Details for: GRIA3

Gene ID: 2892

Symbol: GRIA3

Ensembl ID: ENSG00000125675

Description: glutamate ionotropic receptor AMPA type subunit 3

Associated with

  • Activation of ampa receptors
    (R-HSA-399710)
  • Activation of nmda receptors and postsynaptic events
    (R-HSA-442755)
  • Glutamate binding, activation of ampa receptors and synaptic plasticity
    (R-HSA-399721)
  • Neuronal system
    (R-HSA-112316)
  • Neurotransmitter receptors and postsynaptic signal transmission
    (R-HSA-112314)
  • Protein-protein interactions at synapses
    (R-HSA-6794362)
  • Synaptic adhesion-like molecules
    (R-HSA-8849932)
  • Trafficking of ampa receptors
    (R-HSA-399719)
  • Trafficking of glur2-containing ampa receptors
    (R-HSA-416993)
  • Transmission across chemical synapses
    (R-HSA-112315)
  • Unblocking of nmda receptors, glutamate binding and activation
    (R-HSA-438066)
  • Ampa glutamate receptor activity
    (GO:0004971)
  • Ampa glutamate receptor complex
    (GO:0032281)
  • Amyloid-beta binding
    (GO:0001540)
  • Dendritic spine
    (GO:0043197)
  • Endocytic vesicle membrane
    (GO:0030666)
  • Glutamate receptor signaling pathway
    (GO:0007215)
  • Ionotropic glutamate receptor signaling pathway
    (GO:0035235)
  • Ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
    (GO:0099507)
  • Modulation of chemical synaptic transmission
    (GO:0050804)
  • Monoatomic ion transmembrane transport
    (GO:0034220)
  • Parallel fiber to purkinje cell synapse
    (GO:0098688)
  • Plasma membrane
    (GO:0005886)
  • Postsynaptic density membrane
    (GO:0098839)
  • Regulation of postsynaptic membrane potential
    (GO:0060078)
  • Regulation of presynaptic membrane potential
    (GO:0099505)
  • Synaptic transmission, glutamatergic
    (GO:0035249)
  • Transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
    (GO:1904315)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 4.57
    Marker Score: 6307
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 3.21
    Marker Score: 14843
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 3.11
    Marker Score: 1638
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 2.97
    Marker Score: 942
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.89
    Marker Score: 57434.5
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.6
    Marker Score: 38822
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.59
    Marker Score: 10739.5
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.41
    Marker Score: 88896
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.24
    Marker Score: 8665
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.07
    Marker Score: 127211
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.06
    Marker Score: 864
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.04
    Marker Score: 19233
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.99
    Marker Score: 20584
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.93
    Marker Score: 18314.5
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.92
    Marker Score: 64880
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.88
    Marker Score: 16129
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.79
    Marker Score: 13733
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.71
    Marker Score: 64980
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.7
    Marker Score: 2102
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.66
    Marker Score: 2561
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.65
    Marker Score: 451
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1166
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.56
    Marker Score: 654
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.56
    Marker Score: 1556.5
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.56
    Marker Score: 629
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.51
    Marker Score: 6168
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.5
    Marker Score: 672
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.49
    Marker Score: 2821
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.43
    Marker Score: 706
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 867
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 852
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.25
    Marker Score: 5222
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.17
    Marker Score: 484
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4807
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.13
    Marker Score: 2710
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.08
    Marker Score: 16942
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.08
    Marker Score: 2195
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.05
    Marker Score: 18712
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.03
    Marker Score: 2096
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.01
    Marker Score: 349
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71805
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48030
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.99
    Marker Score: 3820
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 506
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5330
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 372
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.91
    Marker Score: 598.5
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5286
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.86
    Marker Score: 247.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.85
    Marker Score: 512
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.83
    Marker Score: 8396
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.82
    Marker Score: 806
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.81
    Marker Score: 1914
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.81
    Marker Score: 774
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1264
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 707
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 591
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.75
    Marker Score: 867
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.74
    Marker Score: 388
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.74
    Marker Score: 640
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 459
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.71
    Marker Score: 426
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.7
    Marker Score: 361
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.68
    Marker Score: 14584
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.66
    Marker Score: 800
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.64
    Marker Score: 1162.5
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.63
    Marker Score: 143
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.62
    Marker Score: 588
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.62
    Marker Score: 238
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.6
    Marker Score: 337
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.56
    Marker Score: 368
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 175
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.54
    Marker Score: 1918.5
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.54
    Marker Score: 669
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 0.54
    Marker Score: 152
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.52
    Marker Score: 355
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.52
    Marker Score: 625
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.51
    Marker Score: 241
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 472
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.48
    Marker Score: 155
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.48
    Marker Score: 126
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.46
    Marker Score: 4635
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.44
    Marker Score: 250
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.44
    Marker Score: 159
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.44
    Marker Score: 194
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.43
    Marker Score: 189
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.43
    Marker Score: 424
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.42
    Marker Score: 171
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.41
    Marker Score: 107
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.39
    Marker Score: 102

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Other Information

## Summary GRIA3 is a glutamate ionotropic receptor subunit expressed in various cell types, including double-negative thymocytes, inhibitory interneurons, hematopoietic stem cells, and neural cells. It is a key component of the AMPA receptor complex, which is involved in synaptic plasticity and learning and memory. ## Key characteristics * GRIA3 is a type of glutamate receptor that is expressed on the surface of neurons and astrocytes. * It is a subunit of the AMPA receptor complex, which is a multi-subunit complex that is involved in synaptic plasticity and learning and memory. * GRIA3 is a ligand-gated ion channel, which means that it opens when a ligand binds to it. * Activation of GRIA3 by glutamate induces the opening of the AMPA receptor complex, which leads to the depolarization of the postsynaptic neuron. * GRIA3 is significantly expressed in brain regions involved in learning and memory, including the hippocampus, amygdala, and prefrontal cortex. ## Pathways and functions * Activation of GRIA3 by glutamate induces the opening of the AMPA receptor complex, which leads to the depolarization of the postsynaptic neuron. * This depolarization can lead to the activation of downstream signaling pathways, including the NMDA receptor pathway, which is involved in memory and learning. * GRIA3 also plays a role in synaptic plasticity, which is the ability of the brain to change its connections and learn new information. ## Clinical significance GRIA3 gene mutations have been linked to several neurological disorders, including autism, schizophrenia, and Alzheimer's disease. These mutations can lead to changes in the function of GRIA3, which can disrupt synaptic plasticity and learning and memory. This can lead to the development of neurological diseases that are characterized by cognitive impairment. ## Additional information * GRIA3 is a relatively new receptor, and there is still much that is unknown about its function. * However, it is clear that GRIA3 is an important player in synaptic plasticity and learning and memory. * Research into GRIA3 is ongoing, and new insights into its function are likely to be discovered in the future.

Genular Protein ID: 952610626

Symbol: GRIA3_HUMAN

Name: Glutamate receptor 3

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7918660

Title: Human glutamate receptor hGluR3 flip and flop isoforms: cloning and sequencing of the cDNAs and primary structure of the proteins.

PubMed ID: 7918660

DOI: 10.1016/0167-4781(94)90090-6

PubMed ID: 10644433

Title: Characterization of the human glutamate receptor subunit 3 gene (GRIA3), a candidate for bipolar disorder and nonspecific X-linked mental retardation.

PubMed ID: 10644433

DOI: 10.1006/geno.1999.6032

PubMed ID: 10602120

Title: Candidate gene analysis in Rett syndrome and the identification of 21 SNPs in Xq.

PubMed ID: 10602120

DOI: 10.1002/(sici)1096-8628(20000103)90:1<69::aid-ajmg12>3.3.co;2-n

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 21172611

Title: Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins.

PubMed ID: 21172611

DOI: 10.1016/j.neuron.2010.11.026

PubMed ID: 17989220

Title: Mutations in ionotropic AMPA receptor 3 alter channel properties and are associated with moderate cognitive impairment in humans.

PubMed ID: 17989220

DOI: 10.1073/pnas.0708699104

PubMed ID: 30165711

Title: Dominant SCN2A Mutation Causes Familial Episodic Ataxia and Impairment of Speech Development.

PubMed ID: 30165711

DOI: 10.1055/s-0038-1668141

Sequence Information:

  • Length: 894
  • Mass: 101157
  • Checksum: 178589A870E0D102
  • Sequence:
  • MARQKKMGQS VLRAVFFLVL GLLGHSHGGF PNTISIGGLF MRNTVQEHSA FRFAVQLYNT 
    NQNTTEKPFH LNYHVDHLDS SNSFSVTNAF CSQFSRGVYA IFGFYDQMSM NTLTSFCGAL 
    HTSFVTPSFP TDADVQFVIQ MRPALKGAIL SLLGHYKWEK FVYLYDTERG FSILQAIMEA 
    AVQNNWQVTA RSVGNIKDVQ EFRRIIEEMD RRQEKRYLID CEVERINTIL EQVVILGKHS 
    RGYHYMLANL GFTDILLERV MHGGANITGF QIVNNENPMV QQFIQRWVRL DEREFPEAKN 
    APLKYTSALT HDAILVIAEA FRYLRRQRVD VSRRGSAGDC LANPAVPWSQ GIDIERALKM 
    VQVQGMTGNI QFDTYGRRTN YTIDVYEMKV SGSRKAGYWN EYERFVPFSD QQISNDSASS 
    ENRTIVVTTI LESPYVMYKK NHEQLEGNER YEGYCVDLAY EIAKHVRIKY KLSIVGDGKY 
    GARDPETKIW NGMVGELVYG RADIAVAPLT ITLVREEVID FSKPFMSLGI SIMIKKPQKS 
    KPGVFSFLDP LAYEIWMCIV FAYIGVSVVL FLVSRFSPYE WHLEDNNEEP RDPQSPPDPP 
    NEFGIFNSLW FSLGAFMQQG CDISPRSLSG RIVGGVWWFF TLIIISSYTA NLAAFLTVER 
    MVSPIESAED LAKQTEIAYG TLDSGSTKEF FRRSKIAVYE KMWSYMKSAE PSVFTKTTAD 
    GVARVRKSKG KFAFLLESTM NEYIEQRKPC DTMKVGGNLD SKGYGVATPK GSALRNAVNL 
    AVLKLNEQGL LDKLKNKWWY DKGECGSGGG DSKDKTSALS LSNVAGVFYI LVGGLGLAMM 
    VALIEFCYKS RAESKRMKLT KNTQNFKPAP ATNTQNYATY REGYNVYGTE SVKI

Genular Protein ID: 425831096

Symbol: Q17R51_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 824
  • Mass: 93316
  • Checksum: DD96AB26743B82E0
  • Sequence:
  • MARQKKMGQS VLRAVFFLVL GLLGHSHGGF PNTISIGGLF MRNTVQEHSA FRFAVQLYNT 
    NQNTTEKPFH LNYHVDHLDS SNSFSVTNAF CSQFSRGVYA IFGFYDQMSM NTLTSFCGAL 
    HTSFVTPSFP TDADVQFVIQ MRPALKGAIL SLLGHYKWEK FVYLYDTERG FSILQAIMEA 
    AVQNNWQVTA RSVGNIKDVQ EFRRIIEEMD RRQEKRYLID CEVERINTIL EQVVILGKHS 
    RGYHYMLANL GFTDILLERV MHGGANITGF QIVNNENPMV QQFIQRWVRL DEREFPEAKN 
    APLKYTSALT HDAILVIAEA FRYLRRQRVD VSRRGSAGDC LANPAVPWSQ GIDIERALKM 
    VQVQGMTGNI QFDTYGRRTN YTIDVYEMKV SGSRKAGYWN EYERFVPFSD QQISNDSASS 
    ENRTIVVTTI LESPYVMYKK NHEQLEGNER YEGYCVDLAY EIAKHVRIKY KLSIVGDGKY 
    GARDPETKIW NGMVGELVYG RADIAVAPLT ITLVREEVID FSKPFMSLGI SIMIKKPQKS 
    KPGVFSFLDP LAYEIWMCIV FAYIGVSVVL FLVSRFSPYE WHLEDNNEEP RDPQSPPDPP 
    NEFGIFNSLW FSLGAFMQQG CDISPRSLSG RIVGGVWWFF TLIIISSYTA NLAAFLTVER 
    MVSPIESAED LAKQTEIAYG TLDSGSTKEF FRRSKIAVYE KMWSYMKSAE PSVFTKTTAD 
    GVARVRKSKG KFAFLLESTM NEYIEQRKPC DTMKVGGNLD SKGYGVATPK GSALGNAVNL 
    AVLKLNEQGL LDKLKNKWWY DKGECGSGGG DSKNACKPCS IETQ

Genular Protein ID: 699961311

Symbol: Q5XKG2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

Sequence Information:

  • Length: 144
  • Mass: 16147
  • Checksum: 609D48ED8500D058
  • Sequence:
  • MARQKKMGQS VLRAVFFLVL GLLGHSHGGF PNTISIGGLF MRNTVQEHSA FRFAVQLYNT 
    NQNTTEKPFH LNYHVDHLDS SNSFSVTNAC PAERDYLPWP GSIRENNWTA LPCCKDHGLL 
    HLKCSPGGAR QNWAYCIWGV TGEL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.