YBX1 | ENSG00000065978 | NCBI 4904

Details for: YBX1

Gene ID: 4904

Symbol: YBX1

Ensembl ID: ENSG00000065978

Description: Y-box binding protein 1

Associated with

Cytokine signaling in immune system
(R-HSA-1280215)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Immune system
(R-HSA-168256)
Interferon gamma signaling
(R-HSA-877300)
Interferon signaling
(R-HSA-913531)
Metabolism of rna
(R-HSA-8953854)
Mrna splicing
(R-HSA-72172)
Mrna splicing - major pathway
(R-HSA-72163)
Mrna splicing - minor pathway
(R-HSA-72165)
Noncanonical activation of notch3
(R-HSA-9017802)
Notch3 activation and transmission of signal to the nucleus
(R-HSA-9013507)
Processing of capped intron-containing pre-mrna
(R-HSA-72203)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by notch
(R-HSA-157118)
Signaling by notch3
(R-HSA-9012852)
Signaling by tgf-beta receptor complex
(R-HSA-170834)
Signaling by tgfb family members
(R-HSA-9006936)
Signal transduction
(R-HSA-162582)
Smad2/smad3:smad4 heterotrimer regulates transcription
(R-HSA-2173796)
Transcriptional activity of smad2/smad3:smad4 heterotrimer
(R-HSA-2173793)
C5-methylcytidine-containing rna reader activity
(GO:0062153)
Cellular response to interleukin-7
(GO:0098761)
Chromatin binding
(GO:0003682)
Crd-mediated mrna stability complex
(GO:0070937)
Crd-mediated mrna stabilization
(GO:0070934)
Cytoplasm
(GO:0005737)
Cytoplasmic stress granule
(GO:0010494)
Cytosol
(GO:0005829)
Dna binding
(GO:0003677)
Double-stranded dna binding
(GO:0003690)
Embryonic morphogenesis
(GO:0048598)
Endoplasmic reticulum
(GO:0005783)
Epidermis development
(GO:0008544)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Gtpase binding
(GO:0051020)
Histone pre-mrna 3'end processing complex
(GO:0071204)
Intracellular membrane-bounded organelle
(GO:0043231)
In utero embryonic development
(GO:0001701)
Mirna binding
(GO:0035198)
Mirna transport
(GO:1990428)
Mrna binding
(GO:0003729)
Mrna processing
(GO:0006397)
Mrna stabilization
(GO:0048255)
Negative regulation of cellular senescence
(GO:2000773)
Negative regulation of nuclear-transcribed mrna catabolic process, deadenylation-dependent decay
(GO:1900152)
Negative regulation of striated muscle cell differentiation
(GO:0051154)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative regulation of translation
(GO:0017148)
Nucleic acid binding
(GO:0003676)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
P-body
(GO:0000932)
Plasma membrane
(GO:0005886)
Positive regulation of cell division
(GO:0051781)
Positive regulation of cytoplasmic translation
(GO:2000767)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Protein localization to cytoplasmic stress granule
(GO:1903608)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of gene expression
(GO:0010468)
Ribonucleoprotein complex
(GO:1990904)
Rna binding
(GO:0003723)
Rna splicing
(GO:0008380)
Rna transport
(GO:0050658)
Sequence-specific double-stranded dna binding
(GO:1990837)
Single-stranded dna binding
(GO:0003697)
Synapse
(GO:0045202)
Trna transport
(GO:0051031)
U12-type spliceosomal complex
(GO:0005689)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 689.5744
Cell Significance Index: -107.2600
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 578.5288
Cell Significance Index: -146.7400
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 452.5818
Cell Significance Index: -186.4400
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 409.3959
Cell Significance Index: -166.3200
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 383.1314
Cell Significance Index: -180.8900
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 354.4231
Cell Significance Index: -182.3100
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 271.0417
Cell Significance Index: -181.8800
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 174.2354
Cell Significance Index: -166.3500
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 122.3483
Cell Significance Index: -150.8500
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 46.2488
Cell Significance Index: -182.5000
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 41.2964
Cell Significance Index: -126.8400
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 27.5080
Cell Significance Index: -73.6900
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 25.7289
Cell Significance Index: -56.3100
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 7.8155
Cell Significance Index: 367.3200
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 6.9771
Cell Significance Index: 123.3000
Cell Name: granulosa cell (CL0000501)
Fold Change: 6.9683
Cell Significance Index: 183.2300
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 6.7437
Cell Significance Index: 234.3400
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 6.3212
Cell Significance Index: 68.7200
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 6.2341
Cell Significance Index: 130.4900
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 5.9725
Cell Significance Index: 67.8500
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 5.5809
Cell Significance Index: 766.4200
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 5.0898
Cell Significance Index: 625.8400
Cell Name: lactocyte (CL0002325)
Fold Change: 5.0039
Cell Significance Index: 646.4700
Cell Name: early pro-B cell (CL0002046)
Fold Change: 4.8888
Cell Significance Index: 315.4000
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 4.8591
Cell Significance Index: 139.2900
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 4.4283
Cell Significance Index: 798.2800
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 4.4279
Cell Significance Index: 81.8400
Cell Name: cell in vitro (CL0001034)
Fold Change: 4.4251
Cell Significance Index: 2416.6300
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 3.7785
Cell Significance Index: 267.2300
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 3.7292
Cell Significance Index: 439.7900
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 3.6017
Cell Significance Index: 1592.4100
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 3.0676
Cell Significance Index: 26.3600
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 2.8661
Cell Significance Index: 133.6300
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.5467
Cell Significance Index: 189.8100
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 2.3440
Cell Significance Index: 68.8400
Cell Name: odontoblast (CL0000060)
Fold Change: 1.9739
Cell Significance Index: 253.0400
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 1.6659
Cell Significance Index: 284.4700
Cell Name: peg cell (CL4033014)
Fold Change: 1.4963
Cell Significance Index: 34.5700
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.4955
Cell Significance Index: 78.5200
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 1.4375
Cell Significance Index: 90.6000
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.1584
Cell Significance Index: 31.5300
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.9870
Cell Significance Index: 195.8700
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.8725
Cell Significance Index: 8.0400
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.8569
Cell Significance Index: 22.8800
Cell Name: theca cell (CL0000503)
Fold Change: 0.8340
Cell Significance Index: 4.9000
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.7456
Cell Significance Index: 564.3800
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.7055
Cell Significance Index: 9.0400
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.6381
Cell Significance Index: 39.2200
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.6343
Cell Significance Index: 32.9500
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.6289
Cell Significance Index: 37.7600
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.5203
Cell Significance Index: 381.4800
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4752
Cell Significance Index: 47.0100
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.4656
Cell Significance Index: 88.6100
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.2529
Cell Significance Index: 8.8900
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.1908
Cell Significance Index: 8.6500
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.1882
Cell Significance Index: 67.5200
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.1117
Cell Significance Index: 1.8700
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.0383
Cell Significance Index: 6.2300
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0227
Cell Significance Index: 15.7100
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0085
Cell Significance Index: 1.7100
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0197
Cell Significance Index: -14.5600
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0267
Cell Significance Index: -50.3000
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0388
Cell Significance Index: -3.9600
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0804
Cell Significance Index: -148.2700
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0953
Cell Significance Index: -59.5000
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0961
Cell Significance Index: -147.9100
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.1132
Cell Significance Index: -153.8700
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1262
Cell Significance Index: -36.3200
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.2174
Cell Significance Index: -138.0600
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.2333
Cell Significance Index: -131.5600
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.3353
Cell Significance Index: -152.1800
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.3715
Cell Significance Index: -78.2400
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.4112
Cell Significance Index: -32.5700
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.4678
Cell Significance Index: -53.4000
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.5926
Cell Significance Index: -15.1400
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.7065
Cell Significance Index: -48.8600
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.8085
Cell Significance Index: -4.8900
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.9844
Cell Significance Index: -143.1000
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -1.0210
Cell Significance Index: -32.7000
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -1.0406
Cell Significance Index: -121.2700
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -1.0406
Cell Significance Index: -119.2200
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -1.3545
Cell Significance Index: -37.8600
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -1.3820
Cell Significance Index: -77.5500
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -1.4032
Cell Significance Index: -21.0300
Cell Name: retinal rod cell (CL0000604)
Fold Change: -1.4043
Cell Significance Index: -16.7400
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -1.5600
Cell Significance Index: -41.7300
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -1.6054
Cell Significance Index: -34.7800
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -1.7172
Cell Significance Index: -178.8000
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -1.8717
Cell Significance Index: -143.6300
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -2.3256
Cell Significance Index: -31.7300
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -2.3400
Cell Significance Index: -157.3400
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -2.3981
Cell Significance Index: -41.3400
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -2.9531
Cell Significance Index: -181.0500
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: -2.9574
Cell Significance Index: -22.8000
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -2.9930
Cell Significance Index: -155.9000
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -3.4132
Cell Significance Index: -28.6700
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: -3.5979
Cell Significance Index: -25.8400
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -3.6198
Cell Significance Index: -106.6200
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -3.6453
Cell Significance Index: -93.7000
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -3.6620
Cell Significance Index: -161.9800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** 1. **DNA-binding protein**: YB-1 is a DNA-binding protein that binds to specific DNA sequences, thereby regulating gene expression. 2. **Transcription factor**: YB-1 acts as a transcription factor, regulating the expression of genes involved in inflammation, immune response, and cell proliferation. 3. **Multifunctional**: YB-1 is involved in various cellular processes, including gene expression, immune response, cell growth, and DNA repair. 4. **Protein localization**: YB-1 localizes to the nucleus, cytoplasm, and cytosol, where it regulates gene expression and interacts with various proteins. **Pathways and Functions:** 1. **Immune response**: YB-1 regulates the expression of genes involved in immune response, including cytokines, chemokines, and immune cell activation. 2. **Gene expression**: YB-1 regulates the expression of genes involved in gene expression, including transcriptional activators and repressors. 3. **Cell growth and proliferation**: YB-1 regulates the expression of genes involved in cell growth and proliferation, including oncogenes and tumor suppressors. 4. **DNA repair**: YB-1 is involved in DNA repair mechanisms, including base excision repair and nucleotide excision repair. **Clinical Significance:** 1. **Cancer**: YB-1 is overexpressed in various types of cancer, suggesting its potential as a therapeutic target. 2. **Immune disorders**: YB-1 plays a crucial role in immune response, and its dysregulation can contribute to immune disorders, such as autoimmune diseases and immunodeficiency. 3. **Inflammation**: YB-1 regulates the expression of genes involved in inflammation, and its dysregulation can contribute to inflammatory diseases, such as arthritis and asthma. 4. **Regenerative medicine**: YB-1 is involved in tissue regeneration and repair, and its dysregulation can contribute to tissue damage and disease. **Significantly Expressed Cells:** 1. **Early promyelocyte**: YB-1 is highly expressed in early promyelocytes, a stage of myeloid cell development. 2. **Fibroblast of mammary gland**: YB-1 is expressed in fibroblasts of the mammary gland, where it regulates gene expression and cell growth. 3. **CD38-negative naive B cell**: YB-1 is expressed in CD38-negative naive B cells, where it regulates immune response and gene expression. 4. **Mature T cell**: YB-1 is expressed in mature T cells, where it regulates immune response and gene expression. In conclusion, YB-1 is a multifunctional protein that plays a crucial role in various cellular processes, including gene expression, immune response, and cell growth. Its dysregulation can contribute to various diseases, including cancer, immune disorders, and inflammatory diseases. Further research is needed to fully understand the mechanisms of YB-1 and its clinical significance.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

CCAAT-binding transcription factor I subunit A

Genular Protein ID: 1933072296

Symbol: YBOX1_HUMAN

Name: CCAAT-binding transcription factor I subunit A

UniProtKB Accession Codes:

P67809 P16990 P16991 Q14972 Q15325 Q5FVF0

Database IDs:

Citations:

PubMed ID: 2977358

Title: Two human genes isolated by a novel method encode DNA-binding proteins containing a common region of homology.

PubMed ID: 2977358

DOI: 10.1016/0378-1119(88)90514-8

PubMed ID: 3174636

Title: Characterization of the cDNA encoding a protein binding to the major histocompatibility complex class II Y box.

PubMed ID: 3174636

DOI: 10.1073/pnas.85.19.7322

PubMed ID: 1891370

Title: Full length cDNA sequence encoding a nuclease-sensitive element DNA binding protein.

PubMed ID: 1891370

DOI: 10.1093/nar/19.17.4771

PubMed ID: 8188694

Title: A human protein containing a 'cold shock' domain binds specifically to H-DNA upstream from the human gamma-globin genes.

PubMed ID: 8188694

DOI: 10.1016/s0021-9258(17)36764-9

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10817758

Title: Nucleolin and YB-1 are required for JNK-mediated interleukin-2 mRNA stabilization during T-cell activation.

PubMed ID: 10817758

PubMed ID: 11698476

Title: Y box-binding factor promotes eosinophil survival by stabilizing granulocyte-macrophage colony-stimulating factor mRNA.

PubMed ID: 11698476

DOI: 10.4049/jimmunol.167.10.5970

PubMed ID: 12604611

Title: Splicing factor SRp30c interaction with Y-box protein-1 confers nuclear YB-1 shuttling and alternative splice site selection.

PubMed ID: 12604611

DOI: 10.1074/jbc.m212518200

PubMed ID: 14559993

Title: Regulation of alternative splicing by SRrp86 and its interacting proteins.

PubMed ID: 14559993

DOI: 10.1128/mcb.23.21.7437-7447.2003

PubMed ID: 15136035

Title: The Ankrd2 protein, a link between the sarcomere and the nucleus in skeletal muscle.

PubMed ID: 15136035

DOI: 10.1016/j.jmb.2004.03.071

PubMed ID: 14718551

Title: YB-1 promotes strand separation in vitro of duplex DNA containing either mispaired bases or cisplatin modifications, exhibits endonucleolytic activities and binds several DNA repair proteins.

PubMed ID: 14718551

DOI: 10.1093/nar/gkh170

PubMed ID: 15146077

Title: The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome.

PubMed ID: 15146077

DOI: 10.1261/rna.7320604

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 15806160

Title: Akt phosphorylates the Y-box binding protein 1 at Ser102 located in the cold shock domain and affects the anchorage-independent growth of breast cancer cells.

PubMed ID: 15806160

DOI: 10.1038/sj.onc.1208590

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17932509

Title: Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells.

PubMed ID: 17932509

DOI: 10.1038/sj.embor.7401088

PubMed ID: 17487921

Title: Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line.

PubMed ID: 17487921

DOI: 10.1002/elps.200600782

PubMed ID: 17289661

Title: Molecular composition of IMP1 ribonucleoprotein granules.

PubMed ID: 17289661

DOI: 10.1074/mcp.m600346-mcp200

PubMed ID: 18851979

Title: RBBP6 interacts with multifunctional protein YB-1 through its RING finger domain, leading to ubiquitination and proteosomal degradation of YB-1.

PubMed ID: 18851979

DOI: 10.1016/j.jmb.2008.09.060

PubMed ID: 18335541

Title: MBNL1 associates with YB-1 in cytoplasmic stress granules.

PubMed ID: 18335541

DOI: 10.1002/jnr.21655

PubMed ID: 18809583

Title: Regulatory role of human AP-endonuclease (APE1/Ref-1) in YB-1-mediated activation of the multidrug resistance gene MDR1.

PubMed ID: 18809583

DOI: 10.1128/mcb.00244-08

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19483673

Title: Y-box protein-1 is actively secreted through a non-classical pathway and acts as an extracellular mitogen.

PubMed ID: 19483673

DOI: 10.1038/embor.2009.81

PubMed ID: 19561594

Title: Rapid and systematic analysis of the RNA recognition specificities of RNA-binding proteins.

PubMed ID: 19561594

DOI: 10.1038/nbt.1550

PubMed ID: 19029303

Title: Control of c-myc mRNA stability by IGF2BP1-associated cytoplasmic RNPs.

PubMed ID: 19029303

DOI: 10.1261/rna.1175909

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25229427

Title: DERA is the human deoxyribose phosphate aldolase and is involved in stress response.

PubMed ID: 25229427

DOI: 10.1016/j.bbamcr.2014.09.007

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 26845719

Title: Two new isoforms of the human hepatoma-derived growth factor interact with components of the cytoskeleton.

PubMed ID: 26845719

DOI: 10.1515/hsz-2015-0273

PubMed ID: 27559612

Title: Y-box protein 1 is required to sort microRNAs into exosomes in cells and in a cell-free reaction.

PubMed ID: 27559612

DOI: 10.7554/elife.19276

PubMed ID: 28341602

Title: Cytosolic YB-1 and NSUN2 are the only proteins recognizing specific motifs present in mRNAs enriched in exosomes.

PubMed ID: 28341602

DOI: 10.1016/j.bbapap.2017.03.010

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 29073095

Title: Broad role for YBX1 in defining the small noncoding RNA composition of exosomes.

PubMed ID: 29073095

DOI: 10.1073/pnas.1712108114

PubMed ID: 29712925

Title: The RNA-binding protein YBX1 regulates epidermal progenitors at a posttranscriptional level.

PubMed ID: 29712925

DOI: 10.1038/s41467-018-04092-0

PubMed ID: 11851341

Title: The solution structure and DNA-binding properties of the cold-shock domain of the human Y-box protein YB-1.

PubMed ID: 11851341

DOI: 10.1006/jmbi.2001.5334

PubMed ID: 31358969

Title: 5-methylcytosine promotes pathogenesis of bladder cancer through stabilizing mRNAs.

PubMed ID: 31358969

DOI: 10.1038/s41556-019-0361-y

Sequence Information:

Length: 324
Mass: 35924
Checksum: DF0114BF974AEDB8
Sequence:

MSSEAETQQP PAAPPAAPAL SAADTKPGTT GSGAGSGGPG GLTSAAPAGG DKKVIATKVL 
GTVKWFNVRN GYGFINRNDT KEDVFVHQTA IKKNNPRKYL RSVGDGETVE FDVVEGEKGA 
EAANVTGPGG VPVQGSKYAA DRNHYRRYPR RRGPPRNYQQ NYQNSESGEK NEGSESAPEG 
QAQQRRPYRR RRFPPYYMRR PYGRRPQYSN PPVQGEVMEG ADNQGAGEQG RPVRQNMYRG 
YRPRFRRGPP RQRQPREDGN EEDKENQGDE TQGQQPPQRR YRRNFNYRRR RPENPKPQDG 
KETKAADPPA ENSSAPEAEQ GGAE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: YBX1

Associated with

Cells (max top 100)

Other Information

Two human genes isolated by a novel method encode DNA-binding proteins containing a common region of homology. PubMed ID: 2977358

Characterization of the cDNA encoding a protein binding to the major histocompatibility complex class II Y box. PubMed ID: 3174636

Full length cDNA sequence encoding a nuclease-sensitive element DNA binding protein. PubMed ID: 1891370

A human protein containing a 'cold shock' domain binds specifically to H-DNA upstream from the human gamma-globin genes. PubMed ID: 8188694

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Nucleolin and YB-1 are required for JNK-mediated interleukin-2 mRNA stabilization during T-cell activation. PubMed ID: 10817758

Y box-binding factor promotes eosinophil survival by stabilizing granulocyte-macrophage colony-stimulating factor mRNA. PubMed ID: 11698476

Splicing factor SRp30c interaction with Y-box protein-1 confers nuclear YB-1 shuttling and alternative splice site selection. PubMed ID: 12604611

Regulation of alternative splicing by SRrp86 and its interacting proteins. PubMed ID: 14559993

The Ankrd2 protein, a link between the sarcomere and the nucleus in skeletal muscle. PubMed ID: 15136035

YB-1 promotes strand separation in vitro of duplex DNA containing either mispaired bases or cisplatin modifications, exhibits endonucleolytic activities and binds several DNA repair proteins. PubMed ID: 14718551

The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. PubMed ID: 15146077

Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. PubMed ID: 15592455

Akt phosphorylates the Y-box binding protein 1 at Ser102 located in the cold shock domain and affects the anchorage-independent growth of breast cancer cells. PubMed ID: 15806160

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

A probability-based approach for high-throughput protein phosphorylation analysis and site localization. PubMed ID: 16964243

Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells. PubMed ID: 17932509

Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line. PubMed ID: 17487921

Molecular composition of IMP1 ribonucleoprotein granules. PubMed ID: 17289661

RBBP6 interacts with multifunctional protein YB-1 through its RING finger domain, leading to ubiquitination and proteosomal degradation of YB-1. PubMed ID: 18851979

MBNL1 associates with YB-1 in cytoplasmic stress granules. PubMed ID: 18335541

Regulatory role of human AP-endonuclease (APE1/Ref-1) in YB-1-mediated activation of the multidrug resistance gene MDR1. PubMed ID: 18809583

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Y-box protein-1 is actively secreted through a non-classical pathway and acts as an extracellular mitogen. PubMed ID: 19483673

Rapid and systematic analysis of the RNA recognition specificities of RNA-binding proteins. PubMed ID: 19561594

Control of c-myc mRNA stability by IGF2BP1-associated cytoplasmic RNPs. PubMed ID: 19029303

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

DERA is the human deoxyribose phosphate aldolase and is involved in stress response. PubMed ID: 25229427

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Two new isoforms of the human hepatoma-derived growth factor interact with components of the cytoskeleton. PubMed ID: 26845719

Y-box protein 1 is required to sort microRNAs into exosomes in cells and in a cell-free reaction. PubMed ID: 27559612

Cytosolic YB-1 and NSUN2 are the only proteins recognizing specific motifs present in mRNAs enriched in exosomes. PubMed ID: 28341602

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Broad role for YBX1 in defining the small noncoding RNA composition of exosomes. PubMed ID: 29073095

The RNA-binding protein YBX1 regulates epidermal progenitors at a posttranscriptional level. PubMed ID: 29712925

The solution structure and DNA-binding properties of the cold-shock domain of the human Y-box protein YB-1. PubMed ID: 11851341

5-methylcytosine promotes pathogenesis of bladder cancer through stabilizing mRNAs. PubMed ID: 31358969