Details for: HNRNPC
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 758.8147
Cell Significance Index: -118.0300 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 437.6420
Cell Significance Index: -111.0100 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 362.6553
Cell Significance Index: -149.4000 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 314.9976
Cell Significance Index: -127.9700 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 311.2539
Cell Significance Index: -146.9500 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 273.9775
Cell Significance Index: -140.9300 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 219.7394
Cell Significance Index: -147.4500 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 134.7064
Cell Significance Index: -128.6100 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 113.3374
Cell Significance Index: -139.7400 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 40.6890
Cell Significance Index: -109.0000 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 37.4881
Cell Significance Index: -147.9300 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 36.6634
Cell Significance Index: -112.6100 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 23.6956
Cell Significance Index: -51.8600 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 6.5936
Cell Significance Index: 176.0600 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 6.0006
Cell Significance Index: 208.5200 - Cell Name: kidney cell (CL1000497)
Fold Change: 5.2804
Cell Significance Index: 42.1600 - Cell Name: granulosa cell (CL0000501)
Fold Change: 4.3280
Cell Significance Index: 113.8100 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 3.9534
Cell Significance Index: 82.7500 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 3.8892
Cell Significance Index: 182.7900 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 3.8445
Cell Significance Index: 104.6500 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 3.5684
Cell Significance Index: 490.0400 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 3.3814
Cell Significance Index: 398.7700 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 3.3677
Cell Significance Index: 414.0900 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 3.3611
Cell Significance Index: 36.5400 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 3.3301
Cell Significance Index: 95.4600 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 3.1086
Cell Significance Index: 616.9100 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 3.0801
Cell Significance Index: 198.7100 - Cell Name: cell in vitro (CL0001034)
Fold Change: 3.0760
Cell Significance Index: 1679.8800 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 3.0010
Cell Significance Index: 541.0000 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 2.9221
Cell Significance Index: 153.4200 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 2.8021
Cell Significance Index: 157.2400 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.7014
Cell Significance Index: 201.3300 - Cell Name: lactocyte (CL0002325)
Fold Change: 2.3973
Cell Significance Index: 309.7200 - Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 1.9564
Cell Significance Index: 12.0400 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 1.9205
Cell Significance Index: 849.0800 - Cell Name: odontoblast (CL0000060)
Fold Change: 1.8389
Cell Significance Index: 235.7400 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.6471
Cell Significance Index: 590.7900 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.5559
Cell Significance Index: 119.4000 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.3866
Cell Significance Index: 38.7500 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 1.3786
Cell Significance Index: 17.6600 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 1.3429
Cell Significance Index: 34.5200 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 1.3078
Cell Significance Index: 92.4900 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.1679
Cell Significance Index: 34.3000 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.0932
Cell Significance Index: 219.3000 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.8851
Cell Significance Index: 40.1200 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.8014
Cell Significance Index: 41.6300 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.6862
Cell Significance Index: 111.6000 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.5489
Cell Significance Index: 25.5900 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.4892
Cell Significance Index: 83.5300 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.4660
Cell Significance Index: 877.3900 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.3644
Cell Significance Index: 22.9700 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.3538
Cell Significance Index: 6.5400 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.3280
Cell Significance Index: 5.5300 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.2953
Cell Significance Index: 187.5800 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 0.2540
Cell Significance Index: 28.9900 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.2341
Cell Significance Index: 106.2600 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1675
Cell Significance Index: 31.8700 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.1571
Cell Significance Index: 2.6300 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.1461
Cell Significance Index: 269.4500 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.1420
Cell Significance Index: 218.6300 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0890
Cell Significance Index: 67.3600 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0373
Cell Significance Index: 50.7700 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0095
Cell Significance Index: -6.9400 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: -0.0178
Cell Significance Index: -16.0700 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0379
Cell Significance Index: -23.6700 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0628
Cell Significance Index: -46.5100 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1432
Cell Significance Index: -14.6300 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1484
Cell Significance Index: -9.9800 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1941
Cell Significance Index: -109.4900 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.2111
Cell Significance Index: -3.7300 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.3338
Cell Significance Index: -70.3100 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.4174
Cell Significance Index: -60.6800 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.4496
Cell Significance Index: -129.3700 - Cell Name: colon goblet cell (CL0009039)
Fold Change: -0.4542
Cell Significance Index: -44.9400 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.5100
Cell Significance Index: -14.7000 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.7149
Cell Significance Index: -42.9200 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.7200
Cell Significance Index: -78.3100 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.7225
Cell Significance Index: -82.7700 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.8216
Cell Significance Index: -20.9900 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.8478
Cell Significance Index: -98.8000 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.9865
Cell Significance Index: -11.7600 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -1.0181
Cell Significance Index: -13.8900 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -1.0249
Cell Significance Index: -45.3400 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -1.0527
Cell Significance Index: -6.3600 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -1.0772
Cell Significance Index: -112.1600 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -1.1359
Cell Significance Index: -10.4600 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -1.2482
Cell Significance Index: -21.3900 - Cell Name: preadipocyte (CL0002334)
Fold Change: -1.2773
Cell Significance Index: -24.9300 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -1.2945
Cell Significance Index: -67.4300 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -1.3489
Cell Significance Index: -106.8300 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -1.3689
Cell Significance Index: -34.2200 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -1.3795
Cell Significance Index: -52.2400 - Cell Name: peg cell (CL4033014)
Fold Change: -1.5392
Cell Significance Index: -35.5600 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -1.5971
Cell Significance Index: -34.6000 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -1.6570
Cell Significance Index: -53.0700 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -1.8256
Cell Significance Index: -26.9500 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -1.9600
Cell Significance Index: -120.4700 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -1.9627
Cell Significance Index: -41.8000 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -1.9656
Cell Significance Index: -52.6700 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -2.1894
Cell Significance Index: -134.2300
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2539948658
Symbol: HNRPC_HUMAN
Name: Heterogeneous nuclear ribonucleoproteins C1/C2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2557628
Title: Primary structures of the heterogeneous nuclear ribonucleoprotein A2, B1, and C2 proteins: a diversity of RNA binding proteins is generated by small peptide inserts.
PubMed ID: 2557628
PubMed ID: 3110598
Title: Primary structure of human nuclear ribonucleoprotein particle C proteins: conservation of sequence and domain structures in heterogeneous nuclear RNA, mRNA, and pre-rRNA-binding proteins.
PubMed ID: 3110598
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 2587210
Title: Primary structure differences between proteins C1 and C2 of HeLa 40S nuclear ribonucleoprotein particles.
PubMed ID: 2587210
PubMed ID: 8264621
Title: The C-protein tetramer binds 230 to 240 nucleotides of pre-mRNA and nucleates the assembly of 40S heterogeneous nuclear ribonucleoprotein particles.
PubMed ID: 8264621
PubMed ID: 7567451
Title: A T to G mutation in the polypyrimidine tract of the second intron of the human beta-globin gene reduces in vitro splicing efficiency: evidence for an increased hnRNP C interaction.
PubMed ID: 7567451
PubMed ID: 11687588
Title: Nuclear DNA helicase II/RNA helicase A binds to filamentous actin.
PubMed ID: 11687588
PubMed ID: 11991638
Title: Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.
PubMed ID: 11991638
PubMed ID: 12564933
Title: Basal and hydrogen peroxide stimulated sites of phosphorylation in heterogeneous nuclear ribonucleoprotein C1/C2.
PubMed ID: 12564933
DOI: 10.1021/bi0268091
PubMed ID: 12509468
Title: Heterogeneous nuclear ribonucleoprotein C modulates translation of c-myc mRNA in a cell cycle phase-dependent manner.
PubMed ID: 12509468
PubMed ID: 14654843
Title: Proteomic characterization of the human centrosome by protein correlation profiling.
PubMed ID: 14654843
DOI: 10.1038/nature02166
PubMed ID: 15082759
Title: SUMO modification of heterogeneous nuclear ribonucleoproteins.
PubMed ID: 15082759
PubMed ID: 16010978
Title: Regulation of urokinase receptor mRNA stability by hnRNP C in lung epithelial cells.
PubMed ID: 16010978
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 16807684
Title: Phosphoproteomic analysis of the human pituitary.
PubMed ID: 16807684
PubMed ID: 17693683
Title: Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction.
PubMed ID: 17693683
PubMed ID: 17289661
Title: Molecular composition of IMP1 ribonucleoprotein granules.
PubMed ID: 17289661
PubMed ID: 19367720
Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.
PubMed ID: 19367720
DOI: 10.1021/pr800500r
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 18318008
Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.
PubMed ID: 18318008
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25218447
Title: Uncovering global SUMOylation signaling networks in a site-specific manner.
PubMed ID: 25218447
DOI: 10.1038/nsmb.2890
PubMed ID: 25114211
Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.
PubMed ID: 25114211
PubMed ID: 25678563
Title: Peptidylprolyl isomerase A governs TARDBP function and assembly in heterogeneous nuclear ribonucleoprotein complexes.
PubMed ID: 25678563
DOI: 10.1093/brain/awv005
PubMed ID: 25772364
Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.
PubMed ID: 25772364
PubMed ID: 25755297
Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.
PubMed ID: 25755297
PubMed ID: 25719671
Title: N(6)-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions.
PubMed ID: 25719671
DOI: 10.1038/nature14234
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 37599448
Title: Nucleo-cytoplasmic shuttling of 14-3-3 epsilon carrying hnRNP C promotes autophagy.
PubMed ID: 37599448
PubMed ID: 1385725
Title: 1H, 13C, and 15N NMR assignments and global folding pattern of the RNA-binding domain of the human hnRNP C proteins.
PubMed ID: 1385725
DOI: 10.1021/bi00142a013
PubMed ID: 1380452
Title: Interaction of the RNA-binding domain of the hnRNP C proteins with RNA.
PubMed ID: 1380452
PubMed ID: 11162094
Title: An antiparallel four-helix bundle orients the high-affinity RNA binding sites in hnRNP C: a mechanism for RNA chaperonin activity.
PubMed ID: 11162094
PubMed ID: 15936032
Title: Solution structure of the symmetric coiled coil tetramer formed by the oligomerization domain of hnRNP C: implications for biological function.
PubMed ID: 15936032
PubMed ID: 37541189
Title: HNRNPC haploinsufficiency affects alternative splicing of intellectual disability-associated genes and causes a neurodevelopmental disorder.
PubMed ID: 37541189
Sequence Information:
- Length: 306
- Mass: 33670
- Checksum: 17BBC78690C69C5C
- Sequence:
MASNVTNKTD PRSMNSRVFI GNLNTLVVKK SDVEAIFSKY GKIVGCSVHK GFAFVQYVNE RNARAAVAGE DGRMIAGQVL DINLAAEPKV NRGKAGVKRS AAEMYGSVTE HPSPSPLLSS SFDLDYDFQR DYYDRMYSYP ARVPPPPPIA RAVVPSKRQR VSGNTSRRGK SGFNSKSGQR GSSKSGKLKG DDLQAIKKEL TQIKQKVDSL LENLEKIEKE QSKQAVEMKN DKSEEEQSSS SVKKDETNVK MESEGGADDS AEEGDLLDDD DNEDRGDDQL ELIKDDEKEA EEGEDDRDSA NGEDDS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.