Details for: GABRG2
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 2.58
Marker Score: 2,595 - Cell Name: neuron (CL0000540)
Fold Change: 2.47
Marker Score: 10,054 - Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 2.33
Marker Score: 88,594 - Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 2.27
Marker Score: 6,479 - Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 2.25
Marker Score: 8,707 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 2.2
Marker Score: 16,866 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 2.18
Marker Score: 9,037 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 2.18
Marker Score: 32,589 - Cell Name: pyramidal neuron (CL0000598)
Fold Change: 2.16
Marker Score: 3,629 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 2.12
Marker Score: 9,788 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 2.11
Marker Score: 77,699 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 2.07
Marker Score: 41,210 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.01
Marker Score: 123,581 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.97
Marker Score: 18,540 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.88
Marker Score: 17,888 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.78
Marker Score: 15,263 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.75
Marker Score: 18,106 - Cell Name: plasma cell (CL0000786)
Fold Change: 1.65
Marker Score: 1,844 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 1.65
Marker Score: 3,355 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.62
Marker Score: 2,496 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.62
Marker Score: 1,175 - Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 1.58
Marker Score: 1,494 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 1.51
Marker Score: 51,069 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.49
Marker Score: 1,803 - Cell Name: GABAergic neuron (CL0000617)
Fold Change: 1.47
Marker Score: 6,117 - Cell Name: rod bipolar cell (CL0000751)
Fold Change: 1.35
Marker Score: 706 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.27
Marker Score: 860 - Cell Name: stellate neuron (CL0000122)
Fold Change: 1.2
Marker Score: 6,446 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.18
Marker Score: 491 - Cell Name: macroglial cell (CL0000126)
Fold Change: 1.15
Marker Score: 2,652 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.15
Marker Score: 4,816 - Cell Name: goblet cell (CL0000160)
Fold Change: 1.13
Marker Score: 7,539 - Cell Name: neuronal brush cell (CL0000555)
Fold Change: 1.13
Marker Score: 3,779 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.1
Marker Score: 507 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.09
Marker Score: 2,073 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1
Marker Score: 2,031 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,823 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48,048 - Cell Name: granule cell (CL0000120)
Fold Change: 1
Marker Score: 7,520 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1
Marker Score: 513 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.99
Marker Score: 466 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,407 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,413 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.94
Marker Score: 378 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5,351 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.92
Marker Score: 554 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2,744 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.91
Marker Score: 329 - Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 0.91
Marker Score: 381 - Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.9
Marker Score: 1,856 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,292 - Cell Name: interneuron (CL0000099)
Fold Change: 0.86
Marker Score: 394 - Cell Name: mast cell (CL0000097)
Fold Change: 0.85
Marker Score: 490 - Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 712 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1,266 - Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 0.78
Marker Score: 212 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.77
Marker Score: 400 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.73
Marker Score: 466 - Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.64
Marker Score: 507 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.61
Marker Score: 600 - Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.61
Marker Score: 756 - Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 0.6
Marker Score: 190 - Cell Name: B cell (CL0000236)
Fold Change: 0.57
Marker Score: 541 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.56
Marker Score: 177 - Cell Name: CNS interneuron (CL0000402)
Fold Change: 0.55
Marker Score: 266 - Cell Name: microglial cell (CL0000129)
Fold Change: 0.54
Marker Score: 987 - Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 0.54
Marker Score: 671 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.53
Marker Score: 8,316 - Cell Name: macrophage (CL0000235)
Fold Change: 0.52
Marker Score: 581 - Cell Name: astrocyte (CL0000127)
Fold Change: 0.5
Marker Score: 431 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: 0.48
Marker Score: 210 - Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: 0.46
Marker Score: 2,436 - Cell Name: brainstem motor neuron (CL2000047)
Fold Change: 0.45
Marker Score: 260 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.45
Marker Score: 443 - Cell Name: germ cell (CL0000586)
Fold Change: 0.44
Marker Score: 772 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.42
Marker Score: 249 - Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 0.41
Marker Score: 474 - Cell Name: glutamatergic neuron (CL0000679)
Fold Change: 0.41
Marker Score: 4,162 - Cell Name: male germ cell (CL0000015)
Fold Change: 0.4
Marker Score: 116 - Cell Name: ganglion interneuron (CL0000397)
Fold Change: 0.4
Marker Score: 122 - Cell Name: glial cell (CL0000125)
Fold Change: 0.39
Marker Score: 429 - Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 0.39
Marker Score: 265 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 0.36
Marker Score: 7,709 - Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.36
Marker Score: 172 - Cell Name: neural cell (CL0002319)
Fold Change: 0.34
Marker Score: 165 - Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.34
Marker Score: 180 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.34
Marker Score: 129 - Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 0.33
Marker Score: 372 - Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.33
Marker Score: 103 - Cell Name: visceromotor neuron (CL0005025)
Fold Change: 0.32
Marker Score: 94 - Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 0.32
Marker Score: 131 - Cell Name: ON-bipolar cell (CL0000749)
Fold Change: 0.31
Marker Score: 918 - Cell Name: ependymal cell (CL0000065)
Fold Change: 0.31
Marker Score: 108 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.3
Marker Score: 149 - Cell Name: mature astrocyte (CL0002627)
Fold Change: 0.3
Marker Score: 196 - Cell Name: myeloid cell (CL0000763)
Fold Change: 0.3
Marker Score: 474 - Cell Name: OFF-bipolar cell (CL0000750)
Fold Change: 0.29
Marker Score: 854 - Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 0.26
Marker Score: 146 - Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: 0.25
Marker Score: 75 - Cell Name: smooth muscle cell (CL0000192)
Fold Change: 0.25
Marker Score: 167
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 312691704
Symbol: GBRG2_HUMAN
Name: Gamma-aminobutyric acid receptor subunit gamma-2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2538761
Title: Importance of a novel GABAA receptor subunit for benzodiazepine pharmacology.
PubMed ID: 2538761
DOI: 10.1038/338582a0
PubMed ID: 11328646
Title: Complete genomic sequence of 195 Kb of human DNA containing the gene GABRG2.
PubMed ID: 11328646
PubMed ID: 15372022
Title: The DNA sequence and comparative analysis of human chromosome 5.
PubMed ID: 15372022
DOI: 10.1038/nature02919
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8382267
Title: Antibodies to the human gamma 2 subunit of the gamma-aminobutyric acidA/benzodiazepine receptor.
PubMed ID: 8382267
PubMed ID: 9892355
Title: GABA(A)-receptor-associated protein links GABA(A) receptors and the cytoskeleton.
PubMed ID: 9892355
DOI: 10.1038/16264
PubMed ID: 23909897
Title: GABA(A) receptors can initiate the formation of functional inhibitory GABAergic synapses.
PubMed ID: 23909897
DOI: 10.1111/ejn.12331
PubMed ID: 25489750
Title: Inhibitory synapse formation in a co-culture model incorporating GABAergic medium spiny neurons and HEK293 cells stably expressing GABAA receptors.
PubMed ID: 25489750
DOI: 10.3791/52115
PubMed ID: 27864268
Title: De novo GABRG2 mutations associated with epileptic encephalopathies.
PubMed ID: 27864268
DOI: 10.1093/brain/aww272
PubMed ID: 29950725
Title: Structure of a human synaptic GABAA receptor.
PubMed ID: 29950725
PubMed ID: 11326274
Title: First genetic evidence of GABA(A) receptor dysfunction in epilepsy: a mutation in the gamma2-subunit gene.
PubMed ID: 11326274
DOI: 10.1038/ng0501-46
PubMed ID: 11326275
Title: Mutant GABA(A) receptor gamma2-subunit in childhood absence epilepsy and febrile seizures.
PubMed ID: 11326275
DOI: 10.1038/ng0501-49
PubMed ID: 16924025
Title: A novel GABRG2 mutation associated with febrile seizures.
PubMed ID: 16924025
PubMed ID: 20485450
Title: Mutational analysis of GABRG2 in a Japanese cohort with childhood epilepsies.
PubMed ID: 20485450
DOI: 10.1038/jhg.2010.47
PubMed ID: 21714819
Title: Novel alpha1 and gamma2 GABAA receptor subunit mutations in families with idiopathic generalized epilepsy.
PubMed ID: 21714819
PubMed ID: 23708187
Title: Targeted resequencing in epileptic encephalopathies identifies de novo mutations in CHD2 and SYNGAP1.
PubMed ID: 23708187
DOI: 10.1038/ng.2646
PubMed ID: 27864847
Title: Diagnostic targeted resequencing in 349 patients with drug-resistant pediatric epilepsies identifies causative mutations in 30 different genes.
PubMed ID: 27864847
DOI: 10.1002/humu.23149
Sequence Information:
- Length: 475
- Mass: 55186
- Checksum: DE142F62846576DF
- Sequence:
MSSPNIWSTG SSVYSTPVFS QKMTVWILLL LSLYPGFTSQ KSDDDYEDYA SNKTWVLTPK VPEGDVTVIL NNLLEGYDNK LRPDIGVKPT LIHTDMYVNS IGPVNAINME YTIDIFFAQT WYDRRLKFNS TIKVLRLNSN MVGKIWIPDT FFRNSKKADA HWITTPNRML RIWNDGRVLY TLRLTIDAEC QLQLHNFPMD EHSCPLEFSS YGYPREEIVY QWKRSSVEVG DTRSWRLYQF SFVGLRNTTE VVKTTSGDYV VMSVYFDLSR RMGYFTIQTY IPCTLIVVLS WVSFWINKDA VPARTSLGIT TVLTMTTLST IARKSLPKVS YVTAMDLFVS VCFIFVFSAL VEYGTLHYFV SNRKPSKDKD KKKKNPLLRM FSFKAPTIDI RPRSATIQMN NATHLQERDE EYGYECLDGK DCASFFCCFE DCRTGAWRHG RIHIRIAKMD SYARIFFPTA FCLFNLVYWV SYLYL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.