Details for: FTH1

Gene ID: 2495

Symbol: FTH1

Ensembl ID: ENSG00000167996

Description: ferritin heavy chain 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 1792.5333
    Cell Significance Index: -278.8200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 1249.1948
    Cell Significance Index: -316.8500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 927.9214
    Cell Significance Index: -382.2600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 799.4745
    Cell Significance Index: -377.4500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 751.6934
    Cell Significance Index: -386.6600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 566.2406
    Cell Significance Index: -379.9600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 270.3747
    Cell Significance Index: -333.3600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 103.2377
    Cell Significance Index: -317.0900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 96.1519
    Cell Significance Index: -379.4200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 69.0144
    Cell Significance Index: -184.8800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 57.2972
    Cell Significance Index: -125.4000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 21.1393
    Cell Significance Index: 390.7100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 18.6353
    Cell Significance Index: 875.8400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 17.8457
    Cell Significance Index: 511.5600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 11.6637
    Cell Significance Index: 612.3900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 11.2056
    Cell Significance Index: 294.6500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 10.9442
    Cell Significance Index: 1413.9200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 10.4635
    Cell Significance Index: 5714.3800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 9.7125
    Cell Significance Index: 1245.0800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 9.2691
    Cell Significance Index: 690.8200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 8.6799
    Cell Significance Index: 1564.7200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 8.4602
    Cell Significance Index: 1040.2600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 8.2855
    Cell Significance Index: 146.4200
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 8.2139
    Cell Significance Index: 50.5500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 8.1815
    Cell Significance Index: 1123.5500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 6.6302
    Cell Significance Index: 309.1300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 5.6947
    Cell Significance Index: 197.8900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 5.2787
    Cell Significance Index: 2333.8400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 4.7000
    Cell Significance Index: 108.5900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 4.6006
    Cell Significance Index: 542.5500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.5942
    Cell Significance Index: 125.0500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 4.5614
    Cell Significance Index: 51.8200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 3.8550
    Cell Significance Index: 248.7100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 3.8372
    Cell Significance Index: 2904.4400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 3.7937
    Cell Significance Index: 300.4600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 3.5827
    Cell Significance Index: 408.9600
  • Cell Name: theca cell (CL0000503)
    Fold Change: 3.4349
    Cell Significance Index: 20.1800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 3.3464
    Cell Significance Index: 571.4100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 3.0022
    Cell Significance Index: 212.3300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.9840
    Cell Significance Index: 592.1800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.8837
    Cell Significance Index: 77.0000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 2.3527
    Cell Significance Index: 1724.9700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.2875
    Cell Significance Index: 21.0700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.0070
    Cell Significance Index: 402.6100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.9225
    Cell Significance Index: 40.2400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.7719
    Cell Significance Index: 9.8800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6713
    Cell Significance Index: 240.8000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.5336
    Cell Significance Index: 15.6700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3263
    Cell Significance Index: 614.3300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2883
    Cell Significance Index: 54.8700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1738
    Cell Significance Index: 110.4000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0544
    Cell Significance Index: 0.9100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0084
    Cell Significance Index: 0.8500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1572
    Cell Significance Index: -116.4600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.2034
    Cell Significance Index: -375.1000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.2585
    Cell Significance Index: -397.9300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2911
    Cell Significance Index: -17.9000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.3145
    Cell Significance Index: -196.4200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.3289
    Cell Significance Index: -447.1700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.3436
    Cell Significance Index: -33.9900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.4169
    Cell Significance Index: -189.2300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.4804
    Cell Significance Index: -270.9400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5099
    Cell Significance Index: -26.4900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.7416
    Cell Significance Index: -156.1900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.8553
    Cell Significance Index: -22.8800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.9028
    Cell Significance Index: -259.7500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.5770
    Cell Significance Index: -229.2400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -1.9983
    Cell Significance Index: -325.0000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -2.0435
    Cell Significance Index: -128.8000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -2.0948
    Cell Significance Index: -94.9500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -2.2051
    Cell Significance Index: -252.6300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -2.2195
    Cell Significance Index: -258.6600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -2.2797
    Cell Significance Index: -80.1100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -2.4807
    Cell Significance Index: -171.5500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -2.7185
    Cell Significance Index: -69.4500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -3.4134
    Cell Significance Index: -355.4200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -3.6727
    Cell Significance Index: -117.6300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -3.7754
    Cell Significance Index: -289.7200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -3.9485
    Cell Significance Index: -265.5000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -4.3129
    Cell Significance Index: -120.5300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -4.3289
    Cell Significance Index: -74.1900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -4.3291
    Cell Significance Index: -59.0700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -4.7870
    Cell Significance Index: -268.6200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -4.8805
    Cell Significance Index: -73.1300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -4.9054
    Cell Significance Index: -58.4800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -5.0879
    Cell Significance Index: -30.7400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -5.4000
    Cell Significance Index: -116.9900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -5.5852
    Cell Significance Index: -335.3100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -6.0381
    Cell Significance Index: -104.0900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -6.1429
    Cell Significance Index: -376.6200
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -6.3388
    Cell Significance Index: -132.2000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -6.7085
    Cell Significance Index: -72.9300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -6.8346
    Cell Significance Index: -356.0100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -7.6004
    Cell Significance Index: -189.9900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -7.6152
    Cell Significance Index: -224.3000
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -7.6325
    Cell Significance Index: -131.1300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -8.8113
    Cell Significance Index: -389.7500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -9.1029
    Cell Significance Index: -334.1600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -9.3341
    Cell Significance Index: -326.9900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -9.6007
    Cell Significance Index: -65.0500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Ferritin Heavy Chain 1 Structure:** The FTH1 protein is a heterodimeric complex consisting of two subunits: the heavy chain (H) and the light chain (L). The heavy chain is responsible for iron binding and sequestration. 2. **Iron Binding and Sequestration:** FTH1 has a high affinity for both ferric and ferrous iron ions, allowing it to bind and sequester iron within the ferritin complex. 3. **Cellular Localization:** FTH1 is primarily localized to the cytoplasm and nucleus, where it regulates iron homeostasis and participates in various cellular processes. 4. **Expression Patterns:** FTH1 is expressed in a wide range of cell types, including secretory cells, malignant cells, and immune cells, such as T cells, B cells, and natural killer cells. **Pathways and Functions:** 1. **Iron Ion Homeostasis:** FTH1 plays a critical role in maintaining iron homeostasis within cells by binding and sequestering iron ions, preventing their oxidative damage and promoting their utilization. 2. **Immune Regulation:** FTH1 is involved in regulating immune responses, including the activation of T cells and the regulation of cell proliferation. 3. **Cell Proliferation:** FTH1 has been shown to inhibit cell proliferation, suggesting a role in tumor suppression. 4. **Vesicle-Mediated Transport:** FTH1 is involved in the transport of small molecules, including iron ions, within cells and between cells. 5. **Regulation of Ferric Iron Binding:** FTH1 regulates the binding of ferric iron ions to other proteins, such as transferrin, promoting the efficient uptake of iron by cells. **Clinical Significance:** 1. **Iron-Related Disorders:** Mutations in the FTH1 gene have been associated with iron-related disorders, such as hemochromatosis and iron overload. 2. **Cancer:** FTH1 has been implicated in the regulation of cell proliferation and tumor suppression, suggesting a potential role in cancer prevention and therapy. 3. **Immune System Disorders:** FTH1 has been shown to play a role in regulating immune responses, making it a potential target for the treatment of immune system disorders. 4. **Neurological Disorders:** FTH1 has been implicated in the regulation of iron homeostasis in the brain, suggesting a potential role in the pathogenesis of neurological disorders, such as Parkinson's disease. In conclusion, the FTH1 gene plays a critical role in maintaining iron homeostasis and regulating immune responses within cells. Its dysregulation has been implicated in various diseases, including iron-related disorders, cancer, and immune system disorders. Further research is necessary to fully understand the functions and clinical significance of the FTH1 gene.

Genular Protein ID: 1093327610

Symbol: FRIH_HUMAN

Name: Ferritin heavy chain

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 6323167

Title: Cloning and sequencing of a full length cDNA coding for a human apoferritin H chain: evidence for a multigene family.

PubMed ID: 6323167

DOI: 10.1002/j.1460-2075.1984.tb01756.x

PubMed ID: 3840162

Title: Structural and functional relationships of human ferritin H and L chains deduced from cDNA clones.

PubMed ID: 3840162

DOI: 10.1016/s0021-9258(17)39094-4

PubMed ID: 3023856

Title: Structure and expression of ferritin genes in a human promyelocytic cell line that differentiates in vitro.

PubMed ID: 3023856

DOI: 10.1128/mcb.6.2.566-573.1986

PubMed ID: 3003694

Title: Structure of gene and pseudogenes of human apoferritin H.

PubMed ID: 3003694

DOI: 10.1093/nar/14.2.721

PubMed ID: 3020541

Title: Cloning, characterization, expression, and chromosomal localization of a human ferritin heavy-chain gene.

PubMed ID: 3020541

DOI: 10.1073/pnas.83.19.7226

PubMed ID: 7916709

Title: Sequence of a cDNA encoding the ferritin H-chain from an 11-week-old human fetal brain.

PubMed ID: 7916709

DOI: 10.1016/0378-1119(93)90380-l

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6589621

Title: Isolation and characterization of a cDNA clone for human ferritin heavy chain.

PubMed ID: 6589621

DOI: 10.1073/pnas.81.15.4751

PubMed ID: 9003196

Title: Dinuclear center of ferritin: studies of iron binding and oxidation show differences in the two iron sites.

PubMed ID: 9003196

DOI: 10.1021/bi961830l

PubMed ID: 11389486

Title: A mutation, in the iron-responsive element of H ferritin mRNA, causing autosomal dominant iron overload.

PubMed ID: 11389486

DOI: 10.1086/321261

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24695223

Title: Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy.

PubMed ID: 24695223

DOI: 10.1038/nature13148

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 26436293

Title: Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis.

PubMed ID: 26436293

DOI: 10.7554/elife.10308

PubMed ID: 37660254

Title: Heterozygous Nonsense Variants in the Ferritin Heavy Chain Gene FTH1 Cause a Neuroferritinopathy.

PubMed ID: 37660254

DOI: 10.1016/j.xhgg.2023.100236

PubMed ID: 1992356

Title: Solving the structure of human H ferritin by genetically engineering intermolecular crystal contacts.

PubMed ID: 1992356

DOI: 10.1038/349541a0

PubMed ID: 9159481

Title: Comparison of the three-dimensional structures of recombinant human H and horse L ferritins at high resolution.

PubMed ID: 9159481

DOI: 10.1006/jmbi.1997.0970

Sequence Information:

  • Length: 183
  • Mass: 21226
  • Checksum: FEF75640A29CCF56
  • Sequence:
  • MTTASTSQVR QNYHQDSEAA INRQINLELY ASYVYLSMSY YFDRDDVALK NFAKYFLHQS 
    HEEREHAEKL MKLQNQRGGR IFLQDIKKPD CDDWESGLNA MECALHLEKN VNQSLLELHK 
    LATDKNDPHL CDFIETHYLN EQVKAIKELG DHVTNLRKMG APESGLAEYL FDKHTLGDSD 
    NES

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.