NPM1 | ENSG00000181163 | NCBI 4869

Details for: NPM1

Gene ID: 4869

Symbol: NPM1

Ensembl ID: ENSG00000181163

Description: nucleophosmin 1

Associated with

Alk mutants bind tkis
(R-HSA-9700645)
Antiviral mechanism by ifn-stimulated genes
(R-HSA-1169410)
Cell cycle
(R-HSA-1640170)
Chromosome maintenance
(R-HSA-73886)
Cytokine signaling in immune system
(R-HSA-1280215)
Deposition of new cenpa-containing nucleosomes at the centromere
(R-HSA-606279)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Hiv infection
(R-HSA-162906)
Host interactions of hiv factors
(R-HSA-162909)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Interactions of rev with host cellular proteins
(R-HSA-177243)
Interferon signaling
(R-HSA-913531)
Metabolism of proteins
(R-HSA-392499)
Nuclear events stimulated by alk signaling in cancer
(R-HSA-9725371)
Nuclear import of rev protein
(R-HSA-180746)
Pkr-mediated signaling
(R-HSA-9833482)
Post-translational protein modification
(R-HSA-597592)
Rna polymerase ii transcription
(R-HSA-73857)
Sars-cov-1 infection
(R-HSA-9678108)
Sars-cov-1-host interactions
(R-HSA-9692914)
Sars-cov infections
(R-HSA-9679506)
Signaling by alk fusions and activated point mutants
(R-HSA-9725370)
Signaling by alk in cancer
(R-HSA-9700206)
Sumo e3 ligases sumoylate target proteins
(R-HSA-3108232)
Sumoylation
(R-HSA-2990846)
Sumoylation of transcription cofactors
(R-HSA-3899300)
Tfap2a acts as a transcriptional repressor during retinoic acid induced cell differentiation
(R-HSA-8869496)
Tp53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
(R-HSA-6804115)
Tp53 regulates transcription of cell cycle genes
(R-HSA-6791312)
Transcriptional regulation by the ap-2 (tfap2) family of transcription factors
(R-HSA-8864260)
Transcriptional regulation by tp53
(R-HSA-3700989)
Viral infection pathways
(R-HSA-9824446)
Cellular response to uv
(GO:0034644)
Cellular senescence
(GO:0090398)
Centrosome cycle
(GO:0007098)
Chromatin binding
(GO:0003682)
Chromatin remodeling
(GO:0006338)
Core promoter sequence-specific dna binding
(GO:0001046)
Cytoplasm
(GO:0005737)
Dna-binding transcription factor binding
(GO:0140297)
Dna repair
(GO:0006281)
Granular component
(GO:0001652)
Histone binding
(GO:0042393)
Intracellular protein transport
(GO:0006886)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of centrosome duplication
(GO:0010826)
Negative regulation of protein kinase activity by regulation of protein phosphorylation
(GO:0044387)
Nf-kappab binding
(GO:0051059)
Nucleocytoplasmic transport
(GO:0006913)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleosome assembly
(GO:0006334)
Nucleus
(GO:0005634)
Positive regulation of cell cycle g2/m phase transition
(GO:1902751)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of nf-kappab transcription factor activity
(GO:0051092)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of translation
(GO:0045727)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein kinase binding
(GO:0019901)
Protein kinase inhibitor activity
(GO:0004860)
Protein localization
(GO:0008104)
Regulation of centriole replication
(GO:0046599)
Regulation of centrosome duplication
(GO:0010824)
Regulation of eif2 alpha phosphorylation by dsrna
(GO:0060735)
Regulation of endodeoxyribonuclease activity
(GO:0032071)
Regulation of endoribonuclease activity
(GO:0060699)
Regulation of mrna stability involved in cellular response to uv
(GO:1902629)
Ribosomal large subunit binding
(GO:0043023)
Ribosomal large subunit biogenesis
(GO:0042273)
Ribosomal large subunit export from nucleus
(GO:0000055)
Ribosomal small subunit binding
(GO:0043024)
Ribosomal small subunit biogenesis
(GO:0042274)
Ribosomal small subunit export from nucleus
(GO:0000056)
Ribosome assembly
(GO:0042255)
Rna binding
(GO:0003723)
Rrna binding
(GO:0019843)
Signal transduction
(GO:0007165)
Tat protein binding
(GO:0030957)
Transcription coactivator activity
(GO:0003713)
Unfolded protein binding
(GO:0051082)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: cell in vitro (CL0001034)
Fold Change: 3.88
Cell Significance Index: 7
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 2.35
Cell Significance Index: 3
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.6
Cell Significance Index: 2
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.57
Cell Significance Index: 2
Cell Name: lactocyte (CL0002325)
Fold Change: 1.47
Cell Significance Index: 2
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.42
Cell Significance Index: 2
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.4
Cell Significance Index: 2
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 1.26
Cell Significance Index: 1
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.26
Cell Significance Index: 1
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.24
Cell Significance Index: 1
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.2
Cell Significance Index: 1
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 1.18
Cell Significance Index: 1
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 1.17
Cell Significance Index: 1
Cell Name: granulosa cell (CL0000501)
Fold Change: 1.17
Cell Significance Index: 1
Cell Name: kidney cell (CL1000497)
Fold Change: 1.16
Cell Significance Index: 1
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.16
Cell Significance Index: 1
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 1.15
Cell Significance Index: 1
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 1.14
Cell Significance Index: 1
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.14
Cell Significance Index: 1
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.13
Cell Significance Index: 1
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.13
Cell Significance Index: 1
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 1.11
Cell Significance Index: 1
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 1.1
Cell Significance Index: 1
Cell Name: theca cell (CL0000503)
Fold Change: 1.08
Cell Significance Index: 1
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.08
Cell Significance Index: 1
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 1.07
Cell Significance Index: 1
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 1.06
Cell Significance Index: 1
Cell Name: peg cell (CL4033014)
Fold Change: 1.04
Cell Significance Index: 1
Cell Name: odontoblast (CL0000060)
Fold Change: 1.04
Cell Significance Index: 1
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 1.02
Cell Significance Index: 1
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 1.02
Cell Significance Index: 1
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 1.02
Cell Significance Index: 1
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 1.02
Cell Significance Index: 1
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 1.02
Cell Significance Index: 1
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: perivascular cell (CL4033054)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 1
Cell Significance Index: 1
Cell Name: chondroblast (CL0000058)
Fold Change: 1
Cell Significance Index: 1
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 1
Cell Significance Index: 1
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 1
Cell Significance Index: 1
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 1
Cell Significance Index: 1
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: centroblast (CL0009112)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: germ cell (CL0000586)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: supporting cell (CL0000630)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: epidermal cell (CL0000362)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: cell (CL0000000)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: epithelial cell of sweat gland (CL1000448)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: sebaceous gland cell (CL2000021)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: radial glial cell (CL0000681)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: pro-T cell (CL0000827)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: glioblast (CL0000030)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: muscle fibroblast (CL1001609)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: embryonic fibroblast (CL2000042)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: neuron associated cell (CL0000095)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: Merkel cell (CL0000242)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: bronchial epithelial cell (CL0002328)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: granular cell of epidermis (CL0002189)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: mesodermal cell (CL0000222)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: hepatic pit cell (CL2000054)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: peridermal cell (CL0000078)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: sensory neuron (CL0000101)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: articular chondrocyte (CL1001607)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: intrahepatic cholangiocyte (CL0002538)
Fold Change: 0.96
Cell Significance Index: 1

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** NPM1 is a 215-kDa protein that belongs to the nucleophosmin family. It is characterized by its high phosphoserine content, which allows it to interact with chromatin and other proteins. NPM1 is a multifunctional protein that regulates various cellular processes, including: 1. Cell cycle regulation: NPM1 promotes cell cycle progression by regulating the activity of cyclin-dependent kinases and the phosphatase activity of Wee1. 2. DNA repair: NPM1 regulates DNA repair processes, including nucleotide excision repair and base excision repair. 3. Transcriptional control: NPM1 regulates the activity of transcription factors, such as NF-κB and AP-2, which are involved in cell proliferation and differentiation. 4. Chromatin remodeling: NPM1 regulates chromatin remodeling by interacting with chromatin-modifying enzymes, such as histone deacetylases and histone acetyltransferases. **Pathways and Functions** NPM1 is involved in several signaling pathways, including: 1. Alk signaling pathway: NPM1 is a downstream effector of the Alk (Anaplastic Lymphoma Kinase) signaling pathway, which is involved in cell proliferation and survival. 2. NF-κB signaling pathway: NPM1 regulates the activity of NF-κB, a transcription factor involved in cell proliferation, differentiation, and survival. 3. AP-2 signaling pathway: NPM1 regulates the activity of AP-2, a transcription factor involved in cell proliferation and differentiation. 4. DNA damage response pathway: NPM1 regulates the activity of DNA damage response proteins, such as ATM and ATR. NPM1's functions include: 1. Cell cycle regulation: NPM1 promotes cell cycle progression by regulating the activity of cyclin-dependent kinases and the phosphatase activity of Wee1. 2. DNA repair: NPM1 regulates DNA repair processes, including nucleotide excision repair and base excision repair. 3. Transcriptional control: NPM1 regulates the activity of transcription factors, such as NF-κB and AP-2, which are involved in cell proliferation and differentiation. 4. Chromatin remodeling: NPM1 regulates chromatin remodeling by interacting with chromatin-modifying enzymes, such as histone deacetylases and histone acetyltransferases. **Clinical Significance** Mutations in the NPM1 gene have been associated with several diseases, including: 1. Acute myeloid leukemia (AML): NPM1 mutations are a common genetic alteration in AML and are associated with a poor prognosis. 2. Solid tumors: NPM1 mutations have been associated with an increased risk of solid tumors, including breast, lung, and colon cancer. 3. Leukemia: NPM1 mutations are a common genetic alteration in leukemia and are associated with a poor prognosis. 4. Cancer therapy: NPM1 is a target for cancer therapy, and inhibitors of NPM1 have been developed to treat AML and other cancers. In conclusion, NPM1 is a multifunctional protein that plays a crucial role in various cellular processes, including cell cycle regulation, DNA repair, and transcriptional control. Mutations in the NPM1 gene have been associated with several diseases, including leukemia and solid tumors, and NPM1 is a target for cancer therapy. Further research is needed to fully understand the mechanisms of NPM1's functions and its role in human disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.