YWHAZ | ENSG00000164924 | NCBI 7534

Details for: YWHAZ

Gene ID: 7534

Symbol: YWHAZ

Ensembl ID: ENSG00000164924

Description: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta

Associated with

Activation of bad and translocation to mitochondria
(R-HSA-111447)
Activation of bh3-only proteins
(R-HSA-114452)
Adaptive immune system
(R-HSA-1280218)
Apoptosis
(R-HSA-109581)
Cell cycle
(R-HSA-1640170)
Cell cycle checkpoints
(R-HSA-69620)
Chk1/chk2(cds1) mediated inactivation of cyclin b:cdk1 complex
(R-HSA-75035)
Cytokine signaling in immune system
(R-HSA-1280215)
Deactivation of the beta-catenin transactivating complex
(R-HSA-3769402)
Disease
(R-HSA-1643685)
Foxo-mediated transcription
(R-HSA-9614085)
G2/m checkpoints
(R-HSA-69481)
G2/m dna damage checkpoint
(R-HSA-69473)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gp1b-ix-v activation signalling
(R-HSA-430116)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Interleukin-3, interleukin-5 and gm-csf signaling
(R-HSA-512988)
Intrinsic pathway for apoptosis
(R-HSA-109606)
Ksrp (khsrp) binds and destabilizes mrna
(R-HSA-450604)
Membrane trafficking
(R-HSA-199991)
Metabolism of rna
(R-HSA-8953854)
Negative regulation of notch4 signaling
(R-HSA-9604323)
Notch4 activation and transmission of signal to the nucleus
(R-HSA-9013700)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Programmed cell death
(R-HSA-5357801)
Rap1 signalling
(R-HSA-392517)
Regulation of localization of foxo transcription factors
(R-HSA-9614399)
Regulation of mrna stability by proteins that bind au-rich elements
(R-HSA-450531)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate pkns
(R-HSA-5625740)
Rna polymerase ii transcription
(R-HSA-73857)
Sars-cov-1 infection
(R-HSA-9678108)
Sars-cov-1 targets host intracellular signalling and regulatory pathways
(R-HSA-9735871)
Sars-cov-1-host interactions
(R-HSA-9692914)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2 targets host intracellular signalling and regulatory pathways
(R-HSA-9755779)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Signaling by interleukins
(R-HSA-449147)
Signaling by notch
(R-HSA-157118)
Signaling by notch4
(R-HSA-9013694)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by wnt
(R-HSA-195721)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Tp53 regulates metabolic genes
(R-HSA-5628897)
Transcriptional regulation by tp53
(R-HSA-3700989)
Translocation of slc2a4 (glut4) to the plasma membrane
(R-HSA-1445148)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Angiogenesis
(GO:0001525)
Blood microparticle
(GO:0072562)
Cadherin binding
(GO:0045296)
Cellular response to glucose starvation
(GO:0042149)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dna-binding transcription factor binding
(GO:0140297)
Erk1 and erk2 cascade
(GO:0070371)
Establishment of golgi localization
(GO:0051683)
Extracellular exosome
(GO:0070062)
Extracellular space
(GO:0005615)
Focal adhesion
(GO:0005925)
Golgi reassembly
(GO:0090168)
Identical protein binding
(GO:0042802)
Lung development
(GO:0030324)
Melanosome
(GO:0042470)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of innate immune response
(GO:0045824)
Negative regulation of protein localization to nucleus
(GO:1900181)
Negative regulation of torc1 signaling
(GO:1904262)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Phosphoserine residue binding
(GO:0050815)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein kinase binding
(GO:0019901)
Protein localization
(GO:0008104)
Protein phosphorylation
(GO:0006468)
Protein sequestering activity
(GO:0140311)
Protein targeting
(GO:0006605)
Regulation of erk1 and erk2 cascade
(GO:0070372)
Regulation of protein stability
(GO:0031647)
Regulation of synapse maturation
(GO:0090128)
Respiratory system process
(GO:0003016)
Rna binding
(GO:0003723)
Signal transduction
(GO:0007165)
Synaptic target recognition
(GO:0008039)
Transmembrane transporter binding
(GO:0044325)
Tube formation
(GO:0035148)
Ubiquitin protein ligase binding
(GO:0031625)
Vesicle
(GO:0031982)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 873.2508
Cell Significance Index: -135.8300
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 506.7745
Cell Significance Index: -128.5400
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 356.3317
Cell Significance Index: -146.7900
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 324.6466
Cell Significance Index: -131.8900
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 301.2141
Cell Significance Index: -142.2100
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 284.2811
Cell Significance Index: -146.2300
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 212.3626
Cell Significance Index: -142.5000
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 139.4616
Cell Significance Index: -133.1500
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 113.4915
Cell Significance Index: -139.9300
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 46.8744
Cell Significance Index: -125.5700
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 38.2587
Cell Significance Index: -117.5100
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 36.5556
Cell Significance Index: -144.2500
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 25.9939
Cell Significance Index: -56.8900
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 6.5062
Cell Significance Index: 1872.0200
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 4.7258
Cell Significance Index: 138.7900
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 4.6992
Cell Significance Index: 40.3800
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 4.4230
Cell Significance Index: 118.1000
Cell Name: early pro-B cell (CL0002046)
Fold Change: 3.7021
Cell Significance Index: 238.8400
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 3.6079
Cell Significance Index: 98.2100
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 3.5584
Cell Significance Index: 419.6400
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 3.5541
Cell Significance Index: 167.0400
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 3.5339
Cell Significance Index: 434.5300
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 3.4357
Cell Significance Index: 619.3600
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 3.1451
Cell Significance Index: 58.1300
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 2.9632
Cell Significance Index: 1310.1000
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 2.9239
Cell Significance Index: 26.9300
Cell Name: cell in vitro (CL0001034)
Fold Change: 2.8585
Cell Significance Index: 1561.0800
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.6843
Cell Significance Index: 538.4600
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 2.6651
Cell Significance Index: 120.8000
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 2.0130
Cell Significance Index: 218.9500
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.9185
Cell Significance Index: 55.2800
Cell Name: peg cell (CL4033014)
Fold Change: 1.8876
Cell Significance Index: 43.6100
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.8763
Cell Significance Index: 257.6700
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.7154
Cell Significance Index: 89.1100
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 1.6815
Cell Significance Index: 118.9200
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.6580
Cell Significance Index: 594.7000
Cell Name: lactocyte (CL0002325)
Fold Change: 1.5682
Cell Significance Index: 202.6000
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.5020
Cell Significance Index: 298.0800
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.4395
Cell Significance Index: 107.2900
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.4051
Cell Significance Index: 73.1900
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.3515
Cell Significance Index: 1220.2700
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.3454
Cell Significance Index: 70.6400
Cell Name: odontoblast (CL0000060)
Fold Change: 1.0044
Cell Significance Index: 128.7600
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.9243
Cell Significance Index: 62.1500
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.7259
Cell Significance Index: 33.8500
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.6935
Cell Significance Index: 19.3800
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.6862
Cell Significance Index: 42.1800
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.6253
Cell Significance Index: 61.8600
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.6122
Cell Significance Index: 116.5100
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.5052
Cell Significance Index: 28.3500
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.4864
Cell Significance Index: 12.7900
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.3980
Cell Significance Index: 30.5500
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.3352
Cell Significance Index: 9.6100
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.1882
Cell Significance Index: 32.1300
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.1647
Cell Significance Index: 310.1400
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0580
Cell Significance Index: 36.8100
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0431
Cell Significance Index: 58.6700
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0089
Cell Significance Index: 13.7800
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0007
Cell Significance Index: 1.3500
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.0004
Cell Significance Index: 0.0100
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0102
Cell Significance Index: -4.6300
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0204
Cell Significance Index: -0.9000
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0431
Cell Significance Index: -31.6400
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0547
Cell Significance Index: -41.4000
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0647
Cell Significance Index: -47.9400
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0927
Cell Significance Index: -57.9000
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1308
Cell Significance Index: -13.3600
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1812
Cell Significance Index: -102.2100
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.2060
Cell Significance Index: -23.5100
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.2271
Cell Significance Index: -8.6000
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.3371
Cell Significance Index: -71.0100
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.4181
Cell Significance Index: -7.0000
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.4854
Cell Significance Index: -70.5600
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.4907
Cell Significance Index: -17.0500
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.6192
Cell Significance Index: -70.9400
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.6440
Cell Significance Index: -13.4800
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.6469
Cell Significance Index: -40.7800
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.7513
Cell Significance Index: -10.2500
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.9209
Cell Significance Index: -107.3200
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -1.0219
Cell Significance Index: -22.1400
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -1.1896
Cell Significance Index: -123.8700
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -1.3273
Cell Significance Index: -35.5100
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -1.4598
Cell Significance Index: -36.4900
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -1.5013
Cell Significance Index: -118.9000
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -1.6452
Cell Significance Index: -9.9400
Cell Name: pro-T cell (CL0000827)
Fold Change: -1.9091
Cell Significance Index: -48.7700
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.9909
Cell Significance Index: -122.0600
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -2.1205
Cell Significance Index: -36.3400
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -2.1538
Cell Significance Index: -30.6600
Cell Name: preadipocyte (CL0002334)
Fold Change: -2.1801
Cell Significance Index: -42.5500
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -2.2112
Cell Significance Index: -25.1200
Cell Name: cortical interneuron (CL0008031)
Fold Change: -2.2610
Cell Significance Index: -54.2300
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -2.3747
Cell Significance Index: -61.0400
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: -2.4439
Cell Significance Index: -15.0400
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -2.4886
Cell Significance Index: -37.2900
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -2.5705
Cell Significance Index: -32.9200
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -2.5758
Cell Significance Index: -69.0200
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -2.6064
Cell Significance Index: -83.4800
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -2.9736
Cell Significance Index: -97.3600
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -3.0246
Cell Significance Index: -96.3300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** The YWHAZ gene encodes a 14-3-3 protein, which is a conserved family of proteins that bind to and regulate the activity of various signaling proteins. The YWHAZ protein is characterized by its ability to bind to and regulate the activity of numerous protein kinases, phosphatases, and other signaling molecules. The protein has a unique structure, consisting of two zinc fingers that bind to specific amino acid sequences on target proteins. The YWHAZ protein has been shown to have both pro-apoptotic and anti-apoptotic functions, depending on the context of its expression and the specific signaling pathways involved. **Pathways and Functions** The YWHAZ protein is involved in a wide range of cellular processes, including: 1. **Apoptosis regulation**: YWHAZ has been shown to regulate apoptosis by binding to and modulating the activity of pro-apoptotic and anti-apoptotic proteins, such as Bax and Bcl-2. 2. **Immune response**: YWHAZ has been found to be involved in the regulation of immune responses, including the activation of T cells and the regulation of cytokine signaling pathways. 3. **Cell cycle checkpoints**: YWHAZ has been shown to regulate cell cycle checkpoints, including the G2/M checkpoint, by binding to and modulating the activity of key proteins involved in these pathways. 4. **Signaling pathways**: YWHAZ has been found to regulate a wide range of signaling pathways, including those involved in cell growth, differentiation, and survival. 5. **Viral infection**: YWHAZ has been shown to regulate viral infection pathways, including the regulation of SARS-CoV-1 and SARS-CoV-2 infection. **Clinical Significance** The YWHAZ gene has been implicated in various diseases, including: 1. **Cancer**: YWHAZ has been found to be overexpressed in several types of cancer, including breast, lung, and colon cancer. 2. **Immunodeficiency**: YWHAZ has been shown to be involved in the regulation of immune responses, and its dysregulation has been implicated in immunodeficiency disorders. 3. **Infectious diseases**: YWHAZ has been found to regulate viral infection pathways, and its dysregulation has been implicated in SARS-CoV-1 and SARS-CoV-2 infections. 4. **Cardiovascular disease**: YWHAZ has been shown to regulate signaling pathways involved in cardiovascular disease, including those related to blood pressure regulation and atherosclerosis. In conclusion, the YWHAZ gene plays a crucial role in regulating various cellular processes, including apoptosis, immune response, and signaling pathways. Its dysregulation has been implicated in various diseases, including cancer, immunodeficiency, and infectious diseases. Further studies are needed to fully understand the mechanisms by which YWHAZ regulates these processes and to explore its potential as a therapeutic target.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

14-3-3 protein zeta/delta

Genular Protein ID: 3470497501

Symbol: 1433Z_HUMAN

Name: 14-3-3 protein zeta/delta

UniProtKB Accession Codes:

P63104 A8K1N0 B7Z465 P29213 P29312 Q32P43 Q5XJ08 Q6GPI2 Q6IN74 Q6NUR9 Q6P3U9 Q86V33

Database IDs:

Citations:

PubMed ID: 1577711

Title: Cloning and expression of a human 14-3-3 protein mediating phospholipolysis. Identification of an arachidonoyl-enzyme intermediate during catalysis.

PubMed ID: 1577711

DOI: 10.1016/s0021-9258(19)50334-9

PubMed ID: 9512661

Title: Two unique 5' untranslated regions in mRNAs encoding human 14-3-3 zeta: differential expression in hemopoietic cells.

PubMed ID: 9512661

DOI: 10.1016/s0167-4781(97)00171-1

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 23572552

Title: ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding.

PubMed ID: 23572552

DOI: 10.1128/mbio.00098-13

PubMed ID: 9360956

Title: 14-3-3 is phosphorylated by casein kinase I on residue 233. Phosphorylation at this site in vivo regulates Raf/14-3-3 interaction.

PubMed ID: 9360956

DOI: 10.1074/jbc.272.46.28882

PubMed ID: 10455159

Title: Nuclear localization of protein kinase U-alpha is regulated by 14-3-3.

PubMed ID: 10455159

DOI: 10.1074/jbc.274.35.24865

PubMed ID: 11427721

Title: Role of a pineal cAMP-operated arylalkylamine N-acetyltransferase/14-3-3-binding switch in melatonin synthesis.

PubMed ID: 11427721

DOI: 10.1073/pnas.141118798

PubMed ID: 11956222

Title: Identification of 14-3-3zeta as a protein kinase B/Akt substrate.

PubMed ID: 11956222

DOI: 10.1074/jbc.m203167200

PubMed ID: 12589811

Title: The interaction between ADAM 22 and 14-3-3zeta: regulation of cell adhesion and spreading.

PubMed ID: 12589811

DOI: 10.1016/s0006-291x(03)00056-1

PubMed ID: 12865427

Title: The dimeric versus monomeric status of 14-3-3zeta is controlled by phosphorylation of Ser58 at the dimer interface.

PubMed ID: 12865427

DOI: 10.1074/jbc.m304689200

PubMed ID: 14578935

Title: Cellular stabilization of the melatonin rhythm enzyme induced by nonhydrolyzable phosphonate incorporation.

PubMed ID: 14578935

DOI: 10.1038/nsb1005

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15071501

Title: JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteins.

PubMed ID: 15071501

DOI: 10.1038/sj.emboj.7600194

PubMed ID: 15159416

Title: A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia.

PubMed ID: 15159416

DOI: 10.1083/jcb.200401136

PubMed ID: 16114898

Title: 14-3-3 protein interacts with nuclear localization sequence of forkhead transcription factor FoxO4.

PubMed ID: 16114898

DOI: 10.1021/bi050618r

PubMed ID: 15660133

Title: Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin.

PubMed ID: 15660133

DOI: 10.1038/sj.emboj.7600543

PubMed ID: 15883165

Title: Sphingosine activates protein kinase A type II by a novel cAMP-independent mechanism.

PubMed ID: 15883165

DOI: 10.1074/jbc.m409081200

PubMed ID: 15696159

Title: JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage.

PubMed ID: 15696159

DOI: 10.1038/ncb1228

PubMed ID: 15644438

Title: Melatonin synthesis: 14-3-3-dependent activation and inhibition of arylalkylamine N-acetyltransferase mediated by phosphoserine-205.

PubMed ID: 15644438

DOI: 10.1073/pnas.0406871102

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16376338

Title: Protein kinase A phosphorylates and regulates dimerization of 14-3-3 epsilon.

PubMed ID: 16376338

DOI: 10.1016/j.febslet.2005.12.024

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

PubMed ID: 16959763

Title: Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling.

PubMed ID: 16959763

DOI: 10.1074/mcp.m600147-mcp200

PubMed ID: 17913709

Title: Regulation of Nox1 activity via PKA-mediated phosphorylation of NoxA1 and 14-3-3 binding.

PubMed ID: 17913709

DOI: 10.1074/jbc.m704754200

PubMed ID: 14970201

Title: p21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to GEF-H1, a microtubule-localized Rho exchange factor.

PubMed ID: 14970201

DOI: 10.1074/jbc.m400084200

PubMed ID: 19172738

Title: Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein.

PubMed ID: 19172738

DOI: 10.1038/emboj.2008.159

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19640509

Title: SLITRK1 binds 14-3-3 and regulates neurite outgrowth in a phosphorylation-dependent manner.

PubMed ID: 19640509

DOI: 10.1016/j.biopsych.2009.05.033

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26047703

Title: Suppression of death-associated protein kinase 2 by interaction with 14-3-3 proteins.

PubMed ID: 26047703

DOI: 10.1016/j.bbrc.2015.05.105

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27030597

Title: Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation.

PubMed ID: 27030597

DOI: 10.1126/scitranslmed.aaf1471

PubMed ID: 29357390

Title: Herpesvirus deconjugases inhibit the IFN response by promoting TRIM25 autoubiquitination and functional inactivation of the RIG-I signalosome.

PubMed ID: 29357390

DOI: 10.1371/journal.ppat.1006852

PubMed ID: 31710640

Title: 14-3-3 scaffold proteins mediate the inactivation of trim25 and inhibition of the type I interferon response by herpesvirus deconjugases.

PubMed ID: 31710640

DOI: 10.1371/journal.ppat.1008146

PubMed ID: 35662396

Title: Itaconate is a lysosomal inducer that promotes antibacterial innate immunity.

PubMed ID: 35662396

DOI: 10.1016/j.molcel.2022.05.009

PubMed ID: 10488331

Title: Structural analysis of 14-3-3 phosphopeptide complexes identifies a dual role for the nuclear export signal of 14-3-3 in ligand binding.

PubMed ID: 10488331

DOI: 10.1016/s1097-2765(00)80363-9

PubMed ID: 11336675

Title: Crystal structure of the 14-3-3zeta:serotonin N-acetyltransferase complex. a role for scaffolding in enzyme regulation.

PubMed ID: 11336675

DOI: 10.1016/s0092-8674(01)00316-6

PubMed ID: 16246723

Title: Molecular basis for the recognition of phosphorylated and phosphoacetylated histone h3 by 14-3-3.

PubMed ID: 16246723

DOI: 10.1016/j.molcel.2005.08.032

PubMed ID: 17235285

Title: Phosphorylation-independent interaction between 14-3-3 and exoenzyme S: from structure to pathogenesis.

PubMed ID: 17235285

DOI: 10.1038/sj.emboj.7601530

PubMed ID: 31024343

Title: A YWHAZ variant associated with cardiofaciocutaneous syndrome activates the RAF-ERK pathway.

PubMed ID: 31024343

DOI: 10.3389/fphys.2019.00388

Sequence Information:

Length: 245
Mass: 27745
Checksum: D464DF2286BBFE60
Sequence:

MDKNELVQKA KLAEQAERYD DMAACMKSVT EQGAELSNEE RNLLSVAYKN VVGARRSSWR 
VVSSIEQKTE GAEKKQQMAR EYREKIETEL RDICNDVLSL LEKFLIPNAS QAESKVFYLK 
MKGDYYRYLA EVAAGDDKKG IVDQSQQAYQ EAFEISKKEM QPTHPIRLGL ALNFSVFYYE 
ILNSPEKACS LAKTAFDEAI AELDTLSEES YKDSTLIMQL LRDNLTLWTS DTQGDEAEAG 
EGGEN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: YWHAZ

Associated with

Cells (max top 100)

Other Information

Cloning and expression of a human 14-3-3 protein mediating phospholipolysis. Identification of an arachidonoyl-enzyme intermediate during catalysis. PubMed ID: 1577711

Two unique 5' untranslated regions in mRNAs encoding human 14-3-3 zeta: differential expression in hemopoietic cells. PubMed ID: 9512661

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. PubMed ID: 12665801

ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding. PubMed ID: 23572552

14-3-3 is phosphorylated by casein kinase I on residue 233. Phosphorylation at this site in vivo regulates Raf/14-3-3 interaction. PubMed ID: 9360956

Nuclear localization of protein kinase U-alpha is regulated by 14-3-3. PubMed ID: 10455159

Role of a pineal cAMP-operated arylalkylamine N-acetyltransferase/14-3-3-binding switch in melatonin synthesis. PubMed ID: 11427721

Identification of 14-3-3zeta as a protein kinase B/Akt substrate. PubMed ID: 11956222

The interaction between ADAM 22 and 14-3-3zeta: regulation of cell adhesion and spreading. PubMed ID: 12589811

The dimeric versus monomeric status of 14-3-3zeta is controlled by phosphorylation of Ser58 at the dimer interface. PubMed ID: 12865427

Cellular stabilization of the melatonin rhythm enzyme induced by nonhydrolyzable phosphonate incorporation. PubMed ID: 14578935

Proteomic characterization of the human centrosome by protein correlation profiling. PubMed ID: 14654843

JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteins. PubMed ID: 15071501

A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia. PubMed ID: 15159416

14-3-3 protein interacts with nuclear localization sequence of forkhead transcription factor FoxO4. PubMed ID: 16114898

Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin. PubMed ID: 15660133

Sphingosine activates protein kinase A type II by a novel cAMP-independent mechanism. PubMed ID: 15883165

JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage. PubMed ID: 15696159

Melatonin synthesis: 14-3-3-dependent activation and inhibition of arylalkylamine N-acetyltransferase mediated by phosphoserine-205. PubMed ID: 15644438

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

Protein kinase A phosphorylates and regulates dimerization of 14-3-3 epsilon. PubMed ID: 16376338

Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. PubMed ID: 17081065

Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling. PubMed ID: 16959763

Regulation of Nox1 activity via PKA-mediated phosphorylation of NoxA1 and 14-3-3 binding. PubMed ID: 17913709

p21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to GEF-H1, a microtubule-localized Rho exchange factor. PubMed ID: 14970201

Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein. PubMed ID: 19172738

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

SLITRK1 binds 14-3-3 and regulates neurite outgrowth in a phosphorylation-dependent manner. PubMed ID: 19640509

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Suppression of death-associated protein kinase 2 by interaction with 14-3-3 proteins. PubMed ID: 26047703

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation. PubMed ID: 27030597

Herpesvirus deconjugases inhibit the IFN response by promoting TRIM25 autoubiquitination and functional inactivation of the RIG-I signalosome. PubMed ID: 29357390

14-3-3 scaffold proteins mediate the inactivation of trim25 and inhibition of the type I interferon response by herpesvirus deconjugases. PubMed ID: 31710640

Itaconate is a lysosomal inducer that promotes antibacterial innate immunity. PubMed ID: 35662396

Structural analysis of 14-3-3 phosphopeptide complexes identifies a dual role for the nuclear export signal of 14-3-3 in ligand binding. PubMed ID: 10488331

Crystal structure of the 14-3-3zeta:serotonin N-acetyltransferase complex. a role for scaffolding in enzyme regulation. PubMed ID: 11336675

Molecular basis for the recognition of phosphorylated and phosphoacetylated histone h3 by 14-3-3. PubMed ID: 16246723

Phosphorylation-independent interaction between 14-3-3 and exoenzyme S: from structure to pathogenesis. PubMed ID: 17235285

A YWHAZ variant associated with cardiofaciocutaneous syndrome activates the RAF-ERK pathway. PubMed ID: 31024343