Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 843.5096
Cell Significance Index: -398.2400 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 836.6686
Cell Significance Index: -430.3700 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 595.9714
Cell Significance Index: -399.9100 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 75.9670
Cell Significance Index: -203.5100 - Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 58.6264
Cell Significance Index: 466.4600 - Cell Name: Sertoli cell (CL0000216)
Fold Change: 55.6520
Cell Significance Index: 780.6000 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 50.8087
Cell Significance Index: 1865.1500 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: 48.2217
Cell Significance Index: 3819.1600 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 45.5900
Cell Significance Index: 33426.4200 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 26.9470
Cell Significance Index: 397.7400 - Cell Name: abnormal cell (CL0001061)
Fold Change: 13.2491
Cell Significance Index: 1353.4000 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 13.1958
Cell Significance Index: 692.8300 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 13.1697
Cell Significance Index: 358.4700 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 12.6192
Cell Significance Index: 143.3600 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 12.5969
Cell Significance Index: 570.9800 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 12.1005
Cell Significance Index: 111.4300 - Cell Name: cell in vitro (CL0001034)
Fold Change: 11.4465
Cell Significance Index: 6251.1900 - Cell Name: pro-T cell (CL0000827)
Fold Change: 10.4403
Cell Significance Index: 266.7200 - Cell Name: peg cell (CL4033014)
Fold Change: 9.6544
Cell Significance Index: 223.0500 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 9.6476
Cell Significance Index: 145.3900 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 9.1142
Cell Significance Index: 1251.6300 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 8.6688
Cell Significance Index: 1065.9100 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 8.6292
Cell Significance Index: 248.6300 - Cell Name: granulosa cell (CL0000501)
Fold Change: 8.2562
Cell Significance Index: 217.1000 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 7.9960
Cell Significance Index: 372.8100 - Cell Name: seromucus secreting cell (CL0000159)
Fold Change: 7.9760
Cell Significance Index: 166.3500 - Cell Name: lactocyte (CL0002325)
Fold Change: 7.4285
Cell Significance Index: 959.7100 - Cell Name: odontoblast (CL0000060)
Fold Change: 7.3953
Cell Significance Index: 948.0300 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 7.0412
Cell Significance Index: 1269.3000 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 6.7021
Cell Significance Index: 432.3900 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 6.6438
Cell Significance Index: 495.1600 - Cell Name: hepatic pit cell (CL2000054)
Fold Change: 6.5960
Cell Significance Index: 17.6700 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 5.5074
Cell Significance Index: 191.3800 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 5.3670
Cell Significance Index: 530.9200 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 5.2928
Cell Significance Index: 575.7000 - Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 5.0507
Cell Significance Index: 38.9300 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 4.9856
Cell Significance Index: 4501.6200 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 4.6568
Cell Significance Index: 86.0700 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 4.2969
Cell Significance Index: 75.9300 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 4.2620
Cell Significance Index: 3225.9900 - Cell Name: enterocyte (CL0000584)
Fold Change: 4.2167
Cell Significance Index: 26.1600 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 3.9290
Cell Significance Index: 184.6600 - Cell Name: preadipocyte (CL0002334)
Fold Change: 3.6171
Cell Significance Index: 70.6000 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 3.1808
Cell Significance Index: 40.7400 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 2.7587
Cell Significance Index: 79.0800 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 2.6510
Cell Significance Index: 159.1500 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 2.0117
Cell Significance Index: 104.5000 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.9458
Cell Significance Index: 697.9300 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.2659
Cell Significance Index: 251.2300 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.2359
Cell Significance Index: 247.9200 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 1.1993
Cell Significance Index: 42.1400 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.0301
Cell Significance Index: 196.0300 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.6487
Cell Significance Index: 44.8600 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.5424
Cell Significance Index: 15.9300 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.3545
Cell Significance Index: 57.6600 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.3457
Cell Significance Index: 9.2300 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.0353
Cell Significance Index: -0.6000 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1513
Cell Significance Index: -43.5200 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.1831
Cell Significance Index: -344.7200 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.2832
Cell Significance Index: -522.3600 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.3115
Cell Significance Index: -53.1900 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.3441
Cell Significance Index: -529.7000 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.3942
Cell Significance Index: -535.9700 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.4975
Cell Significance Index: -368.5100 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.6124
Cell Significance Index: -388.9400 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.6810
Cell Significance Index: -384.0500 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.8323
Cell Significance Index: -377.7600 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.8630
Cell Significance Index: -58.0300 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.8744
Cell Significance Index: -546.0400 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -1.5118
Cell Significance Index: -173.2000 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -1.5978
Cell Significance Index: -89.6600 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -2.0954
Cell Significance Index: -52.3800 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -2.1500
Cell Significance Index: -452.8500 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -2.3051
Cell Significance Index: -48.2500 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -2.8084
Cell Significance Index: -89.9500 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -2.9789
Cell Significance Index: -433.0200 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -3.1131
Cell Significance Index: -52.1000 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -3.1664
Cell Significance Index: -68.6000 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -3.6017
Cell Significance Index: -375.0200 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -3.7165
Cell Significance Index: -234.2400 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -4.3502
Cell Significance Index: -333.8300 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -4.7636
Cell Significance Index: -101.4500 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -4.9289
Cell Significance Index: -140.6600 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -5.3757
Cell Significance Index: -80.5500 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -5.4184
Cell Significance Index: -332.2000 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -5.4608
Cell Significance Index: -335.6500 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -6.1208
Cell Significance Index: -309.3300 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -6.2262
Cell Significance Index: -255.1200 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -7.2447
Cell Significance Index: -124.8900 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -7.2643
Cell Significance Index: -75.2000 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -7.5033
Cell Significance Index: -200.7100 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -8.6999
Cell Significance Index: -256.2500 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -8.8397
Cell Significance Index: -391.0000 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -10.4816
Cell Significance Index: -367.1900 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -10.7279
Cell Significance Index: -222.5400 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -10.7306
Cell Significance Index: -406.3400 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -10.9604
Cell Significance Index: -130.6600 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -11.1333
Cell Significance Index: -364.5100 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -11.3131
Cell Significance Index: -360.3100 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -11.3975
Cell Significance Index: -292.9700
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 892967728
Symbol: CYB_HUMAN
Name: Cytochrome b
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7219534
Title: Sequence and organization of the human mitochondrial genome.
PubMed ID: 7219534
DOI: 10.1038/290457a0
PubMed ID: 10508508
Title: Reanalysis and revision of the Cambridge reference sequence for human mitochondrial DNA.
PubMed ID: 10508508
DOI: 10.1038/13779
PubMed ID: 7623448
Title: Novel mutations in mitochondrial cytochrome b in fatal post partum cardiomyopathy.
PubMed ID: 7623448
DOI: 10.1007/bf00711378
PubMed ID: 7530363
Title: Recent African origin of modern humans revealed by complete sequences of hominoid mitochondrial DNAs.
PubMed ID: 7530363
PubMed ID: 11130070
Title: Mitochondrial genome variation and the origin of modern humans.
PubMed ID: 11130070
DOI: 10.1038/35047064
PubMed ID: 11553319
Title: Major genomic mitochondrial lineages delineate early human expansions.
PubMed ID: 11553319
PubMed ID: 12022039
Title: Mitochondrial genome diversity of native Americans supports a single early entry of founder populations into America.
PubMed ID: 12022039
DOI: 10.1086/341358
PubMed ID: 6100559
Title: Serendipitous cloning of a mitochondrial cDNA and its polymorphism.
PubMed ID: 6100559
PubMed ID: 11047755
Title: Mitochondrial encephalomyopathy and complex III deficiency associated with a stop-codon mutation in the cytochrome b gene.
PubMed ID: 11047755
DOI: 10.1086/316900
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 1757091
Title: Normal variants of human mitochondrial DNA and translation products: the building of a reference data base.
PubMed ID: 1757091
DOI: 10.1007/bf00206061
PubMed ID: 1732158
Title: Mitochondrial DNA complex I and III mutations associated with Leber's hereditary optic neuropathy.
PubMed ID: 1732158
PubMed ID: 8910895
Title: A novel gly290asp mitochondrial cytochrome b mutation linked to a complex III deficiency in progressive exercise intolerance.
PubMed ID: 8910895
PubMed ID: 9818877
Title: Missense mutation in the mtDNA cytochrome b gene in a patient with myopathy.
PubMed ID: 9818877
PubMed ID: 9806551
Title: Somatic mutations of the mitochondrial genome in human colorectal tumours.
PubMed ID: 9806551
DOI: 10.1038/3108
PubMed ID: 10453733
Title: A mitochondrial cytochrome b mutation but no mutations of nuclearly encoded subunits in ubiquinol cytochrome c reductase (complex III) deficiency.
PubMed ID: 10453733
PubMed ID: 10502593
Title: Exercise intolerance due to mutations in the cytochrome b gene of mitochondrial DNA.
PubMed ID: 10502593
PubMed ID: 10960495
Title: A missense mutation in the mitochondrial cytochrome b gene in a revisited case with histiocytoid cardiomyopathy.
PubMed ID: 10960495
PubMed ID: 11601507
Title: Multisystem disorder associated with a missense mutation in the mitochondrial cytochrome b gene.
PubMed ID: 11601507
DOI: 10.1002/ana.1224
PubMed ID: 11464242
Title: Functional characterization of novel mutations in the human cytochrome b gene.
PubMed ID: 11464242
PubMed ID: 11891837
Title: Septo-optic dysplasia associated with a new mitochondrial cytochrome b mutation.
PubMed ID: 11891837
DOI: 10.1002/ana.10151
PubMed ID: 12905068
Title: Association of the mitochondrial DNA 15497G/A polymorphism with obesity in a middle-aged and elderly Japanese population.
PubMed ID: 12905068
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
Sequence Information:
- Length: 380
- Mass: 42718
- Checksum: 600E520C262E5498
- Sequence:
MTPMRKTNPL MKLINHSFID LPTPSNISAW WNFGSLLGAC LILQITTGLF LAMHYSPDAS TAFSSIAHIT RDVNYGWIIR YLHANGASMF FICLFLHIGR GLYYGSFLYS ETWNIGIILL LATMATAFMG YVLPWGQMSF WGATVITNLL SAIPYIGTDL VQWIWGGYSV DSPTLTRFFT FHFILPFIIA ALATLHLLFL HETGSNNPLG ITSHSDKITF HPYYTIKDAL GLLLFLLSLM TLTLFSPDLL GDPDNYTLAN PLNTPPHIKP EWYFLFAYTI LRSVPNKLGG VLALLLSILI LAMIPILHMS KQQSMMFRPL SQSLYWLLAA DLLILTWIGG QPVSYPFTII GQVASVLYFT TILILMPTIS LIENKMLKWA
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.