Details for: BRINP1

Gene ID: 1620

Symbol: BRINP1

Ensembl ID: ENSG00000078725

Description: BMP/retinoic acid inducible neural specific 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 3.5326
    Cell Significance Index: 100.8100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 3.2350
    Cell Significance Index: 217.5200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 3.1964
    Cell Significance Index: 121.0400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 3.1744
    Cell Significance Index: 54.4000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 3.1169
    Cell Significance Index: 137.8700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.7062
    Cell Significance Index: 542.8600
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 2.6252
    Cell Significance Index: 36.7100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.5437
    Cell Significance Index: 31.5500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.4322
    Cell Significance Index: 872.3800
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 1.9459
    Cell Significance Index: 20.2700
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 1.3194
    Cell Significance Index: 17.6000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.2582
    Cell Significance Index: 870.2400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.9563
    Cell Significance Index: 20.9400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.6799
    Cell Significance Index: 16.4700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.5945
    Cell Significance Index: 36.5400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.4974
    Cell Significance Index: 11.9300
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.2934
    Cell Significance Index: 2.2500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.2817
    Cell Significance Index: 7.2400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0785
    Cell Significance Index: 49.8500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0407
    Cell Significance Index: 5.6000
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.0399
    Cell Significance Index: 0.3800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0016
    Cell Significance Index: 3.0000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0030
    Cell Significance Index: -4.6200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0096
    Cell Significance Index: -18.1500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0119
    Cell Significance Index: -16.2100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0144
    Cell Significance Index: -0.6200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0438
    Cell Significance Index: -2.4600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0511
    Cell Significance Index: -2.6800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0523
    Cell Significance Index: -38.3300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0562
    Cell Significance Index: -41.6300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0627
    Cell Significance Index: -27.7200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0641
    Cell Significance Index: -48.5400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0694
    Cell Significance Index: -13.7800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0734
    Cell Significance Index: -41.4200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0771
    Cell Significance Index: -48.1600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0774
    Cell Significance Index: -42.2500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0801
    Cell Significance Index: -14.4400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0847
    Cell Significance Index: -38.4200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0900
    Cell Significance Index: -0.9800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1185
    Cell Significance Index: -34.0900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1429
    Cell Significance Index: -2.4700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1442
    Cell Significance Index: -18.4800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1493
    Cell Significance Index: -21.7000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1579
    Cell Significance Index: -3.1700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1615
    Cell Significance Index: -16.5000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1793
    Cell Significance Index: -22.0500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1836
    Cell Significance Index: -5.1300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1973
    Cell Significance Index: -6.4600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2145
    Cell Significance Index: -45.1900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2149
    Cell Significance Index: -4.2500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2624
    Cell Significance Index: -44.8100
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.2630
    Cell Significance Index: -3.2800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.2729
    Cell Significance Index: -44.3800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2814
    Cell Significance Index: -36.3600
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.2829
    Cell Significance Index: -3.3000
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.2876
    Cell Significance Index: -3.7300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2955
    Cell Significance Index: -13.8900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3237
    Cell Significance Index: -10.3100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3477
    Cell Significance Index: -40.5200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3543
    Cell Significance Index: -16.5200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.3727
    Cell Significance Index: -36.8700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.4040
    Cell Significance Index: -3.8300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4066
    Cell Significance Index: -42.3400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4140
    Cell Significance Index: -47.4300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4142
    Cell Significance Index: -8.7900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.4357
    Cell Significance Index: -6.2400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4830
    Cell Significance Index: -38.2500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4851
    Cell Significance Index: -12.1000
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.4873
    Cell Significance Index: -6.1500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4896
    Cell Significance Index: -37.5800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.5066
    Cell Significance Index: -37.7600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.5943
    Cell Significance Index: -7.5000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6450
    Cell Significance Index: -40.6500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.6503
    Cell Significance Index: -14.0500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.6607
    Cell Significance Index: -34.3200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6797
    Cell Significance Index: -23.6200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6828
    Cell Significance Index: -23.9200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.7034
    Cell Significance Index: -14.6800
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.7645
    Cell Significance Index: -8.7500
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.7826
    Cell Significance Index: -6.4600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.7831
    Cell Significance Index: -35.5000
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.8993
    Cell Significance Index: -10.7600
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.9542
    Cell Significance Index: -12.7200
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.9803
    Cell Significance Index: -11.1600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -1.0718
    Cell Significance Index: -33.9000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -1.0964
    Cell Significance Index: -21.5800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.1324
    Cell Significance Index: -41.5700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -1.1335
    Cell Significance Index: -7.6800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -1.1525
    Cell Significance Index: -31.3700
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: -1.1667
    Cell Significance Index: -9.1500
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -1.1701
    Cell Significance Index: -12.9100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.2047
    Cell Significance Index: -25.7500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -1.2052
    Cell Significance Index: -42.3500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -1.2166
    Cell Significance Index: -24.2600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.2331
    Cell Significance Index: -36.3200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -1.2416
    Cell Significance Index: -31.0100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.2492
    Cell Significance Index: -35.8100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -1.3021
    Cell Significance Index: -32.4700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -1.3573
    Cell Significance Index: -28.4100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -1.4228
    Cell Significance Index: -37.9900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** BRINP1 is a transcription factor that exhibits neural-specific expression patterns, with significant levels observed in various cell types within the CNS, including macroglial cells, granule cells, cerebral cortex neurons, pyramidal neurons, stellate neurons, astrocytes, and GABAergic cortical interneurons. Its expression is induced by BMP (Bone Morphogenetic Protein) and retinoic acid signaling pathways, which underscores its role as a key regulator of neural development and differentiation. **Pathways and Functions:** BRINP1's involvement in multiple signaling pathways underscores its multifaceted role in the CNS. Notably, it is: 1. **Positive regulator of neuron differentiation**: BRINP1 promotes the differentiation of neurons from neural stem cells, facilitating the development of complex neural circuits. 2. **Negative regulator of cell cycle**: BRINP1 inhibits cell cycle progression, ensuring that neurons do not proliferate excessively and maintaining the delicate balance of neural cell numbers. 3. **Regulator of neurogenesis**: BRINP1 modulates the process of neurogenesis, influencing the generation of new neurons in the adult CNS. 4. **Influencer of behavior and social interactions**: BRINP1's expression has been linked to behavioral responses such as fear, exploration, and social behavior, highlighting its role in shaping neural circuits involved in social cognition. 5. **Modulator of short-term memory**: BRINP1's involvement in the regulation of short-term memory suggests its potential role in the consolidation of memories and the processing of information within the CNS. **Clinical Significance:** The dysregulation of BRINP1 has been implicated in various neurological disorders, including: 1. **Neurodevelopmental disorders**: BRINP1's role in neuronal development and differentiation suggests its involvement in disorders such as autism spectrum disorder (ASD) and schizophrenia. 2. **Neurodegenerative diseases**: BRINP1's regulatory functions in neurogenesis and neuronal survival imply its role in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. 3. **Mental health disorders**: BRINP1's influence on behavior and social interactions suggests its potential involvement in mood disorders, such as depression and anxiety. In conclusion, BRINP1 is a transcription factor with a complex and multifaceted role in the CNS, influencing various signaling pathways and cellular processes. Further research into BRINP1's functions and dysregulation is necessary to elucidate its clinical significance and potential therapeutic applications in neurological disorders.

Genular Protein ID: 1055974052

Symbol: BRNP1_HUMAN

Name: BMP/retinoic acid-inducible neural-specific protein 1

UniProtKB Accession Codes:

O60477 Q6IPV6 Q6P1A0 Q8WU22

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 GO 16 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 RefSeq 1 SMART 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9545632

Title: Structure and methylation-based silencing of a gene (DBCCR1) within a candidate bladder cancer tumor suppressor region at 9q32-q33.

PubMed ID: 9545632

DOI: 10.1006/geno.1997.5165

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11420708

Title: Negative regulation of G(1)/S transition by the candidate bladder tumour suppressor gene DBCCR1.

PubMed ID: 11420708

DOI: 10.1038/sj.onc.1204432

PubMed ID: 14712213

Title: DBCCR1 mediates death in cultured bladder tumor cells.

PubMed ID: 14712213

DOI: 10.1038/sj.onc.1206642

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 761
  • Mass: 88760
  • Checksum: 16FF47082FD52252
  • Sequence:
    • MNWRFVELLY FLFIWGRISV QPSHQEPAGT DQHVSKEFDW LISDRGPFHH SRSYLSFVER 
HRQGFTTRYK IYREFARWKV RNTAIERRDL VRHPVPLMPE FQRSIRLLGR RPTTQQFIDT 
IIKKYGTHLL ISATLGGEEA LTMYMDKSRL DRKSGNATQS VEALHQLASS YFVDRDGTMR 
RLHEIQISTG AIKVTETRTG PLGCNSYDNL DSVSSVLLQS TESKLHLQGL QIIFPQYLQE 
KFVQSALSYI MCNGEGEYLC QNSQCRCQCA EEFPQCNCPI TDIQIMEYTL ANMAKSWAEA 
YKDLENSDEF KSFMKRLPSN HFLTIGSIHQ HWGNDWDLQN RYKLLQSATE AQRQKIQRTA 
RKLFGLSVRC RHNPNHQLPR ERTIQQWLAR VQSLLYCNEN GFWGTFLESQ RSCVCHGSTT 
LCQRPIPCVI GGNNSCAMCS LANISLCGSC NKGYKLYRGR CEPQNVDSER SEQFISFETD 
LDFQDLELKY LLQKMDSRLY VHTTFISNEI RLDTFFDPRW RKRMSLTLKS NKNRMDFIHM 
VIGMSMRICQ MRNSSLDPMF FVYVNPFSGS HSEGWNMPFG EFGYPRWEKI RLQNSQCYNW 
TLLLGNRWKT FFETVHIYLR SRTRLPTLLR NETGQGPVDL SDPSKRQFYI KISDVQVFGY 
SLRFNADLLR SAVQQVNQSY TQGGQFYSSS SVMLLLLDIR DRINRLAPPV APGKPQLDLF 
SCMLKHRLKL TNSEIIRVNH ALDLYNTEIL KQSDQMTAKL C

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.