Details for: S100A6

Gene ID: 6277

Symbol: S100A6

Ensembl ID: ENSG00000197956

Description: S100 calcium binding protein A6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 880.7085
    Cell Significance Index: -136.9900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 686.9684
    Cell Significance Index: -174.2500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 475.3274
    Cell Significance Index: -195.8100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 433.2109
    Cell Significance Index: -176.0000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 394.1561
    Cell Significance Index: -186.0900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 366.9429
    Cell Significance Index: -188.7500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 280.0504
    Cell Significance Index: -187.9200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 185.6626
    Cell Significance Index: -177.2600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 139.8185
    Cell Significance Index: -172.3900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 48.3826
    Cell Significance Index: -190.9200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 45.6429
    Cell Significance Index: -140.1900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 34.1526
    Cell Significance Index: -91.4900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 24.5149
    Cell Significance Index: 453.1000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 16.1701
    Cell Significance Index: 148.9100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 12.8507
    Cell Significance Index: 603.9700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 12.3469
    Cell Significance Index: 2225.7600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 12.2216
    Cell Significance Index: 350.3400
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 12.2181
    Cell Significance Index: 104.9900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 11.4687
    Cell Significance Index: 1410.1800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 10.0199
    Cell Significance Index: 113.8300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 9.9583
    Cell Significance Index: 175.9800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 8.8144
    Cell Significance Index: 258.8700
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 8.5646
    Cell Significance Index: 61.5100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 7.4827
    Cell Significance Index: 4086.4700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 6.9607
    Cell Significance Index: 5268.6800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 6.7848
    Cell Significance Index: 41.7600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 6.7428
    Cell Significance Index: 864.3900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 6.4771
    Cell Significance Index: 836.8000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 6.3922
    Cell Significance Index: 476.4100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 6.3731
    Cell Significance Index: 875.2100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 5.8428
    Cell Significance Index: 577.9800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 4.8645
    Cell Significance Index: 2150.7200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.6140
    Cell Significance Index: 125.5900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 4.2753
    Cell Significance Index: 98.7800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 4.2526
    Cell Significance Index: 221.5100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 3.4078
    Cell Significance Index: 269.9000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 3.1739
    Cell Significance Index: 224.4700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 2.8336
    Cell Significance Index: 2077.5800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.6897
    Cell Significance Index: 139.7200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 2.0936
    Cell Significance Index: 31.3700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.5125
    Cell Significance Index: 29.5200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.4210
    Cell Significance Index: 64.4100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.3584
    Cell Significance Index: 36.2700
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.2813
    Cell Significance Index: 7.9300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.2524
    Cell Significance Index: 80.8000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.1778
    Cell Significance Index: 33.9400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0555
    Cell Significance Index: 200.8600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0456
    Cell Significance Index: 85.7800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0266
    Cell Significance Index: 2.7200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0133
    Cell Significance Index: -24.4900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0305
    Cell Significance Index: -46.9300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0331
    Cell Significance Index: -3.6000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0887
    Cell Significance Index: -65.6900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.1248
    Cell Significance Index: -169.6700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1274
    Cell Significance Index: -80.9400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1652
    Cell Significance Index: -103.1700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1843
    Cell Significance Index: -31.4800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.2263
    Cell Significance Index: -45.4000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2550
    Cell Significance Index: -143.8200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.3159
    Cell Significance Index: -143.3600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3692
    Cell Significance Index: -106.2300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3956
    Cell Significance Index: -83.3300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.4087
    Cell Significance Index: -146.5800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.6791
    Cell Significance Index: -134.7600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.7272
    Cell Significance Index: -12.1700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.7904
    Cell Significance Index: -114.8900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.8288
    Cell Significance Index: -96.5900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.8803
    Cell Significance Index: -12.0100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.9591
    Cell Significance Index: -109.8800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.9680
    Cell Significance Index: -48.9200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -1.0735
    Cell Significance Index: -22.4700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.1315
    Cell Significance Index: -36.2400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -1.1587
    Cell Significance Index: -132.2700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.1776
    Cell Significance Index: -20.3000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -1.1925
    Cell Significance Index: -8.0800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -1.2613
    Cell Significance Index: -51.6800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -1.2705
    Cell Significance Index: -149.8300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.4211
    Cell Significance Index: -66.2600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.4355
    Cell Significance Index: -31.1000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.6571
    Cell Significance Index: -46.3100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.7733
    Cell Significance Index: -184.6400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.8380
    Cell Significance Index: -11.1100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.9651
    Cell Significance Index: -150.8000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -2.2501
    Cell Significance Index: -18.9000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -2.6537
    Cell Significance Index: -69.7800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -2.7879
    Cell Significance Index: -171.3600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -2.8868
    Cell Significance Index: -194.1100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -3.0323
    Cell Significance Index: -64.5800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -3.0481
    Cell Significance Index: -186.8800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -3.1558
    Cell Significance Index: -165.6900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -3.4504
    Cell Significance Index: -119.9000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -3.6067
    Cell Significance Index: -202.3900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -3.6820
    Cell Significance Index: -108.4500
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -3.7041
    Cell Significance Index: -23.0200
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -3.8752
    Cell Significance Index: -80.8200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -4.2141
    Cell Significance Index: -105.3400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -4.3621
    Cell Significance Index: -160.1300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -4.4128
    Cell Significance Index: -118.0400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -4.5707
    Cell Significance Index: -202.1800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -4.7641
    Cell Significance Index: -122.4600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** S100A6 is a calcium-binding protein that exhibits a high degree of homology with other S100 proteins. It is characterized by its ability to bind to calcium ions, which is essential for its biological functions. The protein is also known to form homodimers, which are important for its interactions with other proteins and regulation of cellular processes. **Pathways and Functions** S100A6 is involved in various cellular pathways, including: 1. **Axonogenesis**: S100A6 is involved in the regulation of axon growth and regeneration, which is essential for the development and maintenance of the nervous system. 2. **Calcium-dependent protein binding**: The protein binds to calcium ions, which is essential for its interactions with other proteins and regulation of cellular processes. 3. **Collagen-containing extracellular matrix**: S100A6 is involved in the regulation of collagen deposition and organization in the extracellular matrix, which is essential for tissue development and maintenance. 4. **Signal transduction**: The protein is involved in the regulation of signal transduction pathways, including those involved in cell proliferation, differentiation, and survival. 5. **Protein binding**: S100A6 binds to various proteins, including tropomyosin, collagen, and other S100 proteins, which is essential for its interactions with other proteins and regulation of cellular processes. **Clinical Significance** S100A6 has been implicated in various diseases, including: 1. **Autoimmune disorders**: The protein has been shown to be involved in the regulation of immune responses, including those involved in autoimmune disorders such as rheumatoid arthritis and lupus. 2. **Cancer**: S100A6 has been shown to be overexpressed in various types of cancer, including breast, lung, and colon cancer, and is involved in the regulation of cell proliferation and survival. 3. **Inflammatory disorders**: The protein has been shown to be involved in the regulation of inflammatory responses, including those involved in diseases such as asthma and chronic obstructive pulmonary disease (COPD). In conclusion, S100A6 is a calcium-binding protein that plays a crucial role in various cellular processes, including immune response, cell proliferation, and survival. Its clinical significance is evident in its involvement in various diseases, including autoimmune disorders, cancer, and inflammatory disorders. Further research is needed to fully understand the biological functions of S100A6 and its role in human disease. **Significantly expressed cells** * Secretory cell * Alveolar capillary type 1 endothelial cell * Uterine smooth muscle cell * Kidney loop of Henle thick ascending limb epithelial cell * Epithelial cell of lung * Fibroblast of mammary gland * Mature T cell * Foveolar cell of stomach * Type I pneumocyte * CD14-positive, CD16-negative classical monocyte

Genular Protein ID: 880730076

Symbol: S10A6_HUMAN

Name: Protein S100-A6

UniProtKB Accession Codes:

P06703 D3DV39 Q5RHS4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTC 1 CTD 1 ChEBI 7 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EMBL 16 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3755724

Title: Molecular cloning of the cDNA for a growth factor-inducible gene with strong homology to S-100, a calcium-binding protein.

PubMed ID: 3755724

DOI: 10.1016/s0021-9258(18)67137-6

PubMed ID: 3036810

Title: Structural and functional analysis of a growth-regulated gene, the human calcyclin.

PubMed ID: 3036810

DOI: 10.1016/s0021-9258(18)47567-9

PubMed ID: 2448309

Title: Cloning and characterization of a cDNA encoding a highly conserved, putative calcium binding protein, identified by an anti-prolactin receptor antiserum.

PubMed ID: 2448309

DOI: 10.1016/s0021-9258(18)69220-8

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1482346

Title: Calcyclin and calvasculin exist in human platelets.

PubMed ID: 1482346

DOI: 10.1016/0006-291x(92)90216-8

PubMed ID: 2775283

Title: Identification of a cell cycle-dependent gene product as a sialic acid-binding protein.

PubMed ID: 2775283

DOI: 10.1016/0006-291x(89)92166-9

PubMed ID: 12746458

Title: Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins.

PubMed ID: 12746458

DOI: 10.1074/jbc.m211518200

PubMed ID: 12601007

Title: Calcium- and cell cycle-dependent association of annexin 11 with the nuclear envelope.

PubMed ID: 12601007

DOI: 10.1074/jbc.m212669200

PubMed ID: 19724273

Title: S100A6 binds to annexin 2 in pancreatic cancer cells and promotes pancreatic cancer cell motility.

PubMed ID: 19724273

DOI: 10.1038/sj.bjc.6605289

PubMed ID: 19819244

Title: Posttranslational modifications affect the interaction of S100 proteins with tumor suppressor p53.

PubMed ID: 19819244

DOI: 10.1016/j.jmb.2009.10.002

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20188096

Title: S100 proteins regulate the interaction of Hsp90 with cyclophilin 40 and FKBP52 through their tetratricopeptide repeats.

PubMed ID: 20188096

DOI: 10.1016/j.febslet.2010.02.055

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22399290

Title: S100 proteins modulate protein phosphatase 5 function: a link between CA2+ signal transduction and protein dephosphorylation.

PubMed ID: 22399290

DOI: 10.1074/jbc.m111.329771

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28469040

Title: Mutations in the vesicular trafficking protein annexin A11 are associated with amyotrophic lateral sclerosis.

PubMed ID: 28469040

DOI: 10.1126/scitranslmed.aad9157

PubMed ID: 33831707

Title: Regulation of the tubulin polymerization-promoting protein by Ca2+/S100 proteins.

PubMed ID: 33831707

DOI: 10.1016/j.ceca.2021.102404

PubMed ID: 11937060

Title: Crystal structures of S100A6 in the Ca(2+)-free and Ca(2+)-bound states: the calcium sensor mechanism of S100 proteins revealed at atomic resolution.

PubMed ID: 11937060

DOI: 10.1016/s0969-2126(02)00740-2

Sequence Information:

  • Length: 90
  • Mass: 10180
  • Checksum: 860CBB1416ACBCA1
  • Sequence:
    • MACPLDQAIG LLVAIFHKYS GREGDKHTLS KKELKELIQK ELTIGSKLQD AEIARLMEDL 
DRNKDQEVNF QEYVTFLGAL ALIYNEALKG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.