Details for: SRSF5

Gene ID: 6430

Symbol: SRSF5

Ensembl ID: ENSG00000100650

Description: serine and arginine rich splicing factor 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 765.3080
    Cell Significance Index: -119.0400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 398.9262
    Cell Significance Index: -101.1900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 350.1902
    Cell Significance Index: -144.2600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 321.4221
    Cell Significance Index: -130.5800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 316.0619
    Cell Significance Index: -149.2200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 286.2446
    Cell Significance Index: -147.2400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 222.8689
    Cell Significance Index: -149.5500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 138.0267
    Cell Significance Index: -131.7800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 110.7258
    Cell Significance Index: -136.5200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 43.4177
    Cell Significance Index: -116.3100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 37.0378
    Cell Significance Index: -113.7600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 36.9914
    Cell Significance Index: -145.9700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 35.0317
    Cell Significance Index: -76.6700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 4.7469
    Cell Significance Index: 126.7500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 4.1706
    Cell Significance Index: 218.9800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 3.9797
    Cell Significance Index: 111.2200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 3.9475
    Cell Significance Index: 506.0400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.8855
    Cell Significance Index: 105.7600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 3.6236
    Cell Significance Index: 233.7800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.7879
    Cell Significance Index: 207.7800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.7845
    Cell Significance Index: 501.9600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.7468
    Cell Significance Index: 78.7400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 2.7333
    Cell Significance Index: 297.3100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.6606
    Cell Significance Index: 365.3800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.6537
    Cell Significance Index: 1449.2700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.6205
    Cell Significance Index: 322.2200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.2281
    Cell Significance Index: 104.7200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.1759
    Cell Significance Index: 962.0100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.1591
    Cell Significance Index: 254.6200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.0274
    Cell Significance Index: 406.6900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.0079
    Cell Significance Index: 259.4100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.9761
    Cell Significance Index: 68.6700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.9372
    Cell Significance Index: 191.6300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.8863
    Cell Significance Index: 43.5800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.7774
    Cell Significance Index: 34.6900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.5532
    Cell Significance Index: 109.8500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.5525
    Cell Significance Index: 308.1000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.3120
    Cell Significance Index: 470.6100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.3027
    Cell Significance Index: 34.2600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.1526
    Cell Significance Index: 33.2100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.1434
    Cell Significance Index: 790.8000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.1352
    Cell Significance Index: 8.7500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.0976
    Cell Significance Index: 49.7500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9310
    Cell Significance Index: 48.3700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.8109
    Cell Significance Index: 37.8100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.7845
    Cell Significance Index: 14.5000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6507
    Cell Significance Index: 123.8400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.5846
    Cell Significance Index: 1100.7400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.4955
    Cell Significance Index: 25.8100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.4938
    Cell Significance Index: 313.6100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.4776
    Cell Significance Index: 735.2200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.3815
    Cell Significance Index: 703.5900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3473
    Cell Significance Index: 26.6600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2904
    Cell Significance Index: 47.2300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.2682
    Cell Significance Index: 4.7400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.2341
    Cell Significance Index: 6.8800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1660
    Cell Significance Index: 75.3400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1225
    Cell Significance Index: 166.5500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1163
    Cell Significance Index: 19.8600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0735
    Cell Significance Index: 4.5200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0575
    Cell Significance Index: 42.1800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0154
    Cell Significance Index: 11.6200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0541
    Cell Significance Index: -40.1000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0662
    Cell Significance Index: -4.1800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0666
    Cell Significance Index: -1.1200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1267
    Cell Significance Index: -79.1200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1443
    Cell Significance Index: -14.7400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1675
    Cell Significance Index: -9.4000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1907
    Cell Significance Index: -107.5400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3010
    Cell Significance Index: -3.4200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3412
    Cell Significance Index: -71.8700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3880
    Cell Significance Index: -56.4000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.4329
    Cell Significance Index: -124.5500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.4585
    Cell Significance Index: -6.8700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4907
    Cell Significance Index: -56.2200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5118
    Cell Significance Index: -8.7700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.7534
    Cell Significance Index: -50.6600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.7896
    Cell Significance Index: -5.3500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.8937
    Cell Significance Index: -22.8300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.9200
    Cell Significance Index: -107.2100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.9311
    Cell Significance Index: -19.4900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -1.0304
    Cell Significance Index: -117.6200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.0928
    Cell Significance Index: -113.7900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -1.2754
    Cell Significance Index: -11.7500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.4346
    Cell Significance Index: -31.0800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.4664
    Cell Significance Index: -116.1400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.4770
    Cell Significance Index: -39.5100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.5524
    Cell Significance Index: -21.1800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.6769
    Cell Significance Index: -19.9900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.8520
    Cell Significance Index: -81.9200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.8940
    Cell Significance Index: -32.6500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -1.9382
    Cell Significance Index: -47.2900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.9868
    Cell Significance Index: -121.8100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.9995
    Cell Significance Index: -64.0400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -2.1712
    Cell Significance Index: -54.2800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -2.2394
    Cell Significance Index: -84.8000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -2.3268
    Cell Significance Index: -59.8100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -2.6704
    Cell Significance Index: -76.2100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -2.6900
    Cell Significance Index: -57.5000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -2.8560
    Cell Significance Index: -42.1700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SRSF5 is a serine and arginine rich protein that belongs to the SR family of splicing factors. It is a multifunctional protein that interacts with various RNA-binding proteins and DNA-binding factors to regulate alternative splicing. SRSF5 is predominantly expressed in cells of the immune system, including T cells, natural killer cells, and dendritic cells. Its expression is also detected in other cell types, such as fibroblasts and epithelial cells. The protein is characterized by its ability to bind to specific RNA sequences, including splicing enhancers and silencers, and to regulate the recruitment of other splicing factors to the spliceosome. **Pathways and Functions:** SRSF5 is involved in multiple pathways that regulate gene expression, including: 1. **Alternative Splicing**: SRSF5 plays a crucial role in the recognition and processing of pre-mRNA, facilitating the inclusion or exclusion of specific exons to generate diverse isoforms of proteins. 2. **RNA Binding**: SRSF5 interacts with various RNA-binding proteins to regulate the stability and translation of mRNAs. 3. **Transcriptional Regulation**: SRSF5 regulates the expression of genes involved in immune responses, including the transcription of cytokine genes and the regulation of immune cell development. 4. **Cell Signaling**: SRSF5 is involved in cell signaling pathways, including the regulation of cell proliferation, differentiation, and survival. **Clinical Significance:** Dysregulation of SRSF5 has been implicated in various diseases, including: 1. **Cancer**: Altered splicing patterns have been observed in various types of cancer, including breast cancer, lung cancer, and leukemia. SRSF5 mutations have been identified in some cancer cases. 2. **Autoimmune Disorders**: Dysregulation of SRSF5 has been implicated in autoimmune diseases, including rheumatoid arthritis and multiple sclerosis. 3. **Immunodeficiency**: Mutations in SRSF5 have been associated with immunodeficiency disorders, including severe combined immunodeficiency (SCID). 4. **Neurological Disorders**: SRSF5 has been implicated in neurological disorders, including Alzheimer's disease and amyotrophic lateral sclerosis (ALS). In conclusion, SRSF5 is a complex gene that plays a critical role in regulating gene expression, particularly in the context of alternative splicing. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in maintaining immune homeostasis and overall health. Further research is needed to fully elucidate the mechanisms by which SRSF5 regulates gene expression and to explore its therapeutic potential.

Genular Protein ID: 1593308098

Symbol: SRSF5_HUMAN

Name: Serine/arginine-rich splicing factor 5

UniProtKB Accession Codes:

Q13243 O14797 Q16662 Q49AD6 Q6FGE0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 4 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 5 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7556075

Title: Identification and characterization of three members of the human SR family of pre-mRNA splicing factors.

PubMed ID: 7556075

DOI: 10.1002/j.1460-2075.1995.tb00108.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9434190

Title: Alternative splicing and structure of the human and mouse SFRS5/HRS/SRp40 genes.

PubMed ID: 9434190

DOI: 10.1016/s0378-1119(97)00552-0

PubMed ID: 1577277

Title: SR proteins: a conserved family of pre-mRNA splicing factors.

PubMed ID: 1577277

DOI: 10.1101/gad.6.5.837

PubMed ID: 9531537

Title: A coactivator of pre-mRNA splicing.

PubMed ID: 9531537

DOI: 10.1101/gad.12.7.996

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 272
  • Mass: 31264
  • Checksum: F13AD79845ECBB16
  • Sequence:
    • MSGCRVFIGR LNPAAREKDV ERFFKGYGRI RDIDLKRGFG FVEFEDPRDA DDAVYELDGK 
ELCSERVTIE HARARSRGGR GRGRYSDRFS SRRPRNDRRN APPVRTENRL IVENLSSRVS 
WQDLKDFMRQ AGEVTFADAH RPKLNEGVVE FASYGDLKNA IEKLSGKEIN GRKIKLIEGS 
KRHSRSRSRS RSRTRSSSRS RSRSRSRSRK SYSRSRSRSR SRSRSKSRSV SRSPVPEKSQ 
KRGSSSRSKS PASVDRQRSR SRSRSRSVDS GN

Genular Protein ID: 2845936623

Symbol: Q86U32_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q86U32

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 GO 1 Gene3D 1 IntAct 1 InterPro 3 MINT 1 NCBI Taxonomy 1 OrthoDB 1 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 1 SUPFAM 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 145
  • Mass: 16428
  • Checksum: 4D8FC296C5D9E1E6
  • Sequence:
    • MRQAGEVTFA DAHRPKLNEG VVEFASYGDL KNAIEKLSGK EINGRKIKLI EGSKRHSRSR 
SRSRSRTRSS SRSRSRSRSR SRKSYSRSRS RSRSRSRSKS RSVSRSPVPE KSQKRGSSSR 
SKSPASVDRQ RSRSRSRSRS VDSGN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.