Details for: PCBP2

Gene ID: 5094

Symbol: PCBP2

Ensembl ID: ENSG00000197111

Description: poly(rC) binding protein 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 4.1
    Marker Score: 12923.5
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 4.04
    Marker Score: 213710
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.93
    Marker Score: 133770
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 3.93
    Marker Score: 6735
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.82
    Marker Score: 50440
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 3.74
    Marker Score: 7833
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.57
    Marker Score: 41459
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.52
    Marker Score: 197071
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 3.52
    Marker Score: 47351
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.5
    Marker Score: 22753
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 3.5
    Marker Score: 26036
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.42
    Marker Score: 3655
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 3.35
    Marker Score: 5499.5
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 3.35
    Marker Score: 2993
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 3.31
    Marker Score: 11752
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 3.3
    Marker Score: 3894.5
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 3.27
    Marker Score: 8775.5
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.27
    Marker Score: 780
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 3.26
    Marker Score: 3152
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 3.21
    Marker Score: 4540
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 3.2
    Marker Score: 8982
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 3.19
    Marker Score: 4408
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 3.19
    Marker Score: 13661
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3.17
    Marker Score: 31393
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 3.14
    Marker Score: 2608
  • Cell Name: centroblast (CL0009112)
    Fold Change: 3.13
    Marker Score: 1541
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.13
    Marker Score: 5874
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 3.08
    Marker Score: 2175
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.08
    Marker Score: 3037
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 3.03
    Marker Score: 8987
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 3.03
    Marker Score: 3209.5
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 3.02
    Marker Score: 2286
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.02
    Marker Score: 104558
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.01
    Marker Score: 7345
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 3
    Marker Score: 1873
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 3
    Marker Score: 19540
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 2.99
    Marker Score: 1821
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.99
    Marker Score: 8263
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.98
    Marker Score: 7524
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 2.97
    Marker Score: 2247
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.96
    Marker Score: 5288
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 2.92
    Marker Score: 2598
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.91
    Marker Score: 17270.5
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 2.91
    Marker Score: 754
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.9
    Marker Score: 11190
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.9
    Marker Score: 1822
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 2.9
    Marker Score: 8463
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 2.87
    Marker Score: 1304
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.86
    Marker Score: 4989
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 2.85
    Marker Score: 2421
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 2.85
    Marker Score: 653
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 2.84
    Marker Score: 1886.5
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.84
    Marker Score: 5528
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.84
    Marker Score: 4077
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 2.83
    Marker Score: 2046
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 2.83
    Marker Score: 1873.5
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.83
    Marker Score: 2645
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 2.81
    Marker Score: 2716
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 2.8
    Marker Score: 978
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 2.8
    Marker Score: 2628
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.79
    Marker Score: 28314
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 2.78
    Marker Score: 3428
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 2.77
    Marker Score: 6761
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.77
    Marker Score: 8703
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 2.77
    Marker Score: 1862
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 2.76
    Marker Score: 1127
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 2.76
    Marker Score: 1639
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.76
    Marker Score: 2011
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.76
    Marker Score: 1378
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 2.75
    Marker Score: 5027
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.74
    Marker Score: 4550
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.73
    Marker Score: 6205
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 2.73
    Marker Score: 551
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 2.72
    Marker Score: 2955
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.71
    Marker Score: 7383
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.71
    Marker Score: 5410
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.71
    Marker Score: 5651
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.7
    Marker Score: 1628
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.69
    Marker Score: 3078
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.69
    Marker Score: 27037
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 2.68
    Marker Score: 706
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 2.67
    Marker Score: 5237
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 2.67
    Marker Score: 622
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.67
    Marker Score: 13110
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 2.66
    Marker Score: 754
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.65
    Marker Score: 2979.5
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.65
    Marker Score: 2371
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 2.63
    Marker Score: 2157
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.63
    Marker Score: 29604
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 2.63
    Marker Score: 749
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.63
    Marker Score: 11323
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 2.62
    Marker Score: 3409
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 2.62
    Marker Score: 2893
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 2.61
    Marker Score: 1890
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.61
    Marker Score: 2646
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.6
    Marker Score: 4425
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 2.6
    Marker Score: 920
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 2.6
    Marker Score: 1523
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 2.6
    Marker Score: 731
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.59
    Marker Score: 4120

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Other Information

**Key characteristics:** - PCBP2 is a protein of the immunoglobulin superfamily. - It is expressed in high levels in cells that are activated by the type I interferon response. - It is a key regulator of the expression of type I interferons. - It interacts with the type I interferon receptor (IFNAR1). - It is a negative regulator of the type I interferon response. **Pathways and functions:** - PCBP2 is involved in the regulation of the type I interferon response. - It is a key regulator of the production of type I interferons. - It binds to the type I interferon receptor (IFNAR1) and inhibits its signaling pathway. - This prevents the production of type I interferons, which would inhibit viral replication. **Clinical significance:** - Mutations in PCBP2 have been linked to the development of several autoimmune diseases, including systemic sclerosis and rheumatoid arthritis. - PCBP2 is a potential target for the treatment of autoimmune diseases.

Genular Protein ID: 2119469760

Symbol: PCBP2_HUMAN

Name: Alpha-CP2

UniProtKB Accession Codes:

Q15366 A8K7X6 B4DXP5 F8VYL7 G3V0E8 I6L8F9 Q32Q82 Q59HD4 Q68Y55 Q6IPF4 Q6PKG5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 7 CDD 3 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 14 EPD 1 Ensembl 10 EvolutionaryTrace 1 ExpressionAtlas 1 GO 26 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 5 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 7 Pumba 1 RNAct 1 Reactome 4 RefSeq 7 SASBDB 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 2 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7607214

Title: Characterisation of two major cellular poly(rC)-binding human proteins, each containing three K-homologous (KH) domains.

PubMed ID: 7607214

DOI: 10.1111/j.1432-1033.1995.tb20581.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12414943

Title: Distinct poly(rC) binding protein KH domain determinants for poliovirus translation initiation and viral RNA replication.

PubMed ID: 12414943

DOI: 10.1128/jvi.76.23.12008-12022.2002

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19881509

Title: PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4.

PubMed ID: 19881509

DOI: 10.1038/ni.1815

PubMed ID: 19029303

Title: Control of c-myc mRNA stability by IGF2BP1-associated cytoplasmic RNPs.

PubMed ID: 19029303

DOI: 10.1261/rna.1175909

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24371074

Title: Inhibition of poliovirus-induced cleavage of cellular protein PCBP2 reduces the levels of viral RNA replication.

PubMed ID: 24371074

DOI: 10.1128/jvi.02503-13

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 35322803

Title: PCBP2 maintains antiviral signaling homeostasis by regulating cGAS enzymatic activity via antagonizing its condensation.

PubMed ID: 35322803

DOI: 10.1038/s41467-022-29266-9

PubMed ID: 16186123

Title: Crystal structure of the first KH domain of human poly(C)-binding protein-2 in complex with a C-rich strand of human telomeric DNA at 1.7 A.

PubMed ID: 16186123

DOI: 10.1074/jbc.m508183200

PubMed ID: 17426136

Title: Crystal structure of the third KH domain of human poly(C)-binding protein-2 in complex with a C-rich strand of human telomeric DNA at 1.6 A resolution.

PubMed ID: 17426136

DOI: 10.1093/nar/gkm139

PubMed ID: 17526645

Title: X-ray crystallographic and NMR studies of protein-protein and protein-nucleic acid interactions involving the KH domains from human poly(C)-binding protein-2.

PubMed ID: 17526645

DOI: 10.1261/rna.410107

PubMed ID: 18701464

Title: Structure of a construct of a human poly(C)-binding protein containing the first and second KH domains reveals insights into its regulatory mechanisms.

PubMed ID: 18701464

DOI: 10.1074/jbc.m803046200

Sequence Information:

  • Length: 365
  • Mass: 38580
  • Checksum: 43F035D76FDC2C63
  • Sequence:
    • MDTGVIEGGL NVTLTIRLLM HGKEVGSIIG KKGESVKKMR EESGARINIS EGNCPERIIT 
LAGPTNAIFK AFAMIIDKLE EDISSSMTNS TAASRPPVTL RLVVPASQCG SLIGKGGCKI 
KEIRESTGAQ VQVAGDMLPN STERAITIAG IPQSIIECVK QICVVMLETL SQSPPKGVTI 
PYRPKPSSSP VIFAGGQDRY STGSDSASFP HTTPSMCLNP DLEGPPLEAY TIQGQYAIPQ 
PDLTKLHQLA MQQSHFPMTH GNTGFSGIES SSPEVKGYWG LDASAQTTSH ELTIPNDLIG 
CIIGRQGAKI NEIRQMSGAQ IKIANPVEGS TDRQVTITGS AASISLAQYL INVRLSSETG 
GMGSS

Genular Protein ID: 1998599273

Symbol: A0A384N6B9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A384N6B9

Database IDs:

ARBA 1 AlphaFoldDB 1 Antibodypedia 1 CDD 3 CTD 1 DNASU 1 EMBL 2 ExpressionAtlas 1 GO 3 Gene3D 1 InterPro 3 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 1 PROSITE-ProRule 1 Pfam 1 RefSeq 1 SMART 2 SMR 1 SUPFAM 1 VEuPathDB 1

Sequence Information:

  • Length: 366
  • Mass: 38651
  • Checksum: 3464C973504D90DE
  • Sequence:
    • MDTGVIEGGL NVTLTIRLLM HGKEVGSIIG KKGESVKKMR EESGARINIS EGNCPERIIT 
LAGPTNAIFK AFAMIIDKLE EDISSSMTNS TAASRPPVTL RLVVPASQCG SLIGKGGCKI 
KEIRESTGAQ VQVAGDMLPN STERAITIAG IPQSIIECVK QICVVMLETL SQSPPKGVTI 
PYRPKPSSSP VIFAGGQDRY STGSDSASFP HTTPSMCLNP DLEGPPLEAY TIQGQYAIPQ 
PDLTKLHQLA MQQSHFPMTH GNTGFSGIES SSPEVKGYWA GLDASAQTTS HELTIPNDLI 
GCIIGRQGAK INEIRQMSGA QIKIANPVEG STDRQVTITG SAASISLAQY LINVRLSSET 
GGMGSS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.