Details for: SYT1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 703.3324
Cell Significance Index: -109.4000 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 430.7031
Cell Significance Index: -109.2500 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 261.1983
Cell Significance Index: -107.6000 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 88.7299
Cell Significance Index: -109.4000 - Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 19.8213
Cell Significance Index: 152.7800 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 13.9208
Cell Significance Index: 730.9000 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 13.7514
Cell Significance Index: 235.6600 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 13.1910
Cell Significance Index: 740.2100 - Cell Name: cortical interneuron (CL0008031)
Fold Change: 11.8236
Cell Significance Index: 283.5600 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 10.0651
Cell Significance Index: 618.6500 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 9.6055
Cell Significance Index: 274.1100 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 9.4233
Cell Significance Index: 593.9200 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 8.6738
Cell Significance Index: 3111.1500 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 8.4980
Cell Significance Index: 571.4100 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 7.7127
Cell Significance Index: -16.8800 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 6.8133
Cell Significance Index: 301.3700 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 6.3915
Cell Significance Index: 242.0300 - Cell Name: hippocampal interneuron (CL1001569)
Fold Change: 5.9352
Cell Significance Index: 76.9700 - Cell Name: midget ganglion cell of retina (CL4023188)
Fold Change: 5.9039
Cell Significance Index: 61.5000 - Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: 4.4491
Cell Significance Index: 59.3500 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 4.3742
Cell Significance Index: 3025.3900 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 4.2132
Cell Significance Index: 845.1600 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 3.8764
Cell Significance Index: 84.8800 - Cell Name: OFF-bipolar cell (CL0000750)
Fold Change: 3.3932
Cell Significance Index: 29.8900 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: 3.0746
Cell Significance Index: 46.0700 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 1.7042
Cell Significance Index: 104.4900 - Cell Name: odontoblast (CL0000060)
Fold Change: 1.5012
Cell Significance Index: 192.4400 - Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: 1.1838
Cell Significance Index: 14.3500 - Cell Name: chandelier cell (CL4023083)
Fold Change: 1.0688
Cell Significance Index: 8.6300 - Cell Name: ON-bipolar cell (CL0000749)
Fold Change: 0.9179
Cell Significance Index: 10.3700 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 0.5748
Cell Significance Index: 59.8500 - Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 0.4793
Cell Significance Index: 4.5600 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.4639
Cell Significance Index: 9.9200 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.4386
Cell Significance Index: 825.7400 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: 0.4162
Cell Significance Index: 5.1900 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.4084
Cell Significance Index: 77.7200 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.3046
Cell Significance Index: 275.0600 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.2605
Cell Significance Index: 5.1500 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.2149
Cell Significance Index: 330.8000 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.2133
Cell Significance Index: 9.6700 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.1891
Cell Significance Index: 348.7200 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.1365
Cell Significance Index: 27.0800 - Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.0998
Cell Significance Index: 1.1900 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0478
Cell Significance Index: 65.0000 - Cell Name: glutamatergic neuron (CL0000679)
Fold Change: 0.0349
Cell Significance Index: 0.3800 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0346
Cell Significance Index: -25.6600 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0463
Cell Significance Index: -29.4200 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0776
Cell Significance Index: -2.7300 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0906
Cell Significance Index: -41.1000 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0918
Cell Significance Index: -50.1400 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.1226
Cell Significance Index: -54.2200 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.1241
Cell Significance Index: -91.0000 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.1342
Cell Significance Index: -83.7900 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1345
Cell Significance Index: -75.8700 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.1492
Cell Significance Index: -112.9500 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.1690
Cell Significance Index: -23.2100 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2301
Cell Significance Index: -33.4500 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -0.2459
Cell Significance Index: -40.0000 - Cell Name: colon goblet cell (CL0009039)
Fold Change: -0.2746
Cell Significance Index: -27.1700 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.3081
Cell Significance Index: -19.8800 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.3103
Cell Significance Index: -89.2800 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.3282
Cell Significance Index: -4.7000 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.3454
Cell Significance Index: -72.7600 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.3571
Cell Significance Index: -7.5800 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.3717
Cell Significance Index: -12.1700 - Cell Name: pyramidal neuron (CL0000598)
Fold Change: -0.3833
Cell Significance Index: -2.9400 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.3975
Cell Significance Index: -71.6600 - Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -0.4556
Cell Significance Index: -5.7500 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.4926
Cell Significance Index: -15.6900 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.5241
Cell Significance Index: -89.4900 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.6087
Cell Significance Index: -12.2200 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.6224
Cell Significance Index: -67.7000 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -0.6224
Cell Significance Index: -7.7200 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.6312
Cell Significance Index: -17.6400 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.6320
Cell Significance Index: -18.2100 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.6630
Cell Significance Index: -81.5300 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.6830
Cell Significance Index: -79.6000 - Cell Name: neural cell (CL0002319)
Fold Change: -0.7097
Cell Significance Index: -8.2800 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.7675
Cell Significance Index: -99.1500 - Cell Name: GABAergic neuron (CL0000617)
Fold Change: -0.8075
Cell Significance Index: -10.1900 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.8619
Cell Significance Index: -101.6500 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.9159
Cell Significance Index: -13.9100 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.9562
Cell Significance Index: -97.6800 - Cell Name: neuron (CL0000540)
Fold Change: -0.9674
Cell Significance Index: -9.1700 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.9818
Cell Significance Index: -112.0700 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.9932
Cell Significance Index: -113.7900 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -1.0207
Cell Significance Index: -25.5200 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: -1.0300
Cell Significance Index: -12.3200 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -1.1124
Cell Significance Index: -76.9300 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -1.1895
Cell Significance Index: -94.2100 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -1.2178
Cell Significance Index: -26.3100 - Cell Name: photoreceptor cell (CL0000210)
Fold Change: -1.2282
Cell Significance Index: -17.2500 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -1.3313
Cell Significance Index: -99.2200 - Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
Fold Change: -1.3378
Cell Significance Index: -14.7600 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -1.3416
Cell Significance Index: -10.9400 - Cell Name: Mueller cell (CL0000636)
Fold Change: -1.3492
Cell Significance Index: -10.3800 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -1.4176
Cell Significance Index: -49.2600 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -1.4342
Cell Significance Index: -86.1000 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -1.4348
Cell Significance Index: -110.1100 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -1.4918
Cell Significance Index: -64.8700
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3980123890
Symbol: SYT1_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1840599
Title: Structural and functional conservation of synaptotagmin (p65) in Drosophila and humans.
PubMed ID: 1840599
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11381094
Title: Stonin 2: an adaptor-like protein that interacts with components of the endocytic machinery.
PubMed ID: 11381094
PubMed ID: 19234194
Title: Human SCAMP5, a novel secretory carrier membrane protein, facilitates calcium-triggered cytokine secretion by interaction with SNARE machinery.
PubMed ID: 19234194
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23999003
Title: SYT14L, especially its C2 domain, is involved in regulating melanocyte differentiation.
PubMed ID: 23999003
PubMed ID: 25712080
Title: Novel de novo heterozygous loss-of-function variants in MED13L and further delineation of the MED13L haploinsufficiency syndrome.
PubMed ID: 25712080
DOI: 10.1038/ejhg.2015.19
PubMed ID: 25705886
Title: Identification of a human synaptotagmin-1 mutation that perturbs synaptic vesicle cycling.
PubMed ID: 25705886
DOI: 10.1172/jci79765
PubMed ID: 30107533
Title: SYT1-associated neurodevelopmental disorder: a case series.
PubMed ID: 30107533
DOI: 10.1093/brain/awy209
Sequence Information:
- Length: 422
- Mass: 47573
- Checksum: 467F7C58E411AFA9
- Sequence:
MVSESHHEAL AAPPVTTVAT VLPSNATEPA SPGEGKEDAF SKLKEKFMNE LHKIPLPPWA LIAIAIVAVL LVLTCCFCIC KKCLFKKKNK KKGKEKGGKN AINMKDVKDL GKTMKDQALK DDDAETGLTD GEEKEEPKEE EKLGKLQYSL DYDFQNNQLL VGIIQAAELP ALDMGGTSDP YVKVFLLPDK KKKFETKVHR KTLNPVFNEQ FTFKVPYSEL GGKTLVMAVY DFDRFSKHDI IGEFKVPMNT VDFGHVTEEW RDLQSAEKEE QEKLGDICFS LRYVPTAGKL TVVILEAKNL KKMDVGGLSD PYVKIHLMQN GKRLKKKKTT IKKNTLNPYY NESFSFEVPF EQIQKVQVVV TVLDYDKIGK NDAIGKVFVG YNSTGAELRH WSDMLANPRR PIAQWHTLQV EEEVDAMLAV KK
Genular Protein ID: 590287530
Symbol: J3KQA0_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 11181995
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 16541075
Title: The finished DNA sequence of human chromosome 12.
PubMed ID: 16541075
DOI: 10.1038/nature04569
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
Sequence Information:
- Length: 419
- Mass: 47261
- Checksum: 146FA2B8897EADDB
- Sequence:
MVSESHHEAL AAPPVTTVAT VLPSNATEPA SPGEGKEDAF SKLKEKFMNE LHKIPLPPWA LIAIAIVAVL LVLTCCFCIC KKCLFKKKNK KKGKEKGGKN AINMKDVKDL GKTMKDQDDD AETGLTDGEE KEEPKEEEKL GKLQYSLDYD FQNNQLLVGI IQAAELPALD MGGTSDPYVK VFLLPDKKKK FETKVHRKTL NPVFNEQFTF KVPYSELGGK TLVMAVYDFD RFSKHDIIGE FKVPMNTVDF GHVTEEWRDL QSAEKEEQEK LGDICFSLRY VPTAGKLTVV ILEAKNLKKM DVGGLSDPYV KIHLMQNGKR LKKKKTTIKK NTLNPYYNES FSFEVPFEQI QKVQVVVTVL DYDKIGKNDA IGKVFVGYNS TGAELRHWSD MLANPRRPIA QWHTLQVEEE VDAMLAVKK
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.