Details for: CL4023051

Cell ID: CL4023051

Cell Name: vascular leptomeningeal cell

Marker Score Threshold: 1151
(Derived using integrated single-cell and genomic data)

Description: A transcriptomically distinct type of mesothelial fibroblast that is derived from the neural crest, is localized on blood vessels, and is a key component of the pia and arachnoid membranes surrounding the brain. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: Non-neuronal cells', Author Categories: 'CrossArea_subclass', clusters VLMC.

Synonyms: VLMC

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ATP1A2 (ENSG00000018625)
    Fold Change: 3.52
    Ensembl ID: ENSG00000018625
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 3.4
    Ensembl ID: ENSG00000140836
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 3.25
    Ensembl ID: ENSG00000163697
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 3.18
    Ensembl ID: ENSG00000142599
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 2.97
    Ensembl ID: ENSG00000151914
  • Gene Symbol: ADGRB3 (ENSG00000135298)
    Fold Change: 2.93
    Ensembl ID: ENSG00000135298
  • Gene Symbol: APOD (ENSG00000189058)
    Fold Change: 2.84
    Ensembl ID: ENSG00000189058
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 2.74
    Ensembl ID: ENSG00000156110
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.71
    Ensembl ID: ENSG00000142192
  • Gene Symbol: BCL6 (ENSG00000113916)
    Fold Change: 2.7
    Ensembl ID: ENSG00000113916
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 2.64
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ABCA1 (ENSG00000165029)
    Fold Change: 2.61
    Ensembl ID: ENSG00000165029
  • Gene Symbol: BRAF (ENSG00000157764)
    Fold Change: 2.58
    Ensembl ID: ENSG00000157764
  • Gene Symbol: ABL1 (ENSG00000097007)
    Fold Change: 2.57
    Ensembl ID: ENSG00000097007
  • Gene Symbol: ARHGAP6 (ENSG00000047648)
    Fold Change: 2.54
    Ensembl ID: ENSG00000047648
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 2.42
    Ensembl ID: ENSG00000204217
  • Gene Symbol: KLF9 (ENSG00000119138)
    Fold Change: 2.41
    Ensembl ID: ENSG00000119138
  • Gene Symbol: BCL2 (ENSG00000171791)
    Fold Change: 2.39
    Ensembl ID: ENSG00000171791
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 2.3
    Ensembl ID: ENSG00000170634
  • Gene Symbol: BACH1 (ENSG00000156273)
    Fold Change: 2.3
    Ensembl ID: ENSG00000156273
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.29
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 2.26
    Ensembl ID: ENSG00000087274
  • Gene Symbol: BMPR1A (ENSG00000107779)
    Fold Change: 2.25
    Ensembl ID: ENSG00000107779
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 2.22
    Ensembl ID: ENSG00000069849
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 2.16
    Ensembl ID: ENSG00000172270
  • Gene Symbol: BGN (ENSG00000182492)
    Fold Change: 2.13
    Ensembl ID: ENSG00000182492
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 2.08
    Ensembl ID: ENSG00000137845
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 2.06
    Ensembl ID: ENSG00000148700
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.04
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 2
    Ensembl ID: ENSG00000145362
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 2
    Ensembl ID: ENSG00000174437
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.97
    Ensembl ID: ENSG00000149311
  • Gene Symbol: ADCY3 (ENSG00000138031)
    Fold Change: 1.97
    Ensembl ID: ENSG00000138031
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.95
    Ensembl ID: ENSG00000006125
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.94
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.93
    Ensembl ID: ENSG00000100852
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.91
    Ensembl ID: ENSG00000130402
  • Gene Symbol: AXL (ENSG00000167601)
    Fold Change: 1.87
    Ensembl ID: ENSG00000167601
  • Gene Symbol: BICD1 (ENSG00000151746)
    Fold Change: 1.86
    Ensembl ID: ENSG00000151746
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.86
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ADARB2 (ENSG00000185736)
    Fold Change: 1.85
    Ensembl ID: ENSG00000185736
  • Gene Symbol: ADCY9 (ENSG00000162104)
    Fold Change: 1.85
    Ensembl ID: ENSG00000162104
  • Gene Symbol: BCL2L1 (ENSG00000171552)
    Fold Change: 1.85
    Ensembl ID: ENSG00000171552
  • Gene Symbol: BCKDHB (ENSG00000083123)
    Fold Change: 1.8
    Ensembl ID: ENSG00000083123
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.8
    Ensembl ID: ENSG00000185650
  • Gene Symbol: JAG1 (ENSG00000101384)
    Fold Change: 1.79
    Ensembl ID: ENSG00000101384
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.74
    Ensembl ID: ENSG00000143878
  • Gene Symbol: AUH (ENSG00000148090)
    Fold Change: 1.73
    Ensembl ID: ENSG00000148090
  • Gene Symbol: ACACA (ENSG00000278540)
    Fold Change: 1.72
    Ensembl ID: ENSG00000278540
  • Gene Symbol: ARRB1 (ENSG00000137486)
    Fold Change: 1.72
    Ensembl ID: ENSG00000137486
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.62
    Ensembl ID: ENSG00000197043
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.62
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.59
    Ensembl ID: ENSG00000164111
  • Gene Symbol: XIAP (ENSG00000101966)
    Fold Change: 1.58
    Ensembl ID: ENSG00000101966
  • Gene Symbol: APC (ENSG00000134982)
    Fold Change: 1.57
    Ensembl ID: ENSG00000134982
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.57
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.56
    Ensembl ID: ENSG00000070961
  • Gene Symbol: A2M (ENSG00000175899)
    Fold Change: 1.54
    Ensembl ID: ENSG00000175899
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.52
    Ensembl ID: ENSG00000072110
  • Gene Symbol: GRK3 (ENSG00000100077)
    Fold Change: 1.51
    Ensembl ID: ENSG00000100077
  • Gene Symbol: AP1G1 (ENSG00000166747)
    Fold Change: 1.5
    Ensembl ID: ENSG00000166747
  • Gene Symbol: RND3 (ENSG00000115963)
    Fold Change: 1.48
    Ensembl ID: ENSG00000115963
  • Gene Symbol: ARNT (ENSG00000143437)
    Fold Change: 1.47
    Ensembl ID: ENSG00000143437
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.47
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ATR (ENSG00000175054)
    Fold Change: 1.42
    Ensembl ID: ENSG00000175054
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.39
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ABR (ENSG00000159842)
    Fold Change: 1.38
    Ensembl ID: ENSG00000159842
  • Gene Symbol: AP2A2 (ENSG00000183020)
    Fold Change: 1.38
    Ensembl ID: ENSG00000183020
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.37
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.36
    Ensembl ID: ENSG00000198363
  • Gene Symbol: ATP2B4 (ENSG00000058668)
    Fold Change: 1.36
    Ensembl ID: ENSG00000058668
  • Gene Symbol: ADARB1 (ENSG00000197381)
    Fold Change: 1.36
    Ensembl ID: ENSG00000197381
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 1.33
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ALDH7A1 (ENSG00000164904)
    Fold Change: 1.33
    Ensembl ID: ENSG00000164904
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 1.32
    Ensembl ID: ENSG00000151150
  • Gene Symbol: ATP6V0A1 (ENSG00000033627)
    Fold Change: 1.31
    Ensembl ID: ENSG00000033627
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 1.31
    Ensembl ID: ENSG00000185883
  • Gene Symbol: ABL2 (ENSG00000143322)
    Fold Change: 1.3
    Ensembl ID: ENSG00000143322
  • Gene Symbol: ACVR1 (ENSG00000115170)
    Fold Change: 1.29
    Ensembl ID: ENSG00000115170
  • Gene Symbol: ADCY5 (ENSG00000173175)
    Fold Change: 1.27
    Ensembl ID: ENSG00000173175
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.21
    Ensembl ID: ENSG00000182718
  • Gene Symbol: BMAL1 (ENSG00000133794)
    Fold Change: 1.19
    Ensembl ID: ENSG00000133794
  • Gene Symbol: BMP6 (ENSG00000153162)
    Fold Change: 1.17
    Ensembl ID: ENSG00000153162
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.15
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ATP1B2 (ENSG00000129244)
    Fold Change: 1.14
    Ensembl ID: ENSG00000129244
  • Gene Symbol: AMPH (ENSG00000078053)
    Fold Change: 1.14
    Ensembl ID: ENSG00000078053
  • Gene Symbol: AKT2 (ENSG00000105221)
    Fold Change: 1.14
    Ensembl ID: ENSG00000105221
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 1.1
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ACTA2 (ENSG00000107796)
    Fold Change: 1.1
    Ensembl ID: ENSG00000107796
  • Gene Symbol: ACACB (ENSG00000076555)
    Fold Change: 1.09
    Ensembl ID: ENSG00000076555
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.08
    Ensembl ID: ENSG00000196975
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.08
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.08
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ACO1 (ENSG00000122729)
    Fold Change: 1.07
    Ensembl ID: ENSG00000122729
  • Gene Symbol: ADCY1 (ENSG00000164742)
    Fold Change: 1.07
    Ensembl ID: ENSG00000164742
  • Gene Symbol: AP2A1 (ENSG00000196961)
    Fold Change: 1.06
    Ensembl ID: ENSG00000196961
  • Gene Symbol: ABCB7 (ENSG00000131269)
    Fold Change: 1.05
    Ensembl ID: ENSG00000131269
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.04
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ARL3 (ENSG00000138175)
    Fold Change: 1.03
    Ensembl ID: ENSG00000138175
  • Gene Symbol: ADCY2 (ENSG00000078295)
    Fold Change: 1.03
    Ensembl ID: ENSG00000078295
Hovered Details

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Hovered Details

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**Key Characteristics** The VLMC is a transcriptomically distinct type of mesothelial fibroblast that is characterized by its expression of specific genes, including: * ATP1A2: encodes for a sodium-potassium pump that regulates ion transport across cell membranes. * ZFHX3: encodes for a transcription factor that regulates gene expression and cell adhesion. * APBB2: encodes for a protein that regulates synaptic transmission and cell signaling. * RERE: encodes for a transcriptional corepressor that regulates gene expression and cell differentiation. * DST: encodes for a transcription factor that regulates gene expression and cell adhesion. * ADGRB3: encodes for a G protein-coupled receptor that regulates synaptic transmission and cell signaling. The VLMC is also characterized by its localization to blood vessels and its involvement in various cellular processes, including: * Ion transport: VLMCs regulate ion transport across cell membranes, which is essential for maintaining cellular homeostasis. * Cell adhesion: VLMCs regulate cell adhesion to other cells and to the extracellular matrix, which is essential for maintaining tissue structure and function. * Signaling pathways: VLMCs are involved in various signaling pathways, including those that regulate cell growth, differentiation, and survival. **Clinical Significance** The VLMC is implicated in several neurological disorders, including: * Multiple sclerosis: dysfunction of VLMCs has been linked to the development of multiple sclerosis, a disease characterized by demyelination and axonal loss in the CNS. * Alzheimer's disease: VLMCs have been implicated in the pathogenesis of Alzheimer's disease, a neurodegenerative disorder characterized by cognitive decline and memory loss. * Stroke: VLMCs play a crucial role in maintaining blood vessel integrity, and dysfunction of these cells has been linked to the development of stroke. * Neurodegenerative disorders: VLMCs have been implicated in various neurodegenerative disorders, including Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis. Understanding the role of the VLMC in the CNS and its involvement in neurological disorders is essential for the development of novel therapeutic strategies for these diseases.