Details for: FTH1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 1792.5333
Cell Significance Index: -278.8200 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 1249.1948
Cell Significance Index: -316.8500 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 927.9214
Cell Significance Index: -382.2600 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 799.4745
Cell Significance Index: -377.4500 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 751.6934
Cell Significance Index: -386.6600 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 566.2406
Cell Significance Index: -379.9600 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 270.3747
Cell Significance Index: -333.3600 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 103.2377
Cell Significance Index: -317.0900 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 96.1519
Cell Significance Index: -379.4200 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 69.0144
Cell Significance Index: -184.8800 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 57.2972
Cell Significance Index: -125.4000 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 21.1393
Cell Significance Index: 390.7100 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 18.6353
Cell Significance Index: 875.8400 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 17.8457
Cell Significance Index: 511.5600 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 11.6637
Cell Significance Index: 612.3900 - Cell Name: granulosa cell (CL0000501)
Fold Change: 11.2056
Cell Significance Index: 294.6500 - Cell Name: lactocyte (CL0002325)
Fold Change: 10.9442
Cell Significance Index: 1413.9200 - Cell Name: cell in vitro (CL0001034)
Fold Change: 10.4635
Cell Significance Index: 5714.3800 - Cell Name: odontoblast (CL0000060)
Fold Change: 9.7125
Cell Significance Index: 1245.0800 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 9.2691
Cell Significance Index: 690.8200 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 8.6799
Cell Significance Index: 1564.7200 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 8.4602
Cell Significance Index: 1040.2600 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 8.2855
Cell Significance Index: 146.4200 - Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 8.2139
Cell Significance Index: 50.5500 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 8.1815
Cell Significance Index: 1123.5500 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 6.6302
Cell Significance Index: 309.1300 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 5.6947
Cell Significance Index: 197.8900 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 5.2787
Cell Significance Index: 2333.8400 - Cell Name: peg cell (CL4033014)
Fold Change: 4.7000
Cell Significance Index: 108.5900 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 4.6006
Cell Significance Index: 542.5500 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 4.5942
Cell Significance Index: 125.0500 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 4.5614
Cell Significance Index: 51.8200 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 3.8550
Cell Significance Index: 248.7100 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 3.8372
Cell Significance Index: 2904.4400 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: 3.7937
Cell Significance Index: 300.4600 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 3.5827
Cell Significance Index: 408.9600 - Cell Name: theca cell (CL0000503)
Fold Change: 3.4349
Cell Significance Index: 20.1800 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 3.3464
Cell Significance Index: 571.4100 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 3.0022
Cell Significance Index: 212.3300 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 2.9840
Cell Significance Index: 592.1800 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 2.8837
Cell Significance Index: 77.0000 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 2.3527
Cell Significance Index: 1724.9700 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 2.2875
Cell Significance Index: 21.0700 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.0070
Cell Significance Index: 402.6100 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 1.9225
Cell Significance Index: 40.2400 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.7719
Cell Significance Index: 9.8800 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.6713
Cell Significance Index: 240.8000 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.5336
Cell Significance Index: 15.6700 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.3263
Cell Significance Index: 614.3300 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2883
Cell Significance Index: 54.8700 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.1738
Cell Significance Index: 110.4000 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0544
Cell Significance Index: 0.9100 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.0084
Cell Significance Index: 0.8500 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.1572
Cell Significance Index: -116.4600 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.2034
Cell Significance Index: -375.1000 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.2585
Cell Significance Index: -397.9300 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.2911
Cell Significance Index: -17.9000 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.3145
Cell Significance Index: -196.4200 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.3289
Cell Significance Index: -447.1700 - Cell Name: colon goblet cell (CL0009039)
Fold Change: -0.3436
Cell Significance Index: -33.9900 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.4169
Cell Significance Index: -189.2300 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.4804
Cell Significance Index: -270.9400 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.5099
Cell Significance Index: -26.4900 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.7416
Cell Significance Index: -156.1900 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.8553
Cell Significance Index: -22.8800 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.9028
Cell Significance Index: -259.7500 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -1.5770
Cell Significance Index: -229.2400 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -1.9983
Cell Significance Index: -325.0000 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -2.0435
Cell Significance Index: -128.8000 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -2.0948
Cell Significance Index: -94.9500 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -2.2051
Cell Significance Index: -252.6300 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -2.2195
Cell Significance Index: -258.6600 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -2.2797
Cell Significance Index: -80.1100 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -2.4807
Cell Significance Index: -171.5500 - Cell Name: pro-T cell (CL0000827)
Fold Change: -2.7185
Cell Significance Index: -69.4500 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -3.4134
Cell Significance Index: -355.4200 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -3.6727
Cell Significance Index: -117.6300 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -3.7754
Cell Significance Index: -289.7200 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -3.9485
Cell Significance Index: -265.5000 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -4.3129
Cell Significance Index: -120.5300 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -4.3289
Cell Significance Index: -74.1900 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -4.3291
Cell Significance Index: -59.0700 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -4.7870
Cell Significance Index: -268.6200 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -4.8805
Cell Significance Index: -73.1300 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -4.9054
Cell Significance Index: -58.4800 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -5.0879
Cell Significance Index: -30.7400 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -5.4000
Cell Significance Index: -116.9900 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -5.5852
Cell Significance Index: -335.3100 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -6.0381
Cell Significance Index: -104.0900 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -6.1429
Cell Significance Index: -376.6200 - Cell Name: seromucus secreting cell (CL0000159)
Fold Change: -6.3388
Cell Significance Index: -132.2000 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -6.7085
Cell Significance Index: -72.9300 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -6.8346
Cell Significance Index: -356.0100 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -7.6004
Cell Significance Index: -189.9900 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -7.6152
Cell Significance Index: -224.3000 - Cell Name: monocyte-derived dendritic cell (CL0011031)
Fold Change: -7.6325
Cell Significance Index: -131.1300 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -8.8113
Cell Significance Index: -389.7500 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -9.1029
Cell Significance Index: -334.1600 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -9.3341
Cell Significance Index: -326.9900 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -9.6007
Cell Significance Index: -65.0500
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1093327610
Symbol: FRIH_HUMAN
Name: Ferritin heavy chain
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 6323167
Title: Cloning and sequencing of a full length cDNA coding for a human apoferritin H chain: evidence for a multigene family.
PubMed ID: 6323167
PubMed ID: 3840162
Title: Structural and functional relationships of human ferritin H and L chains deduced from cDNA clones.
PubMed ID: 3840162
PubMed ID: 3023856
Title: Structure and expression of ferritin genes in a human promyelocytic cell line that differentiates in vitro.
PubMed ID: 3023856
PubMed ID: 3003694
Title: Structure of gene and pseudogenes of human apoferritin H.
PubMed ID: 3003694
DOI: 10.1093/nar/14.2.721
PubMed ID: 3020541
Title: Cloning, characterization, expression, and chromosomal localization of a human ferritin heavy-chain gene.
PubMed ID: 3020541
PubMed ID: 7916709
Title: Sequence of a cDNA encoding the ferritin H-chain from an 11-week-old human fetal brain.
PubMed ID: 7916709
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 6589621
Title: Isolation and characterization of a cDNA clone for human ferritin heavy chain.
PubMed ID: 6589621
PubMed ID: 9003196
Title: Dinuclear center of ferritin: studies of iron binding and oxidation show differences in the two iron sites.
PubMed ID: 9003196
DOI: 10.1021/bi961830l
PubMed ID: 11389486
Title: A mutation, in the iron-responsive element of H ferritin mRNA, causing autosomal dominant iron overload.
PubMed ID: 11389486
DOI: 10.1086/321261
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 18318008
Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.
PubMed ID: 18318008
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24695223
Title: Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy.
PubMed ID: 24695223
DOI: 10.1038/nature13148
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 26436293
Title: Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis.
PubMed ID: 26436293
DOI: 10.7554/elife.10308
PubMed ID: 37660254
Title: Heterozygous Nonsense Variants in the Ferritin Heavy Chain Gene FTH1 Cause a Neuroferritinopathy.
PubMed ID: 37660254
PubMed ID: 1992356
Title: Solving the structure of human H ferritin by genetically engineering intermolecular crystal contacts.
PubMed ID: 1992356
DOI: 10.1038/349541a0
PubMed ID: 9159481
Title: Comparison of the three-dimensional structures of recombinant human H and horse L ferritins at high resolution.
PubMed ID: 9159481
Sequence Information:
- Length: 183
- Mass: 21226
- Checksum: FEF75640A29CCF56
- Sequence:
MTTASTSQVR QNYHQDSEAA INRQINLELY ASYVYLSMSY YFDRDDVALK NFAKYFLHQS HEEREHAEKL MKLQNQRGGR IFLQDIKKPD CDDWESGLNA MECALHLEKN VNQSLLELHK LATDKNDPHL CDFIETHYLN EQVKAIKELG DHVTNLRKMG APESGLAEYL FDKHTLGDSD NES
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.