Details for: BRINP1

Gene ID: 1620

Symbol: BRINP1

Ensembl ID: ENSG00000078725

Description: BMP/retinoic acid inducible neural specific 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 3.52
    Marker Score: 8,092
  • Cell Name: granule cell (CL0000120)
    Fold Change: 2.8
    Marker Score: 21,133
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.38
    Marker Score: 6,800
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.38
    Marker Score: 3,995
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 2.37
    Marker Score: 12,747
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.35
    Marker Score: 50,076
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.33
    Marker Score: 88,547
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.25
    Marker Score: 9,323
  • Cell Name: neuron (CL0000540)
    Fold Change: 2.18
    Marker Score: 8,879
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.13
    Marker Score: 42,345
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.1
    Marker Score: 19,763
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.02
    Marker Score: 123,989
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.99
    Marker Score: 1,985
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.99
    Marker Score: 7,692
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.98
    Marker Score: 15,196
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.93
    Marker Score: 1,273
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.86
    Marker Score: 27,883
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.85
    Marker Score: 774
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1.84
    Marker Score: 6,155
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.81
    Marker Score: 17,232
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.77
    Marker Score: 15,246
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.73
    Marker Score: 1,502
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.71
    Marker Score: 7,893
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.69
    Marker Score: 2,095
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.6
    Marker Score: 2,475
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1,162
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.54
    Marker Score: 52,164
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.53
    Marker Score: 15,824
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.46
    Marker Score: 1,815
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.43
    Marker Score: 832
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.41
    Marker Score: 2,676
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.4
    Marker Score: 383
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 864
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.36
    Marker Score: 50,051
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 1.34
    Marker Score: 7,017
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.33
    Marker Score: 513
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.25
    Marker Score: 849
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.22
    Marker Score: 2,485
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.16
    Marker Score: 483
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4,799
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.13
    Marker Score: 545
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.12
    Marker Score: 2,286
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 1.12
    Marker Score: 339
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 499
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.08
    Marker Score: 571
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.07
    Marker Score: 16,690
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 791
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,796
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,021
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.95
    Marker Score: 2,244
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,324
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 371
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,737
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.9
    Marker Score: 3,766
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 0.88
    Marker Score: 291
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.88
    Marker Score: 526
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,287
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.84
    Marker Score: 383
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.79
    Marker Score: 560
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,261
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 705
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.75
    Marker Score: 497
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.75
    Marker Score: 826
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.74
    Marker Score: 330
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 459
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.69
    Marker Score: 203
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.67
    Marker Score: 629
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.66
    Marker Score: 794
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.65
    Marker Score: 1,182
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.57
    Marker Score: 456
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.56
    Marker Score: 267
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.55
    Marker Score: 231
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.54
    Marker Score: 139
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.51
    Marker Score: 426
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 472
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.49
    Marker Score: 157
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.49
    Marker Score: 3,235
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.46
    Marker Score: 4,712
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.46
    Marker Score: 344
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.44
    Marker Score: 248
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.41
    Marker Score: 444
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.41
    Marker Score: 143
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.4
    Marker Score: 460
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.39
    Marker Score: 418
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.39
    Marker Score: 122
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.39
    Marker Score: 232
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 0.38
    Marker Score: 109
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.37
    Marker Score: 773
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.37
    Marker Score: 213
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 369
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.36
    Marker Score: 161

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** BRINP1 is a transcription factor that exhibits neural-specific expression patterns, with significant levels observed in various cell types within the CNS, including macroglial cells, granule cells, cerebral cortex neurons, pyramidal neurons, stellate neurons, astrocytes, and GABAergic cortical interneurons. Its expression is induced by BMP (Bone Morphogenetic Protein) and retinoic acid signaling pathways, which underscores its role as a key regulator of neural development and differentiation. **Pathways and Functions:** BRINP1's involvement in multiple signaling pathways underscores its multifaceted role in the CNS. Notably, it is: 1. **Positive regulator of neuron differentiation**: BRINP1 promotes the differentiation of neurons from neural stem cells, facilitating the development of complex neural circuits. 2. **Negative regulator of cell cycle**: BRINP1 inhibits cell cycle progression, ensuring that neurons do not proliferate excessively and maintaining the delicate balance of neural cell numbers. 3. **Regulator of neurogenesis**: BRINP1 modulates the process of neurogenesis, influencing the generation of new neurons in the adult CNS. 4. **Influencer of behavior and social interactions**: BRINP1's expression has been linked to behavioral responses such as fear, exploration, and social behavior, highlighting its role in shaping neural circuits involved in social cognition. 5. **Modulator of short-term memory**: BRINP1's involvement in the regulation of short-term memory suggests its potential role in the consolidation of memories and the processing of information within the CNS. **Clinical Significance:** The dysregulation of BRINP1 has been implicated in various neurological disorders, including: 1. **Neurodevelopmental disorders**: BRINP1's role in neuronal development and differentiation suggests its involvement in disorders such as autism spectrum disorder (ASD) and schizophrenia. 2. **Neurodegenerative diseases**: BRINP1's regulatory functions in neurogenesis and neuronal survival imply its role in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. 3. **Mental health disorders**: BRINP1's influence on behavior and social interactions suggests its potential involvement in mood disorders, such as depression and anxiety. In conclusion, BRINP1 is a transcription factor with a complex and multifaceted role in the CNS, influencing various signaling pathways and cellular processes. Further research into BRINP1's functions and dysregulation is necessary to elucidate its clinical significance and potential therapeutic applications in neurological disorders.

Genular Protein ID: 1055974052

Symbol: BRNP1_HUMAN

Name: BMP/retinoic acid-inducible neural-specific protein 1

UniProtKB Accession Codes:

O60477 Q6IPV6 Q6P1A0 Q8WU22

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 GO 17 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 RefSeq 1 SMART 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9545632

Title: Structure and methylation-based silencing of a gene (DBCCR1) within a candidate bladder cancer tumor suppressor region at 9q32-q33.

PubMed ID: 9545632

DOI: 10.1006/geno.1997.5165

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11420708

Title: Negative regulation of G(1)/S transition by the candidate bladder tumour suppressor gene DBCCR1.

PubMed ID: 11420708

DOI: 10.1038/sj.onc.1204432

PubMed ID: 14712213

Title: DBCCR1 mediates death in cultured bladder tumor cells.

PubMed ID: 14712213

DOI: 10.1038/sj.onc.1206642

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 761
  • Mass: 88760
  • Checksum: 16FF47082FD52252
  • Sequence:
    • MNWRFVELLY FLFIWGRISV QPSHQEPAGT DQHVSKEFDW LISDRGPFHH SRSYLSFVER 
HRQGFTTRYK IYREFARWKV RNTAIERRDL VRHPVPLMPE FQRSIRLLGR RPTTQQFIDT 
IIKKYGTHLL ISATLGGEEA LTMYMDKSRL DRKSGNATQS VEALHQLASS YFVDRDGTMR 
RLHEIQISTG AIKVTETRTG PLGCNSYDNL DSVSSVLLQS TESKLHLQGL QIIFPQYLQE 
KFVQSALSYI MCNGEGEYLC QNSQCRCQCA EEFPQCNCPI TDIQIMEYTL ANMAKSWAEA 
YKDLENSDEF KSFMKRLPSN HFLTIGSIHQ HWGNDWDLQN RYKLLQSATE AQRQKIQRTA 
RKLFGLSVRC RHNPNHQLPR ERTIQQWLAR VQSLLYCNEN GFWGTFLESQ RSCVCHGSTT 
LCQRPIPCVI GGNNSCAMCS LANISLCGSC NKGYKLYRGR CEPQNVDSER SEQFISFETD 
LDFQDLELKY LLQKMDSRLY VHTTFISNEI RLDTFFDPRW RKRMSLTLKS NKNRMDFIHM 
VIGMSMRICQ MRNSSLDPMF FVYVNPFSGS HSEGWNMPFG EFGYPRWEKI RLQNSQCYNW 
TLLLGNRWKT FFETVHIYLR SRTRLPTLLR NETGQGPVDL SDPSKRQFYI KISDVQVFGY 
SLRFNADLLR SAVQQVNQSY TQGGQFYSSS SVMLLLLDIR DRINRLAPPV APGKPQLDLF 
SCMLKHRLKL TNSEIIRVNH ALDLYNTEIL KQSDQMTAKL C

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.