FTL | ENSG00000087086 | NCBI 2512

Details for: FTL

Gene ID: 2512

Symbol: FTL

Ensembl ID: ENSG00000087086

Description: ferritin light chain

Associated with

Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Golgi associated vesicle biogenesis
(R-HSA-432722)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Iron uptake and transport
(R-HSA-917937)
Membrane trafficking
(R-HSA-199991)
Neutrophil degranulation
(R-HSA-6798695)
Scavenging by class a receptors
(R-HSA-3000480)
Trans-golgi network vesicle budding
(R-HSA-199992)
Transport of small molecules
(R-HSA-382551)
Vesicle-mediated transport
(R-HSA-5653656)
Autolysosome
(GO:0044754)
Autophagosome
(GO:0005776)
Azurophil granule lumen
(GO:0035578)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Ferric iron binding
(GO:0008199)
Ferritin complex
(GO:0070288)
Ferrous iron binding
(GO:0008198)
Identical protein binding
(GO:0042802)
Intracellular iron ion homeostasis
(GO:0006879)
Iron ion binding
(GO:0005506)
Iron ion transport
(GO:0006826)
Membrane
(GO:0016020)
Protein binding
(GO:0005515)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: cell in vitro (CL0001034)
Fold Change: 3.71
Cell Significance Index: 6
Cell Name: neoplastic cell (CL0001063)
Fold Change: 2.43
Cell Significance Index: 3
Cell Name: odontoblast (CL0000060)
Fold Change: 2.01
Cell Significance Index: 2
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 1.8
Cell Significance Index: 2
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.78
Cell Significance Index: 2
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 1.43
Cell Significance Index: 1
Cell Name: lactocyte (CL0002325)
Fold Change: 1.37
Cell Significance Index: 1
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.27
Cell Significance Index: 1
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.26
Cell Significance Index: 1
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.25
Cell Significance Index: 2
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.24
Cell Significance Index: 1
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.24
Cell Significance Index: 1
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.22
Cell Significance Index: 1
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.21
Cell Significance Index: 1
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.2
Cell Significance Index: 1
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.18
Cell Significance Index: 1
Cell Name: granulosa cell (CL0000501)
Fold Change: 1.16
Cell Significance Index: 1
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.14
Cell Significance Index: 1
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.13
Cell Significance Index: 1
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.13
Cell Significance Index: 1
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 1.09
Cell Significance Index: 1
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 1.09
Cell Significance Index: 1
Cell Name: theca cell (CL0000503)
Fold Change: 1.08
Cell Significance Index: 1
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 1.08
Cell Significance Index: 1
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 1.07
Cell Significance Index: 1
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.07
Cell Significance Index: 1
Cell Name: kidney cell (CL1000497)
Fold Change: 1.06
Cell Significance Index: 1
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.04
Cell Significance Index: 1
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 1.03
Cell Significance Index: 1
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 1.02
Cell Significance Index: 1
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 1.02
Cell Significance Index: 1
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 1.02
Cell Significance Index: 1
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: hepatic pit cell (CL2000054)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: cell (CL0000000)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: perivascular cell (CL4033054)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: basal cell of epidermis (CL0002187)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: pro-T cell (CL0000827)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 0.95
Cell Significance Index: 1
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 0.95
Cell Significance Index: 1
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.95
Cell Significance Index: 1
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.95
Cell Significance Index: 1
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 0.95
Cell Significance Index: 1
Cell Name: epidermal cell (CL0000362)
Fold Change: 0.95
Cell Significance Index: 1
Cell Name: epithelial cell of sweat gland (CL1000448)
Fold Change: 0.95
Cell Significance Index: 1
Cell Name: sebaceous gland cell (CL2000021)
Fold Change: 0.95
Cell Significance Index: 1
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 0.95
Cell Significance Index: 1
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 0.95
Cell Significance Index: 1
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.95
Cell Significance Index: 1
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.95
Cell Significance Index: 1
Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.95
Cell Significance Index: 1
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 0.94
Cell Significance Index: 1
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.94
Cell Significance Index: 1
Cell Name: melanocyte of skin (CL1000458)
Fold Change: 0.94
Cell Significance Index: 1
Cell Name: Mueller cell (CL0000636)
Fold Change: 0.94
Cell Significance Index: 1
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.94
Cell Significance Index: 1
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 0.94
Cell Significance Index: 1
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.94
Cell Significance Index: 1
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.94
Cell Significance Index: 1
Cell Name: embryonic fibroblast (CL2000042)
Fold Change: 0.94
Cell Significance Index: 1
Cell Name: Merkel cell (CL0000242)
Fold Change: 0.93
Cell Significance Index: 1
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 0.93
Cell Significance Index: 1
Cell Name: bronchial epithelial cell (CL0002328)
Fold Change: 0.93
Cell Significance Index: 1
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.93
Cell Significance Index: 1
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.93
Cell Significance Index: 1
Cell Name: peg cell (CL4033014)
Fold Change: 0.93
Cell Significance Index: 1
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.93
Cell Significance Index: 1
Cell Name: radial glial cell (CL0000681)
Fold Change: 0.93
Cell Significance Index: 1
Cell Name: muscle fibroblast (CL1001609)
Fold Change: 0.93
Cell Significance Index: 1
Cell Name: chondroblast (CL0000058)
Fold Change: 0.93
Cell Significance Index: 1
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 0.92
Cell Significance Index: 1
Cell Name: intrahepatic cholangiocyte (CL0002538)
Fold Change: 0.92
Cell Significance Index: 1
Cell Name: OFF-bipolar cell (CL0000750)
Fold Change: 0.92
Cell Significance Index: 1
Cell Name: Sertoli cell (CL0000216)
Fold Change: 0.92
Cell Significance Index: 1
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 0.92
Cell Significance Index: 1
Cell Name: enterocyte (CL0000584)
Fold Change: 0.92
Cell Significance Index: 1
Cell Name: ON-bipolar cell (CL0000749)
Fold Change: 0.92
Cell Significance Index: 1
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 0.92
Cell Significance Index: 1
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.91
Cell Significance Index: 1
Cell Name: skin fibroblast (CL0002620)
Fold Change: 0.91
Cell Significance Index: 1
Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: 0.91
Cell Significance Index: 1
Cell Name: malignant cell (CL0001064)
Fold Change: 0.91
Cell Significance Index: 1
Cell Name: monocyte-derived dendritic cell (CL0011031)
Fold Change: 0.91
Cell Significance Index: 1
Cell Name: neuron associated cell (CL0000095)
Fold Change: 0.91
Cell Significance Index: 1
Cell Name: glioblast (CL0000030)
Fold Change: 0.91
Cell Significance Index: 1

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** The ferritin light chain gene (FTL) is characterized by its ability to regulate iron homeostasis and immune function. The protein product of this gene, ferritin light chain, is a subunit of ferritin, which is composed of two heavy chains and four light chains. The FTL gene is highly conserved across species, suggesting its essential role in iron homeostasis and immune function. The gene is also highly expressed in various cell types, including hematopoietic cells, epithelial cells, and immune cells. **Pathways and Functions** The ferritin light chain gene (FTL) is involved in multiple cellular pathways, including: 1. **Iron homeostasis**: Ferritin plays a crucial role in regulating iron levels in cells by sequestering iron ions and preventing their oxidation. 2. **Autolysosome formation**: Ferritin is involved in the formation of autolysosomes, which are cellular structures responsible for the degradation and recycling of cellular components. 3. **Immune system regulation**: Ferritin has been shown to play a role in immune system regulation, including the activation of immune cells and the production of cytokines. 4. **Neutrophil degranulation**: Ferritin has been shown to regulate neutrophil degranulation, a process involved in the clearance of pathogens. 5. **Vesicle-mediated transport**: Ferritin is involved in the transport of small molecules and iron ions within cells. **Clinical Significance** The ferritin light chain gene (FTL) has significant clinical implications, particularly in the context of iron overload and immune system dysfunction. Abnormalities in ferritin levels have been associated with various diseases, including: 1. **Iron overload**: Elevated ferritin levels are often seen in iron overload disorders, such as hemochromatosis. 2. **Immune system dysfunction**: Abnormalities in ferritin levels have been associated with immune system dysfunction, including autoimmune diseases and cancer. 3. **Neutropenia**: Low ferritin levels have been associated with neutropenia, a condition characterized by low white blood cell count. 4. **Anemia**: Abnormalities in ferritin levels have been associated with anemia, particularly iron-deficiency anemia. In conclusion, the ferritin light chain gene (FTL) plays a crucial role in iron homeostasis and immune function. Its dysregulation has significant clinical implications, particularly in the context of iron overload and immune system dysfunction. Further research is needed to fully understand the role of FTL in human disease and to develop therapeutic strategies to modulate ferritin levels in these disorders.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.