UBB | ENSG00000170315 | NCBI 7314

Details for: UBB

Gene ID: 7314

Symbol: UBB

Ensembl ID: ENSG00000170315

Description: ubiquitin B

Associated with

Abc-family proteins mediated transport
(R-HSA-382556)
Abc transporter disorders
(R-HSA-5619084)
Adaptive immune system
(R-HSA-1280218)
Aerobic respiration and respiratory electron transport
(R-HSA-1428517)
Amyloid fiber formation
(R-HSA-977225)
Apoptosis
(R-HSA-109581)
Asparagine n-linked glycosylation
(R-HSA-446203)
Auf1 (hnrnp d0) binds and destabilizes mrna
(R-HSA-450408)
Autophagy
(R-HSA-9612973)
Axon guidance
(R-HSA-422475)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to heat stress
(R-HSA-3371556)
Cellular response to hypoxia
(R-HSA-1234174)
Cellular senescence
(R-HSA-2559583)
Chaperone mediated autophagy
(R-HSA-9613829)
Circadian clock
(R-HSA-400253)
Cytokine signaling in immune system
(R-HSA-1280215)
Cytosolic sensors of pathogen-associated dna
(R-HSA-1834949)
Ddx58/ifih1-mediated induction of interferon-alpha/beta
(R-HSA-168928)
Death receptor signaling
(R-HSA-73887)
Degradation of beta-catenin by the destruction complex
(R-HSA-195253)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of metabolism
(R-HSA-5668914)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Disorders of transmembrane transporters
(R-HSA-5619115)
Dna damage bypass
(R-HSA-73893)
Dna double-strand break repair
(R-HSA-5693532)
Dna repair
(R-HSA-73894)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Fanconi anemia pathway
(R-HSA-6783310)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Hedgehog 'off' state
(R-HSA-5610787)
Hedgehog ligand biogenesis
(R-HSA-5358346)
Hh mutants abrogate ligand secretion
(R-HSA-5387390)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Intracellular signaling by second messengers
(R-HSA-9006925)
Ion channel transport
(R-HSA-983712)
Iron uptake and transport
(R-HSA-917937)
Late endosomal microautophagy
(R-HSA-9615710)
Macroautophagy
(R-HSA-1632852)
Mapk family signaling cascades
(R-HSA-5683057)
Membrane trafficking
(R-HSA-199991)
Metabolism
(R-HSA-1430728)
Metabolism of carbohydrates
(R-HSA-71387)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Mitotic g2-g2/m phases
(R-HSA-453274)
Nervous system development
(R-HSA-9675108)
Nucleotide-binding domain, leucine rich repeat containing receptor (nlr) signaling pathways
(R-HSA-168643)
Nucleotide excision repair
(R-HSA-5696398)
P75 ntr receptor-mediated signalling
(R-HSA-193704)
Peroxisomal protein import
(R-HSA-9033241)
Pip3 activates akt signaling
(R-HSA-1257604)
Plasma lipoprotein assembly, remodeling, and clearance
(R-HSA-174824)
Post-translational protein modification
(R-HSA-597592)
Programmed cell death
(R-HSA-5357801)
Protein localization
(R-HSA-9609507)
Recognition of dna damage by pcna-containing replication complex
(R-HSA-110314)
Regulated necrosis
(R-HSA-5218859)
Regulation of apoptosis
(R-HSA-169911)
Regulation of mitotic cell cycle
(R-HSA-453276)
Regulation of mrna stability by proteins that bind au-rich elements
(R-HSA-450531)
Ripk1-mediated regulated necrosis
(R-HSA-5213460)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by egfr
(R-HSA-177929)
Signaling by egfr in cancer
(R-HSA-1643713)
Signaling by erbb2
(R-HSA-1227986)
Signaling by erbb4
(R-HSA-1236394)
Signaling by fgfr
(R-HSA-190236)
Signaling by hedgehog
(R-HSA-5358351)
Signaling by interleukins
(R-HSA-449147)
Signaling by non-receptor tyrosine kinases
(R-HSA-9006927)
Signaling by notch
(R-HSA-157118)
Signaling by notch1
(R-HSA-1980143)
Signaling by notch1 in cancer
(R-HSA-2644603)
Signaling by notch2
(R-HSA-1980145)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by tgf-beta receptor complex
(R-HSA-170834)
Signaling by tgfb family members
(R-HSA-9006936)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Stimuli-sensing channels
(R-HSA-2672351)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Tcr signaling
(R-HSA-202403)
Toll-like receptor cascades
(R-HSA-168898)
Translesion synthesis by y family dna polymerases bypasses lesions on dna template
(R-HSA-110313)
Transport of small molecules
(R-HSA-382551)
Vesicle-mediated transport
(R-HSA-5653656)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 885.9803
Cell Significance Index: -137.8100
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 607.6642
Cell Significance Index: -154.1300
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 512.9293
Cell Significance Index: -211.3000
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 459.1427
Cell Significance Index: -186.5300
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 431.2651
Cell Significance Index: -203.6100
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 396.0456
Cell Significance Index: -203.7200
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 304.9378
Cell Significance Index: -204.6200
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 198.8808
Cell Significance Index: -189.8800
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 124.4570
Cell Significance Index: -153.4500
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 54.1340
Cell Significance Index: -166.2700
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 52.2421
Cell Significance Index: -206.1500
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 32.6632
Cell Significance Index: -87.5000
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 8.8525
Cell Significance Index: 307.6200
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 8.1585
Cell Significance Index: 233.8700
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 7.9413
Cell Significance Index: 416.9500
Cell Name: odontoblast (CL0000060)
Fold Change: 7.7982
Cell Significance Index: 999.6800
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 6.1258
Cell Significance Index: 108.2500
Cell Name: kidney cell (CL1000497)
Fold Change: 6.1045
Cell Significance Index: 48.7400
Cell Name: theca cell (CL0000503)
Fold Change: 5.9796
Cell Significance Index: 35.1300
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 5.7349
Cell Significance Index: 267.3900
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 5.1401
Cell Significance Index: 241.5800
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 4.9624
Cell Significance Index: 103.8700
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 4.6035
Cell Significance Index: 632.1900
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 4.4658
Cell Significance Index: 549.1100
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 4.3933
Cell Significance Index: 791.9800
Cell Name: granulosa cell (CL0000501)
Fold Change: 4.3917
Cell Significance Index: 115.4800
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 4.2879
Cell Significance Index: 319.5700
Cell Name: cell in vitro (CL0001034)
Fold Change: 4.0463
Cell Significance Index: 2209.7700
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 3.9967
Cell Significance Index: 208.1800
Cell Name: early pro-B cell (CL0002046)
Fold Change: 3.8044
Cell Significance Index: 245.4400
Cell Name: lactocyte (CL0002325)
Fold Change: 3.2320
Cell Significance Index: 417.5500
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 3.1454
Cell Significance Index: 1390.6500
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 2.8562
Cell Significance Index: 336.8300
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 2.5518
Cell Significance Index: 28.9900
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 2.1966
Cell Significance Index: 23.8800
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 2.1699
Cell Significance Index: 370.5300
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.9964
Cell Significance Index: 396.1900
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 1.9225
Cell Significance Index: 135.9700
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.7326
Cell Significance Index: 49.9200
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 1.6174
Cell Significance Index: 184.6200
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.8970
Cell Significance Index: 8.2600
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.7806
Cell Significance Index: 590.8200
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.7392
Cell Significance Index: 38.4000
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.7307
Cell Significance Index: 146.5800
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.6495
Cell Significance Index: 17.6800
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.6457
Cell Significance Index: 473.4400
Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.5902
Cell Significance Index: 7.0400
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.4620
Cell Significance Index: 165.7300
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3787
Cell Significance Index: 72.0700
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.1763
Cell Significance Index: 2.9500
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1700
Cell Significance Index: 16.8200
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.1446
Cell Significance Index: 3.8600
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -0.0626
Cell Significance Index: -10.1800
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0744
Cell Significance Index: -55.1000
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0770
Cell Significance Index: -7.8700
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0798
Cell Significance Index: -150.1800
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.1336
Cell Significance Index: -246.3700
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.1596
Cell Significance Index: -245.7000
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.1628
Cell Significance Index: -101.6500
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.1703
Cell Significance Index: -18.5300
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.1827
Cell Significance Index: -248.4700
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2335
Cell Significance Index: -18.4900
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.2411
Cell Significance Index: -135.9500
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.2575
Cell Significance Index: -163.5400
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.4075
Cell Significance Index: -85.8400
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.4173
Cell Significance Index: -189.3800
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.6223
Cell Significance Index: -179.0600
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.6830
Cell Significance Index: -43.0500
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.8118
Cell Significance Index: -20.7400
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.8540
Cell Significance Index: -25.0800
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.9141
Cell Significance Index: -104.7200
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -1.0360
Cell Significance Index: -63.6800
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -1.0720
Cell Significance Index: -48.5900
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -1.1536
Cell Significance Index: -134.4400
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: -1.1910
Cell Significance Index: -9.1800
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -1.2637
Cell Significance Index: -183.7000
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -1.6682
Cell Significance Index: -93.6100
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -1.6994
Cell Significance Index: -54.4300
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -1.7768
Cell Significance Index: -47.6100
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -1.8004
Cell Significance Index: -121.0600
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -1.9447
Cell Significance Index: -29.1400
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -1.9862
Cell Significance Index: -53.1300
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -1.9924
Cell Significance Index: -207.4600
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -1.9931
Cell Significance Index: -25.5300
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -2.1166
Cell Significance Index: -39.1200
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -2.1377
Cell Significance Index: -59.7400
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: -2.4707
Cell Significance Index: -15.2100
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -2.6264
Cell Significance Index: -201.5500
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -2.8281
Cell Significance Index: -61.2700
Cell Name: gut absorptive cell (CL0000677)
Fold Change: -3.1602
Cell Significance Index: -189.7200
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -3.3073
Cell Significance Index: -202.7700
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -3.5995
Cell Significance Index: -106.0200
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -3.7856
Cell Significance Index: -51.6500
Cell Name: seromucus secreting cell (CL0000159)
Fold Change: -3.8905
Cell Significance Index: -81.1400
Cell Name: type I muscle cell (CL0002211)
Fold Change: -4.1444
Cell Significance Index: -101.1200
Cell Name: peg cell (CL4033014)
Fold Change: -4.6324
Cell Significance Index: -107.0300
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -4.7672
Cell Significance Index: -175.0000
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -4.7803
Cell Significance Index: -81.9200
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -4.8071
Cell Significance Index: -137.1800
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -4.8098
Cell Significance Index: -29.0600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** UBB is a ubiquitin protein that is involved in the formation of ubiquitin chains, which mark proteins for degradation by the proteasome. UBB is unique in that it can form a covalent bond with itself, forming a homodimeric ubiquitin chain. This characteristic allows UBB to interact with other proteins and regulate various cellular processes. UBB is also involved in the regulation of cell cycle progression and apoptosis, and its dysregulation has been implicated in several diseases. **Pathways and Functions** UBB is involved in several cellular pathways, including: 1. **Protein degradation**: UBB is a key component of the UPS, which is responsible for the degradation of proteins that are no longer needed or are damaged. 2. **Cell cycle regulation**: UBB is involved in the regulation of cell cycle progression, particularly in the G2/M phase. 3. **Apoptosis**: UBB is involved in the regulation of apoptosis, particularly in the context of immune cells. 4. **Immune response**: UBB is involved in the regulation of immune responses, particularly in the context of antigen presentation and T cell activation. 5. **Neurodegenerative diseases**: UBB has been implicated in several neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. **Clinical Significance** Dysregulation of UBB has been implicated in several diseases, including: 1. **Autoimmune disorders**: UBB has been implicated in several autoimmune disorders, including rheumatoid arthritis and multiple sclerosis. 2. **Cancer**: UBB has been implicated in several types of cancer, including breast cancer and lung cancer. 3. **Neurodegenerative diseases**: UBB has been implicated in several neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. 4. **Infectious diseases**: UBB has been implicated in several infectious diseases, including tuberculosis and malaria. In conclusion, UBB is a crucial gene that plays a key role in various cellular processes, including protein degradation, cell cycle regulation, and immune response. Dysregulation of UBB has been implicated in several diseases, including autoimmune disorders, cancer, and neurodegenerative diseases. Further research is needed to fully understand the role of UBB in human disease and to develop effective therapeutic strategies to target UBB dysregulation. **Implications for Immunology** The study of UBB has significant implications for immunology, particularly in the context of autoimmune disorders and cancer. For example: 1. **Immunotherapeutic strategies**: Targeting UBB dysregulation may provide a new avenue for immunotherapeutic strategies to treat autoimmune disorders and cancer. 2. **Vaccine development**: UBB may play a role in the development of vaccines against infectious diseases, particularly in the context of antigen presentation and T cell activation. 3. **Immunomodulation**: UBB may be involved in the regulation of immune responses, particularly in the context of chronic inflammation and autoimmune disorders. In summary, UBB is a crucial gene that plays a key role in various cellular processes, including protein degradation, cell cycle regulation, and immune response. Further research is needed to fully understand the role of UBB in human disease and to develop effective therapeutic strategies to target UBB dysregulation.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Polyubiquitin-B

Genular Protein ID: 2474521257

Symbol: UBB_HUMAN

Name: Polyubiquitin-B

UniProtKB Accession Codes:

P0CG47 P02248 P02249 P02250 P62988 Q29120 Q6LBL4 Q6LDU5 Q8WYN8 Q91887 Q91888 Q9BWD6 Q9BX98 Q9UEF2 Q9UEG1 Q9UEK8 Q9UPK7

Database IDs:

Citations:

PubMed ID: 3029682

Title: The human ubiquitin gene family: structure of a gene and pseudogenes from the Ub B subfamily.

PubMed ID: 3029682

DOI: 10.1093/nar/15.2.443

PubMed ID: 14745543

Title: Lineage-specific homogenization of the polyubiquitin gene among human and great apes.

PubMed ID: 14745543

DOI: 10.1007/s00239-003-2532-4

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1128706

Title: Molecular conservation of 74 amino acid sequence of ubiquitin between cattle and man.

PubMed ID: 1128706

DOI: 10.1038/255423a0

PubMed ID: 16443603

Title: Alzheimer disease-specific conformation of hyperphosphorylated paired helical filament-tau is polyubiquitinated through Lys-48, Lys-11, and Lys-6 ubiquitin conjugation.

PubMed ID: 16443603

DOI: 10.1074/jbc.m512786200

PubMed ID: 16543144

Title: Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain.

PubMed ID: 16543144

DOI: 10.1016/j.molcel.2006.02.018

PubMed ID: 15466860

Title: Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis.

PubMed ID: 15466860

DOI: 10.1074/jbc.m402916200

PubMed ID: 18719106

Title: Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks.

PubMed ID: 18719106

DOI: 10.1073/pnas.0805685105

PubMed ID: 19754430

Title: The emerging complexity of protein ubiquitination.

PubMed ID: 19754430

DOI: 10.1042/bst0370937

PubMed ID: 21762696

Title: Mutant ubiquitin (UBB(+1)) associated with neurodegenerative disorders is hydrolyzed by ubiquitin C-terminal hydrolase L3 (UCH-L3).

PubMed ID: 21762696

DOI: 10.1016/j.febslet.2011.06.037

PubMed ID: 9422699

Title: Frameshift mutants of beta amyloid precursor protein and ubiquitin-B in Alzheimer's and Down patients.

PubMed ID: 9422699

DOI: 10.1126/science.279.5348.242

PubMed ID: 14597671

Title: Disease-specific accumulation of mutant ubiquitin as a marker for proteasomal dysfunction in the brain.

PubMed ID: 14597671

DOI: 10.1096/fj.03-0205com

PubMed ID: 24660806

Title: Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65.

PubMed ID: 24660806

DOI: 10.1042/bj20140334

PubMed ID: 24751536

Title: PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity.

PubMed ID: 24751536

DOI: 10.1083/jcb.201402104

PubMed ID: 24784582

Title: Ubiquitin is phosphorylated by PINK1 to activate parkin.

PubMed ID: 24784582

DOI: 10.1038/nature13392

PubMed ID: 25527291

Title: Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis.

PubMed ID: 25527291

DOI: 10.15252/embj.201489847

PubMed ID: 28525742

Title: Ubiquitin Modification by the E3 Ligase/ADP-Ribosyltransferase Dtx3L/Parp9.

PubMed ID: 28525742

DOI: 10.1016/j.molcel.2017.04.028

PubMed ID: 32330457

Title: Threonine ADP-ribosylation of ubiquitin by a bacterial effector family blocks host ubiquitination.

PubMed ID: 32330457

DOI: 10.1016/j.molcel.2020.03.016

PubMed ID: 34239127

Title: K29-linked ubiquitin signaling regulates proteotoxic stress response and cell cycle.

PubMed ID: 34239127

DOI: 10.1038/s41589-021-00823-5

PubMed ID: 30033217

Title: A Structure-Based Strategy for Engineering Selective Ubiquitin Variant Inhibitors of Skp1-Cul1-F-Box Ubiquitin Ligases.

PubMed ID: 30033217

DOI: 10.1016/j.str.2018.06.004

PubMed ID: 25752573

Title: K29-selective ubiquitin binding domain reveals structural basis of specificity and heterotypic nature of K29 polyubiquitin.

PubMed ID: 25752573

DOI: 10.1016/j.molcel.2015.01.041

PubMed ID: 25752577

Title: Assembly and specific recognition of K29- and K33-linked polyubiquitin.

PubMed ID: 25752577

DOI: 10.1016/j.molcel.2015.01.042

PubMed ID: 26161729

Title: Mechanism of phospho-ubiquitin-induced PARKIN activation.

PubMed ID: 26161729

DOI: 10.1038/nature14879

PubMed ID: 26416742

Title:

PubMed ID: 26416742

DOI: 10.1038/nature15531

Sequence Information:

Length: 229
Mass: 25762
Checksum: 33011162F1C48BB1
Sequence:

MQIFVKTLTG KTITLEVEPS DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL EDGRTLSDYN 
IQKESTLHLV LRLRGGMQIF VKTLTGKTIT LEVEPSDTIE NVKAKIQDKE GIPPDQQRLI 
FAGKQLEDGR TLSDYNIQKE STLHLVLRLR GGMQIFVKTL TGKTITLEVE PSDTIENVKA 
KIQDKEGIPP DQQRLIFAGK QLEDGRTLSD YNIQKESTLH LVLRLRGGC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: UBB

Associated with

Cells (max top 100)

Other Information

The human ubiquitin gene family: structure of a gene and pseudogenes from the Ub B subfamily. PubMed ID: 3029682

Lineage-specific homogenization of the polyubiquitin gene among human and great apes. PubMed ID: 14745543

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. PubMed ID: 16625196

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Molecular conservation of 74 amino acid sequence of ubiquitin between cattle and man. PubMed ID: 1128706

Alzheimer disease-specific conformation of hyperphosphorylated paired helical filament-tau is polyubiquitinated through Lys-48, Lys-11, and Lys-6 ubiquitin conjugation. PubMed ID: 16443603

Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain. PubMed ID: 16543144

Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis. PubMed ID: 15466860

Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks. PubMed ID: 18719106

The emerging complexity of protein ubiquitination. PubMed ID: 19754430

Mutant ubiquitin (UBB(+1)) associated with neurodegenerative disorders is hydrolyzed by ubiquitin C-terminal hydrolase L3 (UCH-L3). PubMed ID: 21762696

Frameshift mutants of beta amyloid precursor protein and ubiquitin-B in Alzheimer's and Down patients. PubMed ID: 9422699

Disease-specific accumulation of mutant ubiquitin as a marker for proteasomal dysfunction in the brain. PubMed ID: 14597671

Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65. PubMed ID: 24660806

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity. PubMed ID: 24751536

Ubiquitin is phosphorylated by PINK1 to activate parkin. PubMed ID: 24784582

Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis. PubMed ID: 25527291

Ubiquitin Modification by the E3 Ligase/ADP-Ribosyltransferase Dtx3L/Parp9. PubMed ID: 28525742

Threonine ADP-ribosylation of ubiquitin by a bacterial effector family blocks host ubiquitination. PubMed ID: 32330457

K29-linked ubiquitin signaling regulates proteotoxic stress response and cell cycle. PubMed ID: 34239127

A Structure-Based Strategy for Engineering Selective Ubiquitin Variant Inhibitors of Skp1-Cul1-F-Box Ubiquitin Ligases. PubMed ID: 30033217

K29-selective ubiquitin binding domain reveals structural basis of specificity and heterotypic nature of K29 polyubiquitin. PubMed ID: 25752573

Assembly and specific recognition of K29- and K33-linked polyubiquitin. PubMed ID: 25752577

Mechanism of phospho-ubiquitin-induced PARKIN activation. PubMed ID: 26161729