Details for: PEX5L

Gene ID: 51555

Symbol: PEX5L

Ensembl ID: ENSG00000114757

Description: peroxisomal biogenesis factor 5 like

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.2440
    Cell Significance Index: -22.4200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 4.9783
    Cell Significance Index: 334.7400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 4.1823
    Cell Significance Index: 119.3500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 3.3582
    Cell Significance Index: 673.6500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.3819
    Cell Significance Index: 955.7600
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.3217
    Cell Significance Index: 10.1400
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 1.2916
    Cell Significance Index: 17.2300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.0115
    Cell Significance Index: 362.8100
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.7178
    Cell Significance Index: 6.8300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6797
    Cell Significance Index: 129.3500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4599
    Cell Significance Index: 415.2600
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.4205
    Cell Significance Index: 4.3800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3643
    Cell Significance Index: 20.4400
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.2815
    Cell Significance Index: 3.6500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1391
    Cell Significance Index: 13.7600
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.1035
    Cell Significance Index: 1.2900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0972
    Cell Significance Index: 149.6700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0733
    Cell Significance Index: 135.1700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0711
    Cell Significance Index: 133.9400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0411
    Cell Significance Index: 55.8900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0266
    Cell Significance Index: 4.3200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0433
    Cell Significance Index: -2.6600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0434
    Cell Significance Index: -32.1700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0450
    Cell Significance Index: -0.4900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0479
    Cell Significance Index: -21.7400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0559
    Cell Significance Index: -35.4900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0574
    Cell Significance Index: -32.3800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0650
    Cell Significance Index: -40.6100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0707
    Cell Significance Index: -12.0700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0818
    Cell Significance Index: -11.8900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0821
    Cell Significance Index: -60.1800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0933
    Cell Significance Index: -3.2800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0953
    Cell Significance Index: -72.1100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.1261
    Cell Significance Index: -68.8800
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.1399
    Cell Significance Index: -1.5000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1876
    Cell Significance Index: -53.9800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.1950
    Cell Significance Index: -21.2100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2135
    Cell Significance Index: -44.9600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2703
    Cell Significance Index: -8.6100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.2888
    Cell Significance Index: -52.0700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.3141
    Cell Significance Index: -9.0500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.3429
    Cell Significance Index: -68.0500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3464
    Cell Significance Index: -8.6600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.3914
    Cell Significance Index: -50.1800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4006
    Cell Significance Index: -12.8300
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.4102
    Cell Significance Index: -4.7900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.4123
    Cell Significance Index: -18.6900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.4295
    Cell Significance Index: -52.8100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4629
    Cell Significance Index: -28.4500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.4666
    Cell Significance Index: -64.0800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.4993
    Cell Significance Index: -64.5100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5010
    Cell Significance Index: -57.4000
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.5154
    Cell Significance Index: -6.5100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.5726
    Cell Significance Index: -39.6000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.5906
    Cell Significance Index: -69.6500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6060
    Cell Significance Index: -19.8400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6206
    Cell Significance Index: -64.6200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.6213
    Cell Significance Index: -72.4000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.6319
    Cell Significance Index: -64.5500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.6372
    Cell Significance Index: -48.9000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.6539
    Cell Significance Index: -74.6400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6643
    Cell Significance Index: -14.1000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.6669
    Cell Significance Index: -29.0000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.6801
    Cell Significance Index: -40.8300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.6802
    Cell Significance Index: -19.0100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.6834
    Cell Significance Index: -13.7200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.7297
    Cell Significance Index: -17.5000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.7344
    Cell Significance Index: -18.3200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7676
    Cell Significance Index: -60.8000
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.7749
    Cell Significance Index: -8.5500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.8335
    Cell Significance Index: -16.4800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.8517
    Cell Significance Index: -53.6800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.8664
    Cell Significance Index: -64.5700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.9212
    Cell Significance Index: -32.2700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.9668
    Cell Significance Index: -23.5900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -1.0062
    Cell Significance Index: -21.7400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.0097
    Cell Significance Index: -44.6600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.0456
    Cell Significance Index: -54.9000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -1.0563
    Cell Significance Index: -68.1500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.0649
    Cell Significance Index: -49.6500
  • Cell Name: neuron (CL0000540)
    Fold Change: -1.1277
    Cell Significance Index: -10.6900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -1.1397
    Cell Significance Index: -17.3100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.2147
    Cell Significance Index: -63.1000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -1.2304
    Cell Significance Index: -17.6200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.2441
    Cell Significance Index: -47.1100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.2550
    Cell Significance Index: -27.1900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -1.3251
    Cell Significance Index: -62.2800
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -1.3719
    Cell Significance Index: -17.3100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -1.4516
    Cell Significance Index: -28.5700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.4571
    Cell Significance Index: -37.4600
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -1.4760
    Cell Significance Index: -20.7300
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -1.5068
    Cell Significance Index: -21.1200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.5888
    Cell Significance Index: -33.9600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.6151
    Cell Significance Index: -59.2900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -1.6497
    Cell Significance Index: -34.4300
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -1.7264
    Cell Significance Index: -14.2500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -1.7376
    Cell Significance Index: -24.6900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.8066
    Cell Significance Index: -62.7800
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -1.8472
    Cell Significance Index: -23.0600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -1.8704
    Cell Significance Index: -50.9100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Homology to PEX5:** PEX5L shares a high degree of homology with PEX5, a well-established gene involved in peroxisome biogenesis. This suggests that PEX5L may play a similar role in the biogenesis and function of peroxisomes. 2. **Expression in various tissues:** PEX5L is expressed in a wide range of cell types, including epidermal Langerhans cells, hippocampal granule cells, and cerebral cortex neurons. This indicates that PEX5L may have distinct functions in different tissues. 3. **Association with peroxisome targeting sequences:** PEX5L binds to peroxisome targeting sequences (PTS), which are essential for the import of proteins into the peroxisome matrix. This suggests that PEX5L plays a critical role in the targeting of proteins to peroxisomes. 4. **Regulation of camp-mediated signaling:** PEX5L is involved in the regulation of camp-mediated signaling pathways, which are crucial for various cellular processes, including metabolism and gene expression. **Pathways and Functions:** 1. **Peroxisome biogenesis pathway:** PEX5L is involved in the biogenesis of peroxisomes, which are organelles responsible for the degradation of fatty acids and amino acids. 2. **Protein import into peroxisome matrix:** PEX5L binds to PTS and facilitates the import of proteins into the peroxisome matrix, which is essential for the assembly of peroxisomal enzymes. 3. **Regulation of camp-mediated signaling:** PEX5L is involved in the regulation of camp-mediated signaling pathways, which are crucial for various cellular processes, including metabolism and gene expression. 4. **Regulation of small GTPase binding:** PEX5L regulates the binding of small GTPases to their target proteins, which is essential for various cellular processes, including signal transduction and gene expression. **Clinical Significance:** 1. **Peroxisomal disorders:** Mutations in the PEX5L gene may lead to peroxisomal disorders, such as Zellweger syndrome and infantile Refsum disease, which are characterized by defects in peroxisome biogenesis and function. 2. **Neurological disorders:** PEX5L has been implicated in the pathogenesis of various neurological disorders, including Alzheimer's disease and Parkinson's disease, which are characterized by defects in protein degradation and clearance. 3. **Cancer:** PEX5L may play a role in the development and progression of cancer, as it is involved in the regulation of cell growth and metabolism. 4. **Neurodevelopmental disorders:** PEX5L has been implicated in the pathogenesis of neurodevelopmental disorders, including autism spectrum disorder and schizophrenia, which are characterized by defects in protein degradation and clearance. In conclusion, PEX5L is a multifaceted gene that plays a critical role in peroxisome biogenesis, protein import, and regulation of camp-mediated signaling. Its involvement in various cellular processes, including metabolism and gene expression, underscores its significance in maintaining cellular homeostasis. Further research is needed to elucidate the functional role of PEX5L in different tissues and its potential implications in various diseases.

Genular Protein ID: 2403664369

Symbol: PEX5R_HUMAN

Name: PEX5-related protein

UniProtKB Accession Codes:

Q8IYB4 B7Z2A5 B7Z305 B7Z318 B7Z5Z5 B7Z8P2 E7EUV8 E7EUZ0 E9PEC1 E9PH97 Q9NQD1 Q9P2U3 Q9P2U4

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 8 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 Ensembl 9 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 8 RNAct 1 RefSeq 17 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11463335

Title: Identification of PEX5p-related novel peroxisome-targeting signal 1 (PTS1)-binding proteins in mammals.

PubMed ID: 11463335

DOI: 10.1042/0264-6021:3570635

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 626
  • Mass: 69697
  • Checksum: 07109ABE1B2314C1
  • Sequence:
    • MYQGHMQKSK EQGYGKLSSD EDLEIIVDQK QGKGSRAADK AVAMVMKEIP REESAEEKPL 
LTMTSQLVNE QQESRPLLSP SIDDFLCETK SEAIARPVTS NTAVLTTGLD LLDLSEPVSQ 
TQTKAKKSEP SSKTSSLKKK ADGSDLISTD AEQRGQPLRV PETSSLDLDI QTQLEKWDDV 
KFHGDRNTKG HPMAERKSSS SRTGSKELLW SSEHRSQPEL SGGKSALNSE SASELELVAP 
TQARLTKEHR WGSALLSRNH SLEEEFERAK AAVESDTEFW DKMQAEWEEM ARRNWISENQ 
EAQNQVTISA SEKGYYFHTE NPFKDWPGAF EEGLKRLKEG DLPVTILFME AAILQDPGDA 
EAWQFLGITQ AENENEQAAI VALQRCLELQ PNNLKALMAL AVSYTNTGHQ QDACDALKNW 
IKQNPKYKYL VKSKKGSPGL TRRMSKSPVD SSVLEGVKEL YLEAAHQNGD MIDPDLQTGL 
GVLFHLSGEF NRAIDAFNAA LTVRPEDYSL WNRLGATLAN GDRSEEAVEA YTRALEIQPG 
FIRSRYNLGI SCINLGAYRE AVSNFLTALS LQRKSRNQQQ VPHPAISGNI WAALRIALSL 
MDQPELFQAA NLGDLDVLLR AFNLDP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.