Details for: GRIA3

Gene ID: 2892

Symbol: GRIA3

Ensembl ID: ENSG00000125675

Description: glutamate ionotropic receptor AMPA type subunit 3

Associated with

  • Activation of ampa receptors
    (R-HSA-399710)
  • Activation of nmda receptors and postsynaptic events
    (R-HSA-442755)
  • Glutamate binding, activation of ampa receptors and synaptic plasticity
    (R-HSA-399721)
  • Neuronal system
    (R-HSA-112316)
  • Neurotransmitter receptors and postsynaptic signal transmission
    (R-HSA-112314)
  • Protein-protein interactions at synapses
    (R-HSA-6794362)
  • Synaptic adhesion-like molecules
    (R-HSA-8849932)
  • Trafficking of ampa receptors
    (R-HSA-399719)
  • Trafficking of glur2-containing ampa receptors
    (R-HSA-416993)
  • Transmission across chemical synapses
    (R-HSA-112315)
  • Unblocking of nmda receptors, glutamate binding and activation
    (R-HSA-438066)
  • Ampa glutamate receptor activity
    (GO:0004971)
  • Ampa glutamate receptor complex
    (GO:0032281)
  • Amyloid-beta binding
    (GO:0001540)
  • Calcium-mediated signaling
    (GO:0019722)
  • Dendritic spine
    (GO:0043197)
  • Endocytic vesicle membrane
    (GO:0030666)
  • Glutamate-gated calcium ion channel activity
    (GO:0022849)
  • Glutamate-gated receptor activity
    (GO:0004970)
  • Glutamate receptor signaling pathway
    (GO:0007215)
  • Ionotropic glutamate receptor signaling pathway
    (GO:0035235)
  • Ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
    (GO:0099507)
  • Long-term synaptic potentiation
    (GO:0060291)
  • Modulation of chemical synaptic transmission
    (GO:0050804)
  • Monoatomic ion transmembrane transport
    (GO:0034220)
  • Parallel fiber to purkinje cell synapse
    (GO:0098688)
  • Plasma membrane
    (GO:0005886)
  • Postsynaptic density membrane
    (GO:0098839)
  • Postsynaptic membrane
    (GO:0045211)
  • Protein heterotetramerization
    (GO:0051290)
  • Protein homotetramerization
    (GO:0051289)
  • Regulation of postsynaptic membrane potential
    (GO:0060078)
  • Regulation of presynaptic membrane potential
    (GO:0099505)
  • Synaptic transmission, glutamatergic
    (GO:0035249)
  • Transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
    (GO:1904315)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 234.8967
    Cell Significance Index: -59.5800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 6.1780
    Cell Significance Index: 176.3000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.2134
    Cell Significance Index: -11.4100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 5.1914
    Cell Significance Index: 64.3900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 5.0416
    Cell Significance Index: 223.0000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 4.6304
    Cell Significance Index: 175.3400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 4.1170
    Cell Significance Index: 276.8300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 3.4569
    Cell Significance Index: 1239.9300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 3.2049
    Cell Significance Index: 642.9000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.3699
    Cell Significance Index: 1639.1400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.9685
    Cell Significance Index: 47.2100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.9377
    Cell Significance Index: 119.1000
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 1.6087
    Cell Significance Index: 21.4600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.3471
    Cell Significance Index: 82.5900
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.4850
    Cell Significance Index: 6.2900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2406
    Cell Significance Index: 217.2200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1713
    Cell Significance Index: 32.5900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.1457
    Cell Significance Index: 2.8800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.0275
    Cell Significance Index: 0.3000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0040
    Cell Significance Index: 6.1000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0066
    Cell Significance Index: -4.1300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0130
    Cell Significance Index: -9.6000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0199
    Cell Significance Index: -37.4000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0238
    Cell Significance Index: -43.8800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0312
    Cell Significance Index: -42.3700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0412
    Cell Significance Index: -23.2100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0583
    Cell Significance Index: -3.0600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0666
    Cell Significance Index: -2.3400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0746
    Cell Significance Index: -54.6900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0785
    Cell Significance Index: -49.8300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.1070
    Cell Significance Index: -58.4300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1112
    Cell Significance Index: -4.8300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1119
    Cell Significance Index: -50.7800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.1158
    Cell Significance Index: -51.2200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.1234
    Cell Significance Index: -12.2100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.1303
    Cell Significance Index: -21.1900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1513
    Cell Significance Index: -31.8600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1583
    Cell Significance Index: -3.3600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1707
    Cell Significance Index: -30.7700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1715
    Cell Significance Index: -49.3500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2255
    Cell Significance Index: -38.5000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2378
    Cell Significance Index: -3.4100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.2416
    Cell Significance Index: -47.9500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2628
    Cell Significance Index: -8.3700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2733
    Cell Significance Index: -35.0400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.2759
    Cell Significance Index: -3.4400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2906
    Cell Significance Index: -39.9100
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.2964
    Cell Significance Index: -3.2700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3220
    Cell Significance Index: -9.0000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3278
    Cell Significance Index: -47.6600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.3308
    Cell Significance Index: -40.6700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3335
    Cell Significance Index: -10.9200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3593
    Cell Significance Index: -41.8700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.3679
    Cell Significance Index: -40.0200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3745
    Cell Significance Index: -8.2000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4183
    Cell Significance Index: -32.1000
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.4257
    Cell Significance Index: -4.0500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.4292
    Cell Significance Index: -55.4500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.4397
    Cell Significance Index: -12.6700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4699
    Cell Significance Index: -53.8300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.4960
    Cell Significance Index: -22.4800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.5000
    Cell Significance Index: -58.9600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5211
    Cell Significance Index: -54.2600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5321
    Cell Significance Index: -60.7400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.5474
    Cell Significance Index: -55.9200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6934
    Cell Significance Index: -54.9200
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.6982
    Cell Significance Index: -8.8100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.7085
    Cell Significance Index: -10.7600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.7499
    Cell Significance Index: -55.8900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.7564
    Cell Significance Index: -52.3100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.7579
    Cell Significance Index: -42.5300
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.7620
    Cell Significance Index: -8.8900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.7627
    Cell Significance Index: -19.0700
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.8205
    Cell Significance Index: -11.5000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.8329
    Cell Significance Index: -10.5100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.8850
    Cell Significance Index: -19.1200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.8935
    Cell Significance Index: -8.4700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.9261
    Cell Significance Index: -55.6000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.9472
    Cell Significance Index: -59.7000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.9586
    Cell Significance Index: -33.5800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.9611
    Cell Significance Index: -50.0600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -1.0622
    Cell Significance Index: -22.1700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.1138
    Cell Significance Index: -35.6700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -1.1268
    Cell Significance Index: -52.9600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.1593
    Cell Significance Index: -24.7800
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -1.1941
    Cell Significance Index: -14.2800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.1943
    Cell Significance Index: -62.0400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.2071
    Cell Significance Index: -32.3500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -1.2243
    Cell Significance Index: -30.5400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.2386
    Cell Significance Index: -57.7500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.2776
    Cell Significance Index: -25.6500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -1.2952
    Cell Significance Index: -22.1400
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -1.3912
    Cell Significance Index: -18.5500
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: -1.4119
    Cell Significance Index: -11.4000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.4653
    Cell Significance Index: -38.5300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -1.4833
    Cell Significance Index: -35.9300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.5382
    Cell Significance Index: -39.5400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.5545
    Cell Significance Index: -44.5600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.5905
    Cell Significance Index: -58.3900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -1.5935
    Cell Significance Index: -31.1000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** GRIA3 is a subunit of the AMPA-type glutamate receptor, which is a ligand-gated ion channel composed of four subunits (GRIA1, GRIA2, GRIA3, and GRIN2A). Each subunit has a distinct role in the receptor's function and regulation. 2. **Expression:** GRIA3 is highly expressed in various neuronal populations, including excitatory neurons, interneurons, and hematopoietic stem cells. Its expression is also present in non-neuronal cells, such as double-negative thymocytes and A2 amacrine cells. 3. **Function:** GRIA3 contributes to the regulation of postsynaptic membrane potential, synaptic adhesion, and neurotransmitter release. It interacts with other subunits and proteins to modulate the receptor's activity and trafficking. 4. **Regulation:** GRIA3 is subject to various regulatory mechanisms, including phosphorylation, ubiquitination, and endocytosis. These processes can influence the receptor's activity, localization, and interaction with other proteins. **Pathways and Functions:** 1. **Activation of AMPA Receptors:** GRIA3 plays a crucial role in the activation of AMPA receptors, which are involved in fast synaptic transmission and plasticity. 2. **Postsynaptic Events:** GRIA3 contributes to the regulation of postsynaptic membrane potential, synaptic adhesion, and neurotransmitter release. 3. **Synaptic Plasticity:** GRIA3 is involved in the regulation of synaptic plasticity, including long-term potentiation (LTP) and long-term depression (LTD). 4. **Neurotransmitter Signaling:** GRIA3 modulates neurotransmitter release and uptake, influencing the balance of excitatory and inhibitory neurotransmission. 5. **Regulation of Presynaptic Membrane Potential:** GRIA3 interacts with presynaptic proteins to regulate the presynaptic membrane potential and neurotransmitter release. **Clinical Significance:** 1. **Alzheimer's Disease:** Dysregulation of GRIA3 has been implicated in Alzheimer's disease, a neurodegenerative disorder characterized by synaptic dysfunction and cognitive impairments. 2. **Neurological Disorders:** GRIA3 dysregulation has been linked to other neurological disorders, including epilepsy, Parkinson's disease, and schizophrenia. 3. **Cognitive Impairments:** Alterations in GRIA3 expression and function have been associated with cognitive impairments, including attention deficits and memory disorders. 4. **Therapeutic Targeting:** GRIA3 has emerged as a potential therapeutic target for the treatment of neurological disorders, including Alzheimer's disease and other synaptic dysfunctions. In conclusion, the GRIA3 gene plays a critical role in regulating synaptic transmission, plasticity, and neurotransmission. Its dysregulation has been implicated in various neurological disorders, highlighting the importance of understanding its function and regulation in the context of human disease.

Genular Protein ID: 952610626

Symbol: GRIA3_HUMAN

Name: AMPA-selective glutamate receptor 3

UniProtKB Accession Codes:

P42263 D3DTF1 Q4VXD5 Q4VXD6 Q9HDA0 Q9HDA1 Q9HDA2 Q9P0H1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 11 DrugCentral 1 EMBL 49 Ensembl 2 ExpressionAtlas 1 GO 19 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 3 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 5 RefSeq 2 Rhea 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7918660

Title: Human glutamate receptor hGluR3 flip and flop isoforms: cloning and sequencing of the cDNAs and primary structure of the proteins.

PubMed ID: 7918660

DOI: 10.1016/0167-4781(94)90090-6

PubMed ID: 10644433

Title: Characterization of the human glutamate receptor subunit 3 gene (GRIA3), a candidate for bipolar disorder and nonspecific X-linked mental retardation.

PubMed ID: 10644433

DOI: 10.1006/geno.1999.6032

PubMed ID: 10602120

Title: Candidate gene analysis in Rett syndrome and the identification of 21 SNPs in Xq.

PubMed ID: 10602120

DOI: 10.1002/(sici)1096-8628(20000103)90:1<69::aid-ajmg12>3.3.co;2-n

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 21172611

Title: Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins.

PubMed ID: 21172611

DOI: 10.1016/j.neuron.2010.11.026

PubMed ID: 24721225

Title: X-exome sequencing in Finnish families with intellectual disability--four novel mutations and two novel syndromic phenotypes.

PubMed ID: 24721225

DOI: 10.1186/1750-1172-9-49

PubMed ID: 17989220

Title: Mutations in ionotropic AMPA receptor 3 alter channel properties and are associated with moderate cognitive impairment in humans.

PubMed ID: 17989220

DOI: 10.1073/pnas.0708699104

PubMed ID: 30165711

Title: Dominant SCN2A Mutation Causes Familial Episodic Ataxia and Impairment of Speech Development.

PubMed ID: 30165711

DOI: 10.1055/s-0038-1668141

Sequence Information:

  • Length: 894
  • Mass: 101157
  • Checksum: 178589A870E0D102
  • Sequence:
    • MARQKKMGQS VLRAVFFLVL GLLGHSHGGF PNTISIGGLF MRNTVQEHSA FRFAVQLYNT 
NQNTTEKPFH LNYHVDHLDS SNSFSVTNAF CSQFSRGVYA IFGFYDQMSM NTLTSFCGAL 
HTSFVTPSFP TDADVQFVIQ MRPALKGAIL SLLGHYKWEK FVYLYDTERG FSILQAIMEA 
AVQNNWQVTA RSVGNIKDVQ EFRRIIEEMD RRQEKRYLID CEVERINTIL EQVVILGKHS 
RGYHYMLANL GFTDILLERV MHGGANITGF QIVNNENPMV QQFIQRWVRL DEREFPEAKN 
APLKYTSALT HDAILVIAEA FRYLRRQRVD VSRRGSAGDC LANPAVPWSQ GIDIERALKM 
VQVQGMTGNI QFDTYGRRTN YTIDVYEMKV SGSRKAGYWN EYERFVPFSD QQISNDSASS 
ENRTIVVTTI LESPYVMYKK NHEQLEGNER YEGYCVDLAY EIAKHVRIKY KLSIVGDGKY 
GARDPETKIW NGMVGELVYG RADIAVAPLT ITLVREEVID FSKPFMSLGI SIMIKKPQKS 
KPGVFSFLDP LAYEIWMCIV FAYIGVSVVL FLVSRFSPYE WHLEDNNEEP RDPQSPPDPP 
NEFGIFNSLW FSLGAFMQQG CDISPRSLSG RIVGGVWWFF TLIIISSYTA NLAAFLTVER 
MVSPIESAED LAKQTEIAYG TLDSGSTKEF FRRSKIAVYE KMWSYMKSAE PSVFTKTTAD 
GVARVRKSKG KFAFLLESTM NEYIEQRKPC DTMKVGGNLD SKGYGVATPK GSALRNAVNL 
AVLKLNEQGL LDKLKNKWWY DKGECGSGGG DSKDKTSALS LSNVAGVFYI LVGGLGLAMM 
VALIEFCYKS RAESKRMKLT KNTQNFKPAP ATNTQNYATY REGYNVYGTE SVKI

Genular Protein ID: 425831096

Symbol: Q17R51_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q17R51

Database IDs:

ARBA 12 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 8 Gene3D 3 InterPro 6 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 RefSeq 2 RuleBase 1 SMART 4 SMR 1 SUPFAM 3

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 824
  • Mass: 93316
  • Checksum: DD96AB26743B82E0
  • Sequence:
    • MARQKKMGQS VLRAVFFLVL GLLGHSHGGF PNTISIGGLF MRNTVQEHSA FRFAVQLYNT 
NQNTTEKPFH LNYHVDHLDS SNSFSVTNAF CSQFSRGVYA IFGFYDQMSM NTLTSFCGAL 
HTSFVTPSFP TDADVQFVIQ MRPALKGAIL SLLGHYKWEK FVYLYDTERG FSILQAIMEA 
AVQNNWQVTA RSVGNIKDVQ EFRRIIEEMD RRQEKRYLID CEVERINTIL EQVVILGKHS 
RGYHYMLANL GFTDILLERV MHGGANITGF QIVNNENPMV QQFIQRWVRL DEREFPEAKN 
APLKYTSALT HDAILVIAEA FRYLRRQRVD VSRRGSAGDC LANPAVPWSQ GIDIERALKM 
VQVQGMTGNI QFDTYGRRTN YTIDVYEMKV SGSRKAGYWN EYERFVPFSD QQISNDSASS 
ENRTIVVTTI LESPYVMYKK NHEQLEGNER YEGYCVDLAY EIAKHVRIKY KLSIVGDGKY 
GARDPETKIW NGMVGELVYG RADIAVAPLT ITLVREEVID FSKPFMSLGI SIMIKKPQKS 
KPGVFSFLDP LAYEIWMCIV FAYIGVSVVL FLVSRFSPYE WHLEDNNEEP RDPQSPPDPP 
NEFGIFNSLW FSLGAFMQQG CDISPRSLSG RIVGGVWWFF TLIIISSYTA NLAAFLTVER 
MVSPIESAED LAKQTEIAYG TLDSGSTKEF FRRSKIAVYE KMWSYMKSAE PSVFTKTTAD 
GVARVRKSKG KFAFLLESTM NEYIEQRKPC DTMKVGGNLD SKGYGVATPK GSALGNAVNL 
AVLKLNEQGL LDKLKNKWWY DKGECGSGGG DSKNACKPCS IETQ

Genular Protein ID: 699961311

Symbol: Q5XKG2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5XKG2

Database IDs:

Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 3 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 NCBI Taxonomy 1 OrthoDB 1 PeptideAtlas 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

Sequence Information:

  • Length: 144
  • Mass: 16147
  • Checksum: 609D48ED8500D058
  • Sequence:
    • MARQKKMGQS VLRAVFFLVL GLLGHSHGGF PNTISIGGLF MRNTVQEHSA FRFAVQLYNT 
NQNTTEKPFH LNYHVDHLDS SNSFSVTNAC PAERDYLPWP GSIRENNWTA LPCCKDHGLL 
HLKCSPGGAR QNWAYCIWGV TGEL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.