Details for: HNRNPU

Gene ID: 3192

Symbol: HNRNPU

Ensembl ID: ENSG00000153187

Description: heterogeneous nuclear ribonucleoprotein U

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 810.1181
    Cell Significance Index: -126.0100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 504.5667
    Cell Significance Index: -127.9800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 369.0275
    Cell Significance Index: -152.0200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 325.2651
    Cell Significance Index: -153.5700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 315.2437
    Cell Significance Index: -128.0700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 282.4342
    Cell Significance Index: -145.2800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 229.1504
    Cell Significance Index: -153.7700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 135.4187
    Cell Significance Index: -129.2900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 118.6255
    Cell Significance Index: -146.2600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 49.4464
    Cell Significance Index: -132.4600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 38.1527
    Cell Significance Index: -150.5500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 37.1746
    Cell Significance Index: -114.1800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 5.0042
    Cell Significance Index: 136.2100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 4.8433
    Cell Significance Index: 312.4700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 3.6134
    Cell Significance Index: 444.3000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 3.5949
    Cell Significance Index: 95.9900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.2217
    Cell Significance Index: 442.4300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 3.0368
    Cell Significance Index: 547.4400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.0015
    Cell Significance Index: 86.0400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.8733
    Cell Significance Index: 570.2200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.8643
    Cell Significance Index: 134.6200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.7721
    Cell Significance Index: 125.6500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.4233
    Cell Significance Index: 69.8200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.2219
    Cell Significance Index: 58.4300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.1825
    Cell Significance Index: 122.4700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.1237
    Cell Significance Index: 49.0700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.9170
    Cell Significance Index: 1046.9400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.8897
    Cell Significance Index: 242.2500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.8501
    Cell Significance Index: 817.9900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.6394
    Cell Significance Index: 193.3400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6295
    Cell Significance Index: 326.8800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.6149
    Cell Significance Index: 99.2600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.5131
    Cell Significance Index: 32.7800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.4935
    Cell Significance Index: 535.7100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.4549
    Cell Significance Index: 26.8900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.3302
    Cell Significance Index: 144.6900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.2807
    Cell Significance Index: 44.5100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.2445
    Cell Significance Index: 92.7500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.2384
    Cell Significance Index: 57.7400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.2324
    Cell Significance Index: 87.1600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.1319
    Cell Significance Index: 58.9600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.1111
    Cell Significance Index: 143.5400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0006
    Cell Significance Index: 51.9800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.7986
    Cell Significance Index: 362.4400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6086
    Cell Significance Index: 46.7000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5087
    Cell Significance Index: 351.8300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.4534
    Cell Significance Index: 853.7700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.3723
    Cell Significance Index: 4.2300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3697
    Cell Significance Index: 70.3600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3655
    Cell Significance Index: 7.6500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3548
    Cell Significance Index: 60.5800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2540
    Cell Significance Index: 8.9300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2294
    Cell Significance Index: 145.7100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2044
    Cell Significance Index: 12.8800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1846
    Cell Significance Index: 284.2000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1371
    Cell Significance Index: 252.9300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1193
    Cell Significance Index: 8.0200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0833
    Cell Significance Index: 61.0800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0189
    Cell Significance Index: 25.7600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: -0.0478
    Cell Significance Index: -43.1200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0507
    Cell Significance Index: -38.3800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0697
    Cell Significance Index: -1.3600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0800
    Cell Significance Index: -13.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0843
    Cell Significance Index: -62.4200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0992
    Cell Significance Index: -61.9600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1312
    Cell Significance Index: -2.2000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1529
    Cell Significance Index: -15.6200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1927
    Cell Significance Index: -10.1200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2050
    Cell Significance Index: -115.6000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3805
    Cell Significance Index: -80.1500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3897
    Cell Significance Index: -6.6800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4320
    Cell Significance Index: -62.7900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.4344
    Cell Significance Index: -42.9700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.4633
    Cell Significance Index: -133.3100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.5845
    Cell Significance Index: -29.5400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6754
    Cell Significance Index: -29.8800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.8019
    Cell Significance Index: -83.5000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.8158
    Cell Significance Index: -11.1300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.8947
    Cell Significance Index: -102.5000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.9147
    Cell Significance Index: -29.3000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.9216
    Cell Significance Index: -34.9000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.9364
    Cell Significance Index: -109.1300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.9864
    Cell Significance Index: -112.6000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -1.0794
    Cell Significance Index: -31.7000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -1.1177
    Cell Significance Index: -8.6200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.3772
    Cell Significance Index: -34.4300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.3972
    Cell Significance Index: -110.6600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -1.4994
    Cell Significance Index: -16.3000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.5137
    Cell Significance Index: -38.6700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -1.6538
    Cell Significance Index: -29.2300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.7999
    Cell Significance Index: -50.3000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -1.8551
    Cell Significance Index: -44.4900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -2.0670
    Cell Significance Index: -24.6400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -2.0782
    Cell Significance Index: -19.1400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -2.1315
    Cell Significance Index: -57.0200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -2.4053
    Cell Significance Index: -68.6400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -2.4539
    Cell Significance Index: -150.4500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -2.4546
    Cell Significance Index: -100.5800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -2.5859
    Cell Significance Index: -66.4700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -2.7154
    Cell Significance Index: -57.8300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** HNRNPU is a 69-kDa protein that belongs to the U family of hnRNP proteins. It is characterized by its ability to bind to specific RNA sequences, including the 3'-untranslated region (3'-UTR) of mRNAs, which is essential for mRNA stability and translation. HNRNPU is also involved in the regulation of alternative splicing, which is the process by which a single gene can give rise to multiple RNA transcripts with different sequences. **Pathways and Functions** HNRNPU is involved in various cellular pathways, including: 1. **Alternative Splicing**: HNRNPU regulates the splicing of mRNAs by binding to specific RNA sequences and influencing the recruitment of spliceosomes. 2. **mRNA Stability**: HNRNPU binds to the 3'-UTR of mRNAs, which regulates their stability and translation. 3. **Chromatin Organization**: HNRNPU is involved in the regulation of chromatin organization and the recruitment of transcription factors. 4. **Immune Response**: HNRNPU is expressed in various immune cells, including T cells and monocytes, where it regulates immune responses and cell differentiation. 5. **Cell Cycle Regulation**: HNRNPU is involved in the regulation of the cell cycle, particularly in the G2/M phase. **Clinical Significance** Dysregulation of HNRNPU has been implicated in various diseases, including: 1. **Neurological Disorders**: HNRNPU is involved in the regulation of neuronal function and has been implicated in neurodegenerative diseases such as Alzheimer's and Parkinson's. 2. **Cancer**: HNRNPU is overexpressed in various types of cancer, including breast, lung, and colon cancer, and is associated with poor prognosis. 3. **Autoimmune Diseases**: HNRNPU is involved in the regulation of immune responses and has been implicated in autoimmune diseases such as rheumatoid arthritis and multiple sclerosis. In conclusion, HNRNPU is a versatile RNA-binding protein involved in multiple cellular processes, including alternative splicing, mRNA stability, chromatin organization, and immune response regulation. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the functions and clinical significance of HNRNPU.

Genular Protein ID: 914217558

Symbol: HNRPU_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q00839 O75507 Q8N174 Q96HY9 Q9BQ09

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEBI 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 2 ExpressionAtlas 1 GO 87 Gene3D 3 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 5 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1628625

Title: Primary structure and binding activity of the hnRNP U protein: binding RNA through RGG box.

PubMed ID: 1628625

DOI: 10.1002/j.1460-2075.1992.tb05331.x

PubMed ID: 7509195

Title: hnRNP-U/SAF-A is encoded by two differentially polyadenylated mRNAs in human cells.

PubMed ID: 7509195

DOI: 10.1016/0167-4781(94)90044-2

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7993898

Title: Major cell surface-located protein substrates of an ecto-protein kinase are homologs of known nuclear proteins.

PubMed ID: 7993898

DOI: 10.1021/bi00253a007

PubMed ID: 1324173

Title: Characterization of SAF-A, a novel nuclear DNA binding protein from HeLa cells with high affinity for nuclear matrix/scaffold attachment DNA elements.

PubMed ID: 1324173

DOI: 10.1002/j.1460-2075.1992.tb05422.x

PubMed ID: 8068679

Title: Purification of two isoforms of hnRNP-U and characterization of their nucleic acid binding activity.

PubMed ID: 8068679

DOI: 10.1021/bi00200a024

PubMed ID: 8174554

Title: Nucleic-acid-binding properties of hnRNP-U/SAF-A, a nuclear-matrix protein which binds DNA and RNA in vivo and in vitro.

PubMed ID: 8174554

DOI: 10.1111/j.1432-1033.1994.tb18788.x

PubMed ID: 7753047

Title: Binding sites of the Epstein-Barr virus and C3d receptor (CR2, CD21) for its three intracellular ligands, the p53 anti-oncoprotein, the p68 calcium binding protein and the nuclear p120 ribonucleoprotein.

PubMed ID: 7753047

DOI: 10.1016/0161-5890(95)00005-y

PubMed ID: 9204873

Title: The scaffold/matrix attachment region binding protein hnRNP-U (SAF-A) is directly bound to chromosomal DNA in vivo: a chemical cross-linking study.

PubMed ID: 9204873

DOI: 10.1021/bi970480f

PubMed ID: 9105675

Title: The class III POU factor Brn-4 interacts with other class III POU factors and the heterogeneous nuclear ribonucleoprotein U.

PubMed ID: 9105675

DOI: 10.1016/s0169-328x(96)00238-0

PubMed ID: 9405365

Title: The novel SAR-binding domain of scaffold attachment factor A (SAF-A) is a target in apoptotic nuclear breakdown.

PubMed ID: 9405365

DOI: 10.1093/emboj/16.24.7361

PubMed ID: 9353307

Title: The glucocorticoid receptor is associated with the RNA-binding nuclear matrix protein hnRNP U.

PubMed ID: 9353307

DOI: 10.1074/jbc.272.45.28471

PubMed ID: 10490622

Title: hnRNP U inhibits carboxy-terminal domain phosphorylation by TFIIH and represses RNA polymerase II elongation.

PubMed ID: 10490622

DOI: 10.1128/mcb.19.10.6833

PubMed ID: 10671544

Title: Apoptotic cleavage of scaffold attachment factor A (SAF-A) by caspase-3 occurs at a noncanonical cleavage site.

PubMed ID: 10671544

DOI: 10.1074/jbc.275.7.5031

PubMed ID: 11003645

Title: SAF-Box, a conserved protein domain that specifically recognizes scaffold attachment region DNA.

PubMed ID: 11003645

DOI: 10.1128/mcb.20.20.7480-7489.2000

PubMed ID: 11909954

Title: Scaffold/matrix attachment region elements interact with a p300-scaffold attachment factor A complex and are bound by acetylated nucleosomes.

PubMed ID: 11909954

DOI: 10.1128/mcb.22.8.2598-2606.2002

PubMed ID: 11991638

Title: Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.

PubMed ID: 11991638

DOI: 10.1017/s1355838202021088

PubMed ID: 14608463

Title: Scaffold attachment factor A (SAF-A) is concentrated in inactive X chromosome territories through its RGG domain.

PubMed ID: 14608463

DOI: 10.1007/s00412-003-0258-0

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15563465

Title: A stable proteinaceous structure in the territory of inactive X chromosomes.

PubMed ID: 15563465

DOI: 10.1074/jbc.c400531200

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 15711563

Title: Actin and hnRNP U cooperate for productive transcription by RNA polymerase II.

PubMed ID: 15711563

DOI: 10.1038/nsmb904

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16916646

Title: Inhibition of HIV-1 gene expression by a fragment of hnRNP U.

PubMed ID: 16916646

DOI: 10.1016/j.molcel.2006.07.021

PubMed ID: 17487921

Title: Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line.

PubMed ID: 17487921

DOI: 10.1002/elps.200600782

PubMed ID: 17174306

Title: hnRNP-U enhances the expression of specific genes by stabilizing mRNA.

PubMed ID: 17174306

DOI: 10.1016/j.febslet.2006.11.062

PubMed ID: 18082603

Title: Purification of human telomerase complexes identifies factors involved in telomerase biogenesis and telomere length regulation.

PubMed ID: 18082603

DOI: 10.1016/j.molcel.2007.09.023

PubMed ID: 17289661

Title: Molecular composition of IMP1 ribonucleoprotein granules.

PubMed ID: 17289661

DOI: 10.1074/mcp.m600346-mcp200

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19617346

Title: Physical and functional interaction between heterochromatin protein 1alpha and the RNA-binding protein heterogeneous nuclear ribonucleoprotein U.

PubMed ID: 19617346

DOI: 10.1074/jbc.m109.037929

PubMed ID: 19808671

Title: Identification of a heterogeneous nuclear ribonucleoprotein-recognition region in the HIV Rev protein.

PubMed ID: 19808671

DOI: 10.1074/jbc.m109.021659

PubMed ID: 19029303

Title: Control of c-myc mRNA stability by IGF2BP1-associated cytoplasmic RNPs.

PubMed ID: 19029303

DOI: 10.1261/rna.1175909

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20858735

Title: Interactions of ErbB4 and Kap1 connect the growth factor and DNA damage response pathways.

PubMed ID: 20858735

DOI: 10.1158/1541-7786.mcr-10-0042

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21242313

Title: The nuclear scaffold protein SAF-A is required for kinetochore-microtubule attachment and contributes to the targeting of Aurora-A to mitotic spindles.

PubMed ID: 21242313

DOI: 10.1242/jcs.063347

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22325991

Title: Nuclear matrix factor hnRNP U/SAF-A exerts a global control of alternative splicing by regulating U2 snRNP maturation.

PubMed ID: 22325991

DOI: 10.1016/j.molcel.2012.01.009

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23811339

Title: H19 inhibits RNA polymerase II-mediated transcription by disrupting the hnRNP U-actin complex.

PubMed ID: 23811339

DOI: 10.1016/j.bbagen.2013.06.026

PubMed ID: 23640942

Title: Subcellular localization and RNP formation of IGF2BPs (IGF2 mRNA-binding proteins) is modulated by distinct RNA-binding domains.

PubMed ID: 23640942

DOI: 10.1515/hsz-2013-0111

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25911097

Title: Gemin5 binds to the survival motor neuron mRNA to regulate SMN expression.

PubMed ID: 25911097

DOI: 10.1074/jbc.m115.646257

PubMed ID: 25616961

Title: ALS-linked mutations in ubiquilin-2 or hnRNPA1 reduce interaction between ubiquilin-2 and hnRNPA1.

PubMed ID: 25616961

DOI: 10.1093/hmg/ddv020

PubMed ID: 25986610

Title: Phosphorylation of SAF-A/hnRNP-U serine 59 by polo-like kinase 1 is required for mitosis.

PubMed ID: 25986610

DOI: 10.1128/mcb.01312-14

PubMed ID: 26244333

Title: Xist exon 7 contributes to the stable localization of Xist RNA on the inactive X-chromosome.

PubMed ID: 26244333

DOI: 10.1371/journal.pgen.1005430

PubMed ID: 26030138

Title: Identification of Novel Proteins Co-Purifying with Cockayne Syndrome Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and Chromatin Dynamics.

PubMed ID: 26030138

DOI: 10.1371/journal.pone.0128558

PubMed ID: 28622508

Title: SAF-A regulates interphase chromosome structure through oligomerization with chromatin-associated RNAs.

PubMed ID: 28622508

DOI: 10.1016/j.cell.2017.05.029

PubMed ID: 28190768

Title: Serine ADP-ribosylation depends on HPF1.

PubMed ID: 28190768

DOI: 10.1016/j.molcel.2017.01.003

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 23708187

Title: Targeted resequencing in epileptic encephalopathies identifies de novo mutations in CHD2 and SYNGAP1.

PubMed ID: 23708187

DOI: 10.1038/ng.2646

PubMed ID: 25356899

Title: De novo mutations in moderate or severe intellectual disability.

PubMed ID: 25356899

DOI: 10.1371/journal.pgen.1004772

Sequence Information:

  • Length: 825
  • Mass: 90584
  • Checksum: 5D4EC4188436831F
  • Sequence:
    • MSSSPVNVKK LKVSELKEEL KKRRLSDKGL KAELMERLQA ALDDEEAGGR PAMEPGNGSL 
DLGGDSAGRS GAGLEQEAAA GGDEEEEEEE EEEEGISALD GDQMELGEEN GAAGAADSGP 
MEEEEAASED ENGDDQGFQE GEDELGDEEE GAGDENGHGE QQPQPPATQQ QQPQQQRGAA 
KEAAGKSSGP TSLFAVTVAP PGARQGQQQA GGKKKAEGGG GGGRPGAPAA GDGKTEQKGG 
DKKRGVKRPR EDHGRGYFEY IEENKYSRAK SPQPPVEEED EHFDDTVVCL DTYNCDLHFK 
ISRDRLSASS LTMESFAFLW AGGRASYGVS KGKVCFEMKV TEKIPVRHLY TKDIDIHEVR 
IGWSLTTSGM LLGEEEFSYG YSLKGIKTCN CETEDYGEKF DENDVITCFA NFESDEVELS 
YAKNGQDLGV AFKISKEVLA GRPLFPHVLC HNCAVEFNFG QKEKPYFPIP EEYTFIQNVP 
LEDRVRGPKG PEEKKDCEVV MMIGLPGAGK TTWVTKHAAE NPGKYNILGT NTIMDKMMVA 
GFKKQMADTG KLNTLLQRAP QCLGKFIEIA ARKKRNFILD QTNVSAAAQR RKMCLFAGFQ 
RKAVVVCPKD EDYKQRTQKK AEVEGKDLPE HAVLKMKGNF TLPEVAECFD EITYVELQKE 
EAQKLLEQYK EESKKALPPE KKQNTGSKKS NKNKSGKNQF NRGGGHRGRG GFNMRGGNFR 
GGAPGNRGGY NRRGNMPQRG GGGGGSGGIG YPYPRAPVFP GRGSYSNRGN YNRGGMPNRG 
NYNQNFRGRG NNRGYKNQSQ GYNQWQQGQF WGQKPWSQHY HQGYY

Genular Protein ID: 2637126500

Symbol: Q96BA7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q96BA7

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 32 Gene3D 2 InterPro 6 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 722
  • Mass: 79716
  • Checksum: A35C0DA46EAE6FD2
  • Sequence:
    • MELGEENGAA GAADSGPMEE EEAASEDENG DDQGFQEGED ELGDEEEGAG DENGHGEQQP 
QPPATQQQQP QQQRGAAKEA AGKSSGPTSL FAVTVAPPGA RQGQQQAGGK KKAEGGGGGG 
RPGAPAAGDG KTEQKGGDKK RGVKRPREDH GRGYFEYIEE NKYSRAKSPQ PPVEEEDEHF 
DDTVVCLDTY NCDLHFKISR DRLSASSLTM ESFAFLWAGG RASYGVSKGK VCFEMKVTEK 
IPVRHLYTKD IDIHEVRIGW SLTTSGMLLG EEEFSYGYSL KGIKTCNCET EDYGEKFDEN 
DVITCFANFE SDEVELSYAK NGQDLGVAFK ISKEVLAGRP LFPHVLCHNC AVEFNFGQKE 
KPYFPIPEEY TFIQNVPLED RVRGPKGPEE KKDCEVVMMI GLPGAGKTTW VTKHAAENPG 
KYNILGTNTI MDKMMVAGFK KQMADTGKLN TLLQRAPQCL GKFIEIAARK KRNFILDQTN 
VSAAAQRRKM CLFAGFQRKA VVVCPKDEDY KQRTQKKAEV EGKDLPEHAV LKMKGNFTLP 
EVAECFDEIT YVELQKEEAQ KLLEQYKEES KKALPPEKKQ NTGSKKSNKN KSGKNQFNRG 
GGHRGRGGFN MRGGNFRGGA PGNRGGYNRR GNMPQRGGGG GGSGGIGYPY PRAPVFPGRG 
SYSNRGNYNR GGMPNRGNYN QNFRGRGNNR GYKNQSQGYN QWQQGQFWGQ KPWSQHYHQG 
YY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.