Index: -0.2900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0228
    Cell Significance Index: -0.6000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0230
    Cell Significance Index: -1.1600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0235
    Cell Significance Index: -0.4900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0237
    Cell Significance Index: -0.4000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0243
    Cell Significance Index: -0.9900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0244
    Cell Significance Index: -0.2900
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0247
    Cell Significance Index: -0.2100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0247
    Cell Significance Index: -0.6600
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0247
    Cell Significance Index: -0.3700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0263
    Cell Significance Index: -0.6300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0263
    Cell Significance Index: -0.3800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0264
    Cell Significance Index: -0.2500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0268
    Cell Significance Index: -0.4000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0268
    Cell Significance Index: -0.4300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0271
    Cell Significance Index: -0.6900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0272
    Cell Significance Index: -0.5700
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0274
    Cell Significance Index: -0.5400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0283
    Cell Significance Index: -0.4900
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.0292
    Cell Significance Index: -0.3200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0293
    Cell Significance Index: -0.5900
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0299
    Cell Significance Index: -0.3800
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0304
    Cell Significance Index: -0.3700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location and Structure:** LINC00305 is a long intergenic non-protein coding RNA, which means it is located between two protein-coding genes and does not encode a protein itself. Its structure is characterized by a long primary transcript with multiple exons and introns. 2. **Expression Patterns:** LINC00305 is significantly expressed in various immune cells, including progenitor cells, T cells, plasma cells, dendritic cells, granulocytes, monocytes, B cells, pericytes, and goblet cells. Its expression is also observed in other cell types, including epithelial cells and endothelial cells. 3. **Stability and Regulation:** The stability and regulation of LINC00305 are poorly understood. However, studies suggest that its expression is tightly regulated by various transcriptional and post-transcriptional mechanisms. **Pathways and Functions:** 1. **Immune Cell Development:** LINC00305 has been shown to regulate the development of immune cells, including T cells, B cells, and dendritic cells. Its expression is required for the proper development and differentiation of these cells. 2. **Cell Signaling:** LINC00305 modulates cell signaling pathways, including the NF-κB and JAK/STAT pathways, which are critical for immune cell function and regulation. 3. **Gene Expression Regulation:** LINC00305 regulates the expression of genes involved in immune cell function, including cytokine production, antigen presentation, and cell adhesion. 4. **Epigenetic Regulation:** LINC00305 interacts with epigenetic regulators, such as histone modifiers and DNA methyltransferases, to regulate gene expression and chromatin structure. **Clinical Significance:** 1. **Immune-Related Disorders:** LINC00305 has been implicated in various immune-related disorders, including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, and infectious diseases, such as HIV and tuberculosis. 2. **Cancer:** LINC00305 has been shown to play a role in cancer development and progression, particularly in the context of immune cell infiltration and tumor microenvironment regulation. 3. **Vaccine Development:** LINC00305 has been identified as a potential target for vaccine development, particularly for vaccines aimed at modulating immune cell function and regulation. 4. **Therapeutic Potential:** LINC00305 has been proposed as a potential therapeutic target for the treatment of immune-related disorders, including autoimmune diseases and cancer. In conclusion, LINC00305 is a critical regulator of immune cell function, and its dysregulation has been implicated in various immune-related disorders. Further research is needed to fully understand the mechanisms by which LINC00305 regulates immune cell function and to explore its potential as a therapeutic target.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.