HNRNPC | ENSG00000092199 | NCBI 3183

Details for: HNRNPC

Gene ID: 3183

Symbol: HNRNPC

Ensembl ID: ENSG00000092199

Description: heterogeneous nuclear ribonucleoprotein C

Associated with

Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Mrna splicing
(R-HSA-72172)
Mrna splicing - major pathway
(R-HSA-72163)
Post-translational protein modification
(R-HSA-597592)
Processing of capped intron-containing pre-mrna
(R-HSA-72203)
Rhobtb1 gtpase cycle
(R-HSA-9013422)
Rhobtb2 gtpase cycle
(R-HSA-9013418)
Rhobtb gtpase cycle
(R-HSA-9706574)
Rho gtpase cycle
(R-HSA-9012999)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signal transduction
(R-HSA-162582)
Sumo e3 ligases sumoylate target proteins
(R-HSA-3108232)
Sumoylation
(R-HSA-2990846)
Sumoylation of rna binding proteins
(R-HSA-4570464)
3'-utr-mediated mrna stabilization
(GO:0070935)
Actin cytoskeleton
(GO:0015629)
Catalytic step 2 spliceosome
(GO:0071013)
Chromatin
(GO:0000785)
Chromatin remodeling
(GO:0006338)
Cytosol
(GO:0005829)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Identical protein binding
(GO:0042802)
Membrane
(GO:0016020)
Mrna 3'-utr binding
(GO:0003730)
Mrna splicing, via spliceosome
(GO:0000398)
N6-methyladenosine-containing rna reader activity
(GO:1990247)
Negative regulation of telomere maintenance via telomerase
(GO:0032211)
Nucleoplasm
(GO:0005654)
Nucleosomal dna binding
(GO:0031492)
Nucleus
(GO:0005634)
Osteoblast differentiation
(GO:0001649)
Poly(u) rna binding
(GO:0008266)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Rna binding
(GO:0003723)
Rna splicing
(GO:0008380)
Spliceosomal complex
(GO:0005681)
Telomerase holoenzyme complex
(GO:0005697)
Telomerase rna binding
(GO:0070034)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: cell in vitro (CL0001034)
Fold Change: 1.7
Cell Significance Index: 3
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.35
Cell Significance Index: 1
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.28
Cell Significance Index: 1
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.26
Cell Significance Index: 1
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.24
Cell Significance Index: 1
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 1.18
Cell Significance Index: 1
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 1.16
Cell Significance Index: 1
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.16
Cell Significance Index: 1
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 1.14
Cell Significance Index: 2
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.14
Cell Significance Index: 1
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.11
Cell Significance Index: 1
Cell Name: kidney cell (CL1000497)
Fold Change: 1.11
Cell Significance Index: 1
Cell Name: lactocyte (CL0002325)
Fold Change: 1.1
Cell Significance Index: 1
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.09
Cell Significance Index: 1
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 1.09
Cell Significance Index: 1
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.09
Cell Significance Index: 1
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.08
Cell Significance Index: 1
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.08
Cell Significance Index: 1
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 1.08
Cell Significance Index: 1
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 1.07
Cell Significance Index: 1
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.06
Cell Significance Index: 1
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.06
Cell Significance Index: 1
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.05
Cell Significance Index: 1
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 1.05
Cell Significance Index: 1
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 1.04
Cell Significance Index: 1
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.04
Cell Significance Index: 1
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 1.04
Cell Significance Index: 1
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 1.04
Cell Significance Index: 1
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 1.02
Cell Significance Index: 1
Cell Name: granulosa cell (CL0000501)
Fold Change: 1.02
Cell Significance Index: 1
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 1
Cell Significance Index: 1
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 1
Cell Significance Index: 1
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1
Cell Significance Index: 1
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 1
Cell Significance Index: 1
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 1
Cell Significance Index: 1
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 1
Cell Significance Index: 1
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: perivascular cell (CL4033054)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: chondroblast (CL0000058)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: epidermal cell (CL0000362)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: epithelial cell of sweat gland (CL1000448)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: sebaceous gland cell (CL2000021)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: cell (CL0000000)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: radial glial cell (CL0000681)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: muscle fibroblast (CL1001609)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: embryonic fibroblast (CL2000042)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: glioblast (CL0000030)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: pro-T cell (CL0000827)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: germ cell (CL0000586)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: Merkel cell (CL0000242)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: bronchial epithelial cell (CL0002328)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: odontoblast (CL0000060)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: supporting cell (CL0000630)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: Mueller cell (CL0000636)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: ON-bipolar cell (CL0000749)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: intrahepatic cholangiocyte (CL0002538)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: centroblast (CL0009112)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: late promyelocyte (CL0002151)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: mesodermal cell (CL0000222)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: early promyelocyte (CL0002154)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: sensory neuron (CL0000101)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: colon endothelial cell (CL1001572)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.97
Cell Significance Index: 1

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** HNRNPC is a multifunctional protein that exhibits a range of characteristics, including: 1. **RNA-binding ability**: HNRNPC interacts with various RNA molecules, including mRNA, rRNA, and tRNA, to regulate their stability, processing, and translation. 2. **Spliceosomal complex involvement**: HNRNPC is a component of the spliceosomal complex, which is responsible for the processing of pre-mRNA into mature mRNA. 3. **Telomere maintenance**: HNRNPC is involved in the regulation of telomerase activity, which is essential for maintaining telomere length and preventing telomere shortening. 4. **Post-translational protein modification**: HNRNPC is involved in the sumoylation of target proteins, which is a post-translational modification that regulates protein function and localization. 5. **Signaling pathway involvement**: HNRNPC is involved in various signaling pathways, including the Rho GTPase cycle, which regulates cell migration, proliferation, and differentiation. **Pathways and Functions** HNRNPC is involved in several key pathways, including: 1. **3'-untranslated region (3'-UTR)-mediated mRNA stabilization**: HNRNPC binds to the 3'-UTR of target mRNAs, regulating their stability and translation. 2. **Alternative splicing**: HNRNPC is involved in the regulation of alternative splicing, which is the process by which a single gene gives rise to multiple mRNA transcripts. 3. **Telomere maintenance**: HNRNPC regulates telomerase activity, which is essential for maintaining telomere length and preventing telomere shortening. 4. **Rho GTPase cycle**: HNRNPC is involved in the regulation of the Rho GTPase cycle, which regulates cell migration, proliferation, and differentiation. 5. **Sumoylation**: HNRNPC is involved in the sumoylation of target proteins, which regulates protein function and localization. **Clinical Significance** Dysregulation of HNRNPC has been implicated in various diseases, including: 1. **Cancer**: HNRNPC is overexpressed in several types of cancer, including breast, lung, and prostate cancer. 2. **Neurodegenerative diseases**: HNRNPC has been implicated in neurodegenerative diseases, including Alzheimer's and Parkinson's disease. 3. **Telomere-related disorders**: HNRNPC is involved in the regulation of telomere length, and dysregulation of HNRNPC has been implicated in telomere-related disorders, including premature aging and cancer. 4. **Spliceosomal complex disorders**: HNRNPC is a component of the spliceosomal complex, and dysregulation of HNRNPC has been implicated in spliceosomal complex disorders, including myotonic dystrophy and congenital myasthenic syndrome. In conclusion, HNRNPC is a multifunctional protein that plays a crucial role in various cellular processes, including RNA processing, protein modification, and signaling pathways. Its dysregulation has been implicated in various diseases, highlighting the importance of HNRNPC in maintaining cellular homeostasis.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.