Details for: RAN

Gene ID: 5901

Symbol: RAN

Ensembl ID: ENSG00000132341

Description: RAN, member RAS oncogene family

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 483.1392
    Cell Significance Index: -75.1500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 322.9929
    Cell Significance Index: -81.9300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 294.8433
    Cell Significance Index: -121.4600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 253.2393
    Cell Significance Index: -119.5600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 231.1692
    Cell Significance Index: -118.9100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 178.7981
    Cell Significance Index: -119.9800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 90.6115
    Cell Significance Index: -111.7200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 30.7700
    Cell Significance Index: -121.4200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 25.1184
    Cell Significance Index: -77.1500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 24.1259
    Cell Significance Index: -64.6300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 14.2740
    Cell Significance Index: -31.2400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 7.3119
    Cell Significance Index: 79.4900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 5.2050
    Cell Significance Index: 180.8700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 4.9853
    Cell Significance Index: 104.3500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 4.8999
    Cell Significance Index: 577.8500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 4.8141
    Cell Significance Index: 226.2600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.7109
    Cell Significance Index: 135.0400
  • Cell Name: germ cell (CL0000586)
    Fold Change: 4.7016
    Cell Significance Index: 35.5000
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 4.2558
    Cell Significance Index: 36.5700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 4.2080
    Cell Significance Index: 110.6500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 3.8902
    Cell Significance Index: 114.2500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.3060
    Cell Significance Index: 1805.5000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.1788
    Cell Significance Index: 166.9000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 3.0180
    Cell Significance Index: 371.0900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 3.0011
    Cell Significance Index: 387.7200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.0006
    Cell Significance Index: 223.6400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.9310
    Cell Significance Index: 79.7800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.8183
    Cell Significance Index: 199.3200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.7517
    Cell Significance Index: 21.9700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.5979
    Cell Significance Index: 1148.5900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.5811
    Cell Significance Index: 354.4600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.5688
    Cell Significance Index: 165.7300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.4221
    Cell Significance Index: 436.6300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.9387
    Cell Significance Index: 34.2600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.7495
    Cell Significance Index: 22.4100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.7376
    Cell Significance Index: 19.7400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.4406
    Cell Significance Index: 285.8800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.4054
    Cell Significance Index: 180.1700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.2097
    Cell Significance Index: 32.3000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.0262
    Cell Significance Index: 9.4500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.0206
    Cell Significance Index: 23.5800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8655
    Cell Significance Index: 85.6200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8077
    Cell Significance Index: 41.9600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.8009
    Cell Significance Index: 37.3400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.7559
    Cell Significance Index: 217.5000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6260
    Cell Significance Index: 125.5800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5345
    Cell Significance Index: 86.9400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4572
    Cell Significance Index: 87.0100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.4077
    Cell Significance Index: 308.5700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3477
    Cell Significance Index: 59.3800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1542
    Cell Significance Index: 3.3400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1345
    Cell Significance Index: 48.2300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1031
    Cell Significance Index: 1.7300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0164
    Cell Significance Index: 12.0100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: -0.0215
    Cell Significance Index: -19.4500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0237
    Cell Significance Index: -14.8000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0391
    Cell Significance Index: -28.9300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0403
    Cell Significance Index: -4.1200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0514
    Cell Significance Index: -96.7700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0694
    Cell Significance Index: -127.9800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0796
    Cell Significance Index: -122.5900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0911
    Cell Significance Index: -123.8100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1199
    Cell Significance Index: -3.3500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1364
    Cell Significance Index: -76.9400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1542
    Cell Significance Index: -97.9400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1625
    Cell Significance Index: -10.2400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2313
    Cell Significance Index: -48.7100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.2450
    Cell Significance Index: -111.2000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3222
    Cell Significance Index: -8.2300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3288
    Cell Significance Index: -10.5300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4621
    Cell Significance Index: -52.9400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4800
    Cell Significance Index: -54.8000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.5373
    Cell Significance Index: -62.6200
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.5606
    Cell Significance Index: -3.4500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.6114
    Cell Significance Index: -11.3000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.7240
    Cell Significance Index: -44.5000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.7359
    Cell Significance Index: -106.9700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.7433
    Cell Significance Index: -41.7100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.8996
    Cell Significance Index: -5.4400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.0200
    Cell Significance Index: -27.2900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.0408
    Cell Significance Index: -82.4300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.1576
    Cell Significance Index: -120.5300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.2804
    Cell Significance Index: -86.1000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.4664
    Cell Significance Index: -112.5300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.4710
    Cell Significance Index: -20.0700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.6477
    Cell Significance Index: -44.1500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -1.7213
    Cell Significance Index: -78.0200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.7808
    Cell Significance Index: -109.1800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.9386
    Cell Significance Index: -57.1000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.9837
    Cell Significance Index: -20.5400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -2.1668
    Cell Significance Index: -25.8300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -2.2313
    Cell Significance Index: -47.5200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -2.2358
    Cell Significance Index: -18.7800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -2.4587
    Cell Significance Index: -63.2000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -2.4624
    Cell Significance Index: -18.9800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -2.5230
    Cell Significance Index: -111.6000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -2.5966
    Cell Significance Index: -95.3200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -2.6052
    Cell Significance Index: -44.9100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -2.7741
    Cell Significance Index: -47.5400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -2.9058
    Cell Significance Index: -43.5400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RAN is a small GTP-binding protein that exhibits the following key characteristics: 1. **GTP-binding**: RAN binds to GTP, which activates its function and allows it to interact with other proteins. 2. **GDP-dependent inactivation**: RAN's activity is inhibited when it binds to GDP, which prevents it from interacting with other proteins. 3. **Cycling between active and inactive states**: RAN cycles between its active GTP-bound state and inactive GDP-bound state, regulating its interactions with other proteins. 4. **Regulation of cell cycle and mitosis**: RAN influences the cell cycle and mitosis by regulating the activity of other proteins involved in these processes. 5. **Interaction with various proteins**: RAN interacts with numerous proteins, including importins, exportins, and other GTP-binding proteins, to regulate its function and the function of other proteins. **Pathways and Functions** RAN is involved in various signaling pathways, including: 1. **Cell cycle regulation**: RAN regulates the cell cycle by interacting with proteins involved in DNA replication and mitosis. 2. **Mitosis**: RAN influences mitosis by regulating the activity of proteins involved in chromosome segregation and spindle formation. 3. **Gene expression**: RAN regulates gene expression by interacting with transcription factors and chromatin remodeling complexes. 4. **Nuclear import and export**: RAN regulates the nuclear import and export of proteins and RNAs by interacting with importins and exportins. 5. **HIV infection**: RAN plays a crucial role in the HIV life cycle by regulating the nuclear export of viral RNAs. **Clinical Significance** Dysregulation of RAN has been implicated in various diseases, including: 1. **Cancer**: RAN's dysregulation has been linked to various types of cancer, including leukemia, lymphoma, and breast cancer. 2. **HIV infection**: RAN's dysregulation contributes to the pathogenesis of HIV infection by regulating the nuclear export of viral RNAs. 3. **Neurodegenerative disorders**: RAN's dysregulation has been implicated in neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. 4. **Neurodevelopmental disorders**: RAN's dysregulation has been linked to neurodevelopmental disorders, including autism spectrum disorder and schizophrenia. In conclusion, RAN is a critical regulator of various cellular processes, including cell cycle regulation, mitosis, and gene expression. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding RAN's function and regulation.

Genular Protein ID: 3704913361

Symbol: RAN_HUMAN

Name: GTP-binding nuclear protein Ran

UniProtKB Accession Codes:

P62826 A8K3Z8 P17080 P28746 P28747 Q6IPB2 Q86V08 Q8NI90 Q9CSP3 Q9CWI7 Q9CZA2 Q9UDJ5 Q9UEU9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 11 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 1 DrugCentral 1 EMBL 16 EMDB 2 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 52 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 100 PDBsum 100 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 8 RefSeq 3 Rhea 2 SASBDB 1 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2108320

Title: Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line.

PubMed ID: 2108320

DOI: 10.1128/mcb.10.4.1793-1798.1990

PubMed ID: 1855255

Title: Premature initiation of mitosis in yeast lacking RCC1 or an interacting GTPase.

PubMed ID: 1855255

DOI: 10.1016/0092-8674(91)90624-8

PubMed ID: 8421051

Title: Ran/TC4: a small nuclear GTP-binding protein that regulates DNA synthesis.

PubMed ID: 8421051

DOI: 10.1083/jcb.120.2.313

PubMed ID: 10400640

Title: The linkage of Kennedy's neuron disease to ARA24, the first identified androgen receptor polyglutamine region-associated coactivator.

PubMed ID: 10400640

DOI: 10.1074/jbc.274.29.20229

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1961752

Title: Mitotic regulator protein RCC1 is complexed with a nuclear ras-related polypeptide.

PubMed ID: 1961752

DOI: 10.1073/pnas.88.23.10830

PubMed ID: 8276887

Title: Inhibition of nuclear protein import by nonhydrolyzable analogues of GTP and identification of the small GTPase Ran/TC4 as an essential transport factor.

PubMed ID: 8276887

DOI: 10.1083/jcb.123.6.1649

PubMed ID: 7819259

Title: Interaction of the nuclear GTP-binding protein Ran with its regulatory proteins RCC1 and RanGAP1.

PubMed ID: 7819259

DOI: 10.1021/bi00002a031

PubMed ID: 7891706

Title: Separate domains of the Ran GTPase interact with different factors to regulate nuclear protein import and RNA processing.

PubMed ID: 7891706

DOI: 10.1128/mcb.15.4.2117

PubMed ID: 8896452

Title: Identification of different roles for RanGDP and RanGTP in nuclear protein import.

PubMed ID: 8896452

DOI: 10.1002/j.1460-2075.1996.tb00943.x

PubMed ID: 8636225

Title: RAN/TC4 mutants identify a common requirement for snRNP and protein import into the nucleus.

PubMed ID: 8636225

DOI: 10.1083/jcb.133.3.485

PubMed ID: 8692944

Title: Nuclear protein import: Ran-GTP dissociates the karyopherin alphabeta heterodimer by displacing alpha from an overlapping binding site on beta.

PubMed ID: 8692944

DOI: 10.1073/pnas.93.14.7059

PubMed ID: 9323133

Title: CRM1 is an export receptor for leucine-rich nuclear export signals.

PubMed ID: 9323133

DOI: 10.1016/s0092-8674(00)80371-2

PubMed ID: 9351834

Title: The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus.

PubMed ID: 9351834

DOI: 10.1093/emboj/16.21.6535

PubMed ID: 9428644

Title: RanBP1 is crucial for the release of RanGTP from importin beta-related nuclear transport factors.

PubMed ID: 9428644

DOI: 10.1016/s0014-5793(97)01467-1

PubMed ID: 9822603

Title: NTF2 mediates nuclear import of Ran.

PubMed ID: 9822603

DOI: 10.1093/emboj/17.22.6587

PubMed ID: 9837918

Title: The specificity of the CRM1-Rev nuclear export signal interaction is mediated by RanGTP.

PubMed ID: 9837918

DOI: 10.1074/jbc.273.50.33414

PubMed ID: 10209022

Title: CRM1-mediated recycling of snurportin 1 to the cytoplasm.

PubMed ID: 10209022

DOI: 10.1083/jcb.145.2.255

PubMed ID: 10408446

Title: Generation of GTP-bound Ran by RCC1 is required for chromatin-induced mitotic spindle formation.

PubMed ID: 10408446

DOI: 10.1038/22133

PubMed ID: 10679025

Title: Monoclonal antibodies to NTF2 inhibit nuclear protein import by preventing nuclear translocation of the GTPase Ran.

PubMed ID: 10679025

DOI: 10.1091/mbc.11.2.703

PubMed ID: 11571268

Title: RanBP3 influences interactions between CRM1 and its nuclear protein export substrates.

PubMed ID: 11571268

DOI: 10.1093/embo-reports/kve200

PubMed ID: 11425870

Title: Ran-binding protein 3 is a cofactor for Crm1-mediated nuclear protein export.

PubMed ID: 11425870

DOI: 10.1083/jcb.153.7.1391

PubMed ID: 14500717

Title: Serine/threonine kinase Mirk/Dyrk1B is an inhibitor of epithelial cell migration and is negatively regulated by the Met adaptor Ran-binding protein M.

PubMed ID: 14500717

DOI: 10.1074/jbc.m307556200

PubMed ID: 12194828

Title: Targeting of RCC1 to chromosomes is required for proper mitotic spindle assembly in human cells.

PubMed ID: 12194828

DOI: 10.1016/s0960-9822(02)01076-x

PubMed ID: 12808100

Title: Hydrogen peroxide triggers nuclear export of telomerase reverse transcriptase via Src kinase family-dependent phosphorylation of tyrosine 707.

PubMed ID: 12808100

DOI: 10.1128/mcb.23.13.4598-4610.2003

PubMed ID: 14612415

Title: A multifunctional domain in human CRM1 (exportin 1) mediates RanBP3 binding and multimerization of human T-cell leukemia virus type 1 Rex protein.

PubMed ID: 14612415

DOI: 10.1128/mcb.23.23.8751-8761.2003

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 14684163

Title: A novel MET-interacting protein shares high sequence similarity with RanBPM, but fails to stimulate MET-induced Ras/Erk signaling.

PubMed ID: 14684163

DOI: 10.1016/j.bbrc.2003.11.124

PubMed ID: 15574331

Title: Architecture of CRM1/Exportin1 suggests how cooperativity is achieved during formation of a nuclear export complex.

PubMed ID: 15574331

DOI: 10.1016/j.molcel.2004.11.018

PubMed ID: 16428860

Title: Phosphorylation of RanGAP1 stabilizes its interaction with Ran and RanBP1.

PubMed ID: 16428860

DOI: 10.1247/csf.30.69

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

PubMed ID: 17209048

Title: Human DNA replication-related element binding factor (hDREF) self-association via hATC domain is necessary for its nuclear accumulation and DNA binding.

PubMed ID: 17209048

DOI: 10.1074/jbc.m607180200

PubMed ID: 18591255

Title: A survivin-ran complex regulates spindle formation in tumor cells.

PubMed ID: 18591255

DOI: 10.1128/mcb.02039-07

PubMed ID: 18617507

Title: Proteomics identification of nuclear Ran GTPase as an inhibitor of human VRK1 and VRK2 (vaccinia-related kinase) activities.

PubMed ID: 18617507

DOI: 10.1074/mcp.m700586-mcp200

PubMed ID: 18266911

Title: A new role for nuclear transport factor 2 and Ran: nuclear import of CapG.

PubMed ID: 18266911

DOI: 10.1111/j.1600-0854.2008.00720.x

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19753112

Title: The mitotic arrest deficient protein MAD2B interacts with the small GTPase RAN throughout the cell cycle.

PubMed ID: 19753112

DOI: 10.1371/journal.pone.0007020

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20485264

Title: An allosteric mechanism to displace nuclear export cargo from CRM1 and RanGTP by RanBP1.

PubMed ID: 20485264

DOI: 10.1038/emboj.2010.89

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23878195

Title: Interaction of transportin-SR2 with Ras-related nuclear protein (Ran) GTPase.

PubMed ID: 23878195

DOI: 10.1074/jbc.m113.484345

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25331866

Title: Solution structures of Mengovirus Leader protein, its phosphorylated derivatives, and in complex with nuclear transport regulatory protein, RanGTPase.

PubMed ID: 25331866

DOI: 10.1073/pnas.1411098111

PubMed ID: 26304119

Title: MYCBP2 is a guanosine exchange factor for Ran protein and determines its localization in neurons of dorsal root ganglia.

PubMed ID: 26304119

DOI: 10.1074/jbc.m115.646901

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 29130391

Title: The Vici syndrome protein EPG5 regulates intracellular nucleic acid trafficking linking autophagy to innate and adaptive immunity.

PubMed ID: 29130391

DOI: 10.1080/15548627.2017.1389356

PubMed ID: 29040603

Title: Mitosis-specific acetylation tunes Ran effector binding for chromosome segregation.

PubMed ID: 29040603

DOI: 10.1093/jmcb/mjx045

PubMed ID: 31075303

Title: SIRT7 regulates the nuclear export of NF-kappaB p65 by deacetylating Ran.

PubMed ID: 31075303

DOI: 10.1016/j.bbamcr.2019.05.001

PubMed ID: 7885480

Title: Crystal structure of the nuclear Ras-related protein Ran in its GDP-bound form.

PubMed ID: 7885480

DOI: 10.1038/374378a0

PubMed ID: 10367892

Title: Structural view of the Ran-Importin beta interaction at 2.3 A resolution.

PubMed ID: 10367892

DOI: 10.1016/s0092-8674(00)80774-6

PubMed ID: 10353245

Title: Structure of the nuclear transport complex karyopherin-beta2-Ran x GppNHp.

PubMed ID: 10353245

DOI: 10.1038/20375

PubMed ID: 10078529

Title: Structure of a Ran-binding domain complexed with Ran bound to a GTP analogue: implications for nuclear transport.

PubMed ID: 10078529

DOI: 10.1038/17969

PubMed ID: 11336674

Title: Structural basis for guanine nucleotide exchange on Ran by the regulator of chromosome condensation (RCC1).

PubMed ID: 11336674

DOI: 10.1016/s0092-8674(01)00315-4

PubMed ID: 11832950

Title: RanGAP mediates GTP hydrolysis without an arginine finger.

PubMed ID: 11832950

DOI: 10.1038/415662a

PubMed ID: 18611384

Title: The crystal structure of the Ran-Nup153ZnF2 complex: a general Ran docking site at the nuclear pore complex.

PubMed ID: 18611384

DOI: 10.1016/j.str.2008.03.014

PubMed ID: 19505478

Title: Crystallographic and biochemical analysis of the Ran-binding zinc finger domain.

PubMed ID: 19505478

DOI: 10.1016/j.jmb.2009.06.011

PubMed ID: 19389996

Title: Crystal structure of the nuclear export receptor CRM1 in complex with Snurportin1 and RanGTP.

PubMed ID: 19389996

DOI: 10.1126/science.1173388

PubMed ID: 24915079

Title: Structure of transportin SR2, a karyopherin involved in human disease, in complex with Ran.

PubMed ID: 24915079

DOI: 10.1107/s2053230x14009492

PubMed ID: 24449914

Title: Structural basis for nuclear import of splicing factors by human Transportin 3.

PubMed ID: 24449914

DOI: 10.1073/pnas.1320755111

PubMed ID: 26349033

Title: Structural determinants of nuclear export signal orientation in binding to exportin CRM1.

PubMed ID: 26349033

DOI: 10.7554/elife.10034

PubMed ID: 26272610

Title: Catalysis of GTP hydrolysis by small GTPases at atomic detail by integration of X-ray crystallography, experimental, and theoretical IR spectroscopy.

PubMed ID: 26272610

DOI: 10.1074/jbc.m115.648071

PubMed ID: 27306458

Title: Structure of the exportin Xpo4 in complex with RanGTP and the hypusine-containing translation factor eIF5A.

PubMed ID: 27306458

DOI: 10.1038/ncomms11952

PubMed ID: 28282025

Title: Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals.

PubMed ID: 28282025

DOI: 10.7554/elife.23961

Sequence Information:

  • Length: 216
  • Mass: 24423
  • Checksum: D5C9B7275C34BCE0
  • Sequence:
    • MAAQGEPQVQ FKLVLVGDGG TGKTTFVKRH LTGEFEKKYV ATLGVEVHPL VFHTNRGPIK 
FNVWDTAGQE KFGGLRDGYY IQAQCAIIMF DVTSRVTYKN VPNWHRDLVR VCENIPIVLC 
GNKVDIKDRK VKAKSIVFHR KKNLQYYDIS AKSNYNFEKP FLWLARKLIG DPNLEFVAMP 
ALAPPEVVMD PALAAQYEHD LEVAQTTALP DEDDDL

Genular Protein ID: 1233492739

Symbol: B4DV51_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DV51

Database IDs:

ARBA 4 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 GO 5 Gene3D 1 GeneTree 1 HGNC 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 2 Rhea 2 RuleBase 1 SMART 2 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 128
  • Mass: 14731
  • Checksum: 6F87C0AC20E185EF
  • Sequence:
    • MFDVTSRVTY KNVPNWHRDL VRVCENIPIV LCGNKVDIKD RKVKAKSIVF HRKKNLQYYD 
ISAKSNYNFE KPFLWLARKL IGDPNLEFVA MPALAPPEVV MDPALAAQYE HDLEVAQTTA 
LPDEDDDL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.