Details for: HNRNPU

Gene ID: 3192

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: HNRNPU

Ensembl ID: ENSG00000153187

Description: heterogeneous nuclear ribonucleoprotein U

Cell Significance Landscape

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • hematopoietic stem cell CL0000037
    CSI 109.98
    rCSI 73.1%
    PRS 3.68
  • common myeloid progenitor CL0000049
    CSI 108.55
    rCSI 87.77%
    PRS 3.03
  • granulocyte monocyte progenitor cell CL0000557
    CSI 105.07
    rCSI 90.98%
    PRS 3.46
  • fallopian tube secretory epithelial cell CL4030006
    CSI 98.54
    rCSI 94.85%
    PRS 3.23
  • megakaryocyte-erythroid progenitor cell CL0000050
    CSI 95.66
    rCSI 86.39%
    PRS 2.72
  • CD14-low, CD16-positive monocyte CL0002396
    CSI 88.09
    rCSI 67.87%
    PRS 2.79
  • ciliated epithelial cell CL0000067
    CSI 72.58
    rCSI 63.83%
    PRS 2.25
  • fraction A pre-pro B cell CL0002045
    CSI 71.02
    rCSI 81.3%
    PRS 6.46
  • common dendritic progenitor CL0001029
    CSI 70.91
    rCSI 88.99%
    PRS 3.92
  • pro-B cell CL0000826
    CSI 68.81
    rCSI 56.98%
    PRS 3.1
  • early lymphoid progenitor CL0000936
    CSI 66.03
    rCSI 58%
    PRS 3.46
  • plasmacytoid dendritic cell, human CL0001058
    CSI 64.74
    rCSI 45.2%
    PRS 3.26
  • stem cell CL0000034
    CSI 62.04
    rCSI 59.82%
    PRS 1.31
  • promyelocyte CL0000836
    CSI 60.13
    rCSI 86.73%
    PRS 4.3
  • CD4-positive helper T cell CL0000492
    CSI 59.06
    rCSI 44.68%
    PRS 4.34
  • common lymphoid progenitor CL0000051
    CSI 56.48
    rCSI 75.47%
    PRS 5.93
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 56.26
    rCSI 64.98%
    PRS 2.84
  • BEST4+ enteroycte CL4030026
    CSI 56.16
    rCSI 69.85%
    PRS 3.31
  • intestinal epithelial cell CL0002563
    CSI 55.87
    rCSI 58.39%
    PRS 3.31
  • keratinocyte CL0000312
    CSI 52.86
    rCSI 44.31%
    PRS 3.73
  • promonocyte CL0000559
    CSI 51.8
    rCSI 88.74%
    PRS 4.13
  • epithelial cell of lung CL0000082
    CSI 48.42
    rCSI 40.14%
    PRS 2.9
  • conjunctival epithelial cell CL1000432
    CSI 46.88
    rCSI 71.6%
    PRS 3.12
  • double negative thymocyte CL0002489
    CSI 45.37
    rCSI 31.54%
    PRS 3.63
  • extravillous trophoblast CL0008036
    CSI 44.26
    rCSI 54.75%
    PRS 2.72
  • placental villous trophoblast CL2000060
    CSI 44.23
    rCSI 68.34%
    PRS 2.91
  • transit amplifying cell of colon CL0009011
    CSI 42.93
    rCSI 50.42%
    PRS 3.79
  • group 3 innate lymphoid cell CL0001071
    CSI 40.21
    rCSI 30.21%
    PRS 3.18
  • multi-ciliated epithelial cell CL0005012
    CSI 39.98
    rCSI 39.9%
    PRS 2.61
  • CD16-negative, CD56-bright natural killer cell, human CL0000938
    CSI 39.96
    rCSI 29.96%
    PRS 9.4
  • mature B cell CL0000785
    CSI 39.27
    rCSI 34.14%
    PRS 3.81
  • myeloid dendritic cell CL0000782
    CSI 38.79
    rCSI 56.19%
    PRS 4.55
  • lung ciliated cell CL1000271
    CSI 37.57
    rCSI 43.45%
    PRS 2.25
  • CD16-positive, CD56-dim natural killer cell, human CL0000939
    CSI 37.32
    rCSI 24.87%
    PRS 8.79
  • radial glial cell CL0000681
    CSI 37.1
    rCSI 51.54%
    PRS 3.28
  • respiratory suprabasal cell CL4033048
    CSI 36.93
    rCSI 47.36%
    PRS 3.58
  • intermediate monocyte CL0002393
    CSI 35.09
    rCSI 52.94%
    PRS 3.03
  • small intestine goblet cell CL1000495
    CSI 33.97
    rCSI 74.39%
    PRS 4.33
  • colon epithelial cell CL0011108
    CSI 33.89
    rCSI 35.5%
    PRS 2.89
  • neural crest cell CL0011012
    CSI 32.82
    rCSI 25.94%
    PRS 2.15
  • pancreatic ductal cell CL0002079
    CSI 32.62
    rCSI 63.44%
    PRS 3.16
  • myeloid leukocyte CL0000766
    CSI 31.94
    rCSI 29.47%
    PRS 3.13
  • plasmablast CL0000980
    CSI 31.53
    rCSI 24.8%
    PRS 3.68
  • pancreatic A cell CL0000171
    CSI 31.14
    rCSI 32.62%
    PRS 3.34
  • intestinal crypt stem cell of small intestine CL0009017
    CSI 30.61
    rCSI 82.51%
    PRS 4.06
  • transit amplifying cell CL0009010
    CSI 30.59
    rCSI 46.79%
    PRS 5.07
  • central memory CD4-positive, alpha-beta T cell CL0000904
    CSI 30.5
    rCSI 18.01%
    PRS 4.33
  • mucous neck cell CL0000651
    CSI 30.03
    rCSI 43.29%
    PRS 5.05
  • enteric smooth muscle cell CL0002504
    CSI 29.5
    rCSI 42.1%
    PRS 3.54
  • precursor B cell CL0000817
    CSI 29.05
    rCSI 25.45%
    PRS 4.18
  • Hofbauer cell CL3000001
    CSI 28.27
    rCSI 53.37%
    PRS 3.86
  • mesodermal cell CL0000222
    CSI 28.2
    rCSI 33.85%
    PRS 3.1
  • intestine goblet cell CL0019031
    CSI 27.83
    rCSI 24.71%
    PRS 3.1
  • stromal cell of ovary CL0002132
    CSI 27.4
    rCSI 75.28%
    PRS 5.22
  • intrahepatic cholangiocyte CL0002538
    CSI 27.32
    rCSI 65.56%
    PRS 5.91
  • lung endothelial cell CL1001567
    CSI 27.1
    rCSI 63.18%
    PRS 8.48
  • large pre-B-II cell CL0000957
    CSI 27.07
    rCSI 77.29%
    PRS 5.5
  • lymphoid lineage restricted progenitor cell CL0000838
    CSI 26.14
    rCSI 100%
    PRS 5.13
  • thymocyte CL0000893
    CSI 25.63
    rCSI 91.08%
    PRS 10.25
  • paneth cell of epithelium of small intestine CL1000343
    CSI 25.49
    rCSI 71.43%
    PRS 4.92
  • epithelial cell of lower respiratory tract CL0002632
    CSI 25.02
    rCSI 19.4%
    PRS 2.95
  • enteroendocrine cell of small intestine CL0009006
    CSI 25.01
    rCSI 55.07%
    PRS 4.86
  • central memory CD8-positive, alpha-beta T cell CL0000907
    CSI 24.85
    rCSI 16.74%
    PRS 3.76
  • neuroblast (sensu Vertebrata) CL0000031
    CSI 24.82
    rCSI 31.85%
    PRS 3.09
  • tendon cell CL0000388
    CSI 23.5
    rCSI 61.06%
    PRS 9.74
  • memory B cell CL0000787
    CSI 23.27
    rCSI 22.98%
    PRS 13.75
  • naive thymus-derived CD8-positive, alpha-beta T cell CL0000900
    CSI 23.19
    rCSI 16.29%
    PRS 9.41
  • retinal blood vessel endothelial cell CL0002585
    CSI 22.75
    rCSI 36.34%
    PRS 3.39
  • forebrain radial glial cell CL0013000
    CSI 22.69
    rCSI 72.8%
    PRS 4.75
  • microcirculation associated smooth muscle cell CL0008035
    CSI 22.65
    rCSI 65.59%
    PRS 3.53
  • dendritic cell, human CL0001056
    CSI 22.52
    rCSI 34.59%
    PRS 3.59
  • hematopoietic precursor cell CL0008001
    CSI 22.16
    rCSI 22.8%
    PRS 5.08
  • transitional stage B cell CL0000818
    CSI 22.11
    rCSI 72.38%
    PRS 9.76
  • keratocyte CL0002363
    CSI 21.06
    rCSI 50.63%
    PRS 4.88
  • CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920
    CSI 21.03
    rCSI 41.93%
    PRS 5.32
  • double-positive, alpha-beta thymocyte CL0000809
    CSI 20.71
    rCSI 21.11%
    PRS 4.5
  • transit amplifying cell of small intestine CL0009012
    CSI 20.46
    rCSI 89.8%
    PRS 6.1
  • epithelial cell CL0000066
    CSI 20.36
    rCSI 31.29%
    PRS 4.51
  • conventional dendritic cell CL0000990
    CSI 20.3
    rCSI 16.95%
    PRS 10.24
  • colon goblet cell CL0009039
    CSI 20.21
    rCSI 48.05%
    PRS 4.74
  • basal cell of prostate epithelium CL0002341
    CSI 19.87
    rCSI 57.49%
    PRS 6.87
  • myeloid lineage restricted progenitor cell CL0000839
    CSI 19.86
    rCSI 100%
    PRS 6.2
  • secretory cell CL0000151
    CSI 19.43
    rCSI 20.27%
    PRS 3.17
  • progenitor cell CL0011026
    CSI 19.24
    rCSI 40.93%
    PRS 6.15
  • peripheral nervous system neuron CL2000032
    CSI 19.07
    rCSI 25.98%
    PRS 2.81
  • plasmacytoid dendritic cell CL0000784
    CSI 18.11
    rCSI 18.34%
    PRS 20.56
  • mature T cell CL0002419
    CSI 17.52
    rCSI 13.63%
    PRS 4.49
  • hematopoietic multipotent progenitor cell CL0000837
    CSI 17.41
    rCSI 41.89%
    PRS 4.89
  • naive B cell CL0000788
    CSI 17.34
    rCSI 14.87%
    PRS 9.59
  • class switched memory B cell CL0000972
    CSI 17.28
    rCSI 12.9%
    PRS 5.24
  • glandular epithelial cell CL0000150
    CSI 17.28
    rCSI 45.51%
    PRS 6.1
  • duct epithelial cell CL0000068
    CSI 16.98
    rCSI 24.85%
    PRS 3.28
  • deuterosomal cell CL4033044
    CSI 16.93
    rCSI 57.25%
    PRS 5.35
  • endothelial cell of placenta CL0009092
    CSI 16.64
    rCSI 82.04%
    PRS 4.23
  • tracheal goblet cell CL1000329
    CSI 16.39
    rCSI 35.78%
    PRS 6.36
  • tissue-resident macrophage CL0000864
    CSI 16.22
    rCSI 75.93%
    PRS 8.86
  • perivascular cell CL4033054
    CSI 15.92
    rCSI 21.77%
    PRS 3.53
  • foveolar cell of stomach CL0002179
    CSI 15.73
    rCSI 33.48%
    PRS 5.06
  • colon macrophage CL0009038
    CSI 15.19
    rCSI 70.14%
    PRS 7.01
  • skin fibroblast CL0002620
    CSI 15.18
    rCSI 13.09%
    PRS 5.18
  • CD4-positive, alpha-beta thymocyte CL0000810
    CSI -35.3
    rCSI -28.3%
    PRS 5.8%
  • naive T cell CL0000898
    CSI -34.1
    rCSI -23.7%
    PRS 4.5%
  • vascular leptomeningeal cell CL4023051
    CSI -15.0
    rCSI -26.3%
    PRS 2.5%
  • cardiac neuron CL0010022
    CSI -14.7
    rCSI -47.1%
    PRS 2.3%
  • platelet CL0000233
    CSI -14.6
    rCSI -60.7%
    PRS 9.7%
  • retinal bipolar neuron CL0000748
    CSI -14.4
    rCSI -27.0%
    PRS 2.5%
  • renal alpha-intercalated cell CL0005011
    CSI -14.3
    rCSI -19.2%
    PRS 4.2%
  • renal beta-intercalated cell CL0002201
    CSI -14.1
    rCSI -33.5%
    PRS 4.1%
  • central nervous system macrophage CL0000878
    CSI -12.3
    rCSI -40.6%
    PRS 2.7%
  • inflammatory macrophage CL0000863
    CSI -12.1
    rCSI -20.6%
    PRS 6.4%
  • neural cell CL0002319
    CSI -11.0
    rCSI -41.5%
    PRS 7.0%
  • microglial cell CL0000129
    CSI -10.1
    rCSI -40.6%
    PRS 15.3%
  • inhibitory interneuron CL0000498
    CSI -8.5
    rCSI -19.6%
    PRS 2.9%
  • ependymal cell CL0000065
    CSI -8.4
    rCSI -17.1%
    PRS 1.0%
  • brain vascular cell CL4023072
    CSI -8.0
    rCSI -83.1%
    PRS 3.1%
  • effector CD8-positive, alpha-beta T cell CL0001050
    CSI -8.0
    rCSI -6.1%
    PRS 4.1%
  • dopaminergic neuron CL0000700
    CSI -7.1
    rCSI -40.0%
    PRS 0.9%
  • kidney interstitial alternatively activated macrophage CL1000695
    CSI -6.9
    rCSI -17.9%
    PRS 3.8%
  • midzonal region hepatocyte CL0019028
    CSI -6.5
    rCSI -15.4%
    PRS 5.6%
  • kidney proximal convoluted tubule epithelial cell CL1000838
    CSI -5.9
    rCSI -62.2%
    PRS 38.7%
  • fibroblast of cardiac tissue CL0002548
    CSI -5.7
    rCSI -27.1%
    PRS 1.5%
  • cerebellar neuron CL1001611
    CSI -5.4
    rCSI -47.3%
    PRS 0.8%
  • Schwann cell CL0002573
    CSI -5.4
    rCSI -15.3%
    PRS 4.3%
  • cerebral cortex endothelial cell CL1001602
    CSI -5.3
    rCSI -9.2%
    PRS 2.4%
  • exhausted T cell CL0011025
    CSI -4.6
    rCSI -77.8%
    PRS 16.8%
  • effector CD4-positive, alpha-beta T cell CL0001044
    CSI -4.4
    rCSI -12.5%
    PRS 4.5%
  • endocardial cell CL0002350
    CSI -4.3
    rCSI -20.6%
    PRS 5.4%
  • cerebral cortex neuron CL0010012
    CSI -4.2
    rCSI -16.9%
    PRS 4.0%
  • cardiac endothelial cell CL0010008
    CSI -4.1
    rCSI -16.4%
    PRS 3.6%
  • lung pericyte CL0009089
    CSI -3.2
    rCSI -8.5%
    PRS 3.7%
  • glycinergic amacrine cell CL4030028
    CSI -2.9
    rCSI -7.6%
    PRS 4.5%
  • epicardial adipocyte CL1000309
    CSI -2.8
    rCSI -9.0%
    PRS 5.4%
  • primordial germ cell CL0000670
    CSI -2.7
    rCSI -13.7%
    PRS 24.3%
  • endocrine cell CL0000163
    CSI -2.7
    rCSI -13.9%
    PRS 15.1%
  • CD8-positive, alpha-beta thymocyte CL0000811
    CSI -2.6
    rCSI -4.0%
    PRS 8.0%
  • Bergmann glial cell CL0000644
    CSI -2.5
    rCSI -3.4%
    PRS 3.5%
  • hepatic pit cell CL2000054
    CSI -2.4
    rCSI -32.9%
    PRS 35.7%
  • erythroid lineage cell CL0000764
    CSI -2.4
    rCSI -15.4%
    PRS 8.7%
  • lung interstitial macrophage CL4033043
    CSI -2.4
    rCSI -5.3%
    PRS 8.0%
  • epithelial cell of proximal tubule CL0002306
    CSI -2.3
    rCSI -5.7%
    PRS 3.3%
  • CD4-positive, alpha-beta memory T cell CL0000897
    CSI -2.3
    rCSI -1.6%
    PRS 4.2%
  • basal cell of epidermis CL0002187
    CSI -2.1
    rCSI -3.7%
    PRS 4.4%
  • stratified epithelial cell CL0000079
    CSI -1.9
    rCSI -11.8%
    PRS 16.4%
  • brush cell of tracheobronchial tree CL0002075
    CSI -1.9
    rCSI -5.6%
    PRS 5.5%
  • brush cell CL0002204
    CSI -1.8
    rCSI -3.5%
    PRS 9.2%
  • periportal region hepatocyte CL0019026
    CSI -1.6
    rCSI -6.0%
    PRS 5.3%
  • adipocyte CL0000136
    CSI -1.5
    rCSI -2.0%
    PRS 4.1%
  • astrocyte of the cerebral cortex CL0002605
    CSI -1.5
    rCSI -3.3%
    PRS 2.0%
  • tracheobronchial smooth muscle cell CL0019019
    CSI -1.4
    rCSI -2.5%
    PRS 4.1%
  • kidney interstitial fibroblast CL1000692
    CSI -1.3
    rCSI -6.6%
    PRS 19.4%
  • erythrocyte CL0000232
    CSI -0.8
    rCSI -1.8%
    PRS 4.5%
  • Purkinje cell CL0000121
    CSI -0.8
    rCSI -10.4%
    PRS 27.1%
  • kidney granular cell CL0000648
    CSI -0.8
    rCSI -11.0%
    PRS 34.1%
  • interneuron CL0000099
    CSI -0.8
    rCSI -1.5%
    PRS 2.3%
  • regular ventricular cardiac myocyte CL0002131
    CSI -0.7
    rCSI -4.3%
    PRS 2.6%
  • skeletal muscle satellite cell CL0000594
    CSI -0.6
    rCSI -1.8%
    PRS 13.4%
  • flat midget bipolar cell CL4033033
    CSI -0.5
    rCSI -3.5%
    PRS 5.8%
  • serous secreting cell CL0000313
    CSI -0.4
    rCSI -2.2%
    PRS 16.5%
  • OFFx cell CL4033036
    CSI -0.4
    rCSI -1.9%
    PRS 6.7%
  • decidual natural killer cell, human CL0002343
    CSI -0.3
    rCSI -2.7%
    PRS 29.9%
  • airway submucosal gland duct basal cell CL4033024
    CSI -0.2
    rCSI -1.2%
    PRS 15.5%
  • cytotoxic T cell CL0000910
    CSI -0.1
    rCSI -0.3%
    PRS 5.0%
  • ventricular cardiac muscle cell CL2000046
    CSI 0.0
    rCSI 0.1%
    PRS 14.6%
  • IgM plasma cell CL0000986
    CSI 0.1
    rCSI 0.5%
    PRS 17.2%
  • serotonergic neuron CL0000850
    CSI 0.2
    rCSI 0.8%
    PRS 1.0%
  • NKp44-negative group 3 innate lymphoid cell, human CL0001080
    CSI 0.2
    rCSI 6.1%
    PRS 40.8%
  • regular atrial cardiac myocyte CL0002129
    CSI 0.3
    rCSI 1.0%
    PRS 3.9%
  • pancreatic epsilon cell CL0005019
    CSI 0.3
    rCSI 1.5%
    PRS 7.8%
  • collagen secreting cell CL0000667
    CSI 0.3
    rCSI 1.9%
    PRS 18.5%
  • parietal cell CL0000162
    CSI 0.4
    rCSI 3.1%
    PRS 22.3%
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 0.4
    rCSI 0.7%
    PRS 1.9%
  • Merkel cell CL0000242
    CSI 0.4
    rCSI 9.4%
    PRS 23.5%
  • uterine smooth muscle cell CL0002601
    CSI 0.5
    rCSI 3.1%
    PRS 24.7%
  • helper T cell CL0000912
    CSI 0.6
    rCSI 0.8%
    PRS 4.8%
  • macroglial cell CL0000126
    CSI 0.6
    rCSI 1.5%
    PRS 5.8%
  • L6b glutamatergic cortical neuron CL4023038
    CSI 0.6
    rCSI 1.9%
    PRS 2.0%
  • diffuse bipolar 3b cell CL4033030
    CSI 0.6
    rCSI 4.0%
    PRS 6.5%
  • diffuse bipolar 6 cell CL4033032
    CSI 0.6
    rCSI 3.3%
    PRS 7.7%
  • medium spiny neuron CL1001474
    CSI 0.7
    rCSI 5.7%
    PRS 0.3%
  • pulmonary alveolar type 1 cell CL0002062
    CSI 0.7
    rCSI 3.9%
    PRS 4.8%
  • Mueller cell CL0000636
    CSI 0.7
    rCSI 1.7%
    PRS 3.0%
  • epithelial cell of esophagus CL0002252
    CSI 0.7
    rCSI 7.3%
    PRS 13.0%
  • endothelial cell of venule CL1000414
    CSI 0.7
    rCSI 6.6%
    PRS 20.5%
  • vasa recta descending limb cell CL1001285
    CSI 0.7
    rCSI 5.9%
    PRS 14.6%
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 0.8
    rCSI 2.4%
    PRS 2.2%
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 0.8
    rCSI 1.9%
    PRS 1.9%
  • glial cell CL0000125
    CSI 0.8
    rCSI 3.0%
    PRS 3.4%
  • podocyte CL0000653
    CSI 0.8
    rCSI 3.6%
    PRS 3.1%
  • paneth cell of colon CL0009009
    CSI 0.8
    rCSI 8.3%
    PRS 9.6%
  • kidney loop of Henle epithelial cell CL1000909
    CSI 0.9
    rCSI 17.9%
    PRS 28.6%
  • starburst amacrine cell CL0004232
    CSI 0.9
    rCSI 7.5%
    PRS 6.4%
  • macula densa epithelial cell CL1000850
    CSI 0.9
    rCSI 13.1%
    PRS 39.5%
  • kidney distal convoluted tubule epithelial cell CL1000849
    CSI 0.9
    rCSI 9.7%
    PRS 5.5%
  • diffuse bipolar 3a cell CL4033029
    CSI 0.9
    rCSI 6.3%
    PRS 6.3%
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 0.9
    rCSI 3.6%
    PRS 2.0%
  • cell of skeletal muscle CL0000188
    CSI 1.0
    rCSI 10.4%
    PRS 22.7%
  • endothelial cell of vascular tree CL0002139
    CSI 1.0
    rCSI 5.2%
    PRS 8.3%
  • neuroendocrine cell CL0000165
    CSI 1.0
    rCSI 3.8%
    PRS 6.8%
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 1.0
    rCSI 3.7%
    PRS 1.7%
  • effector memory CD8-positive, alpha-beta T cell CL0000913
    CSI 1.0
    rCSI 0.9%
    PRS 4.9%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.

Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [HNRNPU](/details-gene/3192) (Heterogeneous Nuclear Ribonucleoprotein U) is a multifunctional protein primarily located in the nucleus, where it plays a critical role in fundamental cellular processes including [RNA processing](/details-gene/GO:0006396), [mRNA splicing, via spliceosome](/details-gene/GO:0000398), and the structural [organization of chromatin](/details-gene/GO:0006325). Also known as Scaffold Attachment Factor A (SAF-A), it binds to both DNA and RNA to regulate gene expression, transcription, and the maintenance of nuclear architecture [Link](https://doi.org/10.1002/j.1460-2075.1992.tb05422.x). Expression data indicates that **Overall**, [HNRNPU](/details-gene/3192) is most significant in progenitor and stem cell populations, particularly within the hematopoietic lineage, such as [hematopoietic stem cell](/details-cell/CL0000037) and [common myeloid progenitor](/details-cell/CL0000049). This expression pattern is consistent with its annotated functions in regulating the cell cycle and stem cell proliferation, suggesting it is a key factor in maintaining the undifferentiated state and lineage potential of early developmental cells. Its clinical relevance is noted in association with developmental disorders ([153245](https://omim.org/entry/602869)). ## Cellular Roles and Expression Landscape **Overall**, the expression profile of [HNRNPU](/details-gene/3192) highlights its profound importance in highly proliferative and multipotent cell populations. The gene shows the highest significance in a cascade of hematopoietic progenitors, including [hematopoietic stem cell](/details-cell/CL0000037) (CSI: 109.98), [common myeloid progenitor](/details-cell/CL0000049) (CSI: 108.55), [granulocyte monocyte progenitor cell](/details-cell/CL0000557) (CSI: 105.07), and [megakaryocyte-erythroid progenitor cell](/details-cell/CL0000050) (CSI: 95.66). Its prominence extends to early lymphoid development, as seen in [fraction A pre-pro B cell](/details-cell/CL0002045) and [pro-B cell](/details-cell/CL0000826). This pattern suggests a central role for [HNRNPU](/details-gene/3192) in orchestrating the gene expression programs that govern self-renewal and lineage commitment at the earliest stages of blood cell formation. Beyond hematopoiesis, its high significance in cells such as [fallopian tube secretory epithelial cell](/details-cell/CL4030006) and [ciliated epithelial cell](/details-cell/CL0000067) indicates a broader function in other transcriptionally active or cycling cell types. Conversely, the gene's significance is notably low in terminally differentiated, post-mitotic cells. This is particularly evident in the nervous system, with low scores in [cardiac neuron](/details-cell/CL0010022), [retinal bipolar neuron](/details-cell/CL0000748), and [microglial cell](/details-cell/CL0000129). Furthermore, its low significance in quiescent or mature cell types like [platelet](/details-cell/CL0000233) and [naive T cell](/details-cell/CL0000898) reinforces the hypothesis that its primary functions are associated with cell division, proliferation, and developmental plasticity rather than the maintenance of a terminally differentiated state. ## Pathways and Molecular Function [HNRNPU](/details-gene/3192) is a quintessential nuclear protein with diverse molecular functions centered on nucleic acid binding and regulation. Its involvement in the [Metabolism of rna](/details-gene/R-HSA-8953854) and [Processing of capped intron-containing pre-mrna](/details-gene/R-HSA-72203) pathways is foundational to its identity. Functionally, it acts as a key component of the spliceosome, participating in both [Mrna splicing, via spliceosome](/details-gene/GO:0000398) and the [Regulation of alternative mrna splicing, via spliceosome](/details-gene/GO:0000381). This role allows it to control the diversity of protein isoforms produced within a cell, a critical process in development and differentiation. The protein's high significance in progenitor cells is directly explained by its annotated roles in [Positive regulation of stem cell proliferation](/details-gene/GO:2000648) and [Negative regulation of stem cell differentiation](/details-gene/GO:2000737). It also plays a direct part in the mechanics of cell division, as evidenced by its localization to the [mitotic spindle](/details-gene/GO:0072686) and [kinetochore](/details-gene/GO:0000776), and its role in the [Regulation of mitotic cell cycle](/details-gene/GO:0007346). As a scaffold protein (SAF-A), [HNRNPU](/details-gene/3192) is integral to higher-order [Chromatin organization](/details-gene/GO:0006325) by binding to nuclear matrix/scaffold attachment regions, thereby structuring the genome for active transcription or repression [Link](https://doi.org/10.1021/bi970480f). It exhibits broad binding capabilities, interacting with various forms of DNA and RNA, including [lncRNA binding](/details-gene/GO:0106222) and [promoter-specific chromatin binding](/details-gene/GO:1990841). This functional versatility positions it as a master regulator that integrates transcriptional control, RNA processing, and cell cycle progression. ## Research Directions The striking contrast between the high significance of [HNRNPU](/details-gene/3192) in progenitor cells and its low significance in their terminally differentiated descendants provides a fertile ground for investigation into the mechanisms of cellular differentiation and lineage commitment. **Proposed Hypotheses:** 1. **Role as a Stemness Gatekeeper:** Given its functions in promoting proliferation and inhibiting differentiation, [HNRNPU](/details-gene/3192) may act as a critical gatekeeper of the hematopoietic stem cell state. We hypothesize that its targeted downregulation is a necessary and early event that licenses [hematopoietic stem cell](/details-cell/CL0000037) to exit self-renewal and commit to a specific differentiation trajectory. 2. **Architectural Reprogramming during Differentiation:** As a scaffold attachment factor, [HNRNPU](/details-gene/3192) likely establishes a global chromatin architecture permissive for multipotency. We hypothesize that the loss of [HNRNPU](/details-gene/3192) function during differentiation triggers large-scale chromatin reorganization, leading to the stable silencing of pluripotency-associated genes and the activation of lineage-specific transcriptional programs. **Experimental Approach to Test Hypothesis 1:** To test the role of [HNRNPU](/details-gene/3192) as a stemness gatekeeper, one could utilize a loss-of-function approach in a primary cell model. Specifically, CRISPR-Cas9-mediated knockout of [HNRNPU](/details-gene/3192) would be performed in isolated human CD34+ [hematopoietic stem cell](/details-cell/CL0000037). These modified cells, alongside wild-type controls, would then be subjected to in vitro colony-forming unit (CFU) assays with a cocktail of cytokines that support multilineage differentiation. The resulting colonies (e.g., CFU-GM, BFU-E) would be quantified to assess shifts in lineage potential. Concurrently, single-cell RNA sequencing (scRNA-seq) combined with lineage-specific surface marker analysis by flow cytometry would be used to precisely map the differentiation trajectories and identify whether the loss of [HNRNPU](/details-gene/3192) accelerates differentiation or skews commitment towards a particular hematopoietic fate. **Therapeutic Potential:** As a nuclear protein integral to fundamental processes like RNA splicing and cell division, [HNRNPU](/details-gene/3192) presents a challenging therapeutic target due to the high risk of on-target toxicity in healthy proliferative tissues, such as bone marrow and epithelia. However, its role in maintaining a proliferative, undifferentiated state makes it a potential target for **inhibition** in the context of hematological malignancies. Cancers like acute myeloid leukemia often depend on reactivated developmental programs for uncontrolled self-renewal. Therapeutic strategies aimed at disrupting [HNRNPU](/details-gene/3192)'s function, for example by inhibiting its binding to key RNA or chromatin targets, could theoretically induce differentiation or apoptosis in leukemic stem cells. Development of such therapies would require careful consideration of the therapeutic window to minimize damage to healthy hematopoietic progenitors.

Genular Protein ID: 914217558

Symbol: HNRPU_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1628625

Title: Primary structure and binding activity of the hnRNP U protein: binding RNA through RGG box.

PubMed ID: 1628625

DOI: 10.1002/j.1460-2075.1992.tb05331.x

PubMed ID: 7509195

Title: hnRNP-U/SAF-A is encoded by two differentially polyadenylated mRNAs in human cells.

PubMed ID: 7509195

DOI: 10.1016/0167-4781(94)90044-2

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7993898

Title: Major cell surface-located protein substrates of an ecto-protein kinase are homologs of known nuclear proteins.

PubMed ID: 7993898

DOI: 10.1021/bi00253a007

PubMed ID: 1324173

Title: Characterization of SAF-A, a novel nuclear DNA binding protein from HeLa cells with high affinity for nuclear matrix/scaffold attachment DNA elements.

PubMed ID: 1324173

DOI: 10.1002/j.1460-2075.1992.tb05422.x

PubMed ID: 8068679

Title: Purification of two isoforms of hnRNP-U and characterization of their nucleic acid binding activity.

PubMed ID: 8068679

DOI: 10.1021/bi00200a024

PubMed ID: 8174554

Title: Nucleic-acid-binding properties of hnRNP-U/SAF-A, a nuclear-matrix protein which binds DNA and RNA in vivo and in vitro.

PubMed ID: 8174554

DOI: 10.1111/j.1432-1033.1994.tb18788.x

PubMed ID: 7753047

Title: Binding sites of the Epstein-Barr virus and C3d receptor (CR2, CD21) for its three intracellular ligands, the p53 anti-oncoprotein, the p68 calcium binding protein and the nuclear p120 ribonucleoprotein.

PubMed ID: 7753047

DOI: 10.1016/0161-5890(95)00005-y

PubMed ID: 9204873

Title: The scaffold/matrix attachment region binding protein hnRNP-U (SAF-A) is directly bound to chromosomal DNA in vivo: a chemical cross-linking study.

PubMed ID: 9204873

DOI: 10.1021/bi970480f

PubMed ID: 9105675

Title: The class III POU factor Brn-4 interacts with other class III POU factors and the heterogeneous nuclear ribonucleoprotein U.

PubMed ID: 9105675

DOI: 10.1016/s0169-328x(96)00238-0

PubMed ID: 9405365

Title: The novel SAR-binding domain of scaffold attachment factor A (SAF-A) is a target in apoptotic nuclear breakdown.

PubMed ID: 9405365

DOI: 10.1093/emboj/16.24.7361

PubMed ID: 9353307

Title: The glucocorticoid receptor is associated with the RNA-binding nuclear matrix protein hnRNP U.

PubMed ID: 9353307

DOI: 10.1074/jbc.272.45.28471

PubMed ID: 10490622

Title: hnRNP U inhibits carboxy-terminal domain phosphorylation by TFIIH and represses RNA polymerase II elongation.

PubMed ID: 10490622

DOI: 10.1128/mcb.19.10.6833

PubMed ID: 10671544

Title: Apoptotic cleavage of scaffold attachment factor A (SAF-A) by caspase-3 occurs at a noncanonical cleavage site.

PubMed ID: 10671544

DOI: 10.1074/jbc.275.7.5031

PubMed ID: 11003645

Title: SAF-Box, a conserved protein domain that specifically recognizes scaffold attachment region DNA.

PubMed ID: 11003645

DOI: 10.1128/mcb.20.20.7480-7489.2000

PubMed ID: 11909954

Title: Scaffold/matrix attachment region elements interact with a p300-scaffold attachment factor A complex and are bound by acetylated nucleosomes.

PubMed ID: 11909954

DOI: 10.1128/mcb.22.8.2598-2606.2002

PubMed ID: 11991638

Title: Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.

PubMed ID: 11991638

DOI: 10.1017/s1355838202021088

PubMed ID: 14608463

Title: Scaffold attachment factor A (SAF-A) is concentrated in inactive X chromosome territories through its RGG domain.

PubMed ID: 14608463

DOI: 10.1007/s00412-003-0258-0

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15563465

Title: A stable proteinaceous structure in the territory of inactive X chromosomes.

PubMed ID: 15563465

DOI: 10.1074/jbc.c400531200

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 15711563

Title: Actin and hnRNP U cooperate for productive transcription by RNA polymerase II.

PubMed ID: 15711563

DOI: 10.1038/nsmb904

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16916646

Title: Inhibition of HIV-1 gene expression by a fragment of hnRNP U.

PubMed ID: 16916646

DOI: 10.1016/j.molcel.2006.07.021

PubMed ID: 17487921

Title: Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line.

PubMed ID: 17487921

DOI: 10.1002/elps.200600782

PubMed ID: 17174306

Title: hnRNP-U enhances the expression of specific genes by stabilizing mRNA.

PubMed ID: 17174306

DOI: 10.1016/j.febslet.2006.11.062

PubMed ID: 18082603

Title: Purification of human telomerase complexes identifies factors involved in telomerase biogenesis and telomere length regulation.

PubMed ID: 18082603

DOI: 10.1016/j.molcel.2007.09.023

PubMed ID: 17289661

Title: Molecular composition of IMP1 ribonucleoprotein granules.

PubMed ID: 17289661

DOI: 10.1074/mcp.m600346-mcp200

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19617346

Title: Physical and functional interaction between heterochromatin protein 1alpha and the RNA-binding protein heterogeneous nuclear ribonucleoprotein U.

PubMed ID: 19617346

DOI: 10.1074/jbc.m109.037929

PubMed ID: 19808671

Title: Identification of a heterogeneous nuclear ribonucleoprotein-recognition region in the HIV Rev protein.

PubMed ID: 19808671

DOI: 10.1074/jbc.m109.021659

PubMed ID: 19029303

Title: Control of c-myc mRNA stability by IGF2BP1-associated cytoplasmic RNPs.

PubMed ID: 19029303

DOI: 10.1261/rna.1175909

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20858735

Title: Interactions of ErbB4 and Kap1 connect the growth factor and DNA damage response pathways.

PubMed ID: 20858735

DOI: 10.1158/1541-7786.mcr-10-0042

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21242313

Title: The nuclear scaffold protein SAF-A is required for kinetochore-microtubule attachment and contributes to the targeting of Aurora-A to mitotic spindles.

PubMed ID: 21242313

DOI: 10.1242/jcs.063347

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22325991

Title: Nuclear matrix factor hnRNP U/SAF-A exerts a global control of alternative splicing by regulating U2 snRNP maturation.

PubMed ID: 22325991

DOI: 10.1016/j.molcel.2012.01.009

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23811339

Title: H19 inhibits RNA polymerase II-mediated transcription by disrupting the hnRNP U-actin complex.

PubMed ID: 23811339

DOI: 10.1016/j.bbagen.2013.06.026

PubMed ID: 23640942

Title: Subcellular localization and RNP formation of IGF2BPs (IGF2 mRNA-binding proteins) is modulated by distinct RNA-binding domains.

PubMed ID: 23640942

DOI: 10.1515/hsz-2013-0111

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25911097

Title: Gemin5 binds to the survival motor neuron mRNA to regulate SMN expression.

PubMed ID: 25911097

DOI: 10.1074/jbc.m115.646257

PubMed ID: 25616961

Title: ALS-linked mutations in ubiquilin-2 or hnRNPA1 reduce interaction between ubiquilin-2 and hnRNPA1.

PubMed ID: 25616961

DOI: 10.1093/hmg/ddv020

PubMed ID: 25986610

Title: Phosphorylation of SAF-A/hnRNP-U serine 59 by polo-like kinase 1 is required for mitosis.

PubMed ID: 25986610

DOI: 10.1128/mcb.01312-14

PubMed ID: 26244333

Title: Xist exon 7 contributes to the stable localization of Xist RNA on the inactive X-chromosome.

PubMed ID: 26244333

DOI: 10.1371/journal.pgen.1005430

PubMed ID: 26030138

Title: Identification of Novel Proteins Co-Purifying with Cockayne Syndrome Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and Chromatin Dynamics.

PubMed ID: 26030138

DOI: 10.1371/journal.pone.0128558

PubMed ID: 28622508

Title: SAF-A regulates interphase chromosome structure through oligomerization with chromatin-associated RNAs.

PubMed ID: 28622508

DOI: 10.1016/j.cell.2017.05.029

PubMed ID: 28190768

Title: Serine ADP-ribosylation depends on HPF1.

PubMed ID: 28190768

DOI: 10.1016/j.molcel.2017.01.003

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 23708187

Title: Targeted resequencing in epileptic encephalopathies identifies de novo mutations in CHD2 and SYNGAP1.

PubMed ID: 23708187

DOI: 10.1038/ng.2646

PubMed ID: 25356899

Title: De novo mutations in moderate or severe intellectual disability.

PubMed ID: 25356899

DOI: 10.1371/journal.pgen.1004772

Sequence Information:

  • Length: 825
  • Mass: 90584
  • Checksum: 5D4EC4188436831F
  • Sequence:
  • MSSSPVNVKK LKVSELKEEL KKRRLSDKGL KAELMERLQA ALDDEEAGGR PAMEPGNGSL 
    DLGGDSAGRS GAGLEQEAAA GGDEEEEEEE EEEEGISALD GDQMELGEEN GAAGAADSGP 
    MEEEEAASED ENGDDQGFQE GEDELGDEEE GAGDENGHGE QQPQPPATQQ QQPQQQRGAA 
    KEAAGKSSGP TSLFAVTVAP PGARQGQQQA GGKKKAEGGG GGGRPGAPAA GDGKTEQKGG 
    DKKRGVKRPR EDHGRGYFEY IEENKYSRAK SPQPPVEEED EHFDDTVVCL DTYNCDLHFK 
    ISRDRLSASS LTMESFAFLW AGGRASYGVS KGKVCFEMKV TEKIPVRHLY TKDIDIHEVR 
    IGWSLTTSGM LLGEEEFSYG YSLKGIKTCN CETEDYGEKF DENDVITCFA NFESDEVELS 
    YAKNGQDLGV AFKISKEVLA GRPLFPHVLC HNCAVEFNFG QKEKPYFPIP EEYTFIQNVP 
    LEDRVRGPKG PEEKKDCEVV MMIGLPGAGK TTWVTKHAAE NPGKYNILGT NTIMDKMMVA 
    GFKKQMADTG KLNTLLQRAP QCLGKFIEIA ARKKRNFILD QTNVSAAAQR RKMCLFAGFQ 
    RKAVVVCPKD EDYKQRTQKK AEVEGKDLPE HAVLKMKGNF TLPEVAECFD EITYVELQKE 
    EAQKLLEQYK EESKKALPPE KKQNTGSKKS NKNKSGKNQF NRGGGHRGRG GFNMRGGNFR 
    GGAPGNRGGY NRRGNMPQRG GGGGGSGGIG YPYPRAPVFP GRGSYSNRGN YNRGGMPNRG 
    NYNQNFRGRG NNRGYKNQSQ GYNQWQQGQF WGQKPWSQHY HQGYY

Genular Protein ID: 2637126500

Symbol: Q96BA7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 722
  • Mass: 79716
  • Checksum: A35C0DA46EAE6FD2
  • Sequence:
  • MELGEENGAA GAADSGPMEE EEAASEDENG DDQGFQEGED ELGDEEEGAG DENGHGEQQP 
    QPPATQQQQP QQQRGAAKEA AGKSSGPTSL FAVTVAPPGA RQGQQQAGGK KKAEGGGGGG 
    RPGAPAAGDG KTEQKGGDKK RGVKRPREDH GRGYFEYIEE NKYSRAKSPQ PPVEEEDEHF 
    DDTVVCLDTY NCDLHFKISR DRLSASSLTM ESFAFLWAGG RASYGVSKGK VCFEMKVTEK 
    IPVRHLYTKD IDIHEVRIGW SLTTSGMLLG EEEFSYGYSL KGIKTCNCET EDYGEKFDEN 
    DVITCFANFE SDEVELSYAK NGQDLGVAFK ISKEVLAGRP LFPHVLCHNC AVEFNFGQKE 
    KPYFPIPEEY TFIQNVPLED RVRGPKGPEE KKDCEVVMMI GLPGAGKTTW VTKHAAENPG 
    KYNILGTNTI MDKMMVAGFK KQMADTGKLN TLLQRAPQCL GKFIEIAARK KRNFILDQTN 
    VSAAAQRRKM CLFAGFQRKA VVVCPKDEDY KQRTQKKAEV EGKDLPEHAV LKMKGNFTLP 
    EVAECFDEIT YVELQKEEAQ KLLEQYKEES KKALPPEKKQ NTGSKKSNKN KSGKNQFNRG 
    GGHRGRGGFN MRGGNFRGGA PGNRGGYNRR GNMPQRGGGG GGSGGIGYPY PRAPVFPGRG 
    SYSNRGNYNR GGMPNRGNYN QNFRGRGNNR GYKNQSQGYN QWQQGQFWGQ KPWSQHYHQG 
    YY