Details for: NCL

Gene ID: 4691

Symbol: NCL

Ensembl ID: ENSG00000115053

Description: nucleolin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 585.1031
    Cell Significance Index: -91.0100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 331.9227
    Cell Significance Index: -84.1900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 289.5271
    Cell Significance Index: -119.2700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 262.3708
    Cell Significance Index: -106.5900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 252.2861
    Cell Significance Index: -119.1100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 233.0938
    Cell Significance Index: -119.9000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 178.1983
    Cell Significance Index: -119.5800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 113.8107
    Cell Significance Index: -108.6600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 91.8930
    Cell Significance Index: -113.3000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 39.3488
    Cell Significance Index: -105.4100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 32.7467
    Cell Significance Index: -100.5800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 30.2860
    Cell Significance Index: -119.5100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 18.6147
    Cell Significance Index: -40.7400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 5.6841
    Cell Significance Index: 72.8000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 5.3195
    Cell Significance Index: 57.8300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 4.9451
    Cell Significance Index: 171.8400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 4.6416
    Cell Significance Index: 218.1500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 4.6305
    Cell Significance Index: 635.8900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 4.5786
    Cell Significance Index: 562.9900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.4042
    Cell Significance Index: 119.8800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 3.8777
    Cell Significance Index: 699.0300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.8171
    Cell Significance Index: 109.4200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 3.7878
    Cell Significance Index: 244.3700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.7029
    Cell Significance Index: 2022.2300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 3.3917
    Cell Significance Index: 78.3600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 3.2432
    Cell Significance Index: 85.2800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 3.1319
    Cell Significance Index: 65.5600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.8959
    Cell Significance Index: 341.5100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.8806
    Cell Significance Index: 203.7300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.7586
    Cell Significance Index: 1219.6300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.7123
    Cell Significance Index: 538.2700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.6205
    Cell Significance Index: 136.5000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.4678
    Cell Significance Index: 22.7300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.4594
    Cell Significance Index: 27.9400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.4545
    Cell Significance Index: 317.1100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.2845
    Cell Significance Index: 18.2400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.0942
    Cell Significance Index: 268.4700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.9610
    Cell Significance Index: 146.1500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.8066
    Cell Significance Index: 84.2300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.5663
    Cell Significance Index: 46.0000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.5282
    Cell Significance Index: 44.0300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.3902
    Cell Significance Index: 37.1200
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.2337
    Cell Significance Index: 9.3200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.2144
    Cell Significance Index: 21.4600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.2087
    Cell Significance Index: 63.4600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1523
    Cell Significance Index: 125.3300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8339
    Cell Significance Index: 43.3200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7277
    Cell Significance Index: 15.7700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.6080
    Cell Significance Index: 103.8200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5080
    Cell Significance Index: 23.0300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.3450
    Cell Significance Index: 39.3800
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.3433
    Cell Significance Index: 2.9500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3048
    Cell Significance Index: 275.1700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1998
    Cell Significance Index: 40.0800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1968
    Cell Significance Index: 144.3200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1874
    Cell Significance Index: 141.8200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1790
    Cell Significance Index: 6.2900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1722
    Cell Significance Index: 17.0400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1601
    Cell Significance Index: 57.4300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1217
    Cell Significance Index: 6.8300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1158
    Cell Significance Index: 7.3000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1105
    Cell Significance Index: 21.0300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1049
    Cell Significance Index: 1.7600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0484
    Cell Significance Index: 7.8800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0245
    Cell Significance Index: -46.2000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0265
    Cell Significance Index: -1.6300
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0467
    Cell Significance Index: -0.3600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0468
    Cell Significance Index: -86.2800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0501
    Cell Significance Index: -77.1200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0506
    Cell Significance Index: -37.4700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0660
    Cell Significance Index: -6.7400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0708
    Cell Significance Index: -44.2100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0806
    Cell Significance Index: -109.5700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1169
    Cell Significance Index: -65.9300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1221
    Cell Significance Index: -77.5400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.2059
    Cell Significance Index: -93.4700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2613
    Cell Significance Index: -55.0400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3471
    Cell Significance Index: -99.8700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4134
    Cell Significance Index: -7.6400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4750
    Cell Significance Index: -2.8700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5040
    Cell Significance Index: -57.7400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5782
    Cell Significance Index: -14.7700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.6205
    Cell Significance Index: -90.1900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.7019
    Cell Significance Index: -13.7000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.7289
    Cell Significance Index: -20.3700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.7328
    Cell Significance Index: -85.4000
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.8811
    Cell Significance Index: -5.4200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.8839
    Cell Significance Index: -12.0600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.8912
    Cell Significance Index: -70.5800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.0566
    Cell Significance Index: -33.8400
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -1.0612
    Cell Significance Index: -4.9000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.0729
    Cell Significance Index: -82.3300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.0956
    Cell Significance Index: -13.0600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.1434
    Cell Significance Index: -119.0600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.2504
    Cell Significance Index: -26.6300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.3453
    Cell Significance Index: -33.6300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.3537
    Cell Significance Index: -91.0200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.5690
    Cell Significance Index: -41.9700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.6487
    Cell Significance Index: -101.0800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.7141
    Cell Significance Index: -45.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Nucleolin is a large, multifunctional protein that interacts with various components of the cell, including RNA, DNA, and proteins. Its structure consists of three domains: the N-terminal domain, the C-terminal domain, and the phosphoprotein domain. Nucleolin exhibits high expression levels in cells undergoing rapid proliferation, such as immune cells and cancer cells. Its expression is also regulated by various post-translational modifications, including phosphorylation, ubiquitination, and acetylation. **Pathways and Functions:** Nucleolin is involved in several key cellular processes, including: 1. **RNA processing:** Nucleolin is a crucial component of the nucleolus and cytoplasmic ribonucleoprotein granules, where it regulates rRNA processing, transcription, and translation. 2. **Cell regulation:** Nucleolin modulates cell growth, proliferation, and differentiation by regulating gene expression and protein synthesis. 3. **Immune response:** Nucleolin is expressed in immune cells, where it plays a role in regulating immune responses, including T-cell activation and antibody production. 4. **Angiogenesis:** Nucleolin has been implicated in the regulation of angiogenesis, a process critical for tumor growth and metastasis. **Clinical Significance:** Nucleolin's involvement in various cellular processes makes it a potential target for therapeutic intervention in several diseases, including: 1. **Cancer:** Nucleolin's role in tumor growth, proliferation, and metastasis makes it a potential target for cancer therapy. 2. **Autoimmune diseases:** Nucleolin's expression in immune cells suggests its involvement in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Neurological disorders:** Nucleolin's expression in neurons and glial cells suggests its involvement in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Viral infections:** Nucleolin's role in viral entry and replication makes it a potential target for antiviral therapy. In conclusion, nucleolin is a multifaceted gene that plays a crucial role in various cellular processes, including RNA processing, cell regulation, and immune response. Its expression in immune cells and other cell types suggests its importance in immune system function, and its potential as a therapeutic target in several diseases makes it an area of ongoing research interest.

Genular Protein ID: 2738322058

Symbol: NUCL_HUMAN

Name: Nucleolin

UniProtKB Accession Codes:

P19338 Q53SK1 Q8NB06 Q9UCF0 Q9UDG1

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 4 CORUM 1 CPTAC 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 3 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 29 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 MoonProt 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2737305

Title: Cloning and sequencing of the human nucleolin cDNA.

PubMed ID: 2737305

DOI: 10.1016/0014-5793(89)80692-1

PubMed ID: 2394707

Title: Genomic organization and chromosomal localization of the human nucleolin gene.

PubMed ID: 2394707

DOI: 10.1016/s0021-9258(18)77205-0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 7718615

Title: Purification and partial amino acid sequencing of a fructosyllysine-specific binding protein from cell membranes of the monocyte-like cell line U937.

PubMed ID: 7718615

DOI: 10.1016/0167-4889(95)00028-q

PubMed ID: 7993898

Title: Major cell surface-located protein substrates of an ecto-protein kinase are homologs of known nuclear proteins.

PubMed ID: 7993898

DOI: 10.1021/bi00253a007

PubMed ID: 8321232

Title: Nuclear proteins that bind the pre-mRNA 3' splice site sequence r(UUAG/G) and the human telomeric DNA sequence d(TTAGGG)n.

PubMed ID: 8321232

DOI: 10.1128/mcb.13.7.4301-4310.1993

PubMed ID: 10393184

Title: A novel RNA polymerase II-containing complex potentiates Tat-enhanced HIV-1 transcription.

PubMed ID: 10393184

DOI: 10.1093/emboj/18.13.3688

PubMed ID: 12147681

Title: The anti-HIV cytokine midkine binds the cell surface-expressed nucleolin as a low affinity receptor.

PubMed ID: 12147681

DOI: 10.1074/jbc.m201194200

PubMed ID: 12429849

Title: Functional proteomic analysis of human nucleolus.

PubMed ID: 12429849

DOI: 10.1091/mbc.e02-05-0271

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15044383

Title: Aprataxin, a novel protein that protects against genotoxic stress.

PubMed ID: 15044383

DOI: 10.1093/hmg/ddh122

PubMed ID: 15371412

Title: Nucleolin interacts with telomerase.

PubMed ID: 15371412

DOI: 10.1074/jbc.m407643200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17487921

Title: Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line.

PubMed ID: 17487921

DOI: 10.1002/elps.200600782

PubMed ID: 17674968

Title: Nucleolin modulates the subcellular localization of GDNF-inducible zinc finger protein 1 and its roles in transcription and cell proliferation.

PubMed ID: 17674968

DOI: 10.1016/j.yexcr.2007.07.003

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 17215513

Title: Aurora-B regulates RNA methyltransferase NSUN2.

PubMed ID: 17215513

DOI: 10.1091/mbc.e06-11-1021

PubMed ID: 17289661

Title: Molecular composition of IMP1 ribonucleoprotein granules.

PubMed ID: 17289661

DOI: 10.1074/mcp.m600346-mcp200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19710015

Title: The metastasis efficiency modifier ribosomal RNA processing 1 homolog B (RRP1B) is a chromatin-associated factor.

PubMed ID: 19710015

DOI: 10.1074/jbc.m109.023457

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20858735

Title: Interactions of ErbB4 and Kap1 connect the growth factor and DNA damage response pathways.

PubMed ID: 20858735

DOI: 10.1158/1541-7786.mcr-10-0042

PubMed ID: 20221403

Title: Phosphorylation of human tristetraprolin in response to its interaction with the Cbl interacting protein CIN85.

PubMed ID: 20221403

DOI: 10.1371/journal.pone.0009588

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21081503

Title: RioK1, a new interactor of protein arginine methyltransferase 5 (PRMT5), competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity.

PubMed ID: 21081503

DOI: 10.1074/jbc.m110.148486

PubMed ID: 21474449

Title: Structure and function of the N-terminal nucleolin binding domain of nuclear valosin-containing protein-like 2 (NVL2) harboring a nucleolar localization signal.

PubMed ID: 21474449

DOI: 10.1074/jbc.m110.174680

PubMed ID: 21242313

Title: The nuclear scaffold protein SAF-A is required for kinetochore-microtubule attachment and contributes to the targeting of Aurora-A to mitotic spindles.

PubMed ID: 21242313

DOI: 10.1242/jcs.063347

PubMed ID: 21700224

Title: Human senataxin resolves RNA/DNA hybrids formed at transcriptional pause sites to promote Xrn2-dependent termination.

PubMed ID: 21700224

DOI: 10.1016/j.molcel.2011.04.026

PubMed ID: 21536856

Title: Splicing factor 2-associated protein p32 participates in ribosome biogenesis by regulating the binding of Nop52 and fibrillarin to preribosome particles.

PubMed ID: 21536856

DOI: 10.1074/mcp.m110.006148

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23972994

Title: ABH2 couples regulation of ribosomal DNA transcription with DNA alkylation repair.

PubMed ID: 23972994

DOI: 10.1016/j.celrep.2013.07.027

PubMed ID: 23848194

Title: Nucleolar scaffold protein, WDR46, determines the granular compartmental localization of nucleolin and DDX21.

PubMed ID: 23848194

DOI: 10.1111/gtc.12077

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 24658146

Title: Subcellular fractionation and localization studies reveal a direct interaction of the fragile X mental retardation protein (FMRP) with nucleolin.

PubMed ID: 24658146

DOI: 10.1371/journal.pone.0091465

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 26103640

Title: IGFBP-5 Promotes Fibrosis Independently of Its Translocation to the Nucleus and Its Interaction with Nucleolin and IGF.

PubMed ID: 26103640

DOI: 10.1371/journal.pone.0130546

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 26845719

Title: Two new isoforms of the human hepatoma-derived growth factor interact with components of the cytoskeleton.

PubMed ID: 26845719

DOI: 10.1515/hsz-2015-0273

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 710
  • Mass: 76614
  • Checksum: C97F6E34E5CA6727
  • Sequence:
    • MVKLAKAGKN QGDPKKMAPP PKEVEEDSED EEMSEDEEDD SSGEEVVIPQ KKGKKAAATS 
AKKVVVSPTK KVAVATPAKK AAVTPGKKAA ATPAKKTVTP AKAVTTPGKK GATPGKALVA 
TPGKKGAAIP AKGAKNGKNA KKEDSDEEED DDSEEDEEDD EDEDEDEDEI EPAAMKAAAA 
APASEDEDDE DDEDDEDDDD DEEDDSEEEA METTPAKGKK AAKVVPVKAK NVAEDEDEEE 
DDEDEDDDDD EDDEDDDDED DEEEEEEEEE EPVKEAPGKR KKEMAKQKAA PEAKKQKVEG 
TEPTTAFNLF VGNLNFNKSA PELKTGISDV FAKNDLAVVD VRIGMTRKFG YVDFESAEDL 
EKALELTGLK VFGNEIKLEK PKGKDSKKER DARTLLAKNL PYKVTQDELK EVFEDAAEIR 
LVSKDGKSKG IAYIEFKTEA DAEKTFEEKQ GTEIDGRSIS LYYTGEKGQN QDYRGGKNST 
WSGESKTLVL SNLSYSATEE TLQEVFEKAT FIKVPQNQNG KSKGYAFIEF ASFEDAKEAL 
NSCNKREIEG RAIRLELQGP RGSPNARSQP SKTLFVKGLS EDTTEETLKE SFDGSVRARI 
VTDRETGSSK GFGFVDFNSE EDAKAAKEAM EDGEIDGNKV TLDWAKPKGE GGFGGRGGGR 
GGFGGRGGGR GGRGGFGGRG RGGFGGRGGF RGGRGGGGDH KPQGKKTKFE

Genular Protein ID: 4197580862

Symbol: B3KM80_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KM80

Database IDs:

ARBA 9 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 4 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 GO 3 Gene3D 1 InterPro 9 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 SAM 1 SMART 2 SUPFAM 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 536
  • Mass: 58554
  • Checksum: 2230178D72182E45
  • Sequence:
    • MKAAAAAPAS EDEDDEDDED DEDDDDDEED DSEEEAMETT PAKGKKAAKV VPVKAKNVAE 
DEDEEEDDED EDDDDDEDDE DDDDEDDEEE EEEEEEEPVK EAPGKRKKEM AKQKAAPEAK 
KQKVEGTEPT TAFNLFVGNL NFNKSAPELK TGISDVFAKN DLAVVDVRIG MTRKFGYVDF 
ESAEDLEKAL ELTGLKVFGN EIKLEKPKGK DSKKERDART LLAKNLPYKV TQDELKEVFE 
DAAEIRLVSK DGKSKGIAYI EFKTEADAEK TFEEKQGTEI DGRSISLYYT GEKGQNQDYR 
GGKNSTWSGE SKTLVLSNLS YSATEETLQE VFEKATFIKV PQNQNGKSKG YAFIEFASFE 
DAKEALNSCN KREIEGRAIR LELQGPRGSP NARSQPSKTL FVKGLSEDTT EETLKESFDG 
SVRARIVTDR ETGSSKGFGF VDFNSEEDAK AAKEAMEDGE IDGNKVTLDW AKPKGEGGFG 
GRGGGRGGFG GRGGGRGGRG GFGGRGRGGF GGRGGFRGGR GGGGDHKPQG KKTKFE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.