Details for: CL0000099

Cell ID: CL0000099

Cell Name: interneuron

Marker Score Threshold: 457
(Derived using integrated single-cell and genomic data)

Description: Most generally any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region as contrasted with projection neurons which have axons projecting to other brain regions.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ADCY2 (ENSG00000078295)
    Fold Change: 6.17
    Ensembl ID: ENSG00000078295
  • Gene Symbol: CDH9 (ENSG00000113100)
    Fold Change: 4.96
    Ensembl ID: ENSG00000113100
  • Gene Symbol: CCK (ENSG00000187094)
    Fold Change: 4.5
    Ensembl ID: ENSG00000187094
  • Gene Symbol: ADRA1A (ENSG00000120907)
    Fold Change: 4.4
    Ensembl ID: ENSG00000120907
  • Gene Symbol: ADCY8 (ENSG00000155897)
    Fold Change: 3.87
    Ensembl ID: ENSG00000155897
  • Gene Symbol: MPPED1 (ENSG00000186732)
    Fold Change: 3.18
    Ensembl ID: ENSG00000186732
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.88
    Ensembl ID: ENSG00000075624
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.62
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.48
    Ensembl ID: ENSG00000184009
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 2.43
    Ensembl ID: ENSG00000099622
  • Gene Symbol: CBLB (ENSG00000114423)
    Fold Change: 2.31
    Ensembl ID: ENSG00000114423
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.17
    Ensembl ID: ENSG00000077549
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.12
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ADRA1B (ENSG00000170214)
    Fold Change: 2.08
    Ensembl ID: ENSG00000170214
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 2.06
    Ensembl ID: ENSG00000122545
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 2.06
    Ensembl ID: ENSG00000172757
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 1.99
    Ensembl ID: ENSG00000070831
  • Gene Symbol: CDH12 (ENSG00000154162)
    Fold Change: 1.92
    Ensembl ID: ENSG00000154162
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 1.87
    Ensembl ID: ENSG00000169100
  • Gene Symbol: CACNA1B (ENSG00000148408)
    Fold Change: 1.8
    Ensembl ID: ENSG00000148408
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.78
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1.75
    Ensembl ID: ENSG00000135390
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.74
    Ensembl ID: ENSG00000153113
  • Gene Symbol: CACNA1E (ENSG00000198216)
    Fold Change: 1.64
    Ensembl ID: ENSG00000198216
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 1.64
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.6
    Ensembl ID: ENSG00000127022
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.58
    Ensembl ID: ENSG00000173575
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.55
    Ensembl ID: ENSG00000069849
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.54
    Ensembl ID: ENSG00000116489
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.51
    Ensembl ID: ENSG00000196776
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.5
    Ensembl ID: ENSG00000143761
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.49
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ACVR2A (ENSG00000121989)
    Fold Change: 1.49
    Ensembl ID: ENSG00000121989
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.49
    Ensembl ID: ENSG00000163399
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 1.47
    Ensembl ID: ENSG00000053254
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.45
    Ensembl ID: ENSG00000124172
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 1.45
    Ensembl ID: ENSG00000143933
  • Gene Symbol: KRIT1 (ENSG00000001631)
    Fold Change: 1.44
    Ensembl ID: ENSG00000001631
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.44
    Ensembl ID: ENSG00000130402
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.43
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.42
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ADCY9 (ENSG00000162104)
    Fold Change: 1.4
    Ensembl ID: ENSG00000162104
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.4
    Ensembl ID: ENSG00000104765
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.38
    Ensembl ID: ENSG00000134480
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.38
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.37
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.37
    Ensembl ID: ENSG00000117410
  • Gene Symbol: AP2M1 (ENSG00000161203)
    Fold Change: 1.34
    Ensembl ID: ENSG00000161203
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.34
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.33
    Ensembl ID: ENSG00000160710
  • Gene Symbol: AMY2B (ENSG00000240038)
    Fold Change: 1.33
    Ensembl ID: ENSG00000240038
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.32
    Ensembl ID: ENSG00000135404
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.32
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.31
    Ensembl ID: ENSG00000148700
  • Gene Symbol: CHD1 (ENSG00000153922)
    Fold Change: 1.31
    Ensembl ID: ENSG00000153922
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.31
    Ensembl ID: ENSG00000172270
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.31
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.3
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.3
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.29
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.27
    Ensembl ID: ENSG00000185650
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.27
    Ensembl ID: ENSG00000123505
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.27
    Ensembl ID: ENSG00000142599
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.25
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.23
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.21
    Ensembl ID: ENSG00000169020
  • Gene Symbol: CDH18 (ENSG00000145526)
    Fold Change: 1.21
    Ensembl ID: ENSG00000145526
  • Gene Symbol: ACTN2 (ENSG00000077522)
    Fold Change: 1.21
    Ensembl ID: ENSG00000077522
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.21
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.21
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.21
    Ensembl ID: ENSG00000104763
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.2
    Ensembl ID: ENSG00000005022
  • Gene Symbol: CA3 (ENSG00000164879)
    Fold Change: 1.19
    Ensembl ID: ENSG00000164879
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.18
    Ensembl ID: ENSG00000149311
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.17
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.17
    Ensembl ID: ENSG00000087274
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.15
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ADARB1 (ENSG00000197381)
    Fold Change: 1.14
    Ensembl ID: ENSG00000197381
  • Gene Symbol: CENPC (ENSG00000145241)
    Fold Change: 1.13
    Ensembl ID: ENSG00000145241
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.13
    Ensembl ID: ENSG00000019582
  • Gene Symbol: CDH7 (ENSG00000081138)
    Fold Change: 1.13
    Ensembl ID: ENSG00000081138
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.11
    Ensembl ID: ENSG00000110651
  • Gene Symbol: ADCY5 (ENSG00000173175)
    Fold Change: 1.1
    Ensembl ID: ENSG00000173175
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.1
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.09
    Ensembl ID: ENSG00000137845
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.09
    Ensembl ID: ENSG00000154518
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.08
    Ensembl ID: ENSG00000112576
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.07
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.05
    Ensembl ID: ENSG00000154723
  • Gene Symbol: BMP6 (ENSG00000153162)
    Fold Change: 1.04
    Ensembl ID: ENSG00000153162
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.03
    Ensembl ID: ENSG00000085224
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.02
    Ensembl ID: ENSG00000006125
  • Gene Symbol: LYST (ENSG00000143669)
    Fold Change: 1.02
    Ensembl ID: ENSG00000143669
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.02
    Ensembl ID: ENSG00000174437
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.02
    Ensembl ID: ENSG00000116459
  • Gene Symbol: CFTR (ENSG00000001626)
    Fold Change: 1.02
    Ensembl ID: ENSG00000001626
  • Gene Symbol: LRBA (ENSG00000198589)
    Fold Change: 1.01
    Ensembl ID: ENSG00000198589
  • Gene Symbol: MPPED2 (ENSG00000066382)
    Fold Change: 1.01
    Ensembl ID: ENSG00000066382
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: N/A
    Ensembl ID: ENSG00000162909
  • Gene Symbol: CHRM2 (ENSG00000181072)
    Fold Change: N/A
    Ensembl ID: ENSG00000181072
Hovered Details

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Hovered Details

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**Key Characteristics** * **Cell Type**: Interneuron * **Cell ID**: CL0000099 * **Gene Symbol**: ADCY2 * **Ensembl ID**: ENSG00000078295 * **Pathways/Ontology**: Activation of GABA_B receptors, Adenylate cyclase-activating G protein-coupled receptor signaling pathway, Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, Adenylate cyclase-modulating G protein-coupled receptor signaling pathway, Adenylate cyclase activating pathway, Adenylate cyclase activity, Adenylate cyclase binding, Adora2b mediated anti-inflammatory cytokines production, Anti-inflammatory response favouring Leishmania parasite infection, Aquaporin-mediated transport, Atp binding, Ca-dependent events, Calmodulin induced events, Camp-mediated signaling, Cam pathway, Camp biosynthetic process, Cellular response to forskolin, Cytoplasm, Dag and ip3 signaling, Dendrite, Disease, Fcgr3a-mediated IL10 synthesis, G-protein mediated events, GABA_B receptor activation, G alpha (i) signalling events, G alpha (s) signalling events, G alpha (z) signalling events, Glucagon signaling in metabolic regulation, GPCR downstream signalling, Gper1 signaling, Hedgehog 'off' state, Infectious disease, Integration of energy metabolism, Intracellular signaling by second messengers, Leishmania infection, Leishmania parasite growth and survival, Magnesium ion binding, Manganese ion binding, Membrane, Membrane raft, Metabolism, Neuronal system, Neurotransmitter receptors and postsynaptic signal transmission, Opioid signalling, Parasitic infection pathways, Pka-mediated phosphorylation of CREB, Pka activation, Pka activation in glucagon signalling, Plasma membrane, Plc beta mediated events, Signaling by GPCR, Signaling by hedgehog, Signal transduction, Transmission across chemical synapses, Transport of small molecules, Vasopressin regulates renal water homeostasis via aquaporins * **Cellular Location**: Dendrite, Axon, Cytoplasm, Plasma membrane, Membrane raft * **Function**: Neuronal signaling, Cell-cell adhesion, Neurotransmitter signaling, Energy metabolism **Clinical Significance** Interneurons play a crucial role in various physiological and pathological processes, including: * **Neurological disorders**: Interneurons are involved in the regulation of neurotransmitter signaling, which is impaired in various neurological disorders, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. * **Neuroinflammatory response**: Interneurons are involved in the regulation of the neuroinflammatory response, which is characterized by the activation of immune cells and the release of pro-inflammatory cytokines. * **Leishmania parasite infection**: Interneurons are involved in the regulation of the anti-inflammatory response favoring Leishmania parasite infection, which is characterized by the activation of anti-inflammatory cytokines and the suppression of pro-inflammatory cytokines. * **Energy metabolism**: Interneurons are involved in the regulation of energy metabolism, which is critical for maintaining proper neuronal function and overall health. Overall, the study of interneurons and their associated genes provides valuable insights into the regulation of various physiological and pathological processes, and has important implications for the diagnosis and treatment of neurological disorders.