Details for: MAPT

Gene ID: 4137

Symbol: MAPT

Ensembl ID: ENSG00000186868

Description: microtubule associated protein tau

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 428.8142
    Cell Significance Index: -66.7000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 263.1253
    Cell Significance Index: -66.7400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 175.1194
    Cell Significance Index: -72.1400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 117.6595
    Cell Significance Index: -47.8000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 54.0976
    Cell Significance Index: -66.7000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 6.8683
    Cell Significance Index: 52.9400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 5.9654
    Cell Significance Index: 73.9900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.4184
    Cell Significance Index: -9.6700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 3.6437
    Cell Significance Index: 93.6600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 3.4715
    Cell Significance Index: 1245.1700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 3.3919
    Cell Significance Index: 74.2700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 3.1948
    Cell Significance Index: 54.7500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 3.0408
    Cell Significance Index: 609.9900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.4116
    Cell Significance Index: 126.6200
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 2.1273
    Cell Significance Index: 22.1600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.1111
    Cell Significance Index: 93.3800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.0515
    Cell Significance Index: 1418.8800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.0013
    Cell Significance Index: 75.7900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.7587
    Cell Significance Index: 42.9100
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.6155
    Cell Significance Index: 8.2100
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.5272
    Cell Significance Index: 6.3900
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.4723
    Cell Significance Index: 5.8900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4289
    Cell Significance Index: 32.9200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2140
    Cell Significance Index: 40.7300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.0374
    Cell Significance Index: 0.7400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0369
    Cell Significance Index: 33.3000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0164
    Cell Significance Index: 0.7700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0019
    Cell Significance Index: -3.5600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0198
    Cell Significance Index: -14.6300
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0309
    Cell Significance Index: -0.3900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0329
    Cell Significance Index: -60.6400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0335
    Cell Significance Index: -20.9400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0344
    Cell Significance Index: -19.4200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0369
    Cell Significance Index: -50.1400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0379
    Cell Significance Index: -58.3800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0664
    Cell Significance Index: -8.5800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0728
    Cell Significance Index: -46.2300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0750
    Cell Significance Index: -54.9800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0829
    Cell Significance Index: -37.6300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0960
    Cell Significance Index: -72.6300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1027
    Cell Significance Index: -2.8700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.1041
    Cell Significance Index: -56.8600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1337
    Cell Significance Index: -26.5400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.1409
    Cell Significance Index: -62.2900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1499
    Cell Significance Index: -11.1800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1519
    Cell Significance Index: -31.9900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1871
    Cell Significance Index: -53.8400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1891
    Cell Significance Index: -34.0900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1920
    Cell Significance Index: -27.9100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1958
    Cell Significance Index: -33.4300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2128
    Cell Significance Index: -3.6800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.2391
    Cell Significance Index: -38.8900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2407
    Cell Significance Index: -7.8800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2744
    Cell Significance Index: -2.9900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2864
    Cell Significance Index: -9.1200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2954
    Cell Significance Index: -6.2700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3040
    Cell Significance Index: -15.3600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3043
    Cell Significance Index: -6.1100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3474
    Cell Significance Index: -12.2100
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.3531
    Cell Significance Index: -3.3600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.3822
    Cell Significance Index: -46.9900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.4092
    Cell Significance Index: -40.4800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.4101
    Cell Significance Index: -56.3200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.4270
    Cell Significance Index: -46.4500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4341
    Cell Significance Index: -24.3600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.4360
    Cell Significance Index: -44.5400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4479
    Cell Significance Index: -27.4600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.5209
    Cell Significance Index: -66.7800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.5438
    Cell Significance Index: -64.1300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.5789
    Cell Significance Index: -67.4700
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.6123
    Cell Significance Index: -9.8800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.6235
    Cell Significance Index: -71.4300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.6256
    Cell Significance Index: -5.9300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.6265
    Cell Significance Index: -71.5200
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.6274
    Cell Significance Index: -7.3200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.6428
    Cell Significance Index: -9.2100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6438
    Cell Significance Index: -67.0400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.6624
    Cell Significance Index: -31.1300
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.6669
    Cell Significance Index: -7.1500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6833
    Cell Significance Index: -54.1200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.7415
    Cell Significance Index: -33.6100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.7419
    Cell Significance Index: -51.3100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.7470
    Cell Significance Index: -15.5900
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.7533
    Cell Significance Index: -8.5100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.7861
    Cell Significance Index: -19.6100
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.7919
    Cell Significance Index: -11.1000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7958
    Cell Significance Index: -27.8800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.8014
    Cell Significance Index: -23.0900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.8058
    Cell Significance Index: -17.4100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.8066
    Cell Significance Index: -33.0500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.8300
    Cell Significance Index: -49.8300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.8592
    Cell Significance Index: -27.5200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.8624
    Cell Significance Index: -54.3600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.8779
    Cell Significance Index: -45.7300
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.9502
    Cell Significance Index: -8.3700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.9530
    Cell Significance Index: -67.4000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.9641
    Cell Significance Index: -62.2000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.1083
    Cell Significance Index: -27.7100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -1.1309
    Cell Significance Index: -23.4600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -1.1554
    Cell Significance Index: -14.5800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MAPT is a phosphoprotein that belongs to the tau protein family, which consists of six isoforms (MAPT1-6). These isoforms are generated through alternative splicing and differ in their amino acid sequence and post-translational modifications. MAPT is characterized by its ability to bind to microtubules, actin filaments, and other proteins, thereby regulating microtubule dynamics and cytoskeletal organization. **Pathways and Functions:** MAPT is involved in various cellular pathways, including: 1. **Axonal Transport:** MAPT regulates the transport of proteins, lipids, and organelles along microtubules, ensuring the proper localization and function of cellular components. 2. **Microtubule Organization:** MAPT binds to microtubules and regulates their dynamics, influencing the formation and stability of microtubule-based structures. 3. **Synaptic Plasticity:** MAPT is involved in the regulation of synaptic plasticity, a critical aspect of learning and memory. 4. **Apoptosis:** MAPT can regulate apoptosis by interacting with pro-apoptotic and anti-apoptotic proteins. 5. **Neuroinflammation:** MAPT has been implicated in the regulation of neuroinflammation, a key feature of neurodegenerative diseases. **Clinical Significance:** MAPT is a critical component of neurofibrillary tangles, which are characteristic of Alzheimer's disease and frontotemporal dementia. Abnormal phosphorylation of MAPT has been linked to neurodegeneration, cognitive decline, and motor dysfunction. Mutations in the MAPT gene have been identified in familial cases of Alzheimer's disease and frontotemporal dementia, highlighting the importance of MAPT in maintaining neuronal function and integrity. **Significantly Expressed Cells:** MAPT is expressed in various cell types, including: 1. **Purkinje Cells:** MAPT is highly expressed in Purkinje cells, which are critical for motor coordination and learning. 2. **Astrocytes:** MAPT is also expressed in astrocytes, which play a key role in maintaining the blood-brain barrier and regulating neurotransmitter release. 3. **Neuronal Cells:** MAPT is expressed in various neuronal cells, including inhibitory interneurons and chromaffin cells. **Proteins Associated with MAPT:** MAPT interacts with various proteins, including: 1. **Tau Proteins:** MAPT interacts with other tau proteins to form neurofibrillary tangles. 2. **Actin Filaments:** MAPT binds to actin filaments, regulating microtubule dynamics and cytoskeletal organization. 3. **Microtubules:** MAPT binds to microtubules, regulating their dynamics and stability. In conclusion, MAPT is a multifunctional protein that plays a critical role in various cellular processes, including axonal transport, microtubule organization, and synaptic plasticity. Its dysregulation has been implicated in neurodegenerative diseases, highlighting the importance of MAPT in maintaining neuronal function and integrity. Further research is needed to fully understand the complex role of MAPT in the human brain.

Genular Protein ID: 289674804

Symbol: TAU_HUMAN

Name: Neurofibrillary tangle protein

UniProtKB Accession Codes:

P10636 P18518 Q14799 Q15549 Q15550 Q15551 Q1RMF6 Q53YB1 Q5CZI7 Q5XWF0 Q6QT54 Q9UDJ3 Q9UMH0 Q9UQ96

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 8 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 5 DrugCentral 1 ELM 1 EMBL 50 EMDB 100 Ensembl 28 EvolutionaryTrace 1 ExpressionAtlas 1 GO 100 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MIM 9 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NIAGADS 1 OpenTargets 1 Orphanet 8 PANTHER 2 PDB 100 PDBsum 100 PIR 4 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 9 Pumba 1 RNAct 1 Reactome 3 RefSeq 7 SABIO-RK 1 SASBDB 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3131773

Title: Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau.

PubMed ID: 3131773

DOI: 10.1073/pnas.85.11.4051

PubMed ID: 2498079

Title: Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain.

PubMed ID: 2498079

DOI: 10.1002/j.1460-2075.1989.tb03390.x

PubMed ID: 2516729

Title: The microtubule binding domain of tau protein.

PubMed ID: 2516729

DOI: 10.1016/0896-6273(89)90050-0

PubMed ID: 2484340

Title: Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease.

PubMed ID: 2484340

DOI: 10.1016/0896-6273(89)90210-9

PubMed ID: 1420178

Title: Structure and novel exons of the human tau gene.

PubMed ID: 1420178

DOI: 10.1021/bi00158a027

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1512244

Title: Protein sequence and mass spectrometric analyses of tau in the Alzheimer's disease brain.

PubMed ID: 1512244

DOI: 10.1016/s0021-9258(18)41890-x

PubMed ID: 16443603

Title: Alzheimer disease-specific conformation of hyperphosphorylated paired helical filament-tau is polyubiquitinated through Lys-48, Lys-11, and Lys-6 ubiquitin conjugation.

PubMed ID: 16443603

DOI: 10.1074/jbc.m512786200

PubMed ID: 7706316

Title: Microtubule-associated protein/microtubule affinity-regulating kinase (p110mark). A novel protein kinase that regulates tau-microtubule interactions and dynamic instability by phosphorylation at the Alzheimer-specific site serine 262.

PubMed ID: 7706316

DOI: 10.1074/jbc.270.13.7679

PubMed ID: 2495000

Title: A distinct form of tau is selectively incorporated into Alzheimer's paired helical filaments.

PubMed ID: 2495000

DOI: 10.1016/0006-291x(89)92240-7

PubMed ID: 1899488

Title: A68: a major subunit of paired helical filaments and derivatized forms of normal Tau.

PubMed ID: 1899488

DOI: 10.1126/science.1899488

PubMed ID: 1915258

Title: Identification of 3- and 4-repeat tau isoforms within the PHF in Alzheimer's disease.

PubMed ID: 1915258

DOI: 10.1002/j.1460-2075.1991.tb07820.x

PubMed ID: 15365985

Title: The role of tau (MAPT) in frontotemporal dementia and related tauopathies.

PubMed ID: 15365985

DOI: 10.1002/humu.20086

PubMed ID: 1713721

Title: Molecular characterization of microtubule-associated proteins tau and MAP2.

PubMed ID: 1713721

DOI: 10.1016/0166-2236(91)90105-4

PubMed ID: 8999860

Title: The regulatory Ser262 of microtubule-associated protein tau is phosphorylated by phosphorylase kinase.

PubMed ID: 8999860

DOI: 10.1016/s0021-9258(19)67481-8

PubMed ID: 9326300

Title: Characterization of in vitro glycation sites of tau.

PubMed ID: 9326300

DOI: 10.1046/j.1471-4159.1997.69041709.x

PubMed ID: 9735171

Title: Phosphorylation of tau at both Thr 231 and Ser 262 is required for maximal inhibition of its binding to microtubules.

PubMed ID: 9735171

DOI: 10.1006/abbi.1998.0813

PubMed ID: 9614189

Title: The endogenous and cell cycle-dependent phosphorylation of tau protein in living cells: implications for Alzheimer's disease.

PubMed ID: 9614189

DOI: 10.1091/mbc.9.6.1495

PubMed ID: 10747907

Title: Interaction of tau with the neural membrane cortex is regulated by phosphorylation at sites that are modified in paired helical filaments.

PubMed ID: 10747907

DOI: 10.1074/jbc.m000389200

PubMed ID: 14761950

Title: Casein kinase 1 delta phosphorylates tau and disrupts its binding to microtubules.

PubMed ID: 14761950

DOI: 10.1074/jbc.m314116200

PubMed ID: 14690523

Title: Primed phosphorylation of tau at Thr231 by glycogen synthase kinase 3beta (GSK3beta) plays a critical role in regulating tau's ability to bind and stabilize microtubules.

PubMed ID: 14690523

DOI: 10.1111/j.1471-4159.2004.02155.x

PubMed ID: 14999081

Title: Phosphorylation of tau by fyn: implications for Alzheimer's disease.

PubMed ID: 14999081

DOI: 10.1523/jneurosci.4162-03.2004

PubMed ID: 15953362

Title: Sequestosome 1/p62 shuttles polyubiquitinated tau for proteasomal degradation.

PubMed ID: 15953362

DOI: 10.1111/j.1471-4159.2005.03181.x

PubMed ID: 15546861

Title: Dephosphorylation of tau by protein phosphatase 5: impairment in Alzheimer's disease.

PubMed ID: 15546861

DOI: 10.1074/jbc.m410775200

PubMed ID: 16923168

Title: Tau-tubulin kinase 1 (TTBK1), a neuron-specific tau kinase candidate, is involved in tau phosphorylation and aggregation.

PubMed ID: 16923168

DOI: 10.1111/j.1471-4159.2006.04059.x

PubMed ID: 16982696

Title: Serum- and glucocorticoid-inducible kinase 1 (SGK1) increases neurite formation through microtubule depolymerization by SGK1 and by SGK1 phosphorylation of tau.

PubMed ID: 16982696

DOI: 10.1128/mcb.01017-06

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17562708

Title: Novel phosphorylation sites in tau from Alzheimer brain support a role for casein kinase 1 in disease pathogenesis.

PubMed ID: 17562708

DOI: 10.1074/jbc.m703269200

PubMed ID: 18599021

Title: Role for DYRK family kinases on regulation of apoptosis.

PubMed ID: 18599021

DOI: 10.1016/j.bcp.2008.05.021

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19451179

Title: Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease.

PubMed ID: 19451179

DOI: 10.1093/brain/awp099

PubMed ID: 19542233

Title: Hyperphosphorylation and aggregation of Tau in laforin-deficient mice, an animal model for Lafora disease.

PubMed ID: 19542233

DOI: 10.1074/jbc.m109.009688

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21327254

Title: Identification of O-GlcNAc sites within peptides of the Tau protein and their impact on phosphorylation.

PubMed ID: 21327254

DOI: 10.1039/c0mb00337a

PubMed ID: 21985311

Title: Phosphorylation of microtubule-associated protein tau by AMPK-related kinases.

PubMed ID: 21985311

DOI: 10.1111/j.1471-4159.2011.07523.x

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23666762

Title: Role of individual MARK isoforms in phosphorylation of tau at Ser262 in Alzheimer's disease.

PubMed ID: 23666762

DOI: 10.1007/s12017-013-8232-3

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26014385

Title: LRRK2 Promotes Tau Accumulation, Aggregation and Release.

PubMed ID: 26014385

DOI: 10.1007/s12035-015-9209-z

PubMed ID: 32296178

Title: LRP1 is a master regulator of tau uptake and spread.

PubMed ID: 32296178

DOI: 10.1038/s41586-020-2156-5

PubMed ID: 11313338

Title: 1H NMR study on the binding of Pin1 Trp-Trp domain with phosphothreonine peptides.

PubMed ID: 11313338

DOI: 10.1074/jbc.m010327200

PubMed ID: 32272059

Title: A Translocation Pathway for Vesicle-Mediated Unconventional Protein Secretion.

PubMed ID: 32272059

DOI: 10.1016/j.cell.2020.03.031

PubMed ID: 10899436

Title: Tau mutations in frontotemporal dementia FTDP-17 and their relevance for Alzheimer's disease.

PubMed ID: 10899436

DOI: 10.1016/s0925-4439(00)00037-5

PubMed ID: 9629852

Title: Tau is a candidate gene for chromosome 17 frontotemporal dementia.

PubMed ID: 9629852

DOI: 10.1002/ana.410430617

PubMed ID: 9736786

Title: Segregation of a missense mutation in the microtubule-associated protein tau gene with familial frontotemporal dementia and parkinsonism.

PubMed ID: 9736786

DOI: 10.1093/hmg/7.11.1825

PubMed ID: 9641683

Title: Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17.

PubMed ID: 9641683

DOI: 10.1038/31508

PubMed ID: 9789048

Title: Pathogenic implications of mutations in the tau gene in pallido-ponto-nigral degeneration and related neurodegenerative disorders linked to chromosome 17.

PubMed ID: 9789048

DOI: 10.1073/pnas.95.22.13103

PubMed ID: 10412802

Title: A mutation at codon 279 (N279K) in exon 10 of the Tau gene causes a tauopathy with dementia and supranuclear palsy.

PubMed ID: 10412802

DOI: 10.1007/s004010051052

PubMed ID: 9973279

Title: High prevalence of mutations in the microtubule-associated protein tau in a population study of frontotemporal dementia in the Netherlands.

PubMed ID: 9973279

DOI: 10.1086/302256

PubMed ID: 10553987

Title: FTDP-17: an early-onset phenotype with parkinsonism and epileptic seizures caused by a novel mutation.

PubMed ID: 10553987

DOI: 10.1002/1531-8249(199911)46:5<708::aid-ana5>3.0.co;2-k

PubMed ID: 10214944

Title: Accelerated filament formation from tau protein with specific FTDP-17 missense mutations.

PubMed ID: 10214944

DOI: 10.1016/s0014-5793(99)00294-x

PubMed ID: 10374757

Title: Frontotemporal dementia and corticobasal degeneration in a family with a P301S mutation in tau.

PubMed ID: 10374757

DOI: 10.1097/00005072-199906000-00011

PubMed ID: 10604746

Title: Tau gene mutation G389R causes a tauopathy with abundant pick body-like inclusions and axonal deposits.

PubMed ID: 10604746

DOI: 10.1097/00005072-199912000-00002

PubMed ID: 10489057

Title: A mutation in the microtubule-associated protein tau in pallido-nigro-luysian degeneration.

PubMed ID: 10489057

DOI: 10.1212/wnl.53.4.864

PubMed ID: 10534245

Title: Mutational analysis of the tau gene in progressive supranuclear palsy.

PubMed ID: 10534245

DOI: 10.1212/wnl.53.7.1421

PubMed ID: 10208578

Title: A distinct familial presenile dementia with a novel missense mutation in the tau gene.

PubMed ID: 10208578

DOI: 10.1097/00001756-199902250-00010

PubMed ID: 11117541

Title: Frontotemporal dementia with novel tau pathology and a Glu342Val tau mutation.

PubMed ID: 11117541

DOI: 10.1002/1531-8249(200012)48:6<850::aid-ana5>3.3.co;2-m

PubMed ID: 11117542

Title: Pick's disease is associated with mutations in the tau gene.

PubMed ID: 11117542

DOI: 10.1002/1531-8249(200012)48:6<859::aid-ana6>3.3.co;2-t

PubMed ID: 11089577

Title: Tau gene mutation K257T causes a tauopathy similar to Pick's disease.

PubMed ID: 11089577

DOI: 10.1093/jnen/59.11.990

PubMed ID: 10802785

Title: Two brothers with frontotemporal dementia and parkinsonism with an N279K mutation of the tau gene.

PubMed ID: 10802785

DOI: 10.1212/wnl.54.9.1787

PubMed ID: 11071507

Title: A Japanese patient with frontotemporal dementia and parkinsonism by a tau P301S mutation.

PubMed ID: 11071507

DOI: 10.1212/wnl.55.8.1224

PubMed ID: 11585254

Title: Familial frontotemporal dementia and parkinsonism with a novel N296H mutation in exon 10 of the tau gene and a widespread tau accumulation in the glial cells.

PubMed ID: 11585254

DOI: 10.1007/s004010000333

PubMed ID: 11220749

Title: Familial atypical progressive supranuclear palsy associated with homozygosity for the delN296 mutation in the tau gene.

PubMed ID: 11220749

DOI: 10.1002/1531-8249(20010201)49:2<263::aid-ana50>3.0.co;2-k

PubMed ID: 11601501

Title: Pick's disease associated with the novel Tau gene mutation K369I.

PubMed ID: 11601501

DOI: 10.1002/ana.1223

PubMed ID: 11278002

Title: Effects of FTDP-17 mutations on the in vitro phosphorylation of tau by glycogen synthase kinase 3beta identified by mass spectrometry demonstrate certain mutations exert long-range conformational changes.

PubMed ID: 11278002

DOI: 10.1016/s0014-5793(01)02267-0

PubMed ID: 12473774

Title: Clinical and genetic studies of families with the tau N279K mutation (FTDP-17).

PubMed ID: 12473774

DOI: 10.1212/01.wnl.0000038909.49164.4b

PubMed ID: 11891833

Title: A novel tau mutation, S320F, causes a tauopathy with inclusions similar to those in Pick's disease.

PubMed ID: 11891833

DOI: 10.1002/ana.10140

PubMed ID: 11921059

Title: Late-onset frontotemporal dementia with a novel exon 1 (Arg5His) tau gene mutation.

PubMed ID: 11921059

DOI: 10.1002/ana.10163

PubMed ID: 12325083

Title: An R5L tau mutation in a subject with a progressive supranuclear palsy phenotype.

PubMed ID: 12325083

DOI: 10.1002/ana.10340

PubMed ID: 11906000

Title: Functional effects of tau gene mutations deltaN296 and N296H.

PubMed ID: 11906000

DOI: 10.1046/j.0022-3042.2001.00729.x

PubMed ID: 11889249

Title: Early-onset, rapidly progressive familial tauopathy with R406W mutation.

PubMed ID: 11889249

DOI: 10.1212/wnl.58.5.811

PubMed ID: 12509859

Title: A novel L266V mutation of the tau gene causes frontotemporal dementia with a unique tau pathology.

PubMed ID: 12509859

DOI: 10.1002/ana.10447

PubMed ID: 14595660

Title: An English kindred with a novel recessive tauopathy and respiratory failure.

PubMed ID: 14595660

DOI: 10.1002/ana.10747

PubMed ID: 14517953

Title: Tau (MAPT) mutation arg406trp presenting clinically with Alzheimer disease does not share a common founder in western Europe.

PubMed ID: 14517953

DOI: 10.1002/humu.10269

PubMed ID: 14991829

Title: Progressive supranuclear palsy and Parkinson's disease in a family with a new mutation in the tau gene.

PubMed ID: 14991829

DOI: 10.1002/ana.20006

PubMed ID: 14991828

Title: Tau gene delN296 mutation, Parkinson's disease, and atypical supranuclear palsy.

PubMed ID: 14991828

DOI: 10.1002/ana.20025

PubMed ID: 16240366

Title: Phenotypic heterogeneity within a new family with the MAPT P301S mutation.

PubMed ID: 16240366

DOI: 10.1002/ana.20668

PubMed ID: 16157753

Title: A new mutation of the tau gene, G303V, in early-onset familial progressive supranuclear palsy.

PubMed ID: 16157753

DOI: 10.1001/archneur.62.9.1444

PubMed ID: 15883319

Title: A novel mutation (K317M) in the MAPT gene causes FTDP and motor neuron disease.

PubMed ID: 15883319

DOI: 10.1212/01.wnl.0000160116.65034.12

PubMed ID: 20020531

Title: A thorough assessment of benign genetic variability in GRN and MAPT.

PubMed ID: 20020531

DOI: 10.1002/humu.21152

PubMed ID: 26086902

Title: Homozygous MAPT R406W mutation causing FTDP phenotype: A unique instance of a unique mutation.

PubMed ID: 26086902

DOI: 10.1016/j.gene.2015.06.033

PubMed ID: 32961270

Title: Fibrillation and molecular characteristics are coherent with clinical and pathological features of 4-repeat tauopathy caused by MAPT variant G273R.

PubMed ID: 32961270

DOI: 10.1016/j.nbd.2020.105079

Sequence Information:

  • Length: 758
  • Mass: 78928
  • Checksum: D46C66CDBCD196E8
  • Sequence:
    • MAEPRQEFEV MEDHAGTYGL GDRKDQGGYT MHQDQEGDTD AGLKESPLQT PTEDGSEEPG 
SETSDAKSTP TAEDVTAPLV DEGAPGKQAA AQPHTEIPEG TTAEEAGIGD TPSLEDEAAG 
HVTQEPESGK VVQEGFLREP GPPGLSHQLM SGMPGAPLLP EGPREATRQP SGTGPEDTEG 
GRHAPELLKH QLLGDLHQEG PPLKGAGGKE RPGSKEEVDE DRDVDESSPQ DSPPSKASPA 
QDGRPPQTAA REATSIPGFP AEGAIPLPVD FLSKVSTEIP ASEPDGPSVG RAKGQDAPLE 
FTFHVEITPN VQKEQAHSEE HLGRAAFPGA PGEGPEARGP SLGEDTKEAD LPEPSEKQPA 
AAPRGKPVSR VPQLKARMVS KSKDGTGSDD KKAKTSTRSS AKTLKNRPCL SPKHPTPGSS 
DPLIQPSSPA VCPEPPSSPK YVSSVTSRTG SSGAKEMKLK GADGKTKIAT PRGAAPPGQK 
GQANATRIPA KTPPAPKTPP SSGEPPKSGD RSGYSSPGSP GTPGSRSRTP SLPTPPTREP 
KKVAVVRTPP KSPSSAKSRL QTAPVPMPDL KNVKSKIGST ENLKHQPGGG KVQIINKKLD 
LSNVQSKCGS KDNIKHVPGG GSVQIVYKPV DLSKVTSKCG SLGNIHHKPG GGQVEVKSEK 
LDFKDRVQSK IGSLDNITHV PGGGNKKIET HKLTFRENAK AKTDHGAEIV YKSPVVSGDT 
SPRHLSNVSS TGSIDMVDSP QLATLADEVS ASLAKQGL

Genular Protein ID: 3886868276

Symbol: B3KTM0_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KTM0

Database IDs:

ARBA 14 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 8 InterPro 3 NCBI Taxonomy 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 1 RefSeq 2 RuleBase 1 SAM 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 265
  • Mass: 27673
  • Checksum: F9B669DD2925AF93
  • Sequence:
    • MTKKAKGADG KTKIATPRGQ ANATRIPAKT PPAPKTPPSS GEPPKSGDRS GYSSPGSPGT 
PGSRSRTPSL PTPPTREPKK VAVVRTPPKS PSSAKSRLQT APVPMPDLKN VKSKIGSTEN 
LKHQPGGGKV QIVYKPVDLS KVTSKCGSLG NIHHKPGGGQ VEVKSEKLDF KDRVQSKIGS 
LDNITHVPGG GNKKIETHKL TFRENAKAKT DHGAEIVYKS PVVSGDTSPR HLSNVSSTGS 
IDMVDSPQLA TLADEVSASL AKQGL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.