Details for: GRIA3

Gene ID: 2892

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: GRIA3

Ensembl ID: ENSG00000125675

Description: glutamate ionotropic receptor AMPA type subunit 3

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

  • Activation of ampa receptors
    (R-HSA-399710)
  • Activation of nmda receptors and postsynaptic events
    (R-HSA-442755)
  • Glutamate binding, activation of ampa receptors and synaptic plasticity
    (R-HSA-399721)
  • Neuronal system
    (R-HSA-112316)
  • Neurotransmitter receptors and postsynaptic signal transmission
    (R-HSA-112314)
  • Protein-protein interactions at synapses
    (R-HSA-6794362)
  • Synaptic adhesion-like molecules
    (R-HSA-8849932)
  • Trafficking of ampa receptors
    (R-HSA-399719)
  • Trafficking of glur2-containing ampa receptors
    (R-HSA-416993)
  • Transmission across chemical synapses
    (R-HSA-112315)
  • Unblocking of nmda receptors, glutamate binding and activation
    (R-HSA-438066)
  • Ampa glutamate receptor activity
    (GO:0004971)
  • Ampa glutamate receptor complex
    (GO:0032281)
  • Amyloid-beta binding
    (GO:0001540)
  • Calcium-mediated signaling
    (GO:0019722)
  • Dendritic spine
    (GO:0043197)
  • Endocytic vesicle membrane
    (GO:0030666)
  • Glutamate-gated calcium ion channel activity
    (GO:0022849)
  • Glutamate-gated receptor activity
    (GO:0004970)
  • Glutamate receptor signaling pathway
    (GO:0007215)
  • Ionotropic glutamate receptor signaling pathway
    (GO:0035235)
  • Ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
    (GO:0099507)
  • Long-term synaptic potentiation
    (GO:0060291)
  • Modulation of chemical synaptic transmission
    (GO:0050804)
  • Monoatomic ion transmembrane transport
    (GO:0034220)
  • Parallel fiber to purkinje cell synapse
    (GO:0098688)
  • Plasma membrane
    (GO:0005886)
  • Postsynaptic density membrane
    (GO:0098839)
  • Postsynaptic membrane
    (GO:0045211)
  • Protein heterotetramerization
    (GO:0051290)
  • Protein homotetramerization
    (GO:0051289)
  • Regulation of postsynaptic membrane potential
    (GO:0060078)
  • Regulation of presynaptic membrane potential
    (GO:0099505)
  • Synaptic transmission, glutamatergic
    (GO:0035249)
  • Transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
    (GO:1904315)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • sst GABAergic cortical interneuron CL4023017
    CSI 46.18
    rCSI 59.53%
    PRS 98.43
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 44.1
    rCSI 54.87%
    PRS 97.85
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 29.7
    rCSI 49.86%
    PRS 98.27
  • oligodendrocyte precursor cell CL0002453
    CSI 28.04
    rCSI 61.71%
    PRS 95.77
  • differentiation-committed oligodendrocyte precursor CL4023059
    CSI 27.22
    rCSI 49.46%
    PRS 98.46
  • interneuron CL0000099
    CSI 26.85
    rCSI 53.91%
    PRS 98.8
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 26.77
    rCSI 47.28%
    PRS 98.11
  • sncg GABAergic cortical interneuron CL4023015
    CSI 26.51
    rCSI 42.64%
    PRS 97.99
  • L2/3 intratelencephalic projecting glutamatergic neuron CL4030059
    CSI 24.71
    rCSI 53.59%
    PRS 96.9
  • retina horizontal cell CL0000745
    CSI 23.68
    rCSI 36.09%
    PRS 99.18
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 22.73
    rCSI 55.23%
    PRS 97.43
  • neuroblast (sensu Vertebrata) CL0000031
    CSI 22.36
    rCSI 28.69%
    PRS 99.03
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 22.03
    rCSI 25.44%
    PRS 98.62
  • neuron CL0000540
    CSI 20.7
    rCSI 55.12%
    PRS 96.65
  • L4 intratelencephalic projecting glutamatergic neuron CL4030063
    CSI 19.66
    rCSI 47.02%
    PRS 97.41
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 19.27
    rCSI 60.26%
    PRS 98.32
  • L6b glutamatergic cortical neuron CL4023038
    CSI 19.17
    rCSI 59.91%
    PRS 98.09
  • glutamatergic neuron CL0000679
    CSI 18.33
    rCSI 37.67%
    PRS 96.6
  • VIP GABAergic cortical interneuron CL4023016
    CSI 18.13
    rCSI 21.66%
    PRS 98.1
  • progenitor cell CL0011026
    CSI 16.74
    rCSI 35.6%
    PRS 98.57
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 16.45
    rCSI 59.2%
    PRS 97.78
  • inhibitory interneuron CL0000498
    CSI 16.22
    rCSI 37.44%
    PRS 98.19
  • L5/6 near-projecting glutamatergic neuron CL4030067
    CSI 15.65
    rCSI 51.45%
    PRS 97.04
  • neural cell CL0002319
    CSI 15.55
    rCSI 58.67%
    PRS 96.71
  • glycinergic amacrine cell CL4030028
    CSI 14.86
    rCSI 38.71%
    PRS 97.94
  • retinal bipolar neuron CL0000748
    CSI 14.19
    rCSI 26.58%
    PRS 98.16
  • GABAergic amacrine cell CL4030027
    CSI 13.64
    rCSI 46.73%
    PRS 97.09
  • Mueller cell CL0000636
    CSI 13.34
    rCSI 30.45%
    PRS 98.57
  • H1 horizontal cell CL0004217
    CSI 13.18
    rCSI 52.22%
    PRS 98.13
  • GABAergic neuron CL0000617
    CSI 13.13
    rCSI 43.98%
    PRS 96.41
  • amacrine cell CL0000561
    CSI 12.95
    rCSI 37.53%
    PRS 98.23
  • rod bipolar cell CL0000751
    CSI 12.86
    rCSI 23.12%
    PRS 98.7
  • glioblast CL0000030
    CSI 12.85
    rCSI 20.51%
    PRS 98.48
  • cerebral cortex endothelial cell CL1001602
    CSI 12.49
    rCSI 21.61%
    PRS 98.78
  • hepatic stellate cell CL0000632
    CSI 11.3
    rCSI 42.33%
    PRS 99.32
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 11.04
    rCSI 41.71%
    PRS 97.72
  • astrocyte of the cerebral cortex CL0002605
    CSI 10.55
    rCSI 23.66%
    PRS 98.23
  • cerebral cortex neuron CL0010012
    CSI 10.4
    rCSI 42.39%
    PRS 97.93
  • cardiac muscle cell CL0000746
    CSI 9.52
    rCSI 13.67%
    PRS 98.23
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 9.42
    rCSI 55.47%
    PRS 97.83
  • retinal ganglion cell CL0000740
    CSI 8.92
    rCSI 19.7%
    PRS 98.1
  • serotonergic neuron CL0000850
    CSI 8.36
    rCSI 37.36%
    PRS 96.19
  • vascular leptomeningeal cell CL4023051
    CSI 7.98
    rCSI 13.99%
    PRS 98.91
  • pericyte CL0000669
    CSI 7.87
    rCSI 20.95%
    PRS 93.11
  • pancreatic D cell CL0000173
    CSI 7.5
    rCSI 7.38%
    PRS 99.43
  • neural progenitor cell CL0011020
    CSI 7.36
    rCSI 32.39%
    PRS 96.33
  • dopaminergic neuron CL0000700
    CSI 6.67
    rCSI 37.71%
    PRS 97.54
  • epithelial cell of proximal tubule CL0002306
    CSI 6.5
    rCSI 15.87%
    PRS 98.24
  • Bergmann glial cell CL0000644
    CSI 6.35
    rCSI 8.69%
    PRS 98.46
  • medium spiny neuron CL1001474
    CSI 5.84
    rCSI 50.33%
    PRS 98.07
  • macroglial cell CL0000126
    CSI 5.66
    rCSI 14.54%
    PRS 98.81
  • H2 horizontal cell CL0004218
    CSI 5.46
    rCSI 27.16%
    PRS 98.36
  • basket cell CL0000118
    CSI 5.38
    rCSI 33.71%
    PRS 94.59
  • pancreatic A cell CL0000171
    CSI 5.05
    rCSI 5.29%
    PRS 99.45
  • direct pathway medium spiny neuron CL4023026
    CSI 2.31
    rCSI 55.32%
    PRS 96.87
  • indirect pathway medium spiny neuron CL4023029
    CSI 2.29
    rCSI 55.13%
    PRS 96.83
  • ON parasol ganglion cell CL4033052
    CSI 2.18
    rCSI 30.96%
    PRS 97.93
  • starburst amacrine cell CL0004232
    CSI 2.14
    rCSI 18%
    PRS 96.13
  • OFF midget ganglion cell CL4033047
    CSI 2.11
    rCSI 42.91%
    PRS 97.88
  • pancreatic PP cell CL0002275
    CSI 2.03
    rCSI 8.09%
    PRS 99.2
  • ON midget ganglion cell CL4033046
    CSI 2.01
    rCSI 40.93%
    PRS 97.84
  • type B pancreatic cell CL0000169
    CSI 1.76
    rCSI 3.91%
    PRS 99.24

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [GRIA3](/details-gene/2892) (Glutamate Ionotropic Receptor AMPA Type Subunit 3) is a protein-coding gene located on the X chromosome that encodes the GluA3 subunit of the AMPA-type ionotropic glutamate receptors. These receptors are ligand-gated ion channels that mediate the majority of fast excitatory synaptic transmission in the central nervous system. Consistent with this role, [GRIA3](/details-gene/2892) shows highly significant expression in numerous neuronal populations, particularly in diverse subtypes of GABAergic cortical interneurons, such as [sst GABAergic cortical interneuron](/details-cell/CL4023017) and [pvalb GABAergic cortical interneuron](/details-cell/CL4023018), as well as glutamatergic neurons and [oligodendrocyte precursor cell](/details-cell/CL0002453). Functionally, it is integral to processes including [glutamate receptor signaling](/details-cell/GO:0007215), [synaptic transmission](/details-cell/GO:0035249), and synaptic plasticity. Clinically, mutations in [GRIA3](/details-gene/2892) have been associated with X-linked intellectual disability ([OMIM: 300699](https://omim.org/entry/300699)) and have been investigated as a candidate gene for bipolar disorder ([Link](https://doi.org/10.1006/geno.1999.6032)). ## Cellular Roles and Expression Landscape The expression profile of [GRIA3](/details-gene/2892) underscores its fundamental role in neuronal function and development within the central nervous system. **Overall**, the gene demonstrates its highest significance in various classes of neurons, establishing it as a key component of neural circuitry. It is a particularly strong marker for inhibitory interneurons, with top CSI scores observed in [sst GABAergic cortical interneuron](/details-cell/CL4023017) (CSI: 46.18), [pvalb GABAergic cortical interneuron](/details-cell/CL4023018) (CSI: 44.10), [lamp5 GABAergic cortical interneuron](/details-cell/CL4023011) (CSI: 29.70), and other [interneuron](/details-cell/CL0000099) subtypes. This suggests that [GRIA3](/details-gene/2892)-containing AMPA receptors are critical for modulating the activity of cortical inhibitory circuits. In addition to its role in inhibitory neurons, [GRIA3](/details-gene/2892) is also significantly expressed in excitatory glutamatergic neurons, including [L2/3 intratelencephalic projecting glutamatergic neuron](/details-cell/CL4030059) and [L4 intratelencephalic projecting glutamatergic neuron](/details-cell/CL4030063). This broad expression in both excitatory and inhibitory [neuron](/details-cell/CL0000540) types highlights its central role in maintaining the delicate balance of synaptic communication throughout the cortex. Interestingly, [GRIA3](/details-gene/2892) also shows high significance in glial lineage cells, specifically [oligodendrocyte precursor cell](/details-cell/CL0002453) (CSI: 28.04) and [differentiation-committed oligodendrocyte precursor](/details-cell/CL4023059) (CSI: 27.22). This expression pattern suggests a potential, non-canonical role for glutamate signaling through GluA3-containing receptors in glial development, proliferation, or neuron-glia communication. ## Pathways and Molecular Function The functional annotations for [GRIA3](/details-gene/2892) confirm its identity as a core component of the glutamatergic synapse. The gene product, GluA3, is a subunit of the [Ampa glutamate receptor complex](/details-cell/GO:0032281), which functions as a [glutamate-gated calcium ion channel](/details-cell/GO:0022849) located on the [postsynaptic membrane](/details-cell/GO:0045211). **Biological Processes:** [GRIA3](/details-gene/2892) is centrally involved in the [glutamate receptor signaling pathway](/details-cell/GO:0007215) and is essential for [synaptic transmission, glutamatergic](/details-cell/GO:0035249). Its function is critical for dynamic synaptic processes, including [long-term synaptic potentiation](/details-cell/GO:0060291) and the general [modulation of chemical synaptic transmission](/details-cell/GO:0050804), which are cellular mechanisms underlying learning and memory. **Reactome Pathways:** The gene's involvement is prominent in pathways related to excitatory neurotransmission. These include the direct [Activation of ampa receptors](/details-cell/R-HSA-399710), the overarching [Neuronal system](/details-cell/R-HSA-112316) pathway, and processes governing receptor availability at the synapse, such as [Trafficking of ampa receptors](/details-cell/R-HSA-399719). The function of these receptors is known to be tightly regulated by auxiliary proteins like TARPs and cornichons, which control receptor gating ([Link](https://doi.org/10.1016/j.neuron.2010.11.026)). This elaborate network of interactions highlights the precise control required for proper synaptic function, which is dependent on [GRIA3](/details-gene/2892). ## Research Directions The established role of [GRIA3](/details-gene/2892) in synaptic function and its association with neurodevelopmental disorders provide a strong foundation for further investigation. **Testable Hypotheses:** 1. Given the high expression of [GRIA3](/details-gene/2892) in multiple inhibitory interneuron subtypes, mutations associated with cognitive impairment ([Link](https://doi.org/10.1073/pnas.0708699104)) may preferentially disrupt the function of these cells, leading to an excitatory/inhibitory circuit imbalance that underlies the clinical phenotype. 2. The significant expression of [GRIA3](/details-gene/2892) in [oligodendrocyte precursor cell](/details-cell/CL0002453) suggests a non-canonical role in glial biology. We hypothesize that [GRIA3](/details-gene/2892)-mediated glutamate signaling is essential for the timely proliferation and differentiation of these precursors into myelinating oligodendrocytes during brain development. **Proposed Experiment:** To test hypothesis 1, a knock-in mouse model could be generated expressing a clinically relevant human [GRIA3](/details-gene/2892) mutation. *Ex vivo* brain slices from these mice would be subjected to patch-clamp electrophysiology. Recordings from identified cortical interneurons (e.g., Pvalb-positive or Sst-positive cells) would be used to characterize the amplitude, kinetics, and pharmacology of AMPA receptor-mediated excitatory postsynaptic currents (EPSCs). This cellular-level analysis would be complemented with behavioral assays (e.g., Morris water maze, novel object recognition) to assess cognitive deficits, directly linking altered interneuron physiology to behavioral outcomes. **Therapeutic Potential:** As a central component of excitatory neurotransmission, [GRIA3](/details-gene/2892) presents a challenging therapeutic target due to the risk of widespread, off-target neurological effects. However, for specific disease-causing mutations, targeted strategies could be envisioned. For gain-of-function mutations leading to excitotoxicity, selective negative allosteric modulators (NAMs) could reduce channel activity back to physiological levels. Conversely, for loss-of-function mutations associated with cognitive deficits, positive allosteric modulators (PAMs) could potentially enhance receptor function. The development of subunit-specific modulators would be critical to minimize side effects and precisely tune the activity of circuits affected by [GRIA3](/details-gene/2892) dysregulation.

Genular Protein ID: 952610626

Symbol: GRIA3_HUMAN

Name: AMPA-selective glutamate receptor 3

UniProtKB Accession Codes:

P42263 D3DTF1 Q4VXD5 Q4VXD6 Q9HDA0 Q9HDA1 Q9HDA2 Q9P0H1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 11 DrugCentral 1 EMBL 49 Ensembl 2 ExpressionAtlas 1 GO 19 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 3 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 5 RefSeq 2 Rhea 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7918660

Title: Human glutamate receptor hGluR3 flip and flop isoforms: cloning and sequencing of the cDNAs and primary structure of the proteins.

PubMed ID: 7918660

DOI: 10.1016/0167-4781(94)90090-6

PubMed ID: 10644433

Title: Characterization of the human glutamate receptor subunit 3 gene (GRIA3), a candidate for bipolar disorder and nonspecific X-linked mental retardation.

PubMed ID: 10644433

DOI: 10.1006/geno.1999.6032

PubMed ID: 10602120

Title: Candidate gene analysis in Rett syndrome and the identification of 21 SNPs in Xq.

PubMed ID: 10602120

DOI: 10.1002/(sici)1096-8628(20000103)90:1<69::aid-ajmg12>3.3.co;2-n

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 21172611

Title: Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins.

PubMed ID: 21172611

DOI: 10.1016/j.neuron.2010.11.026

PubMed ID: 24721225

Title: X-exome sequencing in Finnish families with intellectual disability--four novel mutations and two novel syndromic phenotypes.

PubMed ID: 24721225

DOI: 10.1186/1750-1172-9-49

PubMed ID: 17989220

Title: Mutations in ionotropic AMPA receptor 3 alter channel properties and are associated with moderate cognitive impairment in humans.

PubMed ID: 17989220

DOI: 10.1073/pnas.0708699104

PubMed ID: 30165711

Title: Dominant SCN2A Mutation Causes Familial Episodic Ataxia and Impairment of Speech Development.

PubMed ID: 30165711

DOI: 10.1055/s-0038-1668141

Sequence Information:

  • Length: 894
  • Mass: 101157
  • Checksum: 178589A870E0D102
  • Sequence:
    • MARQKKMGQS VLRAVFFLVL GLLGHSHGGF PNTISIGGLF MRNTVQEHSA FRFAVQLYNT 
NQNTTEKPFH LNYHVDHLDS SNSFSVTNAF CSQFSRGVYA IFGFYDQMSM NTLTSFCGAL 
HTSFVTPSFP TDADVQFVIQ MRPALKGAIL SLLGHYKWEK FVYLYDTERG FSILQAIMEA 
AVQNNWQVTA RSVGNIKDVQ EFRRIIEEMD RRQEKRYLID CEVERINTIL EQVVILGKHS 
RGYHYMLANL GFTDILLERV MHGGANITGF QIVNNENPMV QQFIQRWVRL DEREFPEAKN 
APLKYTSALT HDAILVIAEA FRYLRRQRVD VSRRGSAGDC LANPAVPWSQ GIDIERALKM 
VQVQGMTGNI QFDTYGRRTN YTIDVYEMKV SGSRKAGYWN EYERFVPFSD QQISNDSASS 
ENRTIVVTTI LESPYVMYKK NHEQLEGNER YEGYCVDLAY EIAKHVRIKY KLSIVGDGKY 
GARDPETKIW NGMVGELVYG RADIAVAPLT ITLVREEVID FSKPFMSLGI SIMIKKPQKS 
KPGVFSFLDP LAYEIWMCIV FAYIGVSVVL FLVSRFSPYE WHLEDNNEEP RDPQSPPDPP 
NEFGIFNSLW FSLGAFMQQG CDISPRSLSG RIVGGVWWFF TLIIISSYTA NLAAFLTVER 
MVSPIESAED LAKQTEIAYG TLDSGSTKEF FRRSKIAVYE KMWSYMKSAE PSVFTKTTAD 
GVARVRKSKG KFAFLLESTM NEYIEQRKPC DTMKVGGNLD SKGYGVATPK GSALRNAVNL 
AVLKLNEQGL LDKLKNKWWY DKGECGSGGG DSKDKTSALS LSNVAGVFYI LVGGLGLAMM 
VALIEFCYKS RAESKRMKLT KNTQNFKPAP ATNTQNYATY REGYNVYGTE SVKI

Genular Protein ID: 425831096

Symbol: Q17R51_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q17R51

Database IDs:

ARBA 12 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 8 Gene3D 3 InterPro 6 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 RefSeq 2 RuleBase 1 SMART 4 SMR 1 SUPFAM 3

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 824
  • Mass: 93316
  • Checksum: DD96AB26743B82E0
  • Sequence:
    • MARQKKMGQS VLRAVFFLVL GLLGHSHGGF PNTISIGGLF MRNTVQEHSA FRFAVQLYNT 
NQNTTEKPFH LNYHVDHLDS SNSFSVTNAF CSQFSRGVYA IFGFYDQMSM NTLTSFCGAL 
HTSFVTPSFP TDADVQFVIQ MRPALKGAIL SLLGHYKWEK FVYLYDTERG FSILQAIMEA 
AVQNNWQVTA RSVGNIKDVQ EFRRIIEEMD RRQEKRYLID CEVERINTIL EQVVILGKHS 
RGYHYMLANL GFTDILLERV MHGGANITGF QIVNNENPMV QQFIQRWVRL DEREFPEAKN 
APLKYTSALT HDAILVIAEA FRYLRRQRVD VSRRGSAGDC LANPAVPWSQ GIDIERALKM 
VQVQGMTGNI QFDTYGRRTN YTIDVYEMKV SGSRKAGYWN EYERFVPFSD QQISNDSASS 
ENRTIVVTTI LESPYVMYKK NHEQLEGNER YEGYCVDLAY EIAKHVRIKY KLSIVGDGKY 
GARDPETKIW NGMVGELVYG RADIAVAPLT ITLVREEVID FSKPFMSLGI SIMIKKPQKS 
KPGVFSFLDP LAYEIWMCIV FAYIGVSVVL FLVSRFSPYE WHLEDNNEEP RDPQSPPDPP 
NEFGIFNSLW FSLGAFMQQG CDISPRSLSG RIVGGVWWFF TLIIISSYTA NLAAFLTVER 
MVSPIESAED LAKQTEIAYG TLDSGSTKEF FRRSKIAVYE KMWSYMKSAE PSVFTKTTAD 
GVARVRKSKG KFAFLLESTM NEYIEQRKPC DTMKVGGNLD SKGYGVATPK GSALGNAVNL 
AVLKLNEQGL LDKLKNKWWY DKGECGSGGG DSKNACKPCS IETQ

Genular Protein ID: 699961311

Symbol: Q5XKG2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5XKG2

Database IDs:

Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 3 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 NCBI Taxonomy 1 OrthoDB 1 PeptideAtlas 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

Sequence Information:

  • Length: 144
  • Mass: 16147
  • Checksum: 609D48ED8500D058
  • Sequence:
    • MARQKKMGQS VLRAVFFLVL GLLGHSHGGF PNTISIGGLF MRNTVQEHSA FRFAVQLYNT 
NQNTTEKPFH LNYHVDHLDS SNSFSVTNAC PAERDYLPWP GSIRENNWTA LPCCKDHGLL 
HLKCSPGGAR QNWAYCIWGV TGEL