Details for: EEF1D

Gene ID: 1936

Symbol: EEF1D

Ensembl ID: ENSG00000104529

Description: eukaryotic translation elongation factor 1 delta

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.79
    Cell Significance Index: 5
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.22
    Cell Significance Index: 3
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.6
    Cell Significance Index: 2
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.48
    Cell Significance Index: 2
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.46
    Cell Significance Index: 1
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.42
    Cell Significance Index: 2
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.41
    Cell Significance Index: 2
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.4
    Cell Significance Index: 1
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.29
    Cell Significance Index: 1
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.24
    Cell Significance Index: 1
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.21
    Cell Significance Index: 1
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.18
    Cell Significance Index: 1
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.15
    Cell Significance Index: 1
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.14
    Cell Significance Index: 1
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.13
    Cell Significance Index: 1
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.12
    Cell Significance Index: 1
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.12
    Cell Significance Index: 1
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.11
    Cell Significance Index: 1
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.11
    Cell Significance Index: 1
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.1
    Cell Significance Index: 1
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 1.09
    Cell Significance Index: 1
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.09
    Cell Significance Index: 1
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.08
    Cell Significance Index: 1
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.07
    Cell Significance Index: 1
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.06
    Cell Significance Index: 1
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.04
    Cell Significance Index: 1
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.04
    Cell Significance Index: 1
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.04
    Cell Significance Index: 1
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.04
    Cell Significance Index: 1
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.04
    Cell Significance Index: 1
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.03
    Cell Significance Index: 1
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.03
    Cell Significance Index: 1
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.03
    Cell Significance Index: 1
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.03
    Cell Significance Index: 1
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.01
    Cell Significance Index: 1
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.01
    Cell Significance Index: 1
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.01
    Cell Significance Index: 1
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: cell (CL0000000)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 0.97
    Cell Significance Index: 1
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 0.97
    Cell Significance Index: 1
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.97
    Cell Significance Index: 1
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: 0.97
    Cell Significance Index: 1
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.97
    Cell Significance Index: 1
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.97
    Cell Significance Index: 1
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: 0.97
    Cell Significance Index: 1
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.97
    Cell Significance Index: 1
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.97
    Cell Significance Index: 1
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.97
    Cell Significance Index: 1
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: 0.96
    Cell Significance Index: 1
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.96
    Cell Significance Index: 1
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.96
    Cell Significance Index: 1
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.96
    Cell Significance Index: 1
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 0.96
    Cell Significance Index: 1
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.96
    Cell Significance Index: 1
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.96
    Cell Significance Index: 1
  • Cell Name: Merkel cell (CL0000242)
    Fold Change: 0.96
    Cell Significance Index: 1
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.96
    Cell Significance Index: 1
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.96
    Cell Significance Index: 1
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.96
    Cell Significance Index: 1
  • Cell Name: glioblast (CL0000030)
    Fold Change: 0.96
    Cell Significance Index: 1
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.96
    Cell Significance Index: 1
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.96
    Cell Significance Index: 1
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.96
    Cell Significance Index: 1
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.95
    Cell Significance Index: 1
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.95
    Cell Significance Index: 1
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.95
    Cell Significance Index: 1
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.95
    Cell Significance Index: 1
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.95
    Cell Significance Index: 1
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 0.95
    Cell Significance Index: 1
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.95
    Cell Significance Index: 1
  • Cell Name: activated type II NK T cell (CL0000931)
    Fold Change: 0.95
    Cell Significance Index: 1
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.95
    Cell Significance Index: 1
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.95
    Cell Significance Index: 1
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.95
    Cell Significance Index: 1

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** EEF1D is a conserved protein that belongs to the elongation factor 1 family, which includes eEF1E1 and eEF1A. The EEF1D protein is predominantly localized in the cytosol and is involved in the translation elongation process, where it interacts with ribosomes and transfer RNA (tRNA) to facilitate the incorporation of amino acids into the growing polypeptide chain. EEF1D exhibits guanyl-nucleotide exchange factor (GEF) activity, allowing it to exchange GDP for GTP, which is essential for its function in protein synthesis. **Pathways and Functions:** EEF1D is integrated into several signaling pathways that regulate cellular processes, including: 1. **Translation elongation:** EEF1D is a critical component of the eEF1E1 complex, which plays a central role in the translation elongation process. It facilitates the interaction between ribosomes and tRNA, ensuring the accurate incorporation of amino acids into the polypeptide chain. 2. **Cellular response to stress:** EEF1D is involved in the cellular response to stress, including heat shock and oxidative stress. It helps to regulate the translation of stress-related proteins, which are essential for cell survival. 3. **Cell signaling:** EEF1D interacts with various signaling molecules, including cadherins and integrins, to regulate cell adhesion and migration. 4. **Metabolism:** EEF1D is involved in the regulation of protein metabolism, including the translation of mRNAs into proteins and the degradation of misfolded proteins. **Clinical Significance:** EEF1D has been implicated in various diseases, including: 1. **Cancer:** EEF1D is overexpressed in several types of cancer, including breast cancer, lung cancer, and melanoma. It is thought to contribute to tumorigenesis by promoting cell proliferation and survival. 2. **Neurodegenerative diseases:** EEF1D has been linked to neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. It is thought to play a role in the regulation of protein synthesis and aggregation in these diseases. 3. **Immune disorders:** EEF1D is involved in the regulation of immune responses, including the translation of cytokines and chemokines. It is thought to contribute to the development of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. In conclusion, EEF1D is a critical component of the eukaryotic translation elongation factor 1 complex, which plays a central role in protein synthesis and cellular homeostasis. Its dysregulation has been implicated in various diseases, highlighting the importance of EEF1D in maintaining cellular balance and promoting health. Further research is needed to fully elucidate the mechanisms by which EEF1D regulates protein synthesis and its role in disease pathogenesis.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.