Details for: SH3GL3

Gene ID: 6457

Symbol: SH3GL3

Ensembl ID: ENSG00000140600

Description: SH3 domain containing GRB2 like 3, endophilin A3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 215.6571
    Cell Significance Index: -54.7000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 102.4228
    Cell Significance Index: -41.6100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.8594
    Cell Significance Index: -54.6900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.7147
    Cell Significance Index: -8.1300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 3.0527
    Cell Significance Index: 1094.9600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.8631
    Cell Significance Index: 108.4200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.8494
    Cell Significance Index: 571.5900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.6683
    Cell Significance Index: 118.0300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.7147
    Cell Significance Index: 8.8700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.6928
    Cell Significance Index: 19.3600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.4333
    Cell Significance Index: 5.7800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.3915
    Cell Significance Index: 6.7100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3694
    Cell Significance Index: 5.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1007
    Cell Significance Index: 189.6300
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.0841
    Cell Significance Index: 0.8000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.0374
    Cell Significance Index: 0.7400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0184
    Cell Significance Index: -1.0300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0249
    Cell Significance Index: -1.0800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0279
    Cell Significance Index: -51.4700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0327
    Cell Significance Index: -50.3200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0402
    Cell Significance Index: -54.6000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0449
    Cell Significance Index: -19.8400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0450
    Cell Significance Index: -24.5900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0538
    Cell Significance Index: -2.7200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0566
    Cell Significance Index: -41.8900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0638
    Cell Significance Index: -46.7600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0658
    Cell Significance Index: -41.8000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0716
    Cell Significance Index: -54.2000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0896
    Cell Significance Index: -55.9300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0900
    Cell Significance Index: -3.6900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0906
    Cell Significance Index: -51.0700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1058
    Cell Significance Index: -48.0200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1341
    Cell Significance Index: -4.3900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1463
    Cell Significance Index: -4.6600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1509
    Cell Significance Index: -43.4300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1693
    Cell Significance Index: -24.6100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2054
    Cell Significance Index: -4.5000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.2116
    Cell Significance Index: -38.1500
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.2472
    Cell Significance Index: -2.6500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2476
    Cell Significance Index: -28.8600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2640
    Cell Significance Index: -5.3000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2642
    Cell Significance Index: -55.6500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.2700
    Cell Significance Index: -53.5900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.3047
    Cell Significance Index: -37.4700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.3169
    Cell Significance Index: -54.1100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3270
    Cell Significance Index: -6.9400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3563
    Cell Significance Index: -46.0300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.3943
    Cell Significance Index: -54.1500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4105
    Cell Significance Index: -47.0300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4265
    Cell Significance Index: -10.6400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.4805
    Cell Significance Index: -49.0900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.5202
    Cell Significance Index: -11.2400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5349
    Cell Significance Index: -55.7000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.5451
    Cell Significance Index: -38.5500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.5472
    Cell Significance Index: -7.7900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.5640
    Cell Significance Index: -6.5800
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.5708
    Cell Significance Index: -8.0000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.5718
    Cell Significance Index: -6.2300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5752
    Cell Significance Index: -30.2000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5913
    Cell Significance Index: -46.8300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.6231
    Cell Significance Index: -46.4400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.7089
    Cell Significance Index: -6.7200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7165
    Cell Significance Index: -25.1000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.7261
    Cell Significance Index: -55.7200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.7824
    Cell Significance Index: -16.3300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.7894
    Cell Significance Index: -50.9300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.7965
    Cell Significance Index: -41.4900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.8023
    Cell Significance Index: -11.4900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.8488
    Cell Significance Index: -53.5000
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.8763
    Cell Significance Index: -10.4800
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: -0.9342
    Cell Significance Index: -7.1700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.9578
    Cell Significance Index: -45.0200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.0084
    Cell Significance Index: -35.0400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -1.1404
    Cell Significance Index: -14.2200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -1.1554
    Cell Significance Index: -22.7400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.1967
    Cell Significance Index: -43.9300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.2721
    Cell Significance Index: -37.4700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -1.3445
    Cell Significance Index: -33.5800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -1.3859
    Cell Significance Index: -34.5600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -1.3933
    Cell Significance Index: -33.7500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -1.4191
    Cell Significance Index: -9.6100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.5106
    Cell Significance Index: -38.8300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -1.5280
    Cell Significance Index: -30.4700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.5735
    Cell Significance Index: -45.1100
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -1.6387
    Cell Significance Index: -18.0800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -1.6533
    Cell Significance Index: -18.7800
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -1.6710
    Cell Significance Index: -21.0900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.6763
    Cell Significance Index: -28.0600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.7488
    Cell Significance Index: -37.3800
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -1.7498
    Cell Significance Index: -17.9900
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -1.7548
    Cell Significance Index: -55.5000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -1.7827
    Cell Significance Index: -47.6000
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -1.7941
    Cell Significance Index: -23.9200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -1.8011
    Cell Significance Index: -37.7000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.8264
    Cell Significance Index: -48.8600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.8372
    Cell Significance Index: -48.3100
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -1.8611
    Cell Significance Index: -37.8700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -1.8753
    Cell Significance Index: -32.4300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -1.8867
    Cell Significance Index: -54.3600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -1.9185
    Cell Significance Index: -24.2100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SH3GL3 is a member of the SH3 domain-containing GRB2-like family, characterized by its unique SH3 domain and its ability to interact with various proteins involved in membrane trafficking and signaling. The protein is predominantly expressed in neurons, oligodendrocytes, and certain types of immune cells, such as keratinocytes. Its expression is tightly regulated, and dysregulation of SH3GL3 has been implicated in various neurological and autoimmune disorders. **Pathways and Functions:** SH3GL3 plays a critical role in various cellular pathways, including: 1. **Clathrin-mediated endocytosis:** SH3GL3 regulates the endocytic pathway by interacting with clathrin and other proteins involved in membrane trafficking. 2. **Signaling by receptor tyrosine kinases (RTKs):** SH3GL3 modulates the activity of RTKs, such as EGFR, MET, and NTRK1, which are essential for cell growth, differentiation, and survival. 3. **Infectious disease:** SH3GL3 has been implicated in the entry of Listeria monocytogenes into host cells, highlighting its role in immune responses against bacterial infections. 4. **Neurodevelopment and synaptic function:** SH3GL3 is involved in the regulation of neuronal differentiation, synaptic vesicle uncoating, and postsynaptic density formation, underscoring its importance in neuronal function and development. **Clinical Significance:** Dysregulation of SH3GL3 has been linked to various neurological and autoimmune disorders, including: 1. **Neurodegenerative diseases:** SH3GL3 mutations have been associated with neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 2. **Autoimmune disorders:** SH3GL3 has been implicated in autoimmune diseases, such as multiple sclerosis, rheumatoid arthritis, and lupus, highlighting its role in immune system regulation. 3. **Cancer:** SH3GL3 has been identified as a potential oncogene in certain types of cancer, including breast cancer and glioblastoma. In conclusion, SH3GL3 is a multifaceted gene that plays a critical role in membrane trafficking, signaling, and regulation of neuronal function. Its dysregulation has significant implications for various neurological and autoimmune disorders, highlighting the need for further research into the molecular mechanisms underlying SH3GL3's functions.

Genular Protein ID: 3331856356

Symbol: SH3G3_HUMAN

Name: Endophilin-A3

UniProtKB Accession Codes:

Q99963 O43553 O43554

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 6 RefSeq 8 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9169142

Title: A novel SH3-containing human gene family preferentially expressed in the central nervous system.

PubMed ID: 9169142

DOI: 10.1006/geno.1997.4645

PubMed ID: 9809064

Title: SH3GL3 associates with the Huntingtin exon 1 protein and promotes the formation of polygln-containing protein aggregates.

PubMed ID: 9809064

DOI: 10.1016/s1097-2765(00)80142-2

PubMed ID: 10542231

Title: The SH3 domains of endophilin and amphiphysin bind to the proline-rich region of synaptojanin 1 at distinct sites that display an unconventional binding specificity.

PubMed ID: 10542231

DOI: 10.1074/jbc.274.45.32001

PubMed ID: 15919751

Title: Src homology 3-domain growth factor receptor-bound 2-like (endophilin) interacting protein 1, a novel neuronal protein that regulates energy balance.

PubMed ID: 15919751

DOI: 10.1210/en.2005-0282

PubMed ID: 18602463

Title: Ataxin-2 associates with the endocytosis complex and affects EGF receptor trafficking.

PubMed ID: 18602463

DOI: 10.1016/j.cellsig.2008.05.018

PubMed ID: 19807924

Title: Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.

PubMed ID: 19807924

DOI: 10.1186/1471-2172-10-53

PubMed ID: 19545932

Title: Interaction of SH3P13 and DYDC1 protein: a germ cell component that regulates acrosome biogenesis during spermiogenesis.

PubMed ID: 19545932

DOI: 10.1016/j.ejcb.2009.05.001

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23285027

Title: Bin2 is a membrane sculpting N-BAR protein that influences leucocyte podosomes, motility and phagocytosis.

PubMed ID: 23285027

DOI: 10.1371/journal.pone.0052401

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 347
  • Mass: 39285
  • Checksum: D68DA7B28574C4E6
  • Sequence:
    • MSVAGLKKQF HKASQLFSEK ISGAEGTKLD DEFLDMERKI DVTNKVVAEI LSKTTEYLQP 
NPAYRAKLGM LNTVSKIRGQ VKTTGYPQTE GLLGDCMLKY GKELGEDSTF GNALIEVGES 
MKLMAEVKDS LDINVKQTFI DPLQLLQDKD LKEIGHHLKK LEGRRLDYDY KKKRVGKIPD 
EEVRQAVEKF EESKELAERS MFNFLENDVE QVSQLAVFIE AALDYHRQST EILQELQSKL 
QMRISAASSV PRREYKPRPV KRSSSELNGV STTSVVKTTG SNIPMDQPCC RGLYDFEPEN 
QGELGFKEGD IITLTNQIDE NWYEGMIHGE SGFFPINYVE VIVPLPQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.