Details for: FTL

Gene ID: 2512

Symbol: FTL

Ensembl ID: ENSG00000087086

Description: ferritin light chain

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 1875.2102
    Cell Significance Index: -291.6800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 1170.5017
    Cell Significance Index: -296.8900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 899.7503
    Cell Significance Index: -370.6500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 829.1793
    Cell Significance Index: -336.8600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 770.0118
    Cell Significance Index: -363.5400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 719.6552
    Cell Significance Index: -370.1800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 543.5141
    Cell Significance Index: -364.7100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 357.4575
    Cell Significance Index: -341.2800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 263.1238
    Cell Significance Index: -324.4200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 91.8894
    Cell Significance Index: -362.6000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 88.0234
    Cell Significance Index: -270.3600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 61.1249
    Cell Significance Index: -163.7500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 45.6550
    Cell Significance Index: -99.9200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 25.7512
    Cell Significance Index: 475.9500
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 19.0391
    Cell Significance Index: 79.2400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 11.8358
    Cell Significance Index: 339.2800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 10.5242
    Cell Significance Index: 7965.9900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 9.1886
    Cell Significance Index: 1177.9300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 8.4514
    Cell Significance Index: 669.3500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 8.2552
    Cell Significance Index: 387.9900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 7.8395
    Cell Significance Index: 1076.5800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 6.6056
    Cell Significance Index: 346.8200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 6.0425
    Cell Significance Index: 742.9800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 6.0116
    Cell Significance Index: 1083.7100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 5.8540
    Cell Significance Index: 153.9300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 5.4136
    Cell Significance Index: 2956.5100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 4.8033
    Cell Significance Index: 953.2300
  • Cell Name: theca cell (CL0000503)
    Fold Change: 4.6417
    Cell Significance Index: 27.2700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 4.2864
    Cell Significance Index: 553.7800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 4.0258
    Cell Significance Index: 1158.3500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 3.9347
    Cell Significance Index: 1739.6400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 3.3229
    Cell Significance Index: 58.7200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 3.2469
    Cell Significance Index: 169.1300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 3.1892
    Cell Significance Index: 544.5700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 3.1610
    Cell Significance Index: 203.9300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.1530
    Cell Significance Index: 234.9900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.8653
    Cell Significance Index: 337.9100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.7358
    Cell Significance Index: 31.0800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.6743
    Cell Significance Index: 124.6900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.4566
    Cell Significance Index: 51.4200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.3722
    Cell Significance Index: 64.5700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 1.9740
    Cell Significance Index: 1447.3200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.6926
    Cell Significance Index: 49.7100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6411
    Cell Significance Index: 162.3400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.5967
    Cell Significance Index: 55.4900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.4395
    Cell Significance Index: 101.8100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8767
    Cell Significance Index: 166.8500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.7601
    Cell Significance Index: 5.1500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.6329
    Cell Significance Index: 16.9000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4560
    Cell Significance Index: 91.4700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2199
    Cell Significance Index: 78.8600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0285
    Cell Significance Index: 2.9100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0083
    Cell Significance Index: -15.6900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0581
    Cell Significance Index: -0.5300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1017
    Cell Significance Index: -64.5800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1379
    Cell Significance Index: -102.1400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1413
    Cell Significance Index: -2.3700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1913
    Cell Significance Index: -352.8700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.2229
    Cell Significance Index: -343.0800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.2230
    Cell Significance Index: -303.2300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.3012
    Cell Significance Index: -188.0800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.4516
    Cell Significance Index: -254.7000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5054
    Cell Significance Index: -57.7000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.6162
    Cell Significance Index: -279.6900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.7432
    Cell Significance Index: -156.5300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.3575
    Cell Significance Index: -70.5200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.9208
    Cell Significance Index: -279.2100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -2.1317
    Cell Significance Index: -248.4300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -2.1411
    Cell Significance Index: -245.3000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -2.4268
    Cell Significance Index: -149.1600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -2.5428
    Cell Significance Index: -64.9600
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -2.6803
    Cell Significance Index: -19.2500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -2.9453
    Cell Significance Index: -17.8000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -2.9986
    Cell Significance Index: -83.8000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -3.4398
    Cell Significance Index: -358.1700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -3.4694
    Cell Significance Index: -218.6700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -3.5040
    Cell Significance Index: -44.8800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -3.6528
    Cell Significance Index: -165.5700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -3.8831
    Cell Significance Index: -136.4500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -3.9418
    Cell Significance Index: -302.4900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -3.9468
    Cell Significance Index: -126.4100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -3.9904
    Cell Significance Index: -68.7900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -4.3282
    Cell Significance Index: -291.0300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -4.3291
    Cell Significance Index: -65.7500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -4.4156
    Cell Significance Index: -74.3800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -4.8947
    Cell Significance Index: -130.9300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -5.1755
    Cell Significance Index: -76.3900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -5.1845
    Cell Significance Index: -358.5400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -5.2207
    Cell Significance Index: -292.9600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -5.4513
    Cell Significance Index: -84.3400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -5.4979
    Cell Significance Index: -119.1100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -5.8154
    Cell Significance Index: -113.5000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -5.9303
    Cell Significance Index: -363.5800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -6.1229
    Cell Significance Index: -141.4600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -6.1479
    Cell Significance Index: -92.1200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -6.6027
    Cell Significance Index: -176.9200
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -6.8926
    Cell Significance Index: -96.6100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -7.5079
    Cell Significance Index: -221.1400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -7.5945
    Cell Significance Index: -311.1900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -7.9470
    Cell Significance Index: -291.7300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The ferritin light chain gene (FTL) is characterized by its ability to regulate iron homeostasis and immune function. The protein product of this gene, ferritin light chain, is a subunit of ferritin, which is composed of two heavy chains and four light chains. The FTL gene is highly conserved across species, suggesting its essential role in iron homeostasis and immune function. The gene is also highly expressed in various cell types, including hematopoietic cells, epithelial cells, and immune cells. **Pathways and Functions** The ferritin light chain gene (FTL) is involved in multiple cellular pathways, including: 1. **Iron homeostasis**: Ferritin plays a crucial role in regulating iron levels in cells by sequestering iron ions and preventing their oxidation. 2. **Autolysosome formation**: Ferritin is involved in the formation of autolysosomes, which are cellular structures responsible for the degradation and recycling of cellular components. 3. **Immune system regulation**: Ferritin has been shown to play a role in immune system regulation, including the activation of immune cells and the production of cytokines. 4. **Neutrophil degranulation**: Ferritin has been shown to regulate neutrophil degranulation, a process involved in the clearance of pathogens. 5. **Vesicle-mediated transport**: Ferritin is involved in the transport of small molecules and iron ions within cells. **Clinical Significance** The ferritin light chain gene (FTL) has significant clinical implications, particularly in the context of iron overload and immune system dysfunction. Abnormalities in ferritin levels have been associated with various diseases, including: 1. **Iron overload**: Elevated ferritin levels are often seen in iron overload disorders, such as hemochromatosis. 2. **Immune system dysfunction**: Abnormalities in ferritin levels have been associated with immune system dysfunction, including autoimmune diseases and cancer. 3. **Neutropenia**: Low ferritin levels have been associated with neutropenia, a condition characterized by low white blood cell count. 4. **Anemia**: Abnormalities in ferritin levels have been associated with anemia, particularly iron-deficiency anemia. In conclusion, the ferritin light chain gene (FTL) plays a crucial role in iron homeostasis and immune function. Its dysregulation has significant clinical implications, particularly in the context of iron overload and immune system dysfunction. Further research is needed to fully understand the role of FTL in human disease and to develop therapeutic strategies to modulate ferritin levels in these disorders.

Genular Protein ID: 435672394

Symbol: FRIL_HUMAN

Name: Ferritin light chain

UniProtKB Accession Codes:

P02792 B2R4B9 Q6IBT7 Q7Z2W1 Q86WI9 Q8WU07 Q96AU9 Q96CU0 Q9BTZ8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 2 CTD 1 ChEBI 5 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 6 EMBL 22 EMDB 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 7 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 4 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 13 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3840162

Title: Structural and functional relationships of human ferritin H and L chains deduced from cDNA clones.

PubMed ID: 3840162

DOI: 10.1016/s0021-9258(17)39094-4

PubMed ID: 3858810

Title: Structure of human ferritin light subunit messenger RNA: comparison with heavy subunit message and functional implications.

PubMed ID: 3858810

DOI: 10.1073/pnas.82.10.3139

PubMed ID: 3754330

Title: Cloning of the gene coding for human L apoferritin.

PubMed ID: 3754330

DOI: 10.1093/nar/14.7.2863

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3023856

Title: Structure and expression of ferritin genes in a human promyelocytic cell line that differentiates in vitro.

PubMed ID: 3023856

DOI: 10.1128/mcb.6.2.566-573.1986

PubMed ID: 6653779

Title: The amino acid sequence of human liver apoferritin.

PubMed ID: 6653779

DOI: 10.1016/0014-5793(83)80037-4

PubMed ID: 8706699

Title: Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry.

PubMed ID: 8706699

DOI: 10.1111/j.1432-1033.1996.0144u.x

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23940258

Title: Human L-ferritin deficiency is characterized by idiopathic generalized seizures and atypical restless leg syndrome.

PubMed ID: 23940258

DOI: 10.1084/jem.20130315

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24695223

Title: Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy.

PubMed ID: 24695223

DOI: 10.1038/nature13148

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 16790936

Title: Structure of human ferritin L chain.

PubMed ID: 16790936

DOI: 10.1107/s0907444906018294

PubMed ID: 19923220

Title: Unraveling of the E-helices and disruption of 4-fold pores are associated with iron mishandling in a mutant ferritin causing neurodegeneration.

PubMed ID: 19923220

DOI: 10.1074/jbc.m109.042986

PubMed ID: 20159981

Title: Mutant ferritin L-chains that cause neurodegeneration act in a dominant-negative manner to reduce ferritin iron incorporation.

PubMed ID: 20159981

DOI: 10.1074/jbc.m109.096404

PubMed ID: 16116125

Title: Neuroferritinopathy: missense mutation in FTL causing early-onset bilateral pallidal involvement.

PubMed ID: 16116125

DOI: 10.1212/01.wnl.0000178224.81169.c2

PubMed ID: 19176363

Title: A new missense mutation in the L ferritin coding sequence associated with elevated levels of glycosylated ferritin in serum and absence of iron overload.

PubMed ID: 19176363

DOI: 10.3324/haematol.2008.000125

Sequence Information:

  • Length: 175
  • Mass: 20020
  • Checksum: 0DB98081FF976BC2
  • Sequence:
    • MSSQIRQNYS TDVEAAVNSL VNLYLQASYT YLSLGFYFDR DDVALEGVSH FFRELAEEKR 
EGYERLLKMQ NQRGGRALFQ DIKKPAEDEW GKTPDAMKAA MALEKKLNQA LLDLHALGSA 
RTDPHLCDFL ETHFLDEEVK LIKKMGDHLT NLHRLGGPEA GLGEYLFERL TLKHD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.