Details for: GABRG2
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 6.6114
Cell Significance Index: 50.9600 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 3.3517
Cell Significance Index: 1202.2000 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 3.2912
Cell Significance Index: 221.3000 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 2.9171
Cell Significance Index: 83.2500 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.4754
Cell Significance Index: 496.5600 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 1.8832
Cell Significance Index: 41.2400 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 1.8220
Cell Significance Index: 80.5900 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 1.6719
Cell Significance Index: 63.3100 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.6506
Cell Significance Index: 1141.6200 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.6210
Cell Significance Index: 85.1100 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 1.0860
Cell Significance Index: 13.4700 - Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: 0.8508
Cell Significance Index: 11.3500 - Cell Name: OFF-bipolar cell (CL0000750)
Fold Change: 0.8378
Cell Significance Index: 7.3800 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.7181
Cell Significance Index: 44.1400 - Cell Name: hippocampal interneuron (CL1001569)
Fold Change: 0.6323
Cell Significance Index: 8.2000 - Cell Name: pyramidal neuron (CL0000598)
Fold Change: 0.5319
Cell Significance Index: 4.0800 - Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.4695
Cell Significance Index: 11.2600 - Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: 0.3877
Cell Significance Index: 4.7000 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.2402
Cell Significance Index: 27.9900 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.2311
Cell Significance Index: 3.9600 - Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 0.0799
Cell Significance Index: 0.7600 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0107
Cell Significance Index: -7.9400 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0168
Cell Significance Index: -10.4600 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0176
Cell Significance Index: -32.4300 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0181
Cell Significance Index: -34.0900 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0206
Cell Significance Index: -11.6300 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0216
Cell Significance Index: -33.2200 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0252
Cell Significance Index: -34.2200 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0393
Cell Significance Index: -8.2900 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0482
Cell Significance Index: -35.3300 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0542
Cell Significance Index: -34.4200 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.0565
Cell Significance Index: -1.1400 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0752
Cell Significance Index: -34.1200 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0833
Cell Significance Index: -14.2200 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0880
Cell Significance Index: -3.8300 - Cell Name: neural cell (CL0002319)
Fold Change: -0.0943
Cell Significance Index: -1.1000 - Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.0945
Cell Significance Index: -1.0300 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.0980
Cell Significance Index: -2.0800 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1015
Cell Significance Index: -29.2000 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -0.1203
Cell Significance Index: -19.5700 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1453
Cell Significance Index: -4.0600 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: -0.1469
Cell Significance Index: -27.9500 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1761
Cell Significance Index: -20.1800 - Cell Name: neuron (CL0000540)
Fold Change: -0.1815
Cell Significance Index: -1.7200 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.1846
Cell Significance Index: -5.8800 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.1895
Cell Significance Index: -34.1600 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.1917
Cell Significance Index: -3.7900 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.2093
Cell Significance Index: -41.5300 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2340
Cell Significance Index: -34.0100 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.2735
Cell Significance Index: -5.9100 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.2825
Cell Significance Index: -34.7400 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.2957
Cell Significance Index: -18.6400 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.3015
Cell Significance Index: -9.8700 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.3125
Cell Significance Index: -34.0000 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.3384
Cell Significance Index: -38.6300 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3528
Cell Significance Index: -36.7400 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.4114
Cell Significance Index: -13.1800 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.4157
Cell Significance Index: -28.7500 - Cell Name: retinal ganglion cell (CL0000740)
Fold Change: -0.4386
Cell Significance Index: -3.6200 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.4489
Cell Significance Index: -26.9500 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.4703
Cell Significance Index: -36.0900 - Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
Fold Change: -0.5003
Cell Significance Index: -5.5200 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.5047
Cell Significance Index: -17.6800 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: -0.5159
Cell Significance Index: -6.1700 - Cell Name: GABAergic neuron (CL0000617)
Fold Change: -0.5230
Cell Significance Index: -6.6000 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.5416
Cell Significance Index: -13.5100 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.5529
Cell Significance Index: -33.9000 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.5606
Cell Significance Index: -11.7000 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.5845
Cell Significance Index: -8.3700 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -0.5963
Cell Significance Index: -4.0400 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.6200
Cell Significance Index: -34.7900 - Cell Name: ON-bipolar cell (CL0000749)
Fold Change: -0.6347
Cell Significance Index: -7.1700 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.6359
Cell Significance Index: -7.9300 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.6486
Cell Significance Index: -16.1700 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.6902
Cell Significance Index: -35.9500 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.7532
Cell Significance Index: -11.3500 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.7717
Cell Significance Index: -36.2700 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.7737
Cell Significance Index: -40.1900 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.7739
Cell Significance Index: -35.0800 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.7806
Cell Significance Index: -22.4900 - Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -0.8399
Cell Significance Index: -10.6000 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.8560
Cell Significance Index: -39.9100 - Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -0.8615
Cell Significance Index: -17.1800 - Cell Name: secretory cell (CL0000151)
Fold Change: -0.8897
Cell Significance Index: -6.1700 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -0.9471
Cell Significance Index: -18.6400 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.9719
Cell Significance Index: -20.7800 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.9733
Cell Significance Index: -34.2000 - Cell Name: keratinocyte (CL0000312)
Fold Change: -0.9974
Cell Significance Index: -24.9100 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -1.0755
Cell Significance Index: -22.3100 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -1.0978
Cell Significance Index: -34.7200 - Cell Name: interneuron (CL0000099)
Fold Change: -1.1326
Cell Significance Index: -13.2300 - Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
Fold Change: -1.2086
Cell Significance Index: -16.1100 - Cell Name: midget ganglion cell of retina (CL4023188)
Fold Change: -1.2489
Cell Significance Index: -13.0100 - Cell Name: flat midget bipolar cell (CL4033033)
Fold Change: -1.2546
Cell Significance Index: -15.6000 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -1.2782
Cell Significance Index: -36.6400 - Cell Name: chandelier cell (CL4023083)
Fold Change: -1.3134
Cell Significance Index: -10.6100 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -1.3585
Cell Significance Index: -36.3400 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -1.3692
Cell Significance Index: -27.8600 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -1.3778
Cell Significance Index: -29.8500 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -1.3870
Cell Significance Index: -29.5400
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 312691704
Symbol: GBRG2_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2538761
Title: Importance of a novel GABAA receptor subunit for benzodiazepine pharmacology.
PubMed ID: 2538761
DOI: 10.1038/338582a0
PubMed ID: 11328646
Title: Complete genomic sequence of 195 Kb of human DNA containing the gene GABRG2.
PubMed ID: 11328646
PubMed ID: 15372022
Title: The DNA sequence and comparative analysis of human chromosome 5.
PubMed ID: 15372022
DOI: 10.1038/nature02919
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8382267
Title: Antibodies to the human gamma 2 subunit of the gamma-aminobutyric acidA/benzodiazepine receptor.
PubMed ID: 8382267
PubMed ID: 9892355
Title: GABA(A)-receptor-associated protein links GABA(A) receptors and the cytoskeleton.
PubMed ID: 9892355
DOI: 10.1038/16264
PubMed ID: 14993607
Title: Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by alpha5 subunit-containing gamma-aminobutyric acid type A receptors.
PubMed ID: 14993607
PubMed ID: 16412217
Title: Impact of epsilon and theta subunits on pharmacological properties of alpha3beta1 GABAA receptors expressed in Xenopus oocytes.
PubMed ID: 16412217
PubMed ID: 23909897
Title: GABA(A) receptors can initiate the formation of functional inhibitory GABAergic synapses.
PubMed ID: 23909897
DOI: 10.1111/ejn.12331
PubMed ID: 25489750
Title: Inhibitory synapse formation in a co-culture model incorporating GABAergic medium spiny neurons and HEK293 cells stably expressing GABAA receptors.
PubMed ID: 25489750
DOI: 10.3791/52115
PubMed ID: 29950725
Title: Structure of a human synaptic GABAA receptor.
PubMed ID: 29950725
PubMed ID: 30602789
Title: Cryo-EM structure of the human alpha1beta3gamma2 GABAA receptor in a lipid bilayer.
PubMed ID: 30602789
PubMed ID: 27864268
Title: De novo GABRG2 mutations associated with epileptic encephalopathies.
PubMed ID: 27864268
DOI: 10.1093/brain/aww272
PubMed ID: 11326274
Title: First genetic evidence of GABA(A) receptor dysfunction in epilepsy: a mutation in the gamma2-subunit gene.
PubMed ID: 11326274
DOI: 10.1038/ng0501-46
PubMed ID: 11326275
Title: Mutant GABA(A) receptor gamma2-subunit in childhood absence epilepsy and febrile seizures.
PubMed ID: 11326275
DOI: 10.1038/ng0501-49
PubMed ID: 16924025
Title: A novel GABRG2 mutation associated with febrile seizures.
PubMed ID: 16924025
PubMed ID: 20485450
Title: Mutational analysis of GABRG2 in a Japanese cohort with childhood epilepsies.
PubMed ID: 20485450
DOI: 10.1038/jhg.2010.47
PubMed ID: 21714819
Title: Novel alpha1 and gamma2 GABAA receptor subunit mutations in families with idiopathic generalized epilepsy.
PubMed ID: 21714819
PubMed ID: 23708187
Title: Targeted resequencing in epileptic encephalopathies identifies de novo mutations in CHD2 and SYNGAP1.
PubMed ID: 23708187
DOI: 10.1038/ng.2646
PubMed ID: 27864847
Title: Diagnostic targeted resequencing in 349 patients with drug-resistant pediatric epilepsies identifies causative mutations in 30 different genes.
PubMed ID: 27864847
DOI: 10.1002/humu.23149
Sequence Information:
- Length: 475
- Mass: 55186
- Checksum: DE142F62846576DF
- Sequence:
MSSPNIWSTG SSVYSTPVFS QKMTVWILLL LSLYPGFTSQ KSDDDYEDYA SNKTWVLTPK VPEGDVTVIL NNLLEGYDNK LRPDIGVKPT LIHTDMYVNS IGPVNAINME YTIDIFFAQT WYDRRLKFNS TIKVLRLNSN MVGKIWIPDT FFRNSKKADA HWITTPNRML RIWNDGRVLY TLRLTIDAEC QLQLHNFPMD EHSCPLEFSS YGYPREEIVY QWKRSSVEVG DTRSWRLYQF SFVGLRNTTE VVKTTSGDYV VMSVYFDLSR RMGYFTIQTY IPCTLIVVLS WVSFWINKDA VPARTSLGIT TVLTMTTLST IARKSLPKVS YVTAMDLFVS VCFIFVFSAL VEYGTLHYFV SNRKPSKDKD KKKKNPLLRM FSFKAPTIDI RPRSATIQMN NATHLQERDE EYGYECLDGK DCASFFCCFE DCRTGAWRHG RIHIRIAKMD SYARIFFPTA FCLFNLVYWV SYLYL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.