Details for: NRXN3

Gene ID: 9369

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: NRXN3

Ensembl ID: ENSG00000021645

Description: neurexin 3

Cell Significance Landscape

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • VIP GABAergic cortical interneuron CL4023016
    CSI 56.13
    rCSI 67.05%
    PRS 97.19
  • cerebellar granule cell CL0001031
    CSI 55.84
    rCSI 82.08%
    PRS 97.62
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 54.38
    rCSI 67.65%
    PRS 96.84
  • sst GABAergic cortical interneuron CL4023017
    CSI 50.61
    rCSI 65.25%
    PRS 97.55
  • retinal bipolar neuron CL0000748
    CSI 47.9
    rCSI 89.71%
    PRS 97.43
  • interneuron CL0000099
    CSI 42.12
    rCSI 84.57%
    PRS 98.22
  • inhibitory interneuron CL0000498
    CSI 41.32
    rCSI 95.37%
    PRS 97.29
  • sncg GABAergic cortical interneuron CL4023015
    CSI 39.5
    rCSI 63.53%
    PRS 97.04
  • Bergmann glial cell CL0000644
    CSI 35.62
    rCSI 48.74%
    PRS 97.67
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 34.34
    rCSI 57.64%
    PRS 97.56
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 31.11
    rCSI 54.94%
    PRS 97.31
  • glycinergic amacrine cell CL4030028
    CSI 30.36
    rCSI 79.09%
    PRS 96.85
  • L2/3 intratelencephalic projecting glutamatergic neuron CL4030059
    CSI 30.2
    rCSI 65.52%
    PRS 95.4
  • neuron CL0000540
    CSI 29.73
    rCSI 79.17%
    PRS 95.22
  • neural crest cell CL0011012
    CSI 29.11
    rCSI 23.01%
    PRS 98.76
  • choroid plexus epithelial cell CL0000706
    CSI 29.04
    rCSI 47.56%
    PRS 97.95
  • L4 intratelencephalic projecting glutamatergic neuron CL4030063
    CSI 28.2
    rCSI 67.45%
    PRS 96.2
  • neural cell CL0002319
    CSI 27.7
    rCSI 100%
    PRS 95.28
  • adipocyte CL0000136
    CSI 27.42
    rCSI 35.2%
    PRS 97.88
  • cardiac neuron CL0010022
    CSI 27.26
    rCSI 87.23%
    PRS 98.93
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 25.29
    rCSI 61.46%
    PRS 96.29
  • rod bipolar cell CL0000751
    CSI 22.08
    rCSI 39.67%
    PRS 97.92
  • differentiation-committed oligodendrocyte precursor CL4023059
    CSI 21.84
    rCSI 39.68%
    PRS 97.58
  • cerebral cortex endothelial cell CL1001602
    CSI 21.1
    rCSI 36.5%
    PRS 98.18
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 20.78
    rCSI 64.99%
    PRS 97.54
  • glutamatergic neuron CL0000679
    CSI 20.76
    rCSI 42.66%
    PRS 95.25
  • melanocyte CL0000148
    CSI 20.33
    rCSI 15.06%
    PRS 98.58
  • oligodendrocyte CL0000128
    CSI 20.33
    rCSI 60.08%
    PRS 96.04
  • L5/6 near-projecting glutamatergic neuron CL4030067
    CSI 20.29
    rCSI 66.67%
    PRS 95.78
  • oligodendrocyte precursor cell CL0002453
    CSI 19.69
    rCSI 43.32%
    PRS 93.48
  • amacrine cell CL0000561
    CSI 18.97
    rCSI 54.97%
    PRS 97.22
  • vascular leptomeningeal cell CL4023051
    CSI 18.94
    rCSI 33.21%
    PRS 98.28
  • L6b glutamatergic cortical neuron CL4023038
    CSI 18.75
    rCSI 58.61%
    PRS 97.18
  • glioblast CL0000030
    CSI 18.46
    rCSI 29.44%
    PRS 97.73
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 17.18
    rCSI 61.83%
    PRS 96.67
  • Schwann cell CL0002573
    CSI 17.12
    rCSI 48.66%
    PRS 98.29
  • renal interstitial pericyte CL1001318
    CSI 17
    rCSI 46.85%
    PRS 98.98
  • macroglial cell CL0000126
    CSI 16.67
    rCSI 42.86%
    PRS 97.99
  • retinal cone cell CL0000573
    CSI 16.43
    rCSI 26.44%
    PRS 97.33
  • basket cell CL0000118
    CSI 15.96
    rCSI 100%
    PRS 92.67
  • conjunctival epithelial cell CL1000432
    CSI 15.77
    rCSI 24.08%
    PRS 98.99
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 15.75
    rCSI 59.52%
    PRS 96.66
  • chondrocyte CL0000138
    CSI 15.62
    rCSI 24.84%
    PRS 98.12
  • H1 horizontal cell CL0004217
    CSI 15.59
    rCSI 61.75%
    PRS 96.95
  • GABAergic neuron CL0000617
    CSI 15.5
    rCSI 51.92%
    PRS 95.1
  • serotonergic neuron CL0000850
    CSI 15.28
    rCSI 68.24%
    PRS 94.47
  • pulmonary alveolar type 2 cell CL0002063
    CSI 15.21
    rCSI 23.6%
    PRS 99.13
  • OFFx cell CL4033036
    CSI 15
    rCSI 70.56%
    PRS 95.11
  • neuroblast (sensu Vertebrata) CL0000031
    CSI 14.95
    rCSI 19.19%
    PRS 98.43
  • cerebral cortex neuron CL0010012
    CSI 14.78
    rCSI 60.23%
    PRS 96.88
  • retinal ganglion cell CL0000740
    CSI 14.74
    rCSI 32.57%
    PRS 97.12
  • ciliated epithelial cell CL0000067
    CSI 14.62
    rCSI 12.86%
    PRS 97.45
  • lung secretory cell CL1000272
    CSI 14.48
    rCSI 35.83%
    PRS 99.57
  • epithelial cell of proximal tubule CL0002306
    CSI 14.42
    rCSI 35.22%
    PRS 97.5
  • dopaminergic neuron CL0000700
    CSI 13.96
    rCSI 78.91%
    PRS 96.37
  • diffuse bipolar 6 cell CL4033032
    CSI 13.56
    rCSI 71.32%
    PRS 95.24
  • enteric smooth muscle cell CL0002504
    CSI 13.52
    rCSI 19.3%
    PRS 99.36
  • Mueller cell CL0000636
    CSI 13.18
    rCSI 30.08%
    PRS 97.89
  • hepatic stellate cell CL0000632
    CSI 12.8
    rCSI 47.94%
    PRS 98.93
  • fibroblast of lung CL0002553
    CSI 12.75
    rCSI 11.86%
    PRS 99.64
  • S cone cell CL0003050
    CSI 12.5
    rCSI 54.91%
    PRS 98.02
  • GABAergic amacrine cell CL4030027
    CSI 12.43
    rCSI 42.59%
    PRS 95.53
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 11.89
    rCSI 13.73%
    PRS 97.73
  • tracheobronchial smooth muscle cell CL0019019
    CSI 11.83
    rCSI 20.87%
    PRS 99.48
  • astrocyte of the cerebral cortex CL0002605
    CSI 11.83
    rCSI 26.52%
    PRS 97.34
  • H2 horizontal cell CL0004218
    CSI 11.67
    rCSI 58.02%
    PRS 97.27
  • enteroglial cell CL4040002
    CSI 11.66
    rCSI 61.28%
    PRS 98.97
  • ependymal cell CL0000065
    CSI 11.42
    rCSI 23.17%
    PRS 95.13
  • podocyte CL0000653
    CSI 11.35
    rCSI 50.45%
    PRS 99.02
  • endocardial cell CL0002350
    CSI 11.08
    rCSI 53.02%
    PRS 98.65
  • invaginating midget bipolar cell CL4033034
    CSI 11.03
    rCSI 65.15%
    PRS 95.74
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 10.85
    rCSI 15.38%
    PRS 98.88
  • mature astrocyte CL0002627
    CSI 10.82
    rCSI 45.99%
    PRS 97.58
  • diffuse bipolar 3b cell CL4033030
    CSI 10.68
    rCSI 70.86%
    PRS 96.2
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 10.34
    rCSI 60.91%
    PRS 96.73
  • mature microglial cell CL0002629
    CSI 10.31
    rCSI 42.83%
    PRS 97.82
  • stem cell CL0000034
    CSI 10.14
    rCSI 9.78%
    PRS 99.07
  • epithelial cell of lower respiratory tract CL0002632
    CSI 10.09
    rCSI 7.82%
    PRS 99.66
  • flat midget bipolar cell CL4033033
    CSI 10.04
    rCSI 71.77%
    PRS 95.55
  • diffuse bipolar 3a cell CL4033029
    CSI 9.89
    rCSI 67.33%
    PRS 95.93
  • cerebral cortex GABAergic interneuron CL0010011
    CSI 9.87
    rCSI 29.15%
    PRS 99.2
  • parietal epithelial cell CL1000452
    CSI 9.77
    rCSI 26.12%
    PRS 98.51
  • OFF-bipolar cell CL0000750
    CSI 9.59
    rCSI 13.11%
    PRS 98.3
  • brush cell of tracheobronchial tree CL0002075
    CSI 9.53
    rCSI 28.27%
    PRS 99.79
  • glial cell CL0000125
    CSI 9.42
    rCSI 35.86%
    PRS 97.31
  • diffuse bipolar 1 cell CL4033027
    CSI 9.41
    rCSI 70.72%
    PRS 94.93
  • retinal rod cell CL0000604
    CSI 9.38
    rCSI 16.53%
    PRS 97.94
  • diffuse bipolar 2 cell CL4033028
    CSI 9.14
    rCSI 70.84%
    PRS 95.88
  • kidney collecting duct intercalated cell CL1001432
    CSI 9.01
    rCSI 64.33%
    PRS 97.53
  • lung ciliated cell CL1000271
    CSI 8.24
    rCSI 9.53%
    PRS 98.1
  • central nervous system neuron CL2000029
    CSI 8.1
    rCSI 59.56%
    PRS 97.57
  • renal alpha-intercalated cell CL0005011
    CSI 7.93
    rCSI 10.6%
    PRS 99.39
  • mesangial cell CL0000650
    CSI 7.91
    rCSI 32.24%
    PRS 99.39
  • starburst amacrine cell CL0004232
    CSI 7.85
    rCSI 66.06%
    PRS 94.23
  • ciliated columnar cell of tracheobronchial tree CL0002145
    CSI 7.74
    rCSI 17.64%
    PRS 97.25
  • cerebellar neuron CL1001611
    CSI 7.73
    rCSI 68.07%
    PRS 95.14
  • neural progenitor cell CL0011020
    CSI 7.65
    rCSI 33.66%
    PRS 95.54
  • medium spiny neuron CL1001474
    CSI 7.48
    rCSI 64.44%
    PRS 97.05
  • fibroblast of cardiac tissue CL0002548
    CSI 7.43
    rCSI 35.6%
    PRS 99.44
  • pulmonary alveolar type 1 cell CL0002062
    CSI 7.16
    rCSI 41.26%
    PRS 98.6
  • pancreatic ductal cell CL0002079
    CSI 1.7
    rCSI 3.2%
    PRS 99.0%
  • cone retinal bipolar cell CL0000752
    CSI 2.0
    rCSI 26.1%
    PRS 97.2%
  • indirect pathway medium spiny neuron CL4023029
    CSI 2.5
    rCSI 59.3%
    PRS 95.5%
  • direct pathway medium spiny neuron CL4023026
    CSI 2.5
    rCSI 59.6%
    PRS 95.7%
  • ON midget ganglion cell CL4033046
    CSI 2.7
    rCSI 54.7%
    PRS 96.8%
  • corneal epithelial cell CL0000575
    CSI 2.7
    rCSI 7.7%
    PRS 99.2%
  • OFF midget ganglion cell CL4033047
    CSI 2.7
    rCSI 55.2%
    PRS 96.7%
  • basal cell of epidermis CL0002187
    CSI 2.7
    rCSI 4.8%
    PRS 88.4%
  • non-myelinating Schwann cell CL0002376
    CSI 2.8
    rCSI 70.1%
    PRS 100.0%
  • cardiac blood vessel endothelial cell CL0010006
    CSI 2.9
    rCSI 20.3%
    PRS 98.6%
  • midbrain dopaminergic neuron CL2000097
    CSI 2.9
    rCSI 18.7%
    PRS 96.8%
  • airway submucosal gland duct basal cell CL4033024
    CSI 3.7
    rCSI 23.4%
    PRS 99.5%
  • lung pericyte CL0009089
    CSI 3.9
    rCSI 10.4%
    PRS 99.6%
  • ON parasol ganglion cell CL4033052
    CSI 4.0
    rCSI 56.1%
    PRS 96.7%
  • retinal pigment epithelial cell CL0002586
    CSI 4.0
    rCSI 8.0%
    PRS 98.3%
  • regular atrial cardiac myocyte CL0002129
    CSI 4.5
    rCSI 14.5%
    PRS 98.1%
  • suprabasal keratinocyte CL4033013
    CSI 4.6
    rCSI 7.5%
    PRS 90.4%
  • renal beta-intercalated cell CL0002201
    CSI 4.8
    rCSI 11.4%
    PRS 99.2%
  • respiratory suprabasal cell CL4033048
    CSI 4.8
    rCSI 6.2%
    PRS 99.6%
  • brain vascular cell CL4023072
    CSI 4.9
    rCSI 50.7%
    PRS 97.1%
  • blood vessel smooth muscle cell CL0019018
    CSI 5.0
    rCSI 40.2%
    PRS 99.1%
  • kidney distal convoluted tubule epithelial cell CL1000849
    CSI 5.1
    rCSI 53.8%
    PRS 98.2%
  • ON-bipolar cell CL0000749
    CSI 5.6
    rCSI 8.3%
    PRS 98.4%
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 5.7
    rCSI 14.7%
    PRS 99.0%
  • diffuse bipolar 4 cell CL4033031
    CSI 5.7
    rCSI 65.5%
    PRS 93.5%
  • placental villous trophoblast CL2000060
    CSI 6.0
    rCSI 9.2%
    PRS 98.7%
  • bronchus fibroblast of lung CL2000093
    CSI 6.0
    rCSI 4.9%
    PRS 99.3%
  • epicardial adipocyte CL1000309
    CSI 6.0
    rCSI 19.6%
    PRS 98.4%
  • cardiac muscle cell CL0000746
    CSI 6.1
    rCSI 8.7%
    PRS 97.4%
  • kidney loop of Henle thick ascending limb epithelial cell CL1001106
    CSI 6.7
    rCSI 57.8%
    PRS 98.0%
  • retina horizontal cell CL0000745
    CSI 6.8
    rCSI 10.3%
    PRS 98.5%
  • medial ganglionic eminence derived interneuron CL4023063
    CSI 6.8
    rCSI 67.8%
    PRS 83.9%
  • kidney interstitial fibroblast CL1000692
    CSI 7.0
    rCSI 37.4%
    PRS 98.5%
  • regular ventricular cardiac myocyte CL0002131
    CSI 7.1
    rCSI 44.5%
    PRS 97.7%
  • pulmonary alveolar type 1 cell CL0002062
    CSI 7.2
    rCSI 41.3%
    PRS 98.6%
  • fibroblast of cardiac tissue CL0002548
    CSI 7.4
    rCSI 35.6%
    PRS 99.4%
  • medium spiny neuron CL1001474
    CSI 7.5
    rCSI 64.4%
    PRS 97.1%
  • neural progenitor cell CL0011020
    CSI 7.7
    rCSI 33.7%
    PRS 95.5%
  • cerebellar neuron CL1001611
    CSI 7.7
    rCSI 68.1%
    PRS 95.1%
  • ciliated columnar cell of tracheobronchial tree CL0002145
    CSI 7.7
    rCSI 17.6%
    PRS 97.3%
  • starburst amacrine cell CL0004232
    CSI 7.9
    rCSI 66.1%
    PRS 94.2%
  • mesangial cell CL0000650
    CSI 7.9
    rCSI 32.2%
    PRS 99.4%
  • renal alpha-intercalated cell CL0005011
    CSI 7.9
    rCSI 10.6%
    PRS 99.4%
  • central nervous system neuron CL2000029
    CSI 8.1
    rCSI 59.6%
    PRS 97.6%
  • lung ciliated cell CL1000271
    CSI 8.2
    rCSI 9.5%
    PRS 98.1%
  • kidney collecting duct intercalated cell CL1001432
    CSI 9.0
    rCSI 64.3%
    PRS 97.5%
  • diffuse bipolar 2 cell CL4033028
    CSI 9.1
    rCSI 70.8%
    PRS 95.9%
  • retinal rod cell CL0000604
    CSI 9.4
    rCSI 16.5%
    PRS 97.9%
  • diffuse bipolar 1 cell CL4033027
    CSI 9.4
    rCSI 70.7%
    PRS 94.9%
  • glial cell CL0000125
    CSI 9.4
    rCSI 35.9%
    PRS 97.3%
  • brush cell of tracheobronchial tree CL0002075
    CSI 9.5
    rCSI 28.3%
    PRS 99.8%
  • OFF-bipolar cell CL0000750
    CSI 9.6
    rCSI 13.1%
    PRS 98.3%
  • parietal epithelial cell CL1000452
    CSI 9.8
    rCSI 26.1%
    PRS 98.5%
  • cerebral cortex GABAergic interneuron CL0010011
    CSI 9.9
    rCSI 29.2%
    PRS 99.2%
  • diffuse bipolar 3a cell CL4033029
    CSI 9.9
    rCSI 67.3%
    PRS 95.9%
  • flat midget bipolar cell CL4033033
    CSI 10.0
    rCSI 71.8%
    PRS 95.6%
  • epithelial cell of lower respiratory tract CL0002632
    CSI 10.1
    rCSI 7.8%
    PRS 99.7%
  • stem cell CL0000034
    CSI 10.1
    rCSI 9.8%
    PRS 99.1%
  • mature microglial cell CL0002629
    CSI 10.3
    rCSI 42.8%
    PRS 97.8%
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 10.3
    rCSI 60.9%
    PRS 96.7%
  • diffuse bipolar 3b cell CL4033030
    CSI 10.7
    rCSI 70.9%
    PRS 96.2%
  • mature astrocyte CL0002627
    CSI 10.8
    rCSI 46.0%
    PRS 97.6%
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 10.9
    rCSI 15.4%
    PRS 98.9%
  • invaginating midget bipolar cell CL4033034
    CSI 11.0
    rCSI 65.2%
    PRS 95.7%
  • endocardial cell CL0002350
    CSI 11.1
    rCSI 53.0%
    PRS 98.7%
  • podocyte CL0000653
    CSI 11.4
    rCSI 50.5%
    PRS 99.0%
  • ependymal cell CL0000065
    CSI 11.4
    rCSI 23.2%
    PRS 95.1%
  • enteroglial cell CL4040002
    CSI 11.7
    rCSI 61.3%
    PRS 99.0%
  • H2 horizontal cell CL0004218
    CSI 11.7
    rCSI 58.0%
    PRS 97.3%
  • astrocyte of the cerebral cortex CL0002605
    CSI 11.8
    rCSI 26.5%
    PRS 97.3%
  • tracheobronchial smooth muscle cell CL0019019
    CSI 11.8
    rCSI 20.9%
    PRS 99.5%
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 11.9
    rCSI 13.7%
    PRS 97.7%
  • GABAergic amacrine cell CL4030027
    CSI 12.4
    rCSI 42.6%
    PRS 95.5%
  • S cone cell CL0003050
    CSI 12.5
    rCSI 54.9%
    PRS 98.0%
  • fibroblast of lung CL0002553
    CSI 12.8
    rCSI 11.9%
    PRS 99.6%
  • hepatic stellate cell CL0000632
    CSI 12.8
    rCSI 47.9%
    PRS 98.9%
  • Mueller cell CL0000636
    CSI 13.2
    rCSI 30.1%
    PRS 97.9%
  • enteric smooth muscle cell CL0002504
    CSI 13.5
    rCSI 19.3%
    PRS 99.4%
  • diffuse bipolar 6 cell CL4033032
    CSI 13.6
    rCSI 71.3%
    PRS 95.2%
  • dopaminergic neuron CL0000700
    CSI 14.0
    rCSI 78.9%
    PRS 96.4%
  • epithelial cell of proximal tubule CL0002306
    CSI 14.4
    rCSI 35.2%
    PRS 97.5%
  • lung secretory cell CL1000272
    CSI 14.5
    rCSI 35.8%
    PRS 99.6%
  • ciliated epithelial cell CL0000067
    CSI 14.6
    rCSI 12.9%
    PRS 97.5%
  • retinal ganglion cell CL0000740
    CSI 14.7
    rCSI 32.6%
    PRS 97.1%
  • cerebral cortex neuron CL0010012
    CSI 14.8
    rCSI 60.2%
    PRS 96.9%
  • neuroblast (sensu Vertebrata) CL0000031
    CSI 15.0
    rCSI 19.2%
    PRS 98.4%
  • OFFx cell CL4033036
    CSI 15.0
    rCSI 70.6%
    PRS 95.1%
  • pulmonary alveolar type 2 cell CL0002063
    CSI 15.2
    rCSI 23.6%
    PRS 99.1%
  • serotonergic neuron CL0000850
    CSI 15.3
    rCSI 68.2%
    PRS 94.5%
  • GABAergic neuron CL0000617
    CSI 15.5
    rCSI 51.9%
    PRS 95.1%
  • H1 horizontal cell CL0004217
    CSI 15.6
    rCSI 61.8%
    PRS 97.0%
  • chondrocyte CL0000138
    CSI 15.6
    rCSI 24.8%
    PRS 98.1%
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 15.8
    rCSI 59.5%
    PRS 96.7%
  • conjunctival epithelial cell CL1000432
    CSI 15.8
    rCSI 24.1%
    PRS 99.0%
  • basket cell CL0000118
    CSI 16.0
    rCSI 100.0%
    PRS 92.7%
  • retinal cone cell CL0000573
    CSI 16.4
    rCSI 26.4%
    PRS 97.3%
  • macroglial cell CL0000126
    CSI 16.7
    rCSI 42.9%
    PRS 98.0%
  • renal interstitial pericyte CL1001318
    CSI 17.0
    rCSI 46.9%
    PRS 99.0%
  • Schwann cell CL0002573
    CSI 17.1
    rCSI 48.7%
    PRS 98.3%
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 17.2
    rCSI 61.8%
    PRS 96.7%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.

Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

Loading network (please wait)...

Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [NRXN3](/details-gene/9369) (Neurexin-3) is a protein-coding gene located on chromosome 14 that encodes a member of the neurexin family of synaptic cell-adhesion molecules. These proteins are critical for synapse formation, maturation, and function in the central nervous system. Expression data reveals that [NRXN3](/details-gene/9369) is predominantly and highly significantly expressed in a wide array of neuronal subtypes. It serves as a key marker for various GABAergic cortical interneurons, including [VIP](/details-cell/CL4023016), [pvalb](/details-cell/CL4023018), and [sst](/details-cell/CL4023017) expressing cells, as well as [cerebellar granule cells](/details-cell/CL0001031). Functionally, [NRXN3](/details-gene/9369) is integral to [neuron cell-cell adhesion](/details-cell/GO:0007158) and binds to neuroligins at the postsynaptic membrane, a process essential for establishing and maintaining synaptic integrity. The gene undergoes extensive alternative splicing, which generates a vast diversity of protein isoforms, a mechanism thought to contribute to the specification of synaptic connections ([Link](https://doi.org/10.1006/geno.2002.6734)). Clinically, mutations in [NRXN3](/details-gene/9369) have been associated with neurodevelopmental disorders such as Pitt-Hopkins-like syndrome-2 ([153245](https://omim.org/entry/600567)). ## Cellular Roles and Expression Landscape The expression profile of [NRXN3](/details-gene/9369) establishes its fundamental role within the nervous system, with its significance being almost exclusively restricted to neuronal populations. **Overall**, the gene's expression is a defining feature of diverse neuronal cell types across different brain regions. It shows the highest significance in cortical inhibitory interneurons, including [VIP GABAergic cortical interneurons](/details-cell/CL4023016) (CSI: 56.13), [pvalb GABAergic cortical interneurons](/details-cell/CL4023018) (CSI: 54.38), and [sst GABAergic cortical interneurons](/details-cell/CL4023017) (CSI: 50.61). This suggests a crucial role in regulating cortical inhibitory circuits. Concurrently, [NRXN3](/details-gene/9369) is also a top marker in [cerebellar granule cells](/details-cell/CL0001031) (CSI: 55.84), which are excitatory neurons, indicating its importance in both inhibitory and excitatory synaptic transmission. Its high significance extends to other specialized neurons like [retinal bipolar neurons](/details-cell/CL0000748) and various classes of [interneurons](/details-cell/CL0000099), reinforcing its broad but specific function in mediating neural connectivity. While primarily known for its neural functions, some studies suggest neurexins are also expressed in the vascular system, potentially contributing to its functions ([Link](https://doi.org/10.1073/pnas.0809510106)). The data strongly supports that the primary biological footprint of [NRXN3](/details-gene/9369) is within the architecture of the nervous system. ## Pathways and Molecular Function The molecular functions of [NRXN3](/details-gene/9369) are intrinsically linked to its role as a presynaptic cell-adhesion molecule, which is well-supported by its functional annotations. As a transmembrane protein localized to the [plasma membrane](/details-cell/GO:0005886) and specifically the [presynaptic membrane](/details-cell/GO:0042734), it acts as a signaling receptor ([GO:0038023](https://www.ebi.ac.uk/QuickGO/term/GO:0038023)). Its primary involvement is in the [Neurexins and neuroligins](/details-pathway/R-HSA-6794361) pathway, which is a cornerstone of [protein-protein interactions at synapses](/details-pathway/R-HSA-6794362). The protein's function in [neuron cell-cell adhesion](/details-cell/GO:0007158) is mediated through its molecular ability to bind with postsynaptic neuroligin family proteins ([GO:0097109](https://www.ebi.ac.uk/QuickGO/term/GO:0097109)). This trans-synaptic interaction is a key step in synapse organization and signal transmission. Beyond synapse formation, these interactions are implicated in broader biological processes such as [axon guidance](/details-cell/GO:0007411) during development and higher-order functions like [learning](/details-cell/GO:0007612) and [social behavior](/details-cell/GO:0035176) in adults. The extensive repertoire of splice isoforms generated from the [NRXN3](/details-gene/9369) gene is thought to provide a molecular code that helps specify the properties of individual synapses throughout the [neuronal system](/details-pathway/R-HSA-112316) ([Link](https://doi.org/10.1006/geno.2002.6734)). ## Research Directions The specific and high-level expression of [NRXN3](/details-gene/9369) in distinct neuronal subtypes, combined with its known role in neurodevelopment and its processing by disease-relevant enzymes, opens several avenues for future investigation. Based on the available data, several testable hypotheses can be proposed: 1. The high expression of [NRXN3](/details-gene/9369) across multiple, functionally distinct cortical interneuron subtypes ([VIP](/details-cell/CL4023016), [pvalb](/details-cell/CL4023018), [sst](/details-cell/CL4023017)) suggests that cell-type-specific alternative splicing of the [NRXN3](/details-gene/9369) transcript is a key mechanism for establishing the unique synaptic connectivity and function of these different inhibitory microcircuits. 2. Given that neurexin-3β can be processed by α- and γ-secretases, enzymes linked to Alzheimer's disease pathology ([Link](https://doi.org/10.1074/jbc.m110.142521)), it is hypothesized that dysregulation of [NRXN3](/details-gene/9369) cleavage contributes to the synaptic dysfunction and loss that characterizes the early stages of neurodegenerative disorders. To investigate the first hypothesis regarding splice isoform diversity, a compelling experimental approach would be to use single-cell long-read sequencing on human cortical tissue. This would allow for the simultaneous identification of cell types (e.g., [VIP](/details-cell/CL4023016) vs. [pvalb](/details-cell/CL4023018) interneurons) via marker gene expression and the characterization of full-length [NRXN3](/details-gene/9369) splice isoforms expressed within each individual cell. This would directly test whether different interneuron classes utilize a distinct "splicing code" to define their synaptic partnerships. From a therapeutic perspective, [NRXN3](/details-gene/9369) presents a complex target. Its fundamental role in synapse formation makes global inhibition or activation a high-risk strategy due to the potential for severe, widespread neurological side effects. However, for neurodevelopmental disorders stemming from haploinsufficiency, therapies aimed at restoring protein levels, perhaps through gene therapy or small molecules that enhance transcription, could be explored. Furthermore, if specific splice isoforms are linked to disease pathology, antisense oligonucleotides (ASOs) could be designed to selectively modulate the splicing process, correcting the isoform ratio rather than altering the total amount of [NRXN3](/details-gene/9369) protein. This isoform-specific approach represents a more targeted and potentially safer therapeutic strategy.

Genular Protein ID: 3726732186

Symbol: NRX3A_HUMAN

Name: Neurexin-3

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 12379233

Title: Identification and characterization of heart-specific splicing of human neurexin 3 mRNA (NRXN3).

PubMed ID: 12379233

DOI: 10.1016/s0006-291x(02)02403-8

PubMed ID: 11944992

Title: Analysis of the human neurexin genes: alternative splicing and the generation of protein diversity.

PubMed ID: 11944992

DOI: 10.1006/geno.2002.6734

PubMed ID: 9872452

Title: Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 9872452

DOI: 10.1093/dnares/5.5.277

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19926856

Title: The synaptic proteins neurexins and neuroligins are widely expressed in the vascular system and contribute to its functions.

PubMed ID: 19926856

DOI: 10.1073/pnas.0809510106

Sequence Information:

  • Length: 1643
  • Mass: 180599
  • Checksum: E7360348E263C6EC
  • Sequence:
  • MSSTLHSVFF TLKVSILLGS LLGLCLGLEF MGLPNQWARY LRWDASTRSD LSFQFKTNVS 
    TGLLLYLDDG GVCDFLCLSL VDGRVQLRFS MDCAETAVLS NKQVNDSSWH FLMVSRDRLR 
    TVLMLDGEGQ SGELQPQRPY MDVVSDLFLG GVPTDIRPSA LTLDGVQAMP GFKGLILDLK 
    YGNSEPRLLG SRGVQMDAEG PCGERPCENG GICFLLDGHP TCDCSTTGYG GKLCSEDVSQ 
    DPGLSHLMMS EQAREENVAT FRGSEYLCYD LSQNPIQSSS DEITLSFKTW QRNGLILHTG 
    KSADYVNLAL KDGAVSLVIN LGSGAFEAIV EPVNGKFNDN AWHDVKVTRN LRQVTISVDG 
    ILTTTGYTQE DYTMLGSDDF FYVGGSPSTA DLPGSPVSNN FMGCLKEVVY KNNDIRLELS 
    RLARIADTKM KIYGEVVFKC ENVATLDPIN FETPEAYISL PKWNTKRMGS ISFDFRTTEP 
    NGLILFTHGK PQERKDARSQ KNTKVDFFAV ELLDGNLYLL LDMGSGTIKV KATQKKANDG 
    EWYHVDIQRD GRSGTISVNS RRTPFTASGE SEILDLEGDM YLGGLPENRA GLILPTELWT 
    AMLNYGYVGC IRDLFIDGRS KNIRQLAEMQ NAAGVKSSCS RMSAKQCDSY PCKNNAVCKD 
    GWNRFICDCT GTGYWGRTCE REASILSYDG SMYMKIIMPM VMHTEAEDVS FRFMSQRAYG 
    LLVATTSRDS ADTLRLELDG GRVKLMVNLD CIRINCNSSK GPETLYAGQK LNDNEWHTVR 
    VVRRGKSLKL TVDDDVAEGT MVGDHTRLEF HNIETGIMTE KRYISVVPSS FIGHLQSLMF 
    NGLLYIDLCK NGDIDYCELK ARFGLRNIIA DPVTFKTKSS YLSLATLQAY TSMHLFFQFK 
    TTSPDGFILF NSGDGNDFIA VELVKGYIHY VFDLGNGPNV IKGNSDRPLN DNQWHNVVIT 
    RDNSNTHSLK VDTKVVTQVI NGAKNLDLKG DLYMAGLAQG MYSNLPKLVA SRDGFQGCLA 
    SVDLNGRLPD LINDALHRSG QIERGCEGPS TTCQEDSCAN QGVCMQQWEG FTCDCSMTSY 
    SGNQCNDPGA TYIFGKSGGL ILYTWPANDR PSTRSDRLAV GFSTTVKDGI LVRIDSAPGL 
    GDFLQLHIEQ GKIGVVFNIG TVDISIKEER TPVNDGKYHV VRFTRNGGNA TLQVDNWPVN 
    EHYPTGRQLT IFNTQAQIAI GGKDKGRLFQ GQLSGLYYDG LKVLNMAAEN NPNIKINGSV 
    RLVGEVPSIL GTTQTTSMPP EMSTTVMETT TTMATTTTRK NRSTASIQPT SDDLVSSAEC 
    SSDDEDFVEC EPSTTGGELV IPLLVEDPLA TPPIATRAPS ITLPPTFRPL LTIIETTKDS 
    LSMTSEAGLP CLSDQGSDGC DDDGLVISGY GSGETFDSNL PPTDDEDFYT TFSLVTDKSL 
    STSIFEGGYK AHAPKWESKD FRPNKVSETS RTTTTSLSPE LIRFTASSSS GMVPKLPAGK 
    MNNRDLKPQP DIVLLPLPTA YELDSTKLKS PLITSPMFRN VPTANPTEPG IRRVPGASEV 
    IRESSSTTGM VVGIVAAAAL CILILLYAMY KYRNRDEGSY QVDETRNYIS NSAQSNGTLM 
    KEKQQSSKSG HKKQKNKDRE YYV

Genular Protein ID: 4075755670

Symbol: NRX3B_HUMAN

Name: Neurexin-3-beta

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 12379233

Title: Identification and characterization of heart-specific splicing of human neurexin 3 mRNA (NRXN3).

PubMed ID: 12379233

DOI: 10.1016/s0006-291x(02)02403-8

PubMed ID: 11944992

Title: Analysis of the human neurexin genes: alternative splicing and the generation of protein diversity.

PubMed ID: 11944992

DOI: 10.1006/geno.2002.6734

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19926856

Title: The synaptic proteins neurexins and neuroligins are widely expressed in the vascular system and contribute to its functions.

PubMed ID: 19926856

DOI: 10.1073/pnas.0809510106

PubMed ID: 21084300

Title: Processing of the synaptic cell adhesion molecule neurexin-3beta by Alzheimer disease alpha- and gamma-secretases.

PubMed ID: 21084300

DOI: 10.1074/jbc.m110.142521

Sequence Information:

  • Length: 637
  • Mass: 69305
  • Checksum: A0F100DA9D72A149
  • Sequence:
  • MHLRIHARRS PPRRPAWTLG IWFLFWGCIV SSVWSSSNVA SSSSTSSSPG SHSQHEHHFH 
    GSKHHSVPIS IYRSPVSLRG GHAGATYIFG KSGGLILYTW PANDRPSTRS DRLAVGFSTT 
    VKDGILVRID SAPGLGDFLQ LHIEQGKIGV VFNIGTVDIS IKEERTPVND GKYHVVRFTR 
    NGGNATLQVD NWPVNEHYPT GRQLTIFNTQ AQIAIGGKDK GRLFQGQLSG LYYDGLKVLN 
    MAAENNPNIK INGSVRLVGE VPSILGTTQT TSMPPEMSTT VMETTTTMAT TTTRKNRSTA 
    SIQPTSDDLV SSAECSSDDE DFVECEPSTG GELVIPLLVE DPLATPPIAT RAPSITLPPT 
    FRPLLTIIET TKDSLSMTSE AGLPCLSDQG SDGCDDDGLV ISGYGSGETF DSNLPPTDDE 
    DFYTTFSLVT DKSLSTSIFE GGYKAHAPKW ESKDFRPNKV SETSRTTTTS LSPELIRFTA 
    SSSSGMVPKL PAGKMNNRDL KPQPDIVLLP LPTAYELDST KLKSPLITSP MFRNVPTANP 
    TEPGIRRVPG ASEVIRESSS TTGMVVGIVA AAALCILILL YAMYKYRNRD EGSYQVDETR 
    NYISNSAQSN GTLMKEKQQS SKSGHKKQKN KDREYYV

Genular Protein ID: 1992696126

Symbol: A0A0A0MR89_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 1571
  • Mass: 173660
  • Checksum: 39ECDE34CF41CD27
  • Sequence:
  • MSSTLHSVFF TLKVSILLGS LLGLCLGLEF MGLPNQWARY LRWDASTRSD LSFQFKTNVS 
    TGLLLYLDDG GVCDFLCLSL VDGRVQLRFS MDCAETAVLS NKQVNDSSWH FLMVSRDRLR 
    TVLMLDGEGQ SGELQPQRPY MDVVSDLFLG GVPTDIRPSA LTLDGVQAMP GFKGLILDLK 
    YGNSEPRLLG SRGVQMDAEG PCGERPCENG GICFLLDGHP TCDCSTTGYG GKLCSEDVSQ 
    DPGLSHLMMS EQAREENVAT FRGSEYLCYD LSQNPIQSSS DEITLSFKTW QRNGLILHTG 
    KSADYVNLAL KDGAVSLVIN LGSGAFEAIV EPVNGKFNDN AWHDVKVTRN LRQVTISVDG 
    ILTTTGYTQE DYTMLGSDDF FYVGGSPSTA DLPGSPVSNN FMGCLKEVVY KNNDIRLELS 
    RLARIADTKM KIYGEVVFKC ENVATLDPIN FETPEAYISL PKWNTKRMGS ISFDFRTTEP 
    NGLILFTHGK PQERKDARSQ KNTKVDFFAV ELLDGNLYLL LDMGSGTIKV KATQKKANDG 
    EWYHVDIQRD GRSGTISVNS RRTPFTASGE SEILDLEGDM YLGGLPENRA GLILPTELWT 
    AMLNYGYVGC IRDLFIDGRS KNIRQLAEMQ NAAGVKSSCS RMSAKQCDSY PCKNNAVCKD 
    GWNRFICDCT GTGYWGRTCE REASILSYDG SMYMKIIMPM VMHTEAEDVS FRFMSQRAYG 
    LLVATTSRDS ADTLRLELDG GRVKLMVNLD CIRINCNSSK GPETLYAGQK LNDNEWHTVR 
    VVRRGKSLKL TVDDDVAEGT MVGDHTRLEF HNIETGIMTE KRYISVVPSS FIGHLQSLMF 
    NGLLYIDLCK NGDIDYCELK ARFGLRNIIA DPVTFKTKSS YLSLATLQAY TSMHLFFQFK 
    TTSPDGFILF NSGDGNDFIA VELVKGYIHY VFDLGNGPNV IKGNSDRPLN DNQWHNVVIT 
    RDNSNTHSLK VDTKVVTQVI NGAKNLDLKG DLYMAGLAQG MYSNLPKLVA SRDGFQGCLA 
    SVDLNGRLPD LINDALHRSG QIERGCEGPS TTCQEDSCAN QGVCMQQWEG FTCDCSMTSY 
    SGNQCNDPGA TYIFGKSGGL ILYTWPANDR PSTRSDRLAV GFSTTVKDGI LVRIDSAPGL 
    GDFLQLHIEQ GKIGVVFNIG TVDISIKEER TPVNDGKYHV VRFTRNGGNA TLQVDNWPVN 
    EHYPTGNTDN ERFQMVKQKI PFKYNRPVEE WLQEKGRQLT IFNTQAQIAI GGKDKGRLFQ 
    GQLSGLYYDG LKVLNMAAEN NPNIKINGSV RLVGEVPSIL GTTQTTSMPP EMSTTVMETT 
    TTMATTTTRK NRSTASIQPT SDDLVSSAEC SSDDEDFVEC EPSTDKSLST SIFEGGYKAH 
    APKWESKDFR PNKVSETSRT TTTSLSPELI RFTASSSSGM VPKLPAGKMN NRDLKPQPDI 
    VLLPLPTAYE LDSTKLKSPL ITSPMFRNVP TANPTEPGIR RVPGASEVIR ESSSTTGMVV 
    GIVAAAALCI LILLYAMYKY RNRDEGSYQV DETRNYISNS AQSNGTLMKE KQQSSKSGHK 
    KQKNKDREYY V