Details for: NRXN3

Gene ID: 9369

Symbol: NRXN3

Ensembl ID: ENSG00000021645

Description: neurexin 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 459.7794
    Cell Significance Index: -116.6200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 237.7031
    Cell Significance Index: -112.2300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 94.5776
    Cell Significance Index: -116.6100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 29.5359
    Cell Significance Index: -116.5500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 23.2844
    Cell Significance Index: -50.9600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 12.2544
    Cell Significance Index: 210.0100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 10.6286
    Cell Significance Index: 3812.3000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 8.0871
    Cell Significance Index: 357.7100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 7.9828
    Cell Significance Index: 536.7700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 7.8740
    Cell Significance Index: 298.1700
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 7.5198
    Cell Significance Index: 97.5200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 5.9046
    Cell Significance Index: 4083.8400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 4.6859
    Cell Significance Index: 133.7200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 4.2292
    Cell Significance Index: 92.6100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 4.1922
    Cell Significance Index: 840.9500
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 3.7407
    Cell Significance Index: 49.9000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 3.1328
    Cell Significance Index: 175.8000
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 3.1068
    Cell Significance Index: 47.2700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 3.0882
    Cell Significance Index: 1961.3100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.4030
    Cell Significance Index: 476.8800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.5497
    Cell Significance Index: 95.2500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.4648
    Cell Significance Index: 35.1300
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.3635
    Cell Significance Index: 10.5100
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.4290
    Cell Significance Index: 5.2000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3537
    Cell Significance Index: 665.9600
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.2117
    Cell Significance Index: 2.6400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1985
    Cell Significance Index: 179.2400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.1891
    Cell Significance Index: 2.0600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1370
    Cell Significance Index: 24.6900
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.0895
    Cell Significance Index: 1.1300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.0657
    Cell Significance Index: 1.3000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0091
    Cell Significance Index: 4.1300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0051
    Cell Significance Index: -9.3800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0126
    Cell Significance Index: -19.4500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0417
    Cell Significance Index: -56.6500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0787
    Cell Significance Index: -1.5800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0928
    Cell Significance Index: -11.4200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1211
    Cell Significance Index: -89.7200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1281
    Cell Significance Index: -4.5000
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.1324
    Cell Significance Index: -1.2600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.1406
    Cell Significance Index: -76.7700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.1452
    Cell Significance Index: -106.4800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1541
    Cell Significance Index: -22.4000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.1659
    Cell Significance Index: -125.5500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2005
    Cell Significance Index: -113.0600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.2052
    Cell Significance Index: -39.0600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.2127
    Cell Significance Index: -132.8300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.2638
    Cell Significance Index: -116.6300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.3182
    Cell Significance Index: -51.7500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3353
    Cell Significance Index: -96.4800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3491
    Cell Significance Index: -5.0000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.4494
    Cell Significance Index: -44.4600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.4804
    Cell Significance Index: -82.0300
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.5332
    Cell Significance Index: -6.7300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5357
    Cell Significance Index: -11.3700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.5432
    Cell Significance Index: -11.6100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.5686
    Cell Significance Index: -119.7600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.7020
    Cell Significance Index: -76.3500
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.7029
    Cell Significance Index: -8.2000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.7067
    Cell Significance Index: -18.8700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.7225
    Cell Significance Index: -73.8000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.7279
    Cell Significance Index: -99.9700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.7397
    Cell Significance Index: -86.2000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.7639
    Cell Significance Index: -79.5400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.8003
    Cell Significance Index: -34.8000
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.8465
    Cell Significance Index: -9.3400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.8523
    Cell Significance Index: -44.7500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.8556
    Cell Significance Index: -110.5400
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.8931
    Cell Significance Index: -10.6800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.9416
    Cell Significance Index: -27.1300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.9444
    Cell Significance Index: -42.8100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.9720
    Cell Significance Index: -111.3600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.9754
    Cell Significance Index: -115.0300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.0579
    Cell Significance Index: -81.1800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.0999
    Cell Significance Index: -35.0300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.2578
    Cell Significance Index: -41.1800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.2742
    Cell Significance Index: -66.1900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -1.2998
    Cell Significance Index: -89.8900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -1.3093
    Cell Significance Index: -16.2400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.3557
    Cell Significance Index: -83.1200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -1.3661
    Cell Significance Index: -175.1200
  • Cell Name: flat midget bipolar cell (CL4033033)
    Fold Change: -1.4433
    Cell Significance Index: -17.9400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -1.4496
    Cell Significance Index: -108.0400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.4581
    Cell Significance Index: -40.7500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -1.4652
    Cell Significance Index: -87.9600
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -1.4731
    Cell Significance Index: -15.3500
  • Cell Name: neuron (CL0000540)
    Fold Change: -1.4785
    Cell Significance Index: -14.0200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.6510
    Cell Significance Index: -41.2700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -1.6544
    Cell Significance Index: -86.1800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.7590
    Cell Significance Index: -61.6200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -1.7646
    Cell Significance Index: -113.8400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -1.8463
    Cell Significance Index: -39.8900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.8813
    Cell Significance Index: -60.2600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -1.9756
    Cell Significance Index: -49.2800
  • Cell Name: medial ganglionic eminence derived GABAergic cortical interneuron (CL4023069)
    Fold Change: -2.0068
    Cell Significance Index: -18.9600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -2.0222
    Cell Significance Index: -127.4500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -2.0816
    Cell Significance Index: -43.1800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -2.1312
    Cell Significance Index: -44.4800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -2.2135
    Cell Significance Index: -104.0300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -2.5711
    Cell Significance Index: -51.2700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular Localization:** NRXN3 is expressed in various cell types, including Purkinje cells, stellate neurons, cardiac neurons, granule cells, macroglial cells, and oligodendrocytes. 2. **Protein Structure:** The NRXN3 protein consists of two main domains: the extracellular neurexin domain and the intracellular NRXN3A/B domain. The neurexin domain interacts with neuroligins, while the NRXN3A/B domain interacts with other proteins, including neurexins and synaptic scaffolding proteins. 3. **Interactions:** NRXN3 forms complexes with other proteins, including neurexins, neuroligins, and synaptic scaffolding proteins, to regulate synaptic function and neuronal communication. 4. **Expression Patterns:** NRXN3 expression is highly regulated, with varying levels of expression in different cell types and tissues, suggesting a complex role in neurological and behavioral processes. **Pathways and Functions:** 1. **Neurological Signaling:** NRXN3 is involved in the regulation of neuronal signaling, including the formation and function of synapses, which are critical for neuronal communication. 2. **Axon Guidance:** NRXN3 plays a role in axon guidance, a process essential for the development and maintenance of the nervous system. 3. **Cell Adhesion:** NRXN3 is involved in cell adhesion, a process critical for maintaining tissue structure and function. 4. **Synaptic Plasticity:** NRXN3 regulates synaptic plasticity, a process essential for learning and memory. **Clinical Significance:** Dysregulation of NRXN3 has been implicated in various neurological and psychiatric disorders, including: 1. **Autism Spectrum Disorder (ASD):** Studies have shown that NRXN3 mutations are associated with ASD, highlighting the gene's critical role in social behavior and communication. 2. **Schizophrenia:** NRXN3 has been implicated in schizophrenia, a disorder characterized by disruptions in neuronal communication and synaptic function. 3. **Neurodevelopmental Disorders:** NRXN3 may also play a role in other neurodevelopmental disorders, including attention-deficit/hyperactivity disorder (ADHD) and intellectual disability. In conclusion, NRXN3 is a complex gene involved in various neurological and behavioral processes, including cell adhesion, axon guidance, and synaptic plasticity. Further research is needed to fully understand the mechanisms by which NRXN3 regulates neuronal communication and to uncover its potential therapeutic applications in neurological and psychiatric disorders.

Genular Protein ID: 3726732186

Symbol: NRX3A_HUMAN

Name: Neurexin-3

UniProtKB Accession Codes:

Q9Y4C0 A6NGR4 A7MD34 O95378 Q8IUE3 Q9NS47 Q9P1V3 Q9P1V6 Q9UIE2 Q9UIE3 Q9ULA5 Q9Y486

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 10 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 12 Ensembl 2 ExpressionAtlas 1 GO 13 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 MIM 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PROSITE 3 PathwayCommons 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12379233

Title: Identification and characterization of heart-specific splicing of human neurexin 3 mRNA (NRXN3).

PubMed ID: 12379233

DOI: 10.1016/s0006-291x(02)02403-8

PubMed ID: 11944992

Title: Analysis of the human neurexin genes: alternative splicing and the generation of protein diversity.

PubMed ID: 11944992

DOI: 10.1006/geno.2002.6734

PubMed ID: 9872452

Title: Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 9872452

DOI: 10.1093/dnares/5.5.277

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19926856

Title: The synaptic proteins neurexins and neuroligins are widely expressed in the vascular system and contribute to its functions.

PubMed ID: 19926856

DOI: 10.1073/pnas.0809510106

Sequence Information:

  • Length: 1643
  • Mass: 180599
  • Checksum: E7360348E263C6EC
  • Sequence:
    • MSSTLHSVFF TLKVSILLGS LLGLCLGLEF MGLPNQWARY LRWDASTRSD LSFQFKTNVS 
TGLLLYLDDG GVCDFLCLSL VDGRVQLRFS MDCAETAVLS NKQVNDSSWH FLMVSRDRLR 
TVLMLDGEGQ SGELQPQRPY MDVVSDLFLG GVPTDIRPSA LTLDGVQAMP GFKGLILDLK 
YGNSEPRLLG SRGVQMDAEG PCGERPCENG GICFLLDGHP TCDCSTTGYG GKLCSEDVSQ 
DPGLSHLMMS EQAREENVAT FRGSEYLCYD LSQNPIQSSS DEITLSFKTW QRNGLILHTG 
KSADYVNLAL KDGAVSLVIN LGSGAFEAIV EPVNGKFNDN AWHDVKVTRN LRQVTISVDG 
ILTTTGYTQE DYTMLGSDDF FYVGGSPSTA DLPGSPVSNN FMGCLKEVVY KNNDIRLELS 
RLARIADTKM KIYGEVVFKC ENVATLDPIN FETPEAYISL PKWNTKRMGS ISFDFRTTEP 
NGLILFTHGK PQERKDARSQ KNTKVDFFAV ELLDGNLYLL LDMGSGTIKV KATQKKANDG 
EWYHVDIQRD GRSGTISVNS RRTPFTASGE SEILDLEGDM YLGGLPENRA GLILPTELWT 
AMLNYGYVGC IRDLFIDGRS KNIRQLAEMQ NAAGVKSSCS RMSAKQCDSY PCKNNAVCKD 
GWNRFICDCT GTGYWGRTCE REASILSYDG SMYMKIIMPM VMHTEAEDVS FRFMSQRAYG 
LLVATTSRDS ADTLRLELDG GRVKLMVNLD CIRINCNSSK GPETLYAGQK LNDNEWHTVR 
VVRRGKSLKL TVDDDVAEGT MVGDHTRLEF HNIETGIMTE KRYISVVPSS FIGHLQSLMF 
NGLLYIDLCK NGDIDYCELK ARFGLRNIIA DPVTFKTKSS YLSLATLQAY TSMHLFFQFK 
TTSPDGFILF NSGDGNDFIA VELVKGYIHY VFDLGNGPNV IKGNSDRPLN DNQWHNVVIT 
RDNSNTHSLK VDTKVVTQVI NGAKNLDLKG DLYMAGLAQG MYSNLPKLVA SRDGFQGCLA 
SVDLNGRLPD LINDALHRSG QIERGCEGPS TTCQEDSCAN QGVCMQQWEG FTCDCSMTSY 
SGNQCNDPGA TYIFGKSGGL ILYTWPANDR PSTRSDRLAV GFSTTVKDGI LVRIDSAPGL 
GDFLQLHIEQ GKIGVVFNIG TVDISIKEER TPVNDGKYHV VRFTRNGGNA TLQVDNWPVN 
EHYPTGRQLT IFNTQAQIAI GGKDKGRLFQ GQLSGLYYDG LKVLNMAAEN NPNIKINGSV 
RLVGEVPSIL GTTQTTSMPP EMSTTVMETT TTMATTTTRK NRSTASIQPT SDDLVSSAEC 
SSDDEDFVEC EPSTTGGELV IPLLVEDPLA TPPIATRAPS ITLPPTFRPL LTIIETTKDS 
LSMTSEAGLP CLSDQGSDGC DDDGLVISGY GSGETFDSNL PPTDDEDFYT TFSLVTDKSL 
STSIFEGGYK AHAPKWESKD FRPNKVSETS RTTTTSLSPE LIRFTASSSS GMVPKLPAGK 
MNNRDLKPQP DIVLLPLPTA YELDSTKLKS PLITSPMFRN VPTANPTEPG IRRVPGASEV 
IRESSSTTGM VVGIVAAAAL CILILLYAMY KYRNRDEGSY QVDETRNYIS NSAQSNGTLM 
KEKQQSSKSG HKKQKNKDRE YYV

Genular Protein ID: 4075755670

Symbol: NRX3B_HUMAN

Name: Neurexin-3-beta

UniProtKB Accession Codes:

Q9HDB5 A5PKW8 A8MPU5 B3KPM7 Q6NUR0 Q8IUD8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 4 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 Ensembl 3 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 HGNC 1 HOGENOM 1 HPA 1 IntAct 1 InterPro 5 KEGG 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PROSITE 1 PathwayCommons 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 4 Reactome 1 RefSeq 4 SIGNOR 1 SMART 2 SMR 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 12379233

Title: Identification and characterization of heart-specific splicing of human neurexin 3 mRNA (NRXN3).

PubMed ID: 12379233

DOI: 10.1016/s0006-291x(02)02403-8

PubMed ID: 11944992

Title: Analysis of the human neurexin genes: alternative splicing and the generation of protein diversity.

PubMed ID: 11944992

DOI: 10.1006/geno.2002.6734

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19926856

Title: The synaptic proteins neurexins and neuroligins are widely expressed in the vascular system and contribute to its functions.

PubMed ID: 19926856

DOI: 10.1073/pnas.0809510106

PubMed ID: 21084300

Title: Processing of the synaptic cell adhesion molecule neurexin-3beta by Alzheimer disease alpha- and gamma-secretases.

PubMed ID: 21084300

DOI: 10.1074/jbc.m110.142521

Sequence Information:

  • Length: 637
  • Mass: 69305
  • Checksum: A0F100DA9D72A149
  • Sequence:
    • MHLRIHARRS PPRRPAWTLG IWFLFWGCIV SSVWSSSNVA SSSSTSSSPG SHSQHEHHFH 
GSKHHSVPIS IYRSPVSLRG GHAGATYIFG KSGGLILYTW PANDRPSTRS DRLAVGFSTT 
VKDGILVRID SAPGLGDFLQ LHIEQGKIGV VFNIGTVDIS IKEERTPVND GKYHVVRFTR 
NGGNATLQVD NWPVNEHYPT GRQLTIFNTQ AQIAIGGKDK GRLFQGQLSG LYYDGLKVLN 
MAAENNPNIK INGSVRLVGE VPSILGTTQT TSMPPEMSTT VMETTTTMAT TTTRKNRSTA 
SIQPTSDDLV SSAECSSDDE DFVECEPSTG GELVIPLLVE DPLATPPIAT RAPSITLPPT 
FRPLLTIIET TKDSLSMTSE AGLPCLSDQG SDGCDDDGLV ISGYGSGETF DSNLPPTDDE 
DFYTTFSLVT DKSLSTSIFE GGYKAHAPKW ESKDFRPNKV SETSRTTTTS LSPELIRFTA 
SSSSGMVPKL PAGKMNNRDL KPQPDIVLLP LPTAYELDST KLKSPLITSP MFRNVPTANP 
TEPGIRRVPG ASEVIRESSS TTGMVVGIVA AAALCILILL YAMYKYRNRD EGSYQVDETR 
NYISNSAQSN GTLMKEKQQS SKSGHKKQKN KDREYYV

Genular Protein ID: 1992696126

Symbol: A0A0A0MR89_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0A0MR89

Database IDs:

ARBA 8 Antibodypedia 1 Bgee 1 CDD 2 CTD 1 ChiTaRS 1 DisGeNET 1 EMBL 8 Ensembl 2 ExpressionAtlas 1 GO 9 Gene3D 2 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 6 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 PANTHER 2 PROSITE 5 PROSITE-ProRule 1 PaxDb 1 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 2 SMART 3 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 1571
  • Mass: 173660
  • Checksum: 39ECDE34CF41CD27
  • Sequence:
    • MSSTLHSVFF TLKVSILLGS LLGLCLGLEF MGLPNQWARY LRWDASTRSD LSFQFKTNVS 
TGLLLYLDDG GVCDFLCLSL VDGRVQLRFS MDCAETAVLS NKQVNDSSWH FLMVSRDRLR 
TVLMLDGEGQ SGELQPQRPY MDVVSDLFLG GVPTDIRPSA LTLDGVQAMP GFKGLILDLK 
YGNSEPRLLG SRGVQMDAEG PCGERPCENG GICFLLDGHP TCDCSTTGYG GKLCSEDVSQ 
DPGLSHLMMS EQAREENVAT FRGSEYLCYD LSQNPIQSSS DEITLSFKTW QRNGLILHTG 
KSADYVNLAL KDGAVSLVIN LGSGAFEAIV EPVNGKFNDN AWHDVKVTRN LRQVTISVDG 
ILTTTGYTQE DYTMLGSDDF FYVGGSPSTA DLPGSPVSNN FMGCLKEVVY KNNDIRLELS 
RLARIADTKM KIYGEVVFKC ENVATLDPIN FETPEAYISL PKWNTKRMGS ISFDFRTTEP 
NGLILFTHGK PQERKDARSQ KNTKVDFFAV ELLDGNLYLL LDMGSGTIKV KATQKKANDG 
EWYHVDIQRD GRSGTISVNS RRTPFTASGE SEILDLEGDM YLGGLPENRA GLILPTELWT 
AMLNYGYVGC IRDLFIDGRS KNIRQLAEMQ NAAGVKSSCS RMSAKQCDSY PCKNNAVCKD 
GWNRFICDCT GTGYWGRTCE REASILSYDG SMYMKIIMPM VMHTEAEDVS FRFMSQRAYG 
LLVATTSRDS ADTLRLELDG GRVKLMVNLD CIRINCNSSK GPETLYAGQK LNDNEWHTVR 
VVRRGKSLKL TVDDDVAEGT MVGDHTRLEF HNIETGIMTE KRYISVVPSS FIGHLQSLMF 
NGLLYIDLCK NGDIDYCELK ARFGLRNIIA DPVTFKTKSS YLSLATLQAY TSMHLFFQFK 
TTSPDGFILF NSGDGNDFIA VELVKGYIHY VFDLGNGPNV IKGNSDRPLN DNQWHNVVIT 
RDNSNTHSLK VDTKVVTQVI NGAKNLDLKG DLYMAGLAQG MYSNLPKLVA SRDGFQGCLA 
SVDLNGRLPD LINDALHRSG QIERGCEGPS TTCQEDSCAN QGVCMQQWEG FTCDCSMTSY 
SGNQCNDPGA TYIFGKSGGL ILYTWPANDR PSTRSDRLAV GFSTTVKDGI LVRIDSAPGL 
GDFLQLHIEQ GKIGVVFNIG TVDISIKEER TPVNDGKYHV VRFTRNGGNA TLQVDNWPVN 
EHYPTGNTDN ERFQMVKQKI PFKYNRPVEE WLQEKGRQLT IFNTQAQIAI GGKDKGRLFQ 
GQLSGLYYDG LKVLNMAAEN NPNIKINGSV RLVGEVPSIL GTTQTTSMPP EMSTTVMETT 
TTMATTTTRK NRSTASIQPT SDDLVSSAEC SSDDEDFVEC EPSTDKSLST SIFEGGYKAH 
APKWESKDFR PNKVSETSRT TTTSLSPELI RFTASSSSGM VPKLPAGKMN NRDLKPQPDI 
VLLPLPTAYE LDSTKLKSPL ITSPMFRNVP TANPTEPGIR RVPGASEVIR ESSSTTGMVV 
GIVAAAALCI LILLYAMYKY RNRDEGSYQV DETRNYISNS AQSNGTLMKE KQQSSKSGHK 
KQKNKDREYY V

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.