Details for: NPM1

Gene ID: 4869

Symbol: NPM1

Ensembl ID: ENSG00000181163

Description: nucleophosmin 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 8.66
    Marker Score: 6535
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 5.33
    Marker Score: 4170.5
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 5.13
    Marker Score: 4106
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 4.98
    Marker Score: 7673
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 4.69
    Marker Score: 46431.5
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.59
    Marker Score: 156001
  • Cell Name: theca cell (CL0000503)
    Fold Change: 4.57
    Marker Score: 3275.5
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 4.46
    Marker Score: 58775
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 4.45
    Marker Score: 235065.5
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 4.34
    Marker Score: 5650
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 4.19
    Marker Score: 13232
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 4.17
    Marker Score: 1536
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 4.16
    Marker Score: 55947
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 4.13
    Marker Score: 8666.5
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 4.05
    Marker Score: 3450.5
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 4.04
    Marker Score: 2458
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 3.97
    Marker Score: 1789
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 3.97
    Marker Score: 2555
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.92
    Marker Score: 9570.5
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 3.89
    Marker Score: 16673
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.83
    Marker Score: 4095
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.81
    Marker Score: 3752.5
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 3.8
    Marker Score: 2985.5
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.76
    Marker Score: 7059
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 3.74
    Marker Score: 10494
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.73
    Marker Score: 24241
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 3.67
    Marker Score: 3544
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.65
    Marker Score: 42477
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 3.61
    Marker Score: 3037
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 3.6
    Marker Score: 9957
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 3.55
    Marker Score: 6090
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 3.53
    Marker Score: 3153
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 3.53
    Marker Score: 6440
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 3.52
    Marker Score: 10271
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 3.5
    Marker Score: 2050
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 3.49
    Marker Score: 1792.5
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 3.47
    Marker Score: 18258
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 3.44
    Marker Score: 2493
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 3.43
    Marker Score: 5632
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 3.43
    Marker Score: 1116
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 3.41
    Marker Score: 3033.5
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 3.41
    Marker Score: 25384
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 3.39
    Marker Score: 2266
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 3.38
    Marker Score: 16605
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 3.38
    Marker Score: 3982.5
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 3.36
    Marker Score: 2106
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.36
    Marker Score: 802.5
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 3.34
    Marker Score: 3709
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 3.33
    Marker Score: 4906
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 3.33
    Marker Score: 1386
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 3.32
    Marker Score: 21662
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 3.32
    Marker Score: 1093
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.31
    Marker Score: 114749
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 3.29
    Marker Score: 4653
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 3.28
    Marker Score: 2369
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 3.27
    Marker Score: 8771
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 3.27
    Marker Score: 2055
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 3.26
    Marker Score: 1909.5
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 3.26
    Marker Score: 1627
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 3.25
    Marker Score: 2461
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 3.24
    Marker Score: 2145
  • Cell Name: centroblast (CL0009112)
    Fold Change: 3.2
    Marker Score: 1579
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.2
    Marker Score: 12352
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 3.19
    Marker Score: 1113
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.18
    Marker Score: 3840
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 3.18
    Marker Score: 2998
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 3.16
    Marker Score: 7167.5
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 3.15
    Marker Score: 2482
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 3.14
    Marker Score: 2943
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 3.14
    Marker Score: 18648
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 3.14
    Marker Score: 1673.5
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 3.13
    Marker Score: 6254
  • Cell Name: basal cell (CL0000646)
    Fold Change: 3.11
    Marker Score: 4019
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 3.11
    Marker Score: 9212.5
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 3.1
    Marker Score: 24221
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 3.09
    Marker Score: 1384.5
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 3.09
    Marker Score: 2901
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 3.07
    Marker Score: 4884
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 3.07
    Marker Score: 985
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 3.07
    Marker Score: 2547
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 3.06
    Marker Score: 2016
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 3.06
    Marker Score: 3063
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 3.05
    Marker Score: 810
  • Cell Name: basophil (CL0000767)
    Fold Change: 3.05
    Marker Score: 1449
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 3.05
    Marker Score: 5158.5
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 3.04
    Marker Score: 3756
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 3.04
    Marker Score: 1030
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 3.04
    Marker Score: 7665
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 3.04
    Marker Score: 3305.5
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 3.04
    Marker Score: 10778
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 3.04
    Marker Score: 2676
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 3.03
    Marker Score: 802.5
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 3.03
    Marker Score: 1825.5
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 3.02
    Marker Score: 2150
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 3.02
    Marker Score: 1722
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 3.02
    Marker Score: 3335
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 3.01
    Marker Score: 1788
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 3.01
    Marker Score: 5376
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 3
    Marker Score: 1062.5
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 3
    Marker Score: 1727

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Other Information

**Key characteristics:** * NPM1 is a member of the nucleophosmin family of proteins, which are involved in ribosome assembly and function. * It is expressed in a wide range of cell types, including immune cells, stromal cells, and cancer cells. * In immune cells, NPM1 is highly expressed in dendritic cells, macrophages, and neutrophils. * It is also expressed in lymphoid organs, such as lymph nodes and spleen. * NPM1 is a key regulator of immune responses, and its expression is often altered in diseases such as cancer and viral infections. **Pathways and functions:** * NPM1 is involved in the antiviral mechanism of interferons. * It is a key regulator of the cell cycle and chromosome maintenance. * It also plays a role in cytokine signaling in the immune system. * NPM1 is involved in the regulation of inflammation and immune responses. * It is also involved in the metabolism of proteins and the assembly of nucleosomes. **Clinical significance:** * Mutations in NPM1 have been linked to a number of diseases, including cancer and viral infections. * NPM1 is a potential target for cancer therapy. * Studies of NPM1 have led to the development of new diagnostic and therapeutic strategies for cancer and viral infections. **Additional information:** * NPM1 is a highly conserved protein, with a similar gene found in humans, mice, and rats. * It is a multi-exon gene, with multiple transcripts encoding different isoforms of the protein. * NPM1 is a well-studied protein, with a number of important roles in the immune system.

Genular Protein ID: 2547930731

Symbol: NPM_HUMAN

Name: Nucleophosmin

UniProtKB Accession Codes:

P06748 A8K3N7 B5BU00 D3DQL6 P08693 Q12826 Q13440 Q13441 Q14115 Q5EU94 Q5EU95 Q5EU96 Q5EU97 Q5EU98 Q5EU99 Q6V962 Q8WTW5 Q96AT6 Q96DC4 Q96EA5 Q9BYG9 Q9UDJ7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DOSAC-COBS-2DPAGE 1 DisGeNET 1 DisProt 1 DrugBank 1 DrugCentral 1 EMBL 46 EPD 1 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 72 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 7 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 8 PIR 2 PRIDE 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 10 RefSeq 3 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TopDownProteomics 3 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2713355

Title: Characterization of the cDNA encoding human nucleophosmin and studies of its role in normal and abnormal growth.

PubMed ID: 2713355

DOI: 10.1021/bi00429a017

PubMed ID: 2775293

Title: The nucleotide sequence of a human cDNA encoding the highly conserved nucleolar phosphoprotein B23.

PubMed ID: 2775293

DOI: 10.1016/0006-291x(89)92100-1

PubMed ID: 2478125

Title: Isolation and characterization of a molecular cDNA clone of a human mRNA from interferon-treated cells encoding nucleolar protein B23, numatrin.

PubMed ID: 2478125

DOI: 10.1016/0006-291x(89)91699-9

PubMed ID: 9092633

Title: Isolation and characterization of the human nucleophosmin/B23 (NPM) gene: identification of the YY1 binding site at the 5' enhancer region.

PubMed ID: 9092633

DOI: 10.1093/nar/25.6.1225

PubMed ID: 15659725

Title: Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype.

PubMed ID: 15659725

DOI: 10.1056/nejmoa041974

PubMed ID: 16574551

Title: Cytoplasmic nucleophosmin in myeloid sarcoma occurring 20 years after diagnosis of acute myeloid leukaemia.

PubMed ID: 16574551

DOI: 10.1016/s1470-2045(06)70661-1

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8562957

Title: The t(5;17) variant of acute promyelocytic leukemia expresses a nucleophosmin-retinoic acid receptor fusion.

PubMed ID: 8562957

PubMed ID: 8122112

Title: Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma.

PubMed ID: 8122112

DOI: 10.1126/science.8122112

PubMed ID: 8633037

Title: Characterization of the transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with chromosomal translocation t(2;5).

PubMed ID: 8633037

DOI: 10.1073/pnas.93.9.4181

PubMed ID: 2602120

Title: Nucleotide sequence of a cDNA clone representing a third allele of human protein B23.

PubMed ID: 2602120

PubMed ID: 9150948

Title: A two-dimensional gel database of human colon carcinoma proteins.

PubMed ID: 9150948

DOI: 10.1002/elps.1150180344

PubMed ID: 8314759

Title: Nucleolar targeting signal of Rex protein of human T-cell leukemia virus type I specifically binds to nucleolar shuttle protein B-23.

PubMed ID: 8314759

DOI: 10.1016/s0021-9258(19)85191-8

PubMed ID: 12882984

Title: Nucleophosmin interacts with and inhibits the catalytic function of eukaryotic initiation factor 2 kinase PKR.

PubMed ID: 12882984

DOI: 10.1074/jbc.m301392200

PubMed ID: 3944116

Title: Amino acid sequence of protein B23 phosphorylation site.

PubMed ID: 3944116

DOI: 10.1016/s0021-9258(17)36022-2

PubMed ID: 2429957

Title: Amino acid sequence of a specific antigenic peptide of protein B23.

PubMed ID: 2429957

DOI: 10.1016/s0021-9258(18)67023-1

PubMed ID: 7631008

Title: Modification of nucleolar protein B23 after exposure to ionizing radiation.

PubMed ID: 7631008

DOI: 10.2307/3579152

PubMed ID: 8570204

Title: The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1.

PubMed ID: 8570204

PubMed ID: 11051553

Title: Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication.

PubMed ID: 11051553

DOI: 10.1016/s0092-8674(00)00093-3

PubMed ID: 11309377

Title: The nucleolar phosphoprotein B23 interacts with hepatitis delta antigens and modulates the hepatitis delta virus RNA replication.

PubMed ID: 11309377

DOI: 10.1074/jbc.m010087200

PubMed ID: 12058066

Title: The RNA binding activity of a ribosome biogenesis factor, nucleophosmin/B23, is modulated by phosphorylation with a cell cycle-dependent kinase and by association with its subtype.

PubMed ID: 12058066

DOI: 10.1091/mbc.02-03-0036

PubMed ID: 12429849

Title: Functional proteomic analysis of human nucleolus.

PubMed ID: 12429849

DOI: 10.1091/mbc.e02-05-0271

PubMed ID: 12214246

Title: The role of nucleophosmin in centrosome duplication.

PubMed ID: 12214246

DOI: 10.1038/sj.onc.1205708

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15388344

Title: Nek2A kinase regulates the localization of numatrin to centrosome in mitosis.

PubMed ID: 15388344

DOI: 10.1016/j.febslet.2004.08.047

PubMed ID: 15190079

Title: B23/nucleophosmin serine 4 phosphorylation mediates mitotic functions of polo-like kinase 1.

PubMed ID: 15190079

DOI: 10.1074/jbc.m403264200

PubMed ID: 15772089

Title: RPGR ORF15 isoform co-localizes with RPGRIP1 at centrioles and basal bodies and interacts with nucleophosmin.

PubMed ID: 15772089

DOI: 10.1093/hmg/ddi129

PubMed ID: 16107701

Title: Human histone chaperone nucleophosmin enhances acetylation-dependent chromatin transcription.

PubMed ID: 16107701

DOI: 10.1128/mcb.25.17.7534-7545.2005

PubMed ID: 15897463

Title: Sumoylation induced by the Arf tumor suppressor: a p53-independent function.

PubMed ID: 15897463

DOI: 10.1073/pnas.0502978102

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16916647

Title: Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.

PubMed ID: 16916647

DOI: 10.1016/j.molcel.2006.06.026

PubMed ID: 17015463

Title: Interaction between ROCK II and nucleophosmin/B23 in the regulation of centrosome duplication.

PubMed ID: 17015463

DOI: 10.1128/mcb.01383-06

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 17215513

Title: Aurora-B regulates RNA methyltransferase NSUN2.

PubMed ID: 17215513

DOI: 10.1091/mbc.e06-11-1021

PubMed ID: 18259216

Title: The nucleolar SUMO-specific protease SENP3 reverses SUMO modification of nucleophosmin and is required for rRNA processing.

PubMed ID: 18259216

DOI: 10.1038/embor.2008.3

PubMed ID: 19015314

Title: Nucleolar protein B23/nucleophosmin regulates the vertebrate SUMO pathway through SENP3 and SENP5 proteases.

PubMed ID: 19015314

DOI: 10.1083/jcb.200807185

PubMed ID: 18024471

Title: The structure and functions of NPM1/Nucleophosmin/B23, a multifunctional nucleolar acidic protein.

PubMed ID: 18024471

DOI: 10.1093/jb/mvm222

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18809582

Title: Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome.

PubMed ID: 18809582

DOI: 10.1128/mcb.01548-07

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19710015

Title: The metastasis efficiency modifier ribosomal RNA processing 1 homolog B (RRP1B) is a chromatin-associated factor.

PubMed ID: 19710015

DOI: 10.1074/jbc.m109.023457

PubMed ID: 19208757

Title: Nucleolar structure and function are regulated by the deubiquitylating enzyme USP36.

PubMed ID: 19208757

DOI: 10.1242/jcs.044461

PubMed ID: 19188445

Title: APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process.

PubMed ID: 19188445

DOI: 10.1128/mcb.01337-08

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20075868

Title: Nucleolar retention of a translational C/EBPalpha isoform stimulates rDNA transcription and cell size.

PubMed ID: 20075868

DOI: 10.1038/emboj.2009.404

PubMed ID: 20159986

Title: Methylation of ribosomal protein S10 by protein-arginine methyltransferase 5 regulates ribosome biogenesis.

PubMed ID: 20159986

DOI: 10.1074/jbc.m110.103911

PubMed ID: 20926688

Title: RRP1B targets PP1 to mammalian cell nucleoli and is associated with pre-60S ribosomal subunits.

PubMed ID: 20926688

DOI: 10.1091/mbc.e10-04-0287

PubMed ID: 20352051

Title: Polo-like kinase 2-dependent phosphorylation of NPM/B23 on serine 4 triggers centriole duplication.

PubMed ID: 20352051

DOI: 10.1371/journal.pone.0009849

PubMed ID: 20333249

Title: Nucleophosmin phosphorylation by v-cyclin-CDK6 controls KSHV latency.

PubMed ID: 20333249

DOI: 10.1371/journal.ppat.1000818

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21084279

Title: BRCA2 and nucleophosmin coregulate centrosome amplification and form a complex with the Rho effector kinase ROCK2.

PubMed ID: 21084279

DOI: 10.1158/0008-5472.can-10-0030

PubMed ID: 22002061

Title: New centromeric component CENP-W is an RNA-associated nuclear matrix protein that interacts with nucleophosmin/B23 protein.

PubMed ID: 22002061

DOI: 10.1074/jbc.m111.228411

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22528486

Title: Nucleophosmin (NPM1/B23) interacts with activating transcription factor 5 (ATF5) protein and promotes proteasome- and caspase-dependent ATF5 degradation in hepatocellular carcinoma cells.

PubMed ID: 22528486

DOI: 10.1074/jbc.m112.363622

PubMed ID: 23019224

Title: DDX31 regulates the p53-HDM2 pathway and rRNA gene transcription through its interaction with NPM1 in renal cell carcinomas.

PubMed ID: 23019224

DOI: 10.1158/0008-5472.can-12-1645

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22362753

Title: Function of homo- and hetero-oligomers of human nucleoplasmin/nucleophosmin family proteins NPM1, NPM2 and NPM3 during sperm chromatin remodeling.

PubMed ID: 22362753

DOI: 10.1093/nar/gks162

PubMed ID: 23972994

Title: ABH2 couples regulation of ribosomal DNA transcription with DNA alkylation repair.

PubMed ID: 23972994

DOI: 10.1016/j.celrep.2013.07.027

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25956029

Title: The nucleolar protein GLTSCR2 is an upstream negative regulator of the oncogenic Nucleophosmin-MYC axis.

PubMed ID: 25956029

DOI: 10.1016/j.ajpath.2015.03.016

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25818168

Title: GLTSCR2 is an upstream negative regulator of nucleophosmin in cervical cancer.

PubMed ID: 25818168

DOI: 10.1111/jcmm.12474

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28190768

Title: Serine ADP-ribosylation depends on HPF1.

PubMed ID: 28190768

DOI: 10.1016/j.molcel.2017.01.003

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 17879352

Title: Crystal structure of human nucleophosmin-core reveals plasticity of the pentamer-pentamer interface.

PubMed ID: 17879352

DOI: 10.1002/prot.21504

PubMed ID: 18511415

Title: Structural consequences of nucleophosmin mutations in acute myeloid leukemia.

PubMed ID: 18511415

DOI: 10.1074/jbc.m801706200

Sequence Information:

  • Length: 294
  • Mass: 32575
  • Checksum: 620BC7BA2E4A0054
  • Sequence:
    • MEDSMDMDMS PLRPQNYLFG CELKADKDYH FKVDNDENEH QLSLRTVSLG AGAKDELHIV 
EAEAMNYEGS PIKVTLATLK MSVQPTVSLG GFEITPPVVL RLKCGSGPVH ISGQHLVAVE 
EDAESEDEEE EDVKLLSISG KRSAPGGGSK VPQKKVKLAA DEDDDDDDEE DDDEDDDDDD 
FDDEEAEEKA PVKKSIRDTP AKNAQKSNQN GKDSKPSSTP RSKGQESFKK QEKTPKTPKG 
PSSVEDIKAK MQASIEKGGS LPKVEAKFIN YVKNCFRMTD QEAIQDLWQW RKSL

Genular Protein ID: 2825759989

Symbol: A0A0S2Z4G7_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0S2Z4G7

Database IDs:

ARBA 9 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 ExpressionAtlas 1 GO 2 Gene3D 2 GenomeRNAi 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 Pfam 4 RefSeq 1 SAM 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 265
  • Mass: 29465
  • Checksum: 932BEC3377692D91
  • Sequence:
    • MEDSMDMDMS PLRPQNYLFG CELKADKDYH FKVDNDENEH QLSLRTVSLG AGAKDELHIV 
EAEAMNYEGS PIKVTLATLK MSVQPTVSLG GFEITPPVVL RLKCGSGPVH ISGQHLVAVE 
EDAESEDEEE EDVKLLSISG KRSAPGGGSK VPQKKVKLAA DEDDDDDDEE DDDEDDDDDD 
FDDEEAEEKA PVKKGQESFK KQEKTPKTPK GPSSVEDIKA KMQASIEKGG SLPKVEAKFI 
NYVKNCFRMT DQEAIQDLWQ WRKSL

Genular Protein ID: 489050646

Symbol: A0A140VJQ2_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A140VJQ2

Database IDs:

ARBA 5 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 ExpressionAtlas 1 GO 2 Gene3D 1 GenomeRNAi 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 Pfam 2 RefSeq 1 SAM 1 SMR 1 SUPFAM 1 VEuPathDB 1

Sequence Information:

  • Length: 259
  • Mass: 28400
  • Checksum: 6AEAD2909EE0A47A
  • Sequence:
    • MEDSMDMDMS PLRPQNYLFG CELKADKDYH FKVDNDENEH QLSLRTVSLG AGAKDELHIV 
EAEAMNYEGS PIKVTLATLK MSVQPTVSLG GFEITPPVVL RLKCGSGPVH ISGQHLVAVE 
EDAESEDEEE EDVKLLSISG KRSAPGGGSK VPQKKVKLAA DEDDDDDDEE DDDEDDDDDD 
FDDEEAEEKA PVKKSIRDTP AKNAQKSNQN GKDSKPSSTP RSKGQESFKK QEKTPKTPKG 
PSSVEDIKAK MQASIEKAH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.