MIR9 1HG | ENSG00000125462 | NCBI 10485

Details for: MIR9 1HG

Associated with

Molecular_function
(GO:0003674)
Nucleus
(GO:0005634)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

Bergmann glial cell CL0000644

CSI 64.68

rCSI 88.5%

PRS 98.08
glioblast CL0000030

CSI 49.33

rCSI 78.7%

PRS 98.12
macroglial cell CL0000126

CSI 47.3

rCSI 100%

PRS 98.47
Mueller cell CL0000636

CSI 43.82

rCSI 100%

PRS 98.31
radial glial cell CL0000681

CSI 42.87

rCSI 59.56%

PRS 99.45
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 40.59

rCSI 46.88%

PRS 98.31
differentiation-committed oligodendrocyte precursor CL4023059

CSI 39.19

rCSI 71.2%

PRS 98.03
neuroblast (sensu Vertebrata) CL0000031

CSI 32.76

rCSI 42.04%

PRS 98.75
progenitor cell CL0011026

CSI 31.4

rCSI 66.77%

PRS 98.22
astrocyte of the cerebral cortex CL0002605

CSI 29.12

rCSI 65.28%

PRS 97.83
oligodendrocyte precursor cell CL0002453

CSI 26.87

rCSI 59.13%

PRS 94.69
forebrain radial glial cell CL0013000

CSI 24.87

rCSI 79.8%

PRS 99.39
erythrocyte CL0000232

CSI 20.3

rCSI 46.07%

PRS 98.76
interneuron CL0000099

CSI 17.38

rCSI 34.9%

PRS 98.52
cerebral cortex GABAergic interneuron CL0010011

CSI 16.25

rCSI 47.98%

PRS 99.41
cerebral cortex endothelial cell CL1001602

CSI 15.78

rCSI 27.3%

PRS 98.51
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 15.07

rCSI 26.62%

PRS 97.69
sncg GABAergic cortical interneuron CL4023015

CSI 14.69

rCSI 23.63%

PRS 97.53
retinal pigment epithelial cell CL0002586

CSI 13.94

rCSI 27.68%

PRS 98.62
inhibitory interneuron CL0000498

CSI 12.55

rCSI 28.96%

PRS 97.71
mature astrocyte CL0002627

CSI 11.77

rCSI 50.03%

PRS 98.44
lamp5 GABAergic cortical interneuron CL4023011

CSI 11.26

rCSI 18.89%

PRS 97.91
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 11.03

rCSI 26.82%

PRS 96.83
glial cell CL0000125

CSI 10.87

rCSI 41.37%

PRS 97.71
ON-bipolar cell CL0000749

CSI 10.73

rCSI 15.94%

PRS 98.7
cerebellar granule cell CL0001031

CSI 10.57

rCSI 15.53%

PRS 98.03
mature T cell CL0002419

CSI 9.95

rCSI 7.74%

PRS 99.83
neural progenitor cell CL0011020

CSI 9.9

rCSI 43.58%

PRS 96.03
vascular leptomeningeal cell CL4023051

CSI 8.94

rCSI 15.67%

PRS 98.63
Cajal-Retzius cell CL0000695

CSI 8.88

rCSI 69.56%

PRS 99.22
L6b glutamatergic cortical neuron CL4023038

CSI 6.64

rCSI 20.75%

PRS 97.63
VIP GABAergic cortical interneuron CL4023016

CSI 6.51

rCSI 7.78%

PRS 97.67
sst GABAergic cortical interneuron CL4023017

CSI 6.42

rCSI 8.28%

PRS 98.01
retinal cone cell CL0000573

CSI 6.39

rCSI 10.29%

PRS 97.72
amacrine cell CL0000561

CSI 6.23

rCSI 18.06%

PRS 97.75
glutamatergic neuron CL0000679

CSI 6.02

rCSI 12.37%

PRS 95.9
pvalb GABAergic cortical interneuron CL4023018

CSI 5.72

rCSI 7.11%

PRS 97.37
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI 5.17

rCSI 16.17%

PRS 97.93
basal cell of epidermis CL0002187

CSI 5.14

rCSI 9.1%

PRS 89.86
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 5.12

rCSI 18.43%

PRS 97.23
neural crest cell CL0011012

CSI 4.92

rCSI 3.89%

PRS 99.18
retina horizontal cell CL0000745

CSI 4.79

rCSI 7.31%

PRS 98.82
CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203

CSI 4.41

rCSI 5.34%

PRS 92.69
near-projecting glutamatergic cortical neuron CL4023012

CSI 3.12

rCSI 11.78%

PRS 97.27
OFF-bipolar cell CL0000750

CSI 3.11

rCSI 4.25%

PRS 98.64
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 2.8

rCSI 16.47%

PRS 97.27
direct pathway medium spiny neuron CL4023026

CSI 1.5

rCSI 35.93%

PRS 96.28

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description

## Summary [MIR9 1HG](/details-gene/10485) is a non-coding RNA gene located on chromosome 1q22 that functions as the host gene for the microRNA miR-9-1. Functional annotations indicate its involvement in the '[Positive regulation of transcription by rna polymerase ii](/details-go/GO:0045944)', consistent with the role of microRNAs in modulating gene expression networks. Expression data reveals a highly specific profile, with its significance almost exclusively confined to the central nervous system. It is a defining marker for various glial populations, including [Bergmann glial cells](/details-cell/CL0000644) and [macroglial cells](/details-cell/CL0000126), as well as neural progenitor cells and their cancerous counterparts, [glioblasts](/details-cell/CL0000030). This suggests a critical role for [MIR9 1HG](/details-gene/10485) in both normal neurodevelopment and neuropathology. ## Cellular Roles and Expression Landscape **Overall**, the expression landscape of [MIR9 1HG](/details-gene/10485) is dominated by cell types of the central nervous system, particularly those involved in development, structural support, and malignancy. The gene demonstrates its highest significance in specialized glial cells. It is a top marker for [Bergmann glial cells](/details-cell/CL0000644) (CSI: 64.68), [macroglial cells](/details-cell/CL0000126) (CSI: 47.30), and [Mueller cells](/details-cell/CL0000636) (CSI: 43.82) of the retina, highlighting its importance in the function of these supportive neural populations. A prominent theme is its association with neural progenitor and precursor cells. High CSI scores are observed in [radial glial cells](/details-cell/CL0000681) (CSI: 42.87), which act as primary neural stem cells during development, as well as in committed precursors like [neuroblasts](/details-cell/CL0000338) (CSI: 40.59) and [oligodendrocyte precursor cells](/details-cell/CL0002453) (CSI: 26.87). This pattern strongly suggests that [MIR9 1HG](/details-gene/10485) is integral to the processes of neurogenesis and gliogenesis. Furthermore, the high significance of [MIR9 1HG](/details-gene/10485) in [glioblast](/details-cell/CL0000030) (CSI: 49.33), the malignant cell type of glioblastoma, points to a potential role in neural oncology. Its expression in both progenitor cells and their cancerous derivatives suggests that it may regulate pathways related to proliferation and differentiation that are hijacked during tumorigenesis. The restricted expression pattern, with high specificity for neural lineages, underscores its specialized function within the CNS. ## Pathways and Molecular Function The functional annotation of [MIR9 1HG](/details-gene/10485) is consistent with its role as a microRNA host gene. Its association with '[Positive regulation of transcription by rna polymerase ii](/details-go/GO:0045944)' reflects the downstream consequences of its product, miR-9. MicroRNAs primarily function post-transcriptionally by binding to mRNA targets, leading to their degradation or translational repression. This modulation of target genes, which can include transcription factors, ultimately influences the transcriptional landscape of the cell. This regulatory function is highly relevant in the context of its cellular expression. In neural progenitors like [radial glial cells](/details-cell/CL0000681) and [neuroblasts](/details-cell/CL0000338), miR-9 is known to orchestrate the delicate balance between self-renewal and differentiation by targeting key developmental regulators. The gene product's annotated localization to the '[Nucleus](/details-go/GO:0005634)' may reflect the processing of the primary transcript or potentially a less common nuclear function for the mature miRNA itself. ## Research Directions The data strongly implicate [MIR9 1HG](/details-gene/10485) in both the development and pathology of the central nervous system. Its high expression in [glioblast](/details-cell/CL0000030) cells, which often exhibit stem-like properties, suggests its function in normal neural progenitors may be co-opted for malignant purposes. Based on this evidence, several testable hypotheses can be proposed: 1. **Hypothesis on Neurodevelopment:** The high expression of [MIR9 1HG](/details-gene/10485) in [radial glial cells](/details-cell/CL0000681) and [neuroblasts](/details-cell/CL0000338) suggests it is a key regulator of neuronal fate determination. We hypothesize that precise temporal control of [MIR9 1HG](/details-gene/10485) expression is required for the proper transition from neural stem cell proliferation to neuronal or glial differentiation, and its misexpression could lead to developmental abnormalities. 2. **Hypothesis on Oncogenesis:** Given its high significance in [glioblast](/details-cell/CL0000030), we hypothesize that [MIR9 1HG](/details-gene/10485) functions as an onco-miRNA in this context. Its overexpression may promote tumor growth and maintenance by suppressing the expression of tumor suppressor genes, thereby enhancing proliferation and inhibiting apoptosis. A key experiment to test the oncogenesis hypothesis would be to systematically inhibit miR-9 function in patient-derived [glioblast](/details-cell/CL0000030) organoids. Using a chemically modified antisense oligonucleotide (ASO) to specifically block miR-9 activity, one could assess the impact on tumor organoid growth, viability, and invasive potential over time. Subsequent RNA-sequencing and proteomic analyses on treated versus control organoids would enable the identification of direct miR-9 target genes that mediate its pro-tumorigenic effects, providing mechanistic insight into its role in glioblastoma. Given its highly specific expression in the CNS and its elevated levels in [glioblast](/details-cell/CL0000030), [MIR9 1HG](/details-gene/10485) (via its product miR-9) represents a promising therapeutic target. The therapeutic strategy would focus on **inhibition**. The development of brain-penetrant ASOs or other nucleic acid-based therapies to neutralize miR-9 could selectively target tumor cells while potentially sparing non-neural tissues, offering a targeted approach for treating glioblastoma.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.