Details for: NAP1L1

Gene ID: 4673

Symbol: NAP1L1

Ensembl ID: ENSG00000187109

Description: nucleosome assembly protein 1 like 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 805.4249
    Cell Significance Index: -125.2800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 356.5259
    Cell Significance Index: -146.8700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 354.1192
    Cell Significance Index: -89.8200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 311.3053
    Cell Significance Index: -126.4700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 304.4760
    Cell Significance Index: -143.7500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 274.2303
    Cell Significance Index: -141.0600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 215.8200
    Cell Significance Index: -144.8200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 133.2767
    Cell Significance Index: -127.2500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 115.4543
    Cell Significance Index: -142.3500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 42.5922
    Cell Significance Index: -130.8200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 41.1593
    Cell Significance Index: -110.2600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 37.7048
    Cell Significance Index: -148.7900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 26.3595
    Cell Significance Index: -57.6900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 9.6798
    Cell Significance Index: 258.9300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 6.9440
    Cell Significance Index: 241.3000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 6.0360
    Cell Significance Index: 828.9100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 5.4315
    Cell Significance Index: 1562.8100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 4.9249
    Cell Significance Index: 53.5400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 4.4612
    Cell Significance Index: 93.3800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 4.1550
    Cell Significance Index: 2269.1300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 4.0886
    Cell Significance Index: 263.7800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 3.8244
    Cell Significance Index: 470.2400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 3.7942
    Cell Significance Index: 212.9100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 3.7794
    Cell Significance Index: 99.3800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 3.6201
    Cell Significance Index: 170.1400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.3867
    Cell Significance Index: 27.0400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.1022
    Cell Significance Index: 84.4400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.9227
    Cell Significance Index: 377.5900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.7904
    Cell Significance Index: 503.0200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.6465
    Cell Significance Index: 138.9500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.6352
    Cell Significance Index: 75.5400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.6290
    Cell Significance Index: 310.0400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.5791
    Cell Significance Index: 1140.2900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.4761
    Cell Significance Index: 496.7100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.1375
    Cell Significance Index: 424.2000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.1311
    Cell Significance Index: 150.7200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.0967
    Cell Significance Index: 752.0500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.8362
    Cell Significance Index: 23.5200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.7272
    Cell Significance Index: 221.4200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.6403
    Cell Significance Index: 76.4800
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.6221
    Cell Significance Index: 9.5300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.3482
    Cell Significance Index: 36.0000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.2464
    Cell Significance Index: 92.8900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.2222
    Cell Significance Index: 13.8900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1442
    Cell Significance Index: 186.0900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.8189
    Cell Significance Index: 139.8400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.7882
    Cell Significance Index: 23.1500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.6609
    Cell Significance Index: 40.6200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6559
    Cell Significance Index: 592.2700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.5953
    Cell Significance Index: 10.5200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.5689
    Cell Significance Index: 25.1700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3294
    Cell Significance Index: 12.4800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.3272
    Cell Significance Index: 7.5600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2879
    Cell Significance Index: 22.1000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2716
    Cell Significance Index: 18.7800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2303
    Cell Significance Index: 433.7000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2110
    Cell Significance Index: 14.1900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1679
    Cell Significance Index: 2.8100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1050
    Cell Significance Index: 66.6700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1006
    Cell Significance Index: 45.6700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0973
    Cell Significance Index: 149.7500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0854
    Cell Significance Index: 157.4600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0409
    Cell Significance Index: 55.6300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0313
    Cell Significance Index: 23.7100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0306
    Cell Significance Index: 5.8300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0042
    Cell Significance Index: -3.0500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0234
    Cell Significance Index: -17.3700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0479
    Cell Significance Index: -1.3800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0904
    Cell Significance Index: -56.4400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1230
    Cell Significance Index: -12.5600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.1533
    Cell Significance Index: -15.1600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1625
    Cell Significance Index: -5.7100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1719
    Cell Significance Index: -96.9600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1734
    Cell Significance Index: -9.0300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2988
    Cell Significance Index: -8.3500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3443
    Cell Significance Index: -72.5200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4417
    Cell Significance Index: -64.2100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5290
    Cell Significance Index: -27.4800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.7114
    Cell Significance Index: -82.9000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.7801
    Cell Significance Index: -19.9300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.8213
    Cell Significance Index: -94.0900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.8309
    Cell Significance Index: -5.0200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.9617
    Cell Significance Index: -60.6100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -1.0591
    Cell Significance Index: -120.9000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.1308
    Cell Significance Index: -20.9000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.1760
    Cell Significance Index: -122.4500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -1.2090
    Cell Significance Index: -54.8000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.3480
    Cell Significance Index: -106.7600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.3841
    Cell Significance Index: -23.7200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -1.5252
    Cell Significance Index: -14.0500
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -1.5477
    Cell Significance Index: -9.8800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.6945
    Cell Significance Index: -103.8900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.7275
    Cell Significance Index: -29.7800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.7450
    Cell Significance Index: -55.8900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.7569
    Cell Significance Index: -45.1600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.7577
    Cell Significance Index: -50.1600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -1.8277
    Cell Significance Index: -43.8300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.8719
    Cell Significance Index: -25.5400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -2.0029
    Cell Significance Index: -39.0900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -2.0309
    Cell Significance Index: -24.2100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NAP1L1 is a member of the nucleosome assembly protein 1 (NAP1) family, which plays a crucial role in the assembly and disassembly of chromatin structures. The gene is primarily expressed in hematopoietic stem cells, mesenchymal stem cells, and other cell types involved in tissue development and regeneration. NAP1L1 exhibits high sequence similarity to the well-studied NAP1 gene, suggesting a conserved function across species. **Pathways and Functions:** NAP1L1 is involved in various cellular pathways, including: 1. **Chromatin assembly and disassembly**: NAP1L1 plays a critical role in the assembly and disassembly of nucleosomes, the fundamental units of chromatin. 2. **Histone binding**: NAP1L1 interacts with histones, regulating their binding to DNA and influencing chromatin structure. 3. **Cell population proliferation**: NAP1L1 promotes cell population proliferation by regulating the expression of genes involved in cell cycle progression. 4. **Neural precursor cell proliferation**: NAP1L1 is expressed in neural precursor cells, where it regulates their proliferation and differentiation. 5. **Histone chaperone activity**: NAP1L1 acts as a histone chaperone, facilitating the assembly and disassembly of nucleosomes. **Clinical Significance:** NAP1L1's involvement in various cellular processes has significant implications for human disease. Some of the clinical significance of NAP1L1 includes: 1. **Cancer research**: NAP1L1's role in cell population proliferation and histone binding make it a potential target for cancer therapy. 2. **Neurodegenerative diseases**: NAP1L1's involvement in neural precursor cell proliferation and histone chaperone activity may be relevant to neurodegenerative diseases, such as Alzheimer's and Parkinson's. 3. **Regenerative medicine**: NAP1L1's expression in stem cells and its role in chromatin assembly and disassembly make it a potential candidate for regenerative therapies. 4. **Immune regulation**: NAP1L1's interaction with histones and its role in chromatin assembly and disassembly may also influence immune regulation, making it a potential target for immunotherapies. **Conclusion:** In conclusion, NAP1L1 is a gene with a complex and multifaceted function in cellular processes, including chromatin assembly, histone binding, and regulation of cell population proliferation. Its involvement in various disease contexts, including cancer, neurodegenerative diseases, regenerative medicine, and immune regulation, highlights its potential as a therapeutic target. Further research is needed to fully elucidate the mechanisms by which NAP1L1 regulates cellular processes and to explore its therapeutic applications. **Recommendations:** 1. **Further investigation**: Conduct in-depth studies to elucidate the mechanisms by which NAP1L1 regulates chromatin assembly and histone binding. 2. **Therapeutic targeting**: Explore NAP1L1 as a therapeutic target for cancer, neurodegenerative diseases, and regenerative medicine. 3. **Immunological studies**: Investigate NAP1L1's role in immune regulation and its potential as an immunotherapeutic target. By advancing our understanding of NAP1L1's functions and clinical significance, we can unlock new avenues for therapeutic intervention and improve human health outcomes.

Genular Protein ID: 1260355850

Symbol: NP1L1_HUMAN

Name: Nucleosome assembly protein 1-like 1

UniProtKB Accession Codes:

P55209 B3KNT8 B3KV44

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CPTAC 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EMDB 2 Ensembl 4 ExpressionAtlas 1 GO 15 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 7 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8297347

Title: Molecular characterization of hNRP, a cDNA encoding a human nucleosome-assembly-protein-I-related gene product involved in the induction of cell proliferation.

PubMed ID: 8297347

DOI: 10.1042/bj2970389

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15308774

Title: A tagging-via-substrate technology for detection and proteomics of farnesylated proteins.

PubMed ID: 15308774

DOI: 10.1073/pnas.0403413101

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18226242

Title: The histone chaperone protein Nucleosome Assembly Protein-1 (hNAP-1) binds HIV-1 Tat and promotes viral transcription.

PubMed ID: 18226242

DOI: 10.1186/1742-4690-5-8

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 20002496

Title: Functional characterization of human nucleosome assembly protein 1-like proteins as histone chaperones.

PubMed ID: 20002496

DOI: 10.1111/j.1365-2443.2009.01361.x

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21211722

Title: DNA repair factor APLF is a histone chaperone.

PubMed ID: 21211722

DOI: 10.1016/j.molcel.2010.12.008

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23691099

Title: A role for the nucleosome assembly proteins TAF-Ibeta and NAP1 in the activation of BZLF1 expression and Epstein-Barr virus reactivation.

PubMed ID: 23691099

DOI: 10.1371/journal.pone.0063802

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24798879

Title: Nap1 stimulates homologous recombination by RAD51 and RAD54 in higher-ordered chromatin containing histone H1.

PubMed ID: 24798879

DOI: 10.1038/srep04863

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27599637

Title: KSHV encoded LANA recruits Nucleosome Assembly Protein NAP1L1 for regulating viral DNA replication and transcription.

PubMed ID: 27599637

DOI: 10.1038/srep32633

PubMed ID: 26841755

Title: C-terminal acidic domain of histone chaperone human NAP1 is an efficient binding assistant for histone H2A-H2B, but not H3-H4.

PubMed ID: 26841755

DOI: 10.1111/gtc.12339

PubMed ID: 28659470

Title: Hepatitis C Virus NS5A Targets Nucleosome Assembly Protein NAP1L1 To Control the Innate Cellular Response.

PubMed ID: 28659470

DOI: 10.1128/jvi.00880-17

PubMed ID: 28369616

Title: NAP1L1 accelerates activation and decreases pausing to enhance nucleosome remodeling by CSB.

PubMed ID: 28369616

DOI: 10.1093/nar/gkx188

PubMed ID: 29899097

Title: Multiple Host Factors Interact with the Hypervariable Domain of Chikungunya Virus nsP3 and Determine Viral Replication in Cell-Specific Mode.

PubMed ID: 29899097

DOI: 10.1128/jvi.00838-18

Sequence Information:

  • Length: 391
  • Mass: 45374
  • Checksum: E5B2EAA4EAE551D2
  • Sequence:
    • MADIDNKEQS ELDQDLDDVE EVEEEETGEE TKLKARQLTV QMMQNPQILA ALQERLDGLV 
ETPTGYIESL PRVVKRRVNA LKNLQVKCAQ IEAKFYEEVH DLERKYAVLY QPLFDKRFEI 
INAIYEPTEE ECEWKPDEED EISEELKEKA KIEDEKKDEE KEDPKGIPEF WLTVFKNVDL 
LSDMVQEHDE PILKHLKDIK VKFSDAGQPM SFVLEFHFEP NEYFTNEVLT KTYRMRSEPD 
DSDPFSFDGP EIMGCTGCQI DWKKGKNVTL KTIKKKQKHK GRGTVRTVTK TVSNDSFFNF 
FAPPEVPESG DLDDDAEAIL AADFEIGHFL RERIIPRSVL YFTGEAIEDD DDDYDEEGEE 
ADEEGEEEGD EENDPDYDPK KDQNPAECKQ Q

Genular Protein ID: 1108772082

Symbol: F8W543_HUMAN

Name: N/A

UniProtKB Accession Codes:

F8W543

Database IDs:

ARBA 5 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 2 GeneTree 1 HGNC 1 InterPro 2 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 3 RuleBase 1 SAM 1 SMR 1 SUPFAM 1 SwissPalm 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 328
  • Mass: 38200
  • Checksum: 02FC8238E4BDAEAD
  • Sequence:
    • MADIDNLPRV VKRRVNALKN LQVKCAQIEA KFYEEVHDLE RKYAVLYQPL FDKRFEIINA 
IYEPTEEECE WKPDEEDEIS EELKEKAKIE DEKKDEEKED PKGIPEFWLT VFKNVDLLSD 
MVQEHDEPIL KHLKDIKVKF SDAGQPMSFV LEFHFEPNEY FTNEVLTKTY RMRSEPDDSD 
PFSFDGPEIM GCTGCQIDWK KGKNVTLKTI KKKQKHKGRG TVRTVTKTVS NDSFFNFFAP 
PEVPESGDLD DDAEAILAAD FEIGHFLRER IIPRSVLYFT GEAIEDDDDD YDEEGEEADE 
EGEEEGDEEN DPDYDPKKDQ NPAECKQQ

Genular Protein ID: 1775072520

Symbol: Q9H2B0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9H2B0

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PeptideAtlas 1 RefSeq 4

Sequence Information:

  • Length: 51
  • Mass: 5995
  • Checksum: C9FD423E07662614
  • Sequence:
    • MRLKVEIRLF LTKDAIKFQT VEPHLQYLRL ITVNFGVELF FDSEGGLLDC H

Genular Protein ID: 3553459715

Symbol: B7Z2V4_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z2V4

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 5 Gene3D 2 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 Pfam 1 RefSeq 1 RuleBase 1 SAM 1 SUPFAM 1

Sequence Information:

  • Length: 383
  • Mass: 44600
  • Checksum: BFA526E1316D7827
  • Sequence:
    • MADIDNKEQS ELDQDLDDVE EVEEEETGEE TKLKARQLTV QMMQNPQILA ALQERLDGLV 
ETPTGYIESL PRVVKRRVNA LKNLQVKCAQ IEAKFYEEVH DLERKYAVLY QPLFDKRFEI 
ISAIYEPTEE ECEWKPDEED EISEELKEKA KIEDEKKDEE KEDPKGIPEF WLTVFKNVDL 
LSDMVQEHDE PILKHLKDIK VKFSDAGQPM SFVLEFHFEP NEYFTNEVLT KTYRMRSEPD 
DSDPFSFDGP EIMGCTGCQI DWKKGKNVTL KTIKKKQKHK GRGTVRTVTK TVSNDSFFNF 
FAPPEVPESG DLDDDAEAIL AADFEIGHFL RERIIPRSVL YFTGEAIEDD DDDYDEEGEE 
ADEGYQLFEE VKSCSKLFQR WLQ

Genular Protein ID: 3921959577

Symbol: F5H4R6_HUMAN

Name: N/A

UniProtKB Accession Codes:

F5H4R6

Database IDs:

ARBA 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 2 GeneTree 1 HGNC 1 InterPro 2 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 RuleBase 1 SAM 1 SMR 1 SUPFAM 1 SwissPalm 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 383
  • Mass: 44627
  • Checksum: BFAAD5D131695217
  • Sequence:
    • MADIDNKEQS ELDQDLDDVE EVEEEETGEE TKLKARQLTV QMMQNPQILA ALQERLDGLV 
ETPTGYIESL PRVVKRRVNA LKNLQVKCAQ IEAKFYEEVH DLERKYAVLY QPLFDKRFEI 
INAIYEPTEE ECEWKPDEED EISEELKEKA KIEDEKKDEE KEDPKGIPEF WLTVFKNVDL 
LSDMVQEHDE PILKHLKDIK VKFSDAGQPM SFVLEFHFEP NEYFTNEVLT KTYRMRSEPD 
DSDPFSFDGP EIMGCTGCQI DWKKGKNVTL KTIKKKQKHK GRGTVRTVTK TVSNDSFFNF 
FAPPEVPESG DLDDDAEAIL AADFEIGHFL RERIIPRSVL YFTGEAIEDD DDDYDEEGEE 
ADEGYQLFEE VKSCSKLFQR WLQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.