Details for: NRXN3

Gene ID: 9369

Symbol: NRXN3

Ensembl ID: ENSG00000021645

Description: neurexin 3

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 7.67
    Marker Score: 259,095
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 7.55
    Marker Score: 40,535
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 7.07
    Marker Score: 8,807
  • Cell Name: granule cell (CL0000120)
    Fold Change: 6.12
    Marker Score: 46,156
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 6.05
    Marker Score: 13,902
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 5.05
    Marker Score: 16,933
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 4.97
    Marker Score: 23,014
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 4.67
    Marker Score: 3,838
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 4.56
    Marker Score: 10,924
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 3.95
    Marker Score: 2,971
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 3.91
    Marker Score: 20,502
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 3.77
    Marker Score: 15,702
  • Cell Name: bipolar neuron (CL0000103)
    Fold Change: 3.48
    Marker Score: 1,171
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 3.27
    Marker Score: 1,039
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 3.19
    Marker Score: 9,089
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 3.11
    Marker Score: 1,813
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 3.05
    Marker Score: 2,008
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 3.04
    Marker Score: 18,246
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 3.03
    Marker Score: 1,596
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 3.03
    Marker Score: 1,164
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.92
    Marker Score: 58,178
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 2.89
    Marker Score: 1,681
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.88
    Marker Score: 22,092
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.86
    Marker Score: 42,830
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 2.86
    Marker Score: 1,375
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 2.81
    Marker Score: 3,508
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 2.79
    Marker Score: 1,458
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.75
    Marker Score: 104,422
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.67
    Marker Score: 4,488
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.62
    Marker Score: 10,858
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.57
    Marker Score: 1,078
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.47
    Marker Score: 2,848
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.46
    Marker Score: 90,713
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.44
    Marker Score: 714
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 2.39
    Marker Score: 865
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.36
    Marker Score: 9,139
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 2.28
    Marker Score: 753
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.21
    Marker Score: 47,181
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.19
    Marker Score: 20,627
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 2.18
    Marker Score: 1,221
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.14
    Marker Score: 1,279
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2.12
    Marker Score: 21,892
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.08
    Marker Score: 127,994
  • Cell Name: neuron (CL0000540)
    Fold Change: 2.01
    Marker Score: 8,189
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.93
    Marker Score: 18,328
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.92
    Marker Score: 526
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.92
    Marker Score: 2,379
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.91
    Marker Score: 3,891
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.88
    Marker Score: 16,137
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.83
    Marker Score: 7,643
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.82
    Marker Score: 1,264
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.75
    Marker Score: 1,550
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.65
    Marker Score: 2,544
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.64
    Marker Score: 983
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.63
    Marker Score: 470
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.61
    Marker Score: 3,791
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.59
    Marker Score: 503
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.59
    Marker Score: 1,157
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 1.57
    Marker Score: 545
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.47
    Marker Score: 3,469
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.47
    Marker Score: 374
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.46
    Marker Score: 3,209
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 1.46
    Marker Score: 14,800
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.45
    Marker Score: 166,903
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.41
    Marker Score: 1,298
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.4
    Marker Score: 1,331
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 860
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.31
    Marker Score: 409
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.3
    Marker Score: 20,286
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 1.29
    Marker Score: 391
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.21
    Marker Score: 2,461
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.19
    Marker Score: 590
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 1.17
    Marker Score: 303
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.15
    Marker Score: 993
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.13
    Marker Score: 979
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 1.13
    Marker Score: 1,083
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.12
    Marker Score: 414
  • Cell Name: T cell (CL0000084)
    Fold Change: 1.06
    Marker Score: 1,831
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.06
    Marker Score: 440
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.05
    Marker Score: 1,903
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.04
    Marker Score: 1,436
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.03
    Marker Score: 16,561
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 786
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.01
    Marker Score: 3,591
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 1.01
    Marker Score: 481
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,769
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,996
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.99
    Marker Score: 457
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.99
    Marker Score: 701
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.99
    Marker Score: 1,900
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,402
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.98
    Marker Score: 4,082
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 502
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 457
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,411
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.94
    Marker Score: 354
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.92
    Marker Score: 1,114
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,730
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5,160
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular Localization:** NRXN3 is expressed in various cell types, including Purkinje cells, stellate neurons, cardiac neurons, granule cells, macroglial cells, and oligodendrocytes. 2. **Protein Structure:** The NRXN3 protein consists of two main domains: the extracellular neurexin domain and the intracellular NRXN3A/B domain. The neurexin domain interacts with neuroligins, while the NRXN3A/B domain interacts with other proteins, including neurexins and synaptic scaffolding proteins. 3. **Interactions:** NRXN3 forms complexes with other proteins, including neurexins, neuroligins, and synaptic scaffolding proteins, to regulate synaptic function and neuronal communication. 4. **Expression Patterns:** NRXN3 expression is highly regulated, with varying levels of expression in different cell types and tissues, suggesting a complex role in neurological and behavioral processes. **Pathways and Functions:** 1. **Neurological Signaling:** NRXN3 is involved in the regulation of neuronal signaling, including the formation and function of synapses, which are critical for neuronal communication. 2. **Axon Guidance:** NRXN3 plays a role in axon guidance, a process essential for the development and maintenance of the nervous system. 3. **Cell Adhesion:** NRXN3 is involved in cell adhesion, a process critical for maintaining tissue structure and function. 4. **Synaptic Plasticity:** NRXN3 regulates synaptic plasticity, a process essential for learning and memory. **Clinical Significance:** Dysregulation of NRXN3 has been implicated in various neurological and psychiatric disorders, including: 1. **Autism Spectrum Disorder (ASD):** Studies have shown that NRXN3 mutations are associated with ASD, highlighting the gene's critical role in social behavior and communication. 2. **Schizophrenia:** NRXN3 has been implicated in schizophrenia, a disorder characterized by disruptions in neuronal communication and synaptic function. 3. **Neurodevelopmental Disorders:** NRXN3 may also play a role in other neurodevelopmental disorders, including attention-deficit/hyperactivity disorder (ADHD) and intellectual disability. In conclusion, NRXN3 is a complex gene involved in various neurological and behavioral processes, including cell adhesion, axon guidance, and synaptic plasticity. Further research is needed to fully understand the mechanisms by which NRXN3 regulates neuronal communication and to uncover its potential therapeutic applications in neurological and psychiatric disorders.

Genular Protein ID: 3726732186

Symbol: NRX3A_HUMAN

Name: Neurexin-3

UniProtKB Accession Codes:

Q9Y4C0 A6NGR4 A7MD34 O95378 Q8IUE3 Q9NS47 Q9P1V3 Q9P1V6 Q9UIE2 Q9UIE3 Q9ULA5 Q9Y486

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 10 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 12 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 13 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 6 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12379233

Title: Identification and characterization of heart-specific splicing of human neurexin 3 mRNA (NRXN3).

PubMed ID: 12379233

DOI: 10.1016/s0006-291x(02)02403-8

PubMed ID: 11944992

Title: Analysis of the human neurexin genes: alternative splicing and the generation of protein diversity.

PubMed ID: 11944992

DOI: 10.1006/geno.2002.6734

PubMed ID: 9872452

Title: Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 9872452

DOI: 10.1093/dnares/5.5.277

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19926856

Title: The synaptic proteins neurexins and neuroligins are widely expressed in the vascular system and contribute to its functions.

PubMed ID: 19926856

DOI: 10.1073/pnas.0809510106

Sequence Information:

  • Length: 1643
  • Mass: 180599
  • Checksum: E7360348E263C6EC
  • Sequence:
    • MSSTLHSVFF TLKVSILLGS LLGLCLGLEF MGLPNQWARY LRWDASTRSD LSFQFKTNVS 
TGLLLYLDDG GVCDFLCLSL VDGRVQLRFS MDCAETAVLS NKQVNDSSWH FLMVSRDRLR 
TVLMLDGEGQ SGELQPQRPY MDVVSDLFLG GVPTDIRPSA LTLDGVQAMP GFKGLILDLK 
YGNSEPRLLG SRGVQMDAEG PCGERPCENG GICFLLDGHP TCDCSTTGYG GKLCSEDVSQ 
DPGLSHLMMS EQAREENVAT FRGSEYLCYD LSQNPIQSSS DEITLSFKTW QRNGLILHTG 
KSADYVNLAL KDGAVSLVIN LGSGAFEAIV EPVNGKFNDN AWHDVKVTRN LRQVTISVDG 
ILTTTGYTQE DYTMLGSDDF FYVGGSPSTA DLPGSPVSNN FMGCLKEVVY KNNDIRLELS 
RLARIADTKM KIYGEVVFKC ENVATLDPIN FETPEAYISL PKWNTKRMGS ISFDFRTTEP 
NGLILFTHGK PQERKDARSQ KNTKVDFFAV ELLDGNLYLL LDMGSGTIKV KATQKKANDG 
EWYHVDIQRD GRSGTISVNS RRTPFTASGE SEILDLEGDM YLGGLPENRA GLILPTELWT 
AMLNYGYVGC IRDLFIDGRS KNIRQLAEMQ NAAGVKSSCS RMSAKQCDSY PCKNNAVCKD 
GWNRFICDCT GTGYWGRTCE REASILSYDG SMYMKIIMPM VMHTEAEDVS FRFMSQRAYG 
LLVATTSRDS ADTLRLELDG GRVKLMVNLD CIRINCNSSK GPETLYAGQK LNDNEWHTVR 
VVRRGKSLKL TVDDDVAEGT MVGDHTRLEF HNIETGIMTE KRYISVVPSS FIGHLQSLMF 
NGLLYIDLCK NGDIDYCELK ARFGLRNIIA DPVTFKTKSS YLSLATLQAY TSMHLFFQFK 
TTSPDGFILF NSGDGNDFIA VELVKGYIHY VFDLGNGPNV IKGNSDRPLN DNQWHNVVIT 
RDNSNTHSLK VDTKVVTQVI NGAKNLDLKG DLYMAGLAQG MYSNLPKLVA SRDGFQGCLA 
SVDLNGRLPD LINDALHRSG QIERGCEGPS TTCQEDSCAN QGVCMQQWEG FTCDCSMTSY 
SGNQCNDPGA TYIFGKSGGL ILYTWPANDR PSTRSDRLAV GFSTTVKDGI LVRIDSAPGL 
GDFLQLHIEQ GKIGVVFNIG TVDISIKEER TPVNDGKYHV VRFTRNGGNA TLQVDNWPVN 
EHYPTGRQLT IFNTQAQIAI GGKDKGRLFQ GQLSGLYYDG LKVLNMAAEN NPNIKINGSV 
RLVGEVPSIL GTTQTTSMPP EMSTTVMETT TTMATTTTRK NRSTASIQPT SDDLVSSAEC 
SSDDEDFVEC EPSTTGGELV IPLLVEDPLA TPPIATRAPS ITLPPTFRPL LTIIETTKDS 
LSMTSEAGLP CLSDQGSDGC DDDGLVISGY GSGETFDSNL PPTDDEDFYT TFSLVTDKSL 
STSIFEGGYK AHAPKWESKD FRPNKVSETS RTTTTSLSPE LIRFTASSSS GMVPKLPAGK 
MNNRDLKPQP DIVLLPLPTA YELDSTKLKS PLITSPMFRN VPTANPTEPG IRRVPGASEV 
IRESSSTTGM VVGIVAAAAL CILILLYAMY KYRNRDEGSY QVDETRNYIS NSAQSNGTLM 
KEKQQSSKSG HKKQKNKDRE YYV

Genular Protein ID: 4075755670

Symbol: NRX3B_HUMAN

Name: Neurexin-3-beta

UniProtKB Accession Codes:

Q9HDB5 A5PKW8 A8MPU5 B3KPM7 Q6NUR0 Q8IUD8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 4 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 HGNC 1 HOGENOM 1 HPA 1 IntAct 1 InterPro 4 KEGG 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 4 Reactome 1 RefSeq 4 SAM 1 SIGNOR 1 SMART 2 SMR 1 SUPFAM 1 SignaLink 1 UCSC 1 UniProtKB 4 VEuPathDB 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 12379233

Title: Identification and characterization of heart-specific splicing of human neurexin 3 mRNA (NRXN3).

PubMed ID: 12379233

DOI: 10.1016/s0006-291x(02)02403-8

PubMed ID: 11944992

Title: Analysis of the human neurexin genes: alternative splicing and the generation of protein diversity.

PubMed ID: 11944992

DOI: 10.1006/geno.2002.6734

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19926856

Title: The synaptic proteins neurexins and neuroligins are widely expressed in the vascular system and contribute to its functions.

PubMed ID: 19926856

DOI: 10.1073/pnas.0809510106

PubMed ID: 21084300

Title: Processing of the synaptic cell adhesion molecule neurexin-3beta by Alzheimer disease alpha- and gamma-secretases.

PubMed ID: 21084300

DOI: 10.1074/jbc.m110.142521

Sequence Information:

  • Length: 637
  • Mass: 69305
  • Checksum: A0F100DA9D72A149
  • Sequence:
    • MHLRIHARRS PPRRPAWTLG IWFLFWGCIV SSVWSSSNVA SSSSTSSSPG SHSQHEHHFH 
GSKHHSVPIS IYRSPVSLRG GHAGATYIFG KSGGLILYTW PANDRPSTRS DRLAVGFSTT 
VKDGILVRID SAPGLGDFLQ LHIEQGKIGV VFNIGTVDIS IKEERTPVND GKYHVVRFTR 
NGGNATLQVD NWPVNEHYPT GRQLTIFNTQ AQIAIGGKDK GRLFQGQLSG LYYDGLKVLN 
MAAENNPNIK INGSVRLVGE VPSILGTTQT TSMPPEMSTT VMETTTTMAT TTTRKNRSTA 
SIQPTSDDLV SSAECSSDDE DFVECEPSTG GELVIPLLVE DPLATPPIAT RAPSITLPPT 
FRPLLTIIET TKDSLSMTSE AGLPCLSDQG SDGCDDDGLV ISGYGSGETF DSNLPPTDDE 
DFYTTFSLVT DKSLSTSIFE GGYKAHAPKW ESKDFRPNKV SETSRTTTTS LSPELIRFTA 
SSSSGMVPKL PAGKMNNRDL KPQPDIVLLP LPTAYELDST KLKSPLITSP MFRNVPTANP 
TEPGIRRVPG ASEVIRESSS TTGMVVGIVA AAALCILILL YAMYKYRNRD EGSYQVDETR 
NYISNSAQSN GTLMKEKQQS SKSGHKKQKN KDREYYV

Genular Protein ID: 1992696126

Symbol: A0A0A0MR89_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0A0MR89

Database IDs:

ARBA 8 Antibodypedia 1 Bgee 1 CDD 2 CTD 1 ChiTaRS 1 EMBL 8 Ensembl 2 ExpressionAtlas 1 GO 9 Gene3D 2 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 5 MANE-Select 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 PANTHER 2 PROSITE 5 PROSITE-ProRule 1 PaxDb 1 PeptideAtlas 2 Pfam 1 Proteomes 2 RefSeq 1 SAM 2 SMART 3 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

Sequence Information:

  • Length: 1571
  • Mass: 173660
  • Checksum: 39ECDE34CF41CD27
  • Sequence:
    • MSSTLHSVFF TLKVSILLGS LLGLCLGLEF MGLPNQWARY LRWDASTRSD LSFQFKTNVS 
TGLLLYLDDG GVCDFLCLSL VDGRVQLRFS MDCAETAVLS NKQVNDSSWH FLMVSRDRLR 
TVLMLDGEGQ SGELQPQRPY MDVVSDLFLG GVPTDIRPSA LTLDGVQAMP GFKGLILDLK 
YGNSEPRLLG SRGVQMDAEG PCGERPCENG GICFLLDGHP TCDCSTTGYG GKLCSEDVSQ 
DPGLSHLMMS EQAREENVAT FRGSEYLCYD LSQNPIQSSS DEITLSFKTW QRNGLILHTG 
KSADYVNLAL KDGAVSLVIN LGSGAFEAIV EPVNGKFNDN AWHDVKVTRN LRQVTISVDG 
ILTTTGYTQE DYTMLGSDDF FYVGGSPSTA DLPGSPVSNN FMGCLKEVVY KNNDIRLELS 
RLARIADTKM KIYGEVVFKC ENVATLDPIN FETPEAYISL PKWNTKRMGS ISFDFRTTEP 
NGLILFTHGK PQERKDARSQ KNTKVDFFAV ELLDGNLYLL LDMGSGTIKV KATQKKANDG 
EWYHVDIQRD GRSGTISVNS RRTPFTASGE SEILDLEGDM YLGGLPENRA GLILPTELWT 
AMLNYGYVGC IRDLFIDGRS KNIRQLAEMQ NAAGVKSSCS RMSAKQCDSY PCKNNAVCKD 
GWNRFICDCT GTGYWGRTCE REASILSYDG SMYMKIIMPM VMHTEAEDVS FRFMSQRAYG 
LLVATTSRDS ADTLRLELDG GRVKLMVNLD CIRINCNSSK GPETLYAGQK LNDNEWHTVR 
VVRRGKSLKL TVDDDVAEGT MVGDHTRLEF HNIETGIMTE KRYISVVPSS FIGHLQSLMF 
NGLLYIDLCK NGDIDYCELK ARFGLRNIIA DPVTFKTKSS YLSLATLQAY TSMHLFFQFK 
TTSPDGFILF NSGDGNDFIA VELVKGYIHY VFDLGNGPNV IKGNSDRPLN DNQWHNVVIT 
RDNSNTHSLK VDTKVVTQVI NGAKNLDLKG DLYMAGLAQG MYSNLPKLVA SRDGFQGCLA 
SVDLNGRLPD LINDALHRSG QIERGCEGPS TTCQEDSCAN QGVCMQQWEG FTCDCSMTSY 
SGNQCNDPGA TYIFGKSGGL ILYTWPANDR PSTRSDRLAV GFSTTVKDGI LVRIDSAPGL 
GDFLQLHIEQ GKIGVVFNIG TVDISIKEER TPVNDGKYHV VRFTRNGGNA TLQVDNWPVN 
EHYPTGNTDN ERFQMVKQKI PFKYNRPVEE WLQEKGRQLT IFNTQAQIAI GGKDKGRLFQ 
GQLSGLYYDG LKVLNMAAEN NPNIKINGSV RLVGEVPSIL GTTQTTSMPP EMSTTVMETT 
TTMATTTTRK NRSTASIQPT SDDLVSSAEC SSDDEDFVEC EPSTDKSLST SIFEGGYKAH 
APKWESKDFR PNKVSETSRT TTTSLSPELI RFTASSSSGM VPKLPAGKMN NRDLKPQPDI 
VLLPLPTAYE LDSTKLKSPL ITSPMFRNVP TANPTEPGIR RVPGASEVIR ESSSTTGMVV 
GIVAAAALCI LILLYAMYKY RNRDEGSYQV DETRNYISNS AQSNGTLMKE KQQSSKSGHK 
KQKNKDREYY V

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.