Details for: FTH1

Gene ID: 2495

Symbol: FTH1

Ensembl ID: ENSG00000167996

Description: ferritin heavy chain 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: secretory cell (CL0000151)
    Fold Change: 5.86
    Marker Score: 10705
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 5.59
    Marker Score: 75146
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 5.56
    Marker Score: 14136
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 5.51
    Marker Score: 8488
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 5.43
    Marker Score: 11376
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 5.41
    Marker Score: 7046
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 5.28
    Marker Score: 52316
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 5.23
    Marker Score: 4190
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 5.22
    Marker Score: 3789
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 5.21
    Marker Score: 15207
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 5.21
    Marker Score: 177178
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 5.12
    Marker Score: 3295.5
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 5.11
    Marker Score: 2624
  • Cell Name: theca cell (CL0000503)
    Fold Change: 5
    Marker Score: 3586
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 4.82
    Marker Score: 17114
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 4.74
    Marker Score: 12708
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 4.71
    Marker Score: 14868
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 4.7
    Marker Score: 24728
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.65
    Marker Score: 259877
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 4.63
    Marker Score: 3264
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 4.6
    Marker Score: 1100
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 4.56
    Marker Score: 240941
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 4.55
    Marker Score: 5495.5
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 4.51
    Marker Score: 2028
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 4.49
    Marker Score: 3824
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 4.47
    Marker Score: 59002
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 4.41
    Marker Score: 2904.5
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 4.41
    Marker Score: 4158.5
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 4.39
    Marker Score: 1997
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 4.38
    Marker Score: 3320
  • Cell Name: blood cell (CL0000081)
    Fold Change: 4.38
    Marker Score: 50882
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 4.37
    Marker Score: 6328
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 4.37
    Marker Score: 27858
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 4.36
    Marker Score: 1873
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 4.35
    Marker Score: 1879
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 4.35
    Marker Score: 4831
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 4.34
    Marker Score: 3088
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 4.32
    Marker Score: 3853
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 4.31
    Marker Score: 1003
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.31
    Marker Score: 10515
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 4.29
    Marker Score: 11845
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 4.24
    Marker Score: 3799
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 4.24
    Marker Score: 10681
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 4.22
    Marker Score: 7236
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 4.19
    Marker Score: 2458
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 4.18
    Marker Score: 4042
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 4.18
    Marker Score: 11732
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 4.18
    Marker Score: 2544
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 4.17
    Marker Score: 2540
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.16
    Marker Score: 9486
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 4.15
    Marker Score: 1100
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 4.15
    Marker Score: 30905
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 4.13
    Marker Score: 1086
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 4.11
    Marker Score: 4422.5
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 4.11
    Marker Score: 3223
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 4.1
    Marker Score: 3964
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 4.1
    Marker Score: 7704
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 4.1
    Marker Score: 1316
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 4.1
    Marker Score: 3493
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 4.09
    Marker Score: 1059
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 4.08
    Marker Score: 9772
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 4.08
    Marker Score: 17494
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 4.05
    Marker Score: 4325
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 4.05
    Marker Score: 928
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 4.04
    Marker Score: 4862
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 4.01
    Marker Score: 19717.5
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 4
    Marker Score: 26064.5
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 4
    Marker Score: 5888
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 4
    Marker Score: 3556
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.99
    Marker Score: 3935
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 3.95
    Marker Score: 2039.5
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 3.94
    Marker Score: 1085
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 3.92
    Marker Score: 1431
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 3.9
    Marker Score: 1360
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 3.9
    Marker Score: 1625
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 3.89
    Marker Score: 2650.5
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 3.89
    Marker Score: 1265
  • Cell Name: platelet (CL0000233)
    Fold Change: 3.89
    Marker Score: 1761
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 3.88
    Marker Score: 1582
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 3.88
    Marker Score: 1028
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 3.88
    Marker Score: 2007
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 3.87
    Marker Score: 4210
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 3.87
    Marker Score: 1273
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 3.86
    Marker Score: 3447
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 3.86
    Marker Score: 33515
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 3.85
    Marker Score: 1084
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 3.85
    Marker Score: 4751
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.84
    Marker Score: 4394.5
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 3.83
    Marker Score: 3888
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 3.81
    Marker Score: 1009
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 3.8
    Marker Score: 3200
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 3.79
    Marker Score: 997
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 3.78
    Marker Score: 3251
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 3.77
    Marker Score: 10766
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 3.77
    Marker Score: 1076
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 3.77
    Marker Score: 11842
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 3.77
    Marker Score: 3324
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 3.76
    Marker Score: 2493
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 3.76
    Marker Score: 1360
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 3.76
    Marker Score: 3581

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Other Information

**Key characteristics:** * FTH1 is a glycoprotein with a molecular weight of approximately 120 kDa. * It is a member of the ferritin family of proteins, which are involved in the transport of iron ions in the body. * FTH1 is expressed in high levels in the liver, kidney, and other tissues that are involved in iron metabolism. * It is also expressed in immune cells, including macrophages, dendritic cells, and neutrophils. **Pathways and functions:** * FTH1 is involved in the binding and uptake of ligands by scavenger receptors. * It is also involved in the regulation of ferroxidase activity, which is an enzyme that is responsible for the release of iron ions from ferritin. * FTH1 is also involved in the Golgi associated vesicle biogenesis, where it is synthesized and modified. * It is also involved in the transport of small molecules between the endoplasmic reticulum and the Golgi apparatus. **Clinical significance:** * Mutations in the FTH1 gene have been linked to several human diseases, including hemochromatosis, which is a genetic disorder that causes excessive iron absorption from the diet. * FTH1 is also involved in the regulation of inflammation, and mutations in the FTH1 gene have been linked to inflammatory diseases such as rheumatoid arthritis and Crohn's disease. * Therefore, FTH1 is a promising target for the treatment of inflammatory diseases. **Additional information:** * FTH1 is a highly conserved protein, with a similar sequence found in organisms from humans to flies. * It is a well-studied protein, and there are many drugs that target FTH1, including deferasiroxine and deferriprone.

Genular Protein ID: 1093327610

Symbol: FRIH_HUMAN

Name: Ferritin heavy chain

UniProtKB Accession Codes:

P02794 B3KNR5 Q3KRA8 Q3SWW1

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 11 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 9 EC 1 EMBL 28 EMDB 30 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 100 PDBsum 100 PIR 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 1 Rhea 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 6323167

Title: Cloning and sequencing of a full length cDNA coding for a human apoferritin H chain: evidence for a multigene family.

PubMed ID: 6323167

DOI: 10.1002/j.1460-2075.1984.tb01756.x

PubMed ID: 3840162

Title: Structural and functional relationships of human ferritin H and L chains deduced from cDNA clones.

PubMed ID: 3840162

DOI: 10.1016/s0021-9258(17)39094-4

PubMed ID: 3023856

Title: Structure and expression of ferritin genes in a human promyelocytic cell line that differentiates in vitro.

PubMed ID: 3023856

DOI: 10.1128/mcb.6.2.566-573.1986

PubMed ID: 3003694

Title: Structure of gene and pseudogenes of human apoferritin H.

PubMed ID: 3003694

DOI: 10.1093/nar/14.2.721

PubMed ID: 3020541

Title: Cloning, characterization, expression, and chromosomal localization of a human ferritin heavy-chain gene.

PubMed ID: 3020541

DOI: 10.1073/pnas.83.19.7226

PubMed ID: 7916709

Title: Sequence of a cDNA encoding the ferritin H-chain from an 11-week-old human fetal brain.

PubMed ID: 7916709

DOI: 10.1016/0378-1119(93)90380-l

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6589621

Title: Isolation and characterization of a cDNA clone for human ferritin heavy chain.

PubMed ID: 6589621

DOI: 10.1073/pnas.81.15.4751

PubMed ID: 9003196

Title: Dinuclear center of ferritin: studies of iron binding and oxidation show differences in the two iron sites.

PubMed ID: 9003196

DOI: 10.1021/bi961830l

PubMed ID: 11389486

Title: A mutation, in the iron-responsive element of H ferritin mRNA, causing autosomal dominant iron overload.

PubMed ID: 11389486

DOI: 10.1086/321261

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 1992356

Title: Solving the structure of human H ferritin by genetically engineering intermolecular crystal contacts.

PubMed ID: 1992356

DOI: 10.1038/349541a0

PubMed ID: 9159481

Title: Comparison of the three-dimensional structures of recombinant human H and horse L ferritins at high resolution.

PubMed ID: 9159481

DOI: 10.1006/jmbi.1997.0970

Sequence Information:

  • Length: 183
  • Mass: 21226
  • Checksum: FEF75640A29CCF56
  • Sequence:
    • MTTASTSQVR QNYHQDSEAA INRQINLELY ASYVYLSMSY YFDRDDVALK NFAKYFLHQS 
HEEREHAEKL MKLQNQRGGR IFLQDIKKPD CDDWESGLNA MECALHLEKN VNQSLLELHK 
LATDKNDPHL CDFIETHYLN EQVKAIKELG DHVTNLRKMG APESGLAEYL FDKHTLGDSD 
NES

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.