Details for: ADARB1

Gene ID: 104

Symbol: ADARB1

Ensembl ID: ENSG00000197381

Description: adenosine deaminase RNA specific B1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 4.66
    Marker Score: 2590
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.16
    Marker Score: 72986
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.14
    Marker Score: 2591
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.12
    Marker Score: 78362
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 2.06
    Marker Score: 992
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 2.06
    Marker Score: 6896
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.04
    Marker Score: 8448.5
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.82
    Marker Score: 7428
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.8
    Marker Score: 5126
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.78
    Marker Score: 1037
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.71
    Marker Score: 17680
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.7
    Marker Score: 711
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.69
    Marker Score: 33633.5
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.69
    Marker Score: 64117
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.65
    Marker Score: 101550
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.64
    Marker Score: 15409
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.63
    Marker Score: 6302
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.53
    Marker Score: 2945
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.51
    Marker Score: 14343.5
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.47
    Marker Score: 12640
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168736
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.46
    Marker Score: 11229.5
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.37
    Marker Score: 2779
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.36
    Marker Score: 1561
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.35
    Marker Score: 2085
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.34
    Marker Score: 20042
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.33
    Marker Score: 418
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.31
    Marker Score: 783
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.29
    Marker Score: 2627
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.26
    Marker Score: 705
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.25
    Marker Score: 1195
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.25
    Marker Score: 5773
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.24
    Marker Score: 19399
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.23
    Marker Score: 336
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.21
    Marker Score: 908
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.19
    Marker Score: 378
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.14
    Marker Score: 334
  • Cell Name: interneuron (CL0000099)
    Fold Change: 1.14
    Marker Score: 520
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.05
    Marker Score: 629
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 1.02
    Marker Score: 5349
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.01
    Marker Score: 389
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71747
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1
    Marker Score: 1065
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47972
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.98
    Marker Score: 2160
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30401
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.95
    Marker Score: 5088
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2406
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.94
    Marker Score: 1648
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 483
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 438
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2719
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.91
    Marker Score: 6830
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.9
    Marker Score: 5404
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.89
    Marker Score: 519
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.89
    Marker Score: 355
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.88
    Marker Score: 18861
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.88
    Marker Score: 941.5
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.88
    Marker Score: 283
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5006
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.86
    Marker Score: 325
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.86
    Marker Score: 1193
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.86
    Marker Score: 448
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.85
    Marker Score: 1062
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.84
    Marker Score: 550
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.81
    Marker Score: 696
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.8
    Marker Score: 467
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.8
    Marker Score: 1076
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.8
    Marker Score: 640
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.78
    Marker Score: 1801
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.77
    Marker Score: 201
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.75
    Marker Score: 16793
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 574
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.75
    Marker Score: 1218
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.74
    Marker Score: 3115
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.74
    Marker Score: 352
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.74
    Marker Score: 1738
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.73
    Marker Score: 265
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.73
    Marker Score: 662
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 375
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.7
    Marker Score: 685
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.69
    Marker Score: 11007
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.68
    Marker Score: 253
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.65
    Marker Score: 2738
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.64
    Marker Score: 576
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.64
    Marker Score: 2276
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.64
    Marker Score: 493
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.64
    Marker Score: 175
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.63
    Marker Score: 598
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.63
    Marker Score: 334
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.63
    Marker Score: 179
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.63
    Marker Score: 1058
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.63
    Marker Score: 310
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.63
    Marker Score: 693
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.62
    Marker Score: 897
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.61
    Marker Score: 156
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.61
    Marker Score: 329

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Other Information

**Key characteristics:** * ADARB1 is a protein with a molecular weight of approximately 120 kDa. * It is expressed in high levels in cells that are involved in the immune response, including macrophages, dendritic cells, and B cells. * ADARB1 is a member of the ADAR family of RNA-editing deaminases. * It is responsible for the deamination of dsRNA and ssRNA, which is required for the regulation of gene expression. * ADARB1 is a key regulator of the expression of the CD80 and CD86 genes, which are involved in the immune response. **Pathways and functions:** * ADARB1 is involved in the processing of viral RNAs, including those that encode viral proteins. * It is also involved in the processing of non-viral DNA and RNA molecules, including those that are derived from retroviruses. * ADARB1 is involved in the regulation of cell migration and differentiation. * It is also involved in the regulation of apoptosis. **Clinical significance:** * Mutations in ADARB1 have been linked to a number of human diseases, including cancer and autoimmune disorders. * ADARB1 is a potential target for cancer therapy, as it can be used to inhibit the growth of cancer cells. * Inhibition of ADARB1 can lead to the inhibition of cancer cell growth and metastasis. **Additional information:** * ADARB1 is a highly conserved protein, with a similar protein found in other mammals. * It is a ubiquitin-dependent protein, which means that it is targeted for degradation by the proteasome. * It is a member of the RNase P family of RNA-editing enzymes.

Genular Protein ID: 91027349

Symbol: RED1_HUMAN

Name: RNA-editing deaminase 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9149227

Title: Two forms of human double-stranded RNA-specific editase 1 (hRED1) generated by the insertion of an Alu cassette.

PubMed ID: 9149227

PubMed ID: 9143496

Title: Cloning of a human RNA editing deaminase (ADARB1) of glutamate receptors that maps to chromosome 21q22.3.

PubMed ID: 9143496

DOI: 10.1006/geno.1997.4655

PubMed ID: 9111310

Title: Editing of glutamate receptor B subunit ion channel RNAs by four alternatively spliced DRADA2 double-stranded RNA adenosine deaminases.

PubMed ID: 9111310

DOI: 10.1128/mcb.17.5.2413

PubMed ID: 9330641

Title: Map location, genomic organization and expression patterns of the human RED1 RNA editase.

PubMed ID: 9330641

DOI: 10.1007/bf02679972

PubMed ID: 12459255

Title: Phylogenetic comparison of the pre-mRNA adenosine deaminase ADAR2 genes and transcripts: conservation and diversity in editing site sequence and alternative splicing patterns.

PubMed ID: 12459255

DOI: 10.1016/s0378-1119(02)01016-8

PubMed ID: 16297572

Title: Novel splice variants of human ADAR2 mRNA: skipping of the exon encoding the dsRNA-binding domains, and multiple C-terminal splice sites.

PubMed ID: 16297572

DOI: 10.1016/j.gene.2005.07.028

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19156214

Title: Novel exon of mammalian ADAR2 extends open reading frame.

PubMed ID: 19156214

DOI: 10.1371/journal.pone.0004225

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

PubMed ID: 18178553

Title: Down-regulation of RNA editing in pediatric astrocytomas: ADAR2 editing activity inhibits cell migration and proliferation.

PubMed ID: 18178553

DOI: 10.1074/jbc.m708316200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20192758

Title: Functions and regulation of RNA editing by ADAR deaminases.

PubMed ID: 20192758

DOI: 10.1146/annurev-biochem-060208-105251

PubMed ID: 19908260

Title: Human BLCAP transcript: new editing events in normal and cancerous tissues.

PubMed ID: 19908260

DOI: 10.1002/ijc.25022

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 22022963

Title: RNA editing catalyzed by ADAR1 and its function in mammalian cells.

PubMed ID: 22022963

DOI: 10.1134/s0006297911080050

PubMed ID: 21289159

Title: ADAR2 editing enzyme is a novel human immunodeficiency virus-1 proviral factor.

PubMed ID: 21289159

DOI: 10.1099/vir.0.028043-0

PubMed ID: 21182352

Title: Adenosine deaminases acting on RNA, RNA editing, and interferon action.

PubMed ID: 21182352

DOI: 10.1089/jir.2010.0097

PubMed ID: 21211811

Title: Adenosine deaminases acting on RNA (ADARs) are both antiviral and proviral.

PubMed ID: 21211811

DOI: 10.1016/j.virol.2010.12.004

PubMed ID: 22988838

Title: A-to-I editing of protein coding and noncoding RNAs.

PubMed ID: 22988838

DOI: 10.3109/10409238.2012.714350

PubMed ID: 21769729

Title: ADAR proteins: structure and catalytic mechanism.

PubMed ID: 21769729

DOI: 10.1007/82_2011_144

PubMed ID: 22113393

Title: Activity regulation of adenosine deaminases acting on RNA (ADARs).

PubMed ID: 22113393

DOI: 10.1007/s12035-011-8220-2

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 16141067

Title: Inositol hexakisphosphate is bound in the ADAR2 core and required for RNA editing.

PubMed ID: 16141067

DOI: 10.1126/science.1113150

PubMed ID: 32220291

Title: Bi-allelic ADARB1 Variants Associated with Microcephaly, Intellectual Disability, and Seizures.

PubMed ID: 32220291

DOI: 10.1016/j.ajhg.2020.02.015

Sequence Information:

  • Length: 741
  • Mass: 80763
  • Checksum: 02B583414DD59C20
  • Sequence:
  • MDIEDEENMS SSSTDVKENR NLDNVSPKDG STPGPGEGSQ LSNGGGGGPG RKRPLEEGSN 
    GHSKYRLKKR RKTPGPVLPK NALMQLNEIK PGLQYTLLSQ TGPVHAPLFV MSVEVNGQVF 
    EGSGPTKKKA KLHAAEKALR SFVQFPNASE AHLAMGRTLS VNTDFTSDQA DFPDTLFNGF 
    ETPDKAEPPF YVGSNGDDSF SSSGDLSLSA SPVPASLAQP PLPVLPPFPP PSGKNPVMIL 
    NELRPGLKYD FLSESGESHA KSFVMSVVVD GQFFEGSGRN KKLAKARAAQ SALAAIFNLH 
    LDQTPSRQPI PSEGLQLHLP QVLADAVSRL VLGKFGDLTD NFSSPHARRK VLAGVVMTTG 
    TDVKDAKVIS VSTGTKCING EYMSDRGLAL NDCHAEIISR RSLLRFLYTQ LELYLNNKDD 
    QKRSIFQKSE RGGFRLKENV QFHLYISTSP CGDARIFSPH EPILEGSRSY TQAGVQWCNH 
    GSLQPRPPGL LSDPSTSTFQ GAGTTEPADR HPNRKARGQL RTKIESGEGT IPVRSNASIQ 
    TWDGVLQGER LLTMSCSDKI ARWNVVGIQG SLLSIFVEPI YFSSIILGSL YHGDHLSRAM 
    YQRISNIEDL PPLYTLNKPL LSGISNAEAR QPGKAPNFSV NWTVGDSAIE VINATTGKDE 
    LGRASRLCKH ALYCRWMRVH GKVPSHLLRS KITKPNVYHE SKLAAKEYQA AKARLFTAFI 
    KAGLGAWVEK PTEQDQFSLT P

Genular Protein ID: 4078934013

Symbol: A0A994J4V7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

Sequence Information:

  • Length: 733
  • Mass: 80117
  • Checksum: 582F10E015A4AA6A
  • Sequence:
  • MASSTTGPLH MGTFFSIMGR RYKRRRKKRS ERKDRNSLRQ SRNPQKYFAM DIEDEENMSS 
    SSTDVKENRN LDNVSPKDGS TPGPGEGSQL SNGGGGGPGR KRPLEEGSNG HSKYRLKKRR 
    KTPGPVLPKN ALMQLNEIKP GLQYTLLSQT GPVHAPLFVM SVEVNGQVFE GSGPTKKKAK 
    LHAAEKALRS FVQFPNASEA HLAMGRTLSV NTDFTSDQAD FPDTLFNGFE TPDKAEPPFY 
    VGSNGDDSFS SSGDLSLSAS PVPASLAQPP LPVLPPFPPP SGKNPVMILN ELRPGLKYDF 
    LSESGESHAK SFVMSVVVDG QFFEGSGRNK KLAKARAAQS ALAAIFNLHL DQTPSRQPIP 
    SEGLQLHLPQ VLADAVSRLV LGKFGDLTDN FSSPHARRKV LAGVVMTTGT DVKDAKVISV 
    STGTKCINGE YMSDRGLALN DCHAEIISRR SLLRFLYTQL ELYLNNKDDQ KRSIFQKSER 
    GGFRLKENVQ FHLYISTSPC GDARIFSPHE PILEGSRSYT QAGVQWCNHG SLQPRPPGLL 
    SDPSTSTFQG AGTTEPADRH PNRKARGQLR TKIESGEGTI PVRSNASIQT WDGVLQGERL 
    LTMSCSDKIA RWNVVGIQGS LLSIFVEPIY FSSIILGSLY HGDHLSRAMY QRISNIEDLP 
    PLYTLNKPLL SGISNAEARQ PGKAPNFSVN WTVGDSAIEV INATTGKDEL GRASRLCSLP 
    LTTLQDYQAQ RVP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.