Details for: EEF1D

Gene ID: 1936

Symbol: EEF1D

Ensembl ID: ENSG00000104529

Description: eukaryotic translation elongation factor 1 delta

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 5.2
    Marker Score: 10897
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 5.11
    Marker Score: 50597
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 4.74
    Marker Score: 8140
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 4.73
    Marker Score: 13804
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 4.73
    Marker Score: 14922
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 4.7
    Marker Score: 8585
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 4.61
    Marker Score: 243882.5
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.58
    Marker Score: 155755
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 4.5
    Marker Score: 2314
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 4.5
    Marker Score: 4017
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 4.49
    Marker Score: 2894
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 4.49
    Marker Score: 3259
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 4.44
    Marker Score: 3779
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 4.39
    Marker Score: 59040
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 4.28
    Marker Score: 1578
  • Cell Name: blood cell (CL0000081)
    Fold Change: 4.25
    Marker Score: 49400.5
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.2
    Marker Score: 234593
  • Cell Name: theca cell (CL0000503)
    Fold Change: 4.17
    Marker Score: 2985
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 4.16
    Marker Score: 54926
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 4.16
    Marker Score: 2532
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.12
    Marker Score: 10060
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.1
    Marker Score: 9352.5
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 4.1
    Marker Score: 11506
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 4.04
    Marker Score: 17316
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 3.98
    Marker Score: 3846
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 3.96
    Marker Score: 9666
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 3.95
    Marker Score: 10922
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 3.95
    Marker Score: 29424
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.94
    Marker Score: 3885
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 3.93
    Marker Score: 5122
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 3.92
    Marker Score: 5776
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 3.9
    Marker Score: 1269
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 3.9
    Marker Score: 2940
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 3.89
    Marker Score: 4320
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 3.88
    Marker Score: 2277
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.87
    Marker Score: 3301
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 3.87
    Marker Score: 20346
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.84
    Marker Score: 918
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 3.83
    Marker Score: 3407
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 3.82
    Marker Score: 2997
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 3.75
    Marker Score: 1611
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 3.73
    Marker Score: 3506.5
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 3.72
    Marker Score: 3161
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 3.72
    Marker Score: 3132
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.71
    Marker Score: 3965
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.68
    Marker Score: 6920
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 3.65
    Marker Score: 6521
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 3.61
    Marker Score: 12828
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 3.61
    Marker Score: 4232.5
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 3.6
    Marker Score: 3164.5
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 3.53
    Marker Score: 2672
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.53
    Marker Score: 22934
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 3.52
    Marker Score: 2887
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 3.52
    Marker Score: 3136
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 3.49
    Marker Score: 2333.5
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 3.48
    Marker Score: 1962
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 3.47
    Marker Score: 2882
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 3.46
    Marker Score: 22099
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 3.46
    Marker Score: 22539
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 3.45
    Marker Score: 2008
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 3.45
    Marker Score: 7820
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 3.45
    Marker Score: 2450
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 3.44
    Marker Score: 1540
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 3.42
    Marker Score: 1887
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 3.42
    Marker Score: 2265
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 3.4
    Marker Score: 780
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 3.4
    Marker Score: 5577
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 3.38
    Marker Score: 895
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.38
    Marker Score: 3866
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 3.37
    Marker Score: 1108
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 3.36
    Marker Score: 1967
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 3.36
    Marker Score: 891
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 3.35
    Marker Score: 1221.5
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 3.33
    Marker Score: 1387
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 3.32
    Marker Score: 2401
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 3.32
    Marker Score: 25929.5
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 3.32
    Marker Score: 16294
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 3.31
    Marker Score: 3102
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 3.31
    Marker Score: 2970
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 3.31
    Marker Score: 3658
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 3.31
    Marker Score: 8858
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 3.3
    Marker Score: 5078.5
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 3.3
    Marker Score: 2907
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 3.29
    Marker Score: 1315
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 3.29
    Marker Score: 1642
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 3.29
    Marker Score: 3877
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 3.28
    Marker Score: 1489
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 3.27
    Marker Score: 862
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.27
    Marker Score: 12611
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 3.27
    Marker Score: 1405.5
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 3.24
    Marker Score: 2555.5
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 3.24
    Marker Score: 920
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 3.23
    Marker Score: 3517.5
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.23
    Marker Score: 111932
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 3.22
    Marker Score: 1124
  • Cell Name: basophil (CL0000767)
    Fold Change: 3.22
    Marker Score: 1528
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 3.21
    Marker Score: 4436
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 3.21
    Marker Score: 4541
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 3.2
    Marker Score: 2229.5
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 3.2
    Marker Score: 1082

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * EF1D is a member of the EF1 family of translation elongation factors. * It is expressed in a variety of cell types, including CD38-negative naive B cells, mature T cells, and natural T-regulatory cells. * It is a key regulator of protein translation. **Pathways and functions:** * EF1D is involved in the initiation of translation by binding to the 5' cap of mRNA and facilitating the interaction between the mRNA and the ribosome. * It is also involved in the elongation of the polypeptide chain by binding to the guanosine-5'-triphosphate (GTP) binding domain of eEF2 and facilitating the release of the GDP-bound eEF2 from the ribosome. * EF1D is a key regulator of protein translation in eukaryotic cells. **Clinical significance:** * Mutations in EF1D have been linked to a number of human diseases, including cancer and autoimmune disorders. * Inhibitors of EF1D have been shown to be effective in treating these diseases. **Additional information:** * EF1D is a highly conserved protein, with a similar sequence in mice and humans. * It is a well-characterized protein that has been extensively studied in research.

Genular Protein ID: 1276742618

Symbol: EF1D_HUMAN

Name: Elongation factor 1-delta

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8334168

Title: The human leucine zipper-containing guanine-nucleotide exchange protein elongation factor-1 delta.

PubMed ID: 8334168

DOI: 10.1016/0167-4781(93)90097-w

PubMed ID: 9610721

Title: Characterization of human colon cancer antigens recognized by autologous antibodies.

PubMed ID: 9610721

DOI: 10.1002/(sici)1097-0215(19980529)76:5<652::aid-ijc7>3.0.co;2-p

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8168075

Title: Elongation factor 1 delta is enhanced following exposure to ionizing radiation.

PubMed ID: 8168075

PubMed ID: 9677419

Title: Induction of acute translational response genes by homocysteine. Elongation factors-1alpha, -beta, and -delta.

PubMed ID: 9677419

DOI: 10.1074/jbc.273.31.19840

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16807684

Title: Phosphoproteomic analysis of the human pituitary.

PubMed ID: 16807684

DOI: 10.1007/s11102-006-8916-x

PubMed ID: 17487921

Title: Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line.

PubMed ID: 17487921

DOI: 10.1002/elps.200600782

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 17693683

Title: Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction.

PubMed ID: 17693683

DOI: 10.1074/mcp.m700120-mcp200

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 19367720

Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.

PubMed ID: 19367720

DOI: 10.1021/pr800500r

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21597468

Title: Transformation of eEF1Bdelta into heat-shock response transcription factor by alternative splicing.

PubMed ID: 21597468

DOI: 10.1038/embor.2011.82

PubMed ID: 21936567

Title: Unbiased functional proteomics strategy for protein kinase inhibitor validation and identification of bona fide protein kinase substrates: application to identification of as a substrate for CK2.

PubMed ID: 21936567

DOI: 10.1021/pr2008994

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 281
  • Mass: 31122
  • Checksum: CE778D6D5D09BD6C
  • Sequence:
  • MATNFLAHEK IWFDKFKYDD AERRFYEQMN GPVAGASRQE NGASVILRDI ARARENIQKS 
    LAGSSGPGAS SGTSGDHGEL VVRIASLEVE NQSLRGVVQE LQQAISKLEA RLNVLEKSSP 
    GHRATAPQTQ HVSPMRQVEP PAKKPATPAE DDEDDDIDLF GSDNEEEDKE AAQLREERLR 
    QYAEKKAKKP ALVAKSSILL DVKPWDDETD MAQLEACVRS IQLDGLVWGA SKLVPVGYGI 
    RKLQIQCVVE DDKVGTDLLE EEITKFEEHV QSVDIAAFNK I

Genular Protein ID: 450278617

Symbol: B2RAR6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 647
  • Mass: 71450
  • Checksum: A83FCA7085C078E1
  • Sequence:
  • MRSGKASCTL ETVWEDKHKY EEAERRFYEH EATQAAASAQ QLPAEGPAMN GPGQDDPEDA 
    DEAEAPDGGS RRDPRKSQDS RKPLQKKRKR SPKSGLGPVD LALLGLSAER VWLDKSLFDQ 
    AESSYRQKLA DVAAQAAWPP ALAPWGLCTH GNQVACHHVT WGIWVNKSSF DQAERAFVEW 
    SQALLLAPEG SRRQGTPNTG QQVAVPDLAH QPSPPVNGQP PLGSLQALVR EVWLEKPRYD 
    AAERGFYEAL FDGHPPGKVR LQERAGLAEG ARRGRRDRRG RNILGNKRAG LRRADGEAPS 
    ALPYCYFLQK DAEAPWLSKP AYDSAECRHH AAEALRVAWC LEAASLSHRP GPRSGLSVSS 
    LRPNRKMATN FLAHEKIWFD KFKYDDAERR FYEQMNGPVA GASRQENGAS VILRDIARAR 
    ENIQKSLAGS SGPGASSGTS GDHGELVVRI ASLEVENQSL RGVVQELQQA ISKLEARLNV 
    LEKSSPGHRA TAPQTQHVSP MRQVEPPAKK PATPAEDDED DDIDLFGSDN EEEDKEAAQL 
    REERLRQYAE KKAKKPALVA KSSILLDVKP WDDETDMAQL EACVRSIQLD GLVWGASKLV 
    PVGYGIRKLQ IQCVVEDDKV GTDLLEEEIT KFEEHVQSVD IAAFNKI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.