Details for: GRM8

Gene ID: 2918

Symbol: GRM8

Ensembl ID: ENSG00000179603

Description: glutamate metabotropic receptor 8

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 5.38
    Marker Score: 12377
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 5.25
    Marker Score: 27531
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 3.66
    Marker Score: 19673
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 3.49
    Marker Score: 29527.5
  • Cell Name: granule cell (CL0000120)
    Fold Change: 3.31
    Marker Score: 24971
  • Cell Name: interneuron (CL0000099)
    Fold Change: 3.18
    Marker Score: 1454
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 3.01
    Marker Score: 10101
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 2.6
    Marker Score: 7451.5
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 2.57
    Marker Score: 4867
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.19
    Marker Score: 20576
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 2.1
    Marker Score: 940
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 2.02
    Marker Score: 970
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.93
    Marker Score: 2221
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.89
    Marker Score: 116072
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.85
    Marker Score: 17617
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.68
    Marker Score: 3423
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.65
    Marker Score: 2552
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.54
    Marker Score: 56762
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.48
    Marker Score: 889
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167697
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.41
    Marker Score: 14512
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 865
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 850
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.24
    Marker Score: 9523
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.24
    Marker Score: 694
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.23
    Marker Score: 19298
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.21
    Marker Score: 18033
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.19
    Marker Score: 5488
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4802
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.11
    Marker Score: 2623
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 1.07
    Marker Score: 352
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.04
    Marker Score: 4216
  • Cell Name: glial cell (CL0000125)
    Fold Change: 1.03
    Marker Score: 1133
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.03
    Marker Score: 324
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.01
    Marker Score: 875
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1
    Marker Score: 313
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71799
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48024
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1
    Marker Score: 413
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 506
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 461
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5322
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 373
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.9
    Marker Score: 20135
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.9
    Marker Score: 284
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5282
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.87
    Marker Score: 17281
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.86
    Marker Score: 659
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.86
    Marker Score: 292
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.85
    Marker Score: 327
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.84
    Marker Score: 354
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.84
    Marker Score: 219
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.84
    Marker Score: 1183.5
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.83
    Marker Score: 396
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.82
    Marker Score: 299
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.76
    Marker Score: 6537
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.74
    Marker Score: 432
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.72
    Marker Score: 229
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.72
    Marker Score: 1208
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 460
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.68
    Marker Score: 960
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 0.63
    Marker Score: 179
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.63
    Marker Score: 413.5
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.59
    Marker Score: 262
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.58
    Marker Score: 720
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.57
    Marker Score: 1249.5
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 150
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.57
    Marker Score: 451
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.55
    Marker Score: 3330
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.55
    Marker Score: 503
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.54
    Marker Score: 983
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.54
    Marker Score: 298
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.53
    Marker Score: 361
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.53
    Marker Score: 250
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.52
    Marker Score: 379
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.51
    Marker Score: 660
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.5
    Marker Score: 1650
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.5
    Marker Score: 291
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.5
    Marker Score: 1417
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.49
    Marker Score: 18700
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.49
    Marker Score: 322
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.49
    Marker Score: 204
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.48
    Marker Score: 168.5
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.48
    Marker Score: 981
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.46
    Marker Score: 146
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.46
    Marker Score: 145.5
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.45
    Marker Score: 264
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.44
    Marker Score: 377
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.42
    Marker Score: 405
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.42
    Marker Score: 1041
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.41
    Marker Score: 369
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.41
    Marker Score: 233

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Other Information

**Key characteristics:** * GRM8 is a member of the GPCR superfamily, which is a large family of cell surface receptors that are coupled to G proteins. * It is a G protein-coupled receptor, which means that it is a receptor that binds to a G protein and activates it. * GRM8 is expressed in high levels in the central nervous system, where it is involved in a variety of cellular processes, including synaptic plasticity and learning and memory. **Pathways and functions:** * GRM8 is a key component of the Adenylate Cyclase-Inhibiting G Protein-Coupled Receptor Signaling Pathway. This pathway is involved in regulating synaptic transmission, and GRM8 is a key regulator of this pathway. * It is also involved in the regulation of neurogenesis, synapse formation, and neuronal survival. **Clinical significance:** * Mutations in GRM8 have been linked to a number of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. * Blockade of GRM8 signaling has been shown to be neuroprotective in animal models of neurodegenerative diseases. * Therefore, GRM8 is a promising target for the treatment of neurodegenerative diseases. **Additional information:** * GRM8 is a relatively new protein, and its full function is still being elucidated. * It is a very important protein in the central nervous system, and its dysfunction is linked to a number of neurodegenerative diseases. * GRM8 is a promising target for the treatment of neurodegenerative diseases.

Genular Protein ID: 1992905438

Symbol: GRM8_HUMAN

Name: Metabotropic glutamate receptor 8

UniProtKB Accession Codes:

O00222 A4D0Y3 B0FZ74 B0M0L0 O15493 O95945 O95946 Q3MIV9 Q52M02 Q6J165

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EMBL 10 EMDB 1 Ensembl 6 ExpressionAtlas 1 GO 9 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 3 PRINTS 3 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 6 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9299241

Title: The human metabotropic glutamate receptor 8 (GRM8) gene: a disproportionately large gene located at 7q31.3-q32.1.

PubMed ID: 9299241

DOI: 10.1006/geno.1997.4842

PubMed ID: 9473604

Title: Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells.

PubMed ID: 9473604

DOI: 10.1016/s0169-328x(97)00277-5

PubMed ID: 10216218

Title: Cloning and functional expression of alternative spliced variants of the human metabotropic glutamate receptor 8.

PubMed ID: 10216218

DOI: 10.1016/s0169-328x(99)00050-9

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 908
  • Mass: 101741
  • Checksum: 95C2D5883DAF6FDE
  • Sequence:
    • MVCEGKRSAS CPCFFLLTAK FYWILTMMQR THSQEYAHSI RVDGDIILGG LFPVHAKGER 
GVPCGELKKE KGIHRLEAML YAIDQINKDP DLLSNITLGV RILDTCSRDT YALEQSLTFV 
QALIEKDASD VKCANGDPPI FTKPDKISGV IGAAASSVSI MVANILRLFK IPQISYASTA 
PELSDNTRYD FFSRVVPPDS YQAQAMVDIV TALGWNYVST LASEGNYGES GVEAFTQISR 
EIGGVCIAQS QKIPREPRPG EFEKIIKRLL ETPNARAVIM FANEDDIRRI LEAAKKLNQS 
GHFLWIGSDS WGSKIAPVYQ QEEIAEGAVT ILPKRASIDG FDRYFRSRTL ANNRRNVWFA 
EFWEENFGCK LGSHGKRNSH IKKCTGLERI ARDSSYEQEG KVQFVIDAVY SMAYALHNMH 
KDLCPGYIGL CPRMSTIDGK ELLGYIRAVN FNGSAGTPVT FNENGDAPGR YDIFQYQITN 
KSTEYKVIGH WTNQLHLKVE DMQWAHREHT HPASVCSLPC KPGERKKTVK GVPCCWHCER 
CEGYNYQVDE LSCELCPLDQ RPNMNRTGCQ LIPIIKLEWH SPWAVVPVFV AILGIIATTF 
VIVTFVRYND TPIVRASGRE LSYVLLTGIF LCYSITFLMI AAPDTIICSF RRVFLGLGMC 
FSYAALLTKT NRIHRIFEQG KKSVTAPKFI SPASQLVITF SLISVQLLGV FVWFVVDPPH 
IIIDYGEQRT LDPEKARGVL KCDISDLSLI CSLGYSILLM VTCTVYAIKT RGVPETFNEA 
KPIGFTMYTT CIIWLAFIPI FFGTAQSAEK MYIQTTTLTV SMSLSASVSL GMLYMPKVYI 
IIFHPEQNVQ KRKRSFKAVV TAATMQSKLI QKGNDRPNGE VKSELCESLE TNTSSTKTTY 
ISYSNHSI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.