Details for: PCBP2
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 664.5013
Cell Significance Index: -103.3600 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 408.0532
Cell Significance Index: -103.5000 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 343.9636
Cell Significance Index: -141.7000 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 283.9516
Cell Significance Index: -134.0600 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 275.6397
Cell Significance Index: -141.7900 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 200.5299
Cell Significance Index: -134.5600 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 102.6395
Cell Significance Index: -126.5500 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 36.3662
Cell Significance Index: -97.4200 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 35.2732
Cell Significance Index: -108.3400 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 34.3762
Cell Significance Index: -135.6500 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 20.9085
Cell Significance Index: -45.7600 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 7.1966
Cell Significance Index: 92.1700 - Cell Name: granulosa cell (CL0000501)
Fold Change: 6.2845
Cell Significance Index: 165.2500 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 4.8719
Cell Significance Index: 574.5500 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 3.4139
Cell Significance Index: 160.4500 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 3.3908
Cell Significance Index: 465.6500 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 3.3092
Cell Significance Index: 213.4900 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 3.2070
Cell Significance Index: 91.9300 - Cell Name: cell in vitro (CL0001034)
Fold Change: 3.1849
Cell Significance Index: 1739.3600 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 3.1020
Cell Significance Index: 64.9300 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 3.0047
Cell Significance Index: 223.9400 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 2.8516
Cell Significance Index: 201.6800 - Cell Name: lactocyte (CL0002325)
Fold Change: 2.8165
Cell Significance Index: 363.8700 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.7797
Cell Significance Index: 75.6600 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: 2.7555
Cell Significance Index: 41.8500 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 2.7437
Cell Significance Index: 337.3700 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 2.6696
Cell Significance Index: 1180.2900 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 2.6245
Cell Significance Index: 473.1200 - Cell Name: kidney cell (CL1000497)
Fold Change: 2.6114
Cell Significance Index: 20.8500 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 2.4166
Cell Significance Index: 479.5900 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 2.3238
Cell Significance Index: 62.0500 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 2.1258
Cell Significance Index: 23.1100 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 2.1019
Cell Significance Index: 98.0000 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.9405
Cell Significance Index: 35.8700 - Cell Name: odontoblast (CL0000060)
Fold Change: 1.8147
Cell Significance Index: 232.6300 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.6014
Cell Significance Index: 460.7800 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 1.5986
Cell Significance Index: 28.2500 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.5422
Cell Significance Index: 43.1000 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.4631
Cell Significance Index: 293.5000 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 1.4339
Cell Significance Index: 244.8400 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 1.4222
Cell Significance Index: 49.4200 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 1.1868
Cell Significance Index: 74.8000 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.8816
Cell Significance Index: 143.3900 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.8438
Cell Significance Index: 302.6500 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.8032
Cell Significance Index: 9.1300 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.5122
Cell Significance Index: 26.8900 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.4778
Cell Significance Index: 90.9200 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.3416
Cell Significance Index: 19.1700 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.3403
Cell Significance Index: 17.6800 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.3317
Cell Significance Index: 299.5200 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.2063
Cell Significance Index: 7.2500 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.1366
Cell Significance Index: 3.9400 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.1297
Cell Significance Index: 2.1700 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.1164
Cell Significance Index: 85.3500 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.1125
Cell Significance Index: 85.1600 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0484
Cell Significance Index: 91.2000 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.0068
Cell Significance Index: 0.5200 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0095
Cell Significance Index: -0.9700 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0298
Cell Significance Index: -18.9400 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0357
Cell Significance Index: -65.8500 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0485
Cell Significance Index: -30.3000 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0498
Cell Significance Index: -76.7000 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0553
Cell Significance Index: -40.9800 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0892
Cell Significance Index: -121.3000 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.1331
Cell Significance Index: -60.3900 - Cell Name: germ cell (CL0000586)
Fold Change: -0.1357
Cell Significance Index: -1.0200 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1728
Cell Significance Index: -97.4400 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.3259
Cell Significance Index: -9.5700 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.3341
Cell Significance Index: -70.3700 - Cell Name: colon goblet cell (CL0009039)
Fold Change: -0.3699
Cell Significance Index: -36.5900 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.4873
Cell Significance Index: -70.8400 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.6398
Cell Significance Index: -17.1200 - Cell Name: peg cell (CL4033014)
Fold Change: -0.6475
Cell Significance Index: -14.9600 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.7017
Cell Significance Index: -80.3900 - Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: -0.7411
Cell Significance Index: -4.5800 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.8465
Cell Significance Index: -98.6500 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.8630
Cell Significance Index: -98.5100 - Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: -0.8718
Cell Significance Index: -5.3700 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.8910
Cell Significance Index: -40.3900 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.9164
Cell Significance Index: -23.4100 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.9218
Cell Significance Index: -63.7500 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.9392
Cell Significance Index: -30.0800 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -1.0936
Cell Significance Index: -86.6200 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -1.0961
Cell Significance Index: -67.3700 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -1.1614
Cell Significance Index: -78.0900 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -1.2338
Cell Significance Index: -128.4700 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -1.2549
Cell Significance Index: -75.3400 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -1.4837
Cell Significance Index: -74.9800 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -1.4845
Cell Significance Index: -25.4400 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -1.5106
Cell Significance Index: -20.6100 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -1.5630
Cell Significance Index: -41.8800 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -1.5794
Cell Significance Index: -39.4800 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -1.7641
Cell Significance Index: -16.2500 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.9830
Cell Significance Index: -121.5800 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -2.0341
Cell Significance Index: -52.2900 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -2.0410
Cell Significance Index: -24.3300 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -2.0542
Cell Significance Index: -60.5100 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -2.0755
Cell Significance Index: -12.5400 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -2.2285
Cell Significance Index: -98.5700 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -2.6657
Cell Significance Index: -100.9500
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2119469760
Symbol: PCBP2_HUMAN
Name: Alpha-CP2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7607214
Title: Characterisation of two major cellular poly(rC)-binding human proteins, each containing three K-homologous (KH) domains.
PubMed ID: 7607214
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16541075
Title: The finished DNA sequence of human chromosome 12.
PubMed ID: 16541075
DOI: 10.1038/nature04569
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12414943
Title: Distinct poly(rC) binding protein KH domain determinants for poliovirus translation initiation and viral RNA replication.
PubMed ID: 12414943
PubMed ID: 14654843
Title: Proteomic characterization of the human centrosome by protein correlation profiling.
PubMed ID: 14654843
DOI: 10.1038/nature02166
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 17924679
Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.
PubMed ID: 17924679
DOI: 10.1021/pr070152u
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 19881509
Title: PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4.
PubMed ID: 19881509
DOI: 10.1038/ni.1815
PubMed ID: 19029303
Title: Control of c-myc mRNA stability by IGF2BP1-associated cytoplasmic RNPs.
PubMed ID: 19029303
DOI: 10.1261/rna.1175909
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24371074
Title: Inhibition of poliovirus-induced cleavage of cellular protein PCBP2 reduces the levels of viral RNA replication.
PubMed ID: 24371074
DOI: 10.1128/jvi.02503-13
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 35322803
Title: PCBP2 maintains antiviral signaling homeostasis by regulating cGAS enzymatic activity via antagonizing its condensation.
PubMed ID: 35322803
PubMed ID: 16186123
Title: Crystal structure of the first KH domain of human poly(C)-binding protein-2 in complex with a C-rich strand of human telomeric DNA at 1.7 A.
PubMed ID: 16186123
PubMed ID: 17426136
Title: Crystal structure of the third KH domain of human poly(C)-binding protein-2 in complex with a C-rich strand of human telomeric DNA at 1.6 A resolution.
PubMed ID: 17426136
DOI: 10.1093/nar/gkm139
PubMed ID: 17526645
Title: X-ray crystallographic and NMR studies of protein-protein and protein-nucleic acid interactions involving the KH domains from human poly(C)-binding protein-2.
PubMed ID: 17526645
DOI: 10.1261/rna.410107
PubMed ID: 18701464
Title: Structure of a construct of a human poly(C)-binding protein containing the first and second KH domains reveals insights into its regulatory mechanisms.
PubMed ID: 18701464
Sequence Information:
- Length: 365
- Mass: 38580
- Checksum: 43F035D76FDC2C63
- Sequence:
MDTGVIEGGL NVTLTIRLLM HGKEVGSIIG KKGESVKKMR EESGARINIS EGNCPERIIT LAGPTNAIFK AFAMIIDKLE EDISSSMTNS TAASRPPVTL RLVVPASQCG SLIGKGGCKI KEIRESTGAQ VQVAGDMLPN STERAITIAG IPQSIIECVK QICVVMLETL SQSPPKGVTI PYRPKPSSSP VIFAGGQDRY STGSDSASFP HTTPSMCLNP DLEGPPLEAY TIQGQYAIPQ PDLTKLHQLA MQQSHFPMTH GNTGFSGIES SSPEVKGYWG LDASAQTTSH ELTIPNDLIG CIIGRQGAKI NEIRQMSGAQ IKIANPVEGS TDRQVTITGS AASISLAQYL INVRLSSETG GMGSS
Genular Protein ID: 1998599273
Symbol: A0A384N6B9_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 366
- Mass: 38651
- Checksum: 3464C973504D90DE
- Sequence:
MDTGVIEGGL NVTLTIRLLM HGKEVGSIIG KKGESVKKMR EESGARINIS EGNCPERIIT LAGPTNAIFK AFAMIIDKLE EDISSSMTNS TAASRPPVTL RLVVPASQCG SLIGKGGCKI KEIRESTGAQ VQVAGDMLPN STERAITIAG IPQSIIECVK QICVVMLETL SQSPPKGVTI PYRPKPSSSP VIFAGGQDRY STGSDSASFP HTTPSMCLNP DLEGPPLEAY TIQGQYAIPQ PDLTKLHQLA MQQSHFPMTH GNTGFSGIES SSPEVKGYWA GLDASAQTTS HELTIPNDLI GCIIGRQGAK INEIRQMSGA QIKIANPVEG STDRQVTITG SAASISLAQY LINVRLSSET GGMGSS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.