Details for: FTL
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 1875.2102
Cell Significance Index: -291.6800 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 1170.5017
Cell Significance Index: -296.8900 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 899.7503
Cell Significance Index: -370.6500 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 829.1793
Cell Significance Index: -336.8600 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 770.0118
Cell Significance Index: -363.5400 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 719.6552
Cell Significance Index: -370.1800 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 543.5141
Cell Significance Index: -364.7100 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 357.4575
Cell Significance Index: -341.2800 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 263.1238
Cell Significance Index: -324.4200 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 91.8894
Cell Significance Index: -362.6000 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 88.0234
Cell Significance Index: -270.3600 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 61.1249
Cell Significance Index: -163.7500 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 45.6550
Cell Significance Index: -99.9200 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 25.7512
Cell Significance Index: 475.9500 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 19.0391
Cell Significance Index: 79.2400 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 11.8358
Cell Significance Index: 339.2800 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 10.5242
Cell Significance Index: 7965.9900 - Cell Name: odontoblast (CL0000060)
Fold Change: 9.1886
Cell Significance Index: 1177.9300 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: 8.4514
Cell Significance Index: 669.3500 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 8.2552
Cell Significance Index: 387.9900 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 7.8395
Cell Significance Index: 1076.5800 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 6.6056
Cell Significance Index: 346.8200 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 6.0425
Cell Significance Index: 742.9800 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 6.0116
Cell Significance Index: 1083.7100 - Cell Name: granulosa cell (CL0000501)
Fold Change: 5.8540
Cell Significance Index: 153.9300 - Cell Name: cell in vitro (CL0001034)
Fold Change: 5.4136
Cell Significance Index: 2956.5100 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 4.8033
Cell Significance Index: 953.2300 - Cell Name: theca cell (CL0000503)
Fold Change: 4.6417
Cell Significance Index: 27.2700 - Cell Name: lactocyte (CL0002325)
Fold Change: 4.2864
Cell Significance Index: 553.7800 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 4.0258
Cell Significance Index: 1158.3500 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 3.9347
Cell Significance Index: 1739.6400 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 3.3229
Cell Significance Index: 58.7200 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 3.2469
Cell Significance Index: 169.1300 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 3.1892
Cell Significance Index: 544.5700 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 3.1610
Cell Significance Index: 203.9300 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 3.1530
Cell Significance Index: 234.9900 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 2.8653
Cell Significance Index: 337.9100 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 2.7358
Cell Significance Index: 31.0800 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 2.6743
Cell Significance Index: 124.6900 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 2.4566
Cell Significance Index: 51.4200 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.3722
Cell Significance Index: 64.5700 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 1.9740
Cell Significance Index: 1447.3200 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.6926
Cell Significance Index: 49.7100 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.6411
Cell Significance Index: 162.3400 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 1.5967
Cell Significance Index: 55.4900 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 1.4395
Cell Significance Index: 101.8100 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.8767
Cell Significance Index: 166.8500 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 0.7601
Cell Significance Index: 5.1500 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.6329
Cell Significance Index: 16.9000 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.4560
Cell Significance Index: 91.4700 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.2199
Cell Significance Index: 78.8600 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.0285
Cell Significance Index: 2.9100 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0083
Cell Significance Index: -15.6900 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.0581
Cell Significance Index: -0.5300 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.1017
Cell Significance Index: -64.5800 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.1379
Cell Significance Index: -102.1400 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.1413
Cell Significance Index: -2.3700 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.1913
Cell Significance Index: -352.8700 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.2229
Cell Significance Index: -343.0800 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.2230
Cell Significance Index: -303.2300 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.3012
Cell Significance Index: -188.0800 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.4516
Cell Significance Index: -254.7000 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.5054
Cell Significance Index: -57.7000 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.6162
Cell Significance Index: -279.6900 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.7432
Cell Significance Index: -156.5300 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -1.3575
Cell Significance Index: -70.5200 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -1.9208
Cell Significance Index: -279.2100 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -2.1317
Cell Significance Index: -248.4300 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -2.1411
Cell Significance Index: -245.3000 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -2.4268
Cell Significance Index: -149.1600 - Cell Name: pro-T cell (CL0000827)
Fold Change: -2.5428
Cell Significance Index: -64.9600 - Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: -2.6803
Cell Significance Index: -19.2500 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -2.9453
Cell Significance Index: -17.8000 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -2.9986
Cell Significance Index: -83.8000 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -3.4398
Cell Significance Index: -358.1700 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -3.4694
Cell Significance Index: -218.6700 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -3.5040
Cell Significance Index: -44.8800 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -3.6528
Cell Significance Index: -165.5700 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -3.8831
Cell Significance Index: -136.4500 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -3.9418
Cell Significance Index: -302.4900 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -3.9468
Cell Significance Index: -126.4100 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -3.9904
Cell Significance Index: -68.7900 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -4.3282
Cell Significance Index: -291.0300 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -4.3291
Cell Significance Index: -65.7500 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -4.4156
Cell Significance Index: -74.3800 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -4.8947
Cell Significance Index: -130.9300 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -5.1755
Cell Significance Index: -76.3900 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -5.1845
Cell Significance Index: -358.5400 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -5.2207
Cell Significance Index: -292.9600 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -5.4513
Cell Significance Index: -84.3400 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -5.4979
Cell Significance Index: -119.1100 - Cell Name: preadipocyte (CL0002334)
Fold Change: -5.8154
Cell Significance Index: -113.5000 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -5.9303
Cell Significance Index: -363.5800 - Cell Name: peg cell (CL4033014)
Fold Change: -6.1229
Cell Significance Index: -141.4600 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -6.1479
Cell Significance Index: -92.1200 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -6.6027
Cell Significance Index: -176.9200 - Cell Name: melanocyte of skin (CL1000458)
Fold Change: -6.8926
Cell Significance Index: -96.6100 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -7.5079
Cell Significance Index: -221.1400 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -7.5945
Cell Significance Index: -311.1900 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -7.9470
Cell Significance Index: -291.7300
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 435672394
Symbol: FRIL_HUMAN
Name: Ferritin light chain
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3840162
Title: Structural and functional relationships of human ferritin H and L chains deduced from cDNA clones.
PubMed ID: 3840162
PubMed ID: 3858810
Title: Structure of human ferritin light subunit messenger RNA: comparison with heavy subunit message and functional implications.
PubMed ID: 3858810
PubMed ID: 3754330
Title: Cloning of the gene coding for human L apoferritin.
PubMed ID: 3754330
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 15057824
Title: The DNA sequence and biology of human chromosome 19.
PubMed ID: 15057824
DOI: 10.1038/nature02399
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 3023856
Title: Structure and expression of ferritin genes in a human promyelocytic cell line that differentiates in vitro.
PubMed ID: 3023856
PubMed ID: 6653779
Title: The amino acid sequence of human liver apoferritin.
PubMed ID: 6653779
PubMed ID: 8706699
Title: Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry.
PubMed ID: 8706699
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23940258
Title: Human L-ferritin deficiency is characterized by idiopathic generalized seizures and atypical restless leg syndrome.
PubMed ID: 23940258
DOI: 10.1084/jem.20130315
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24695223
Title: Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy.
PubMed ID: 24695223
DOI: 10.1038/nature13148
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 16790936
PubMed ID: 19923220
Title: Unraveling of the E-helices and disruption of 4-fold pores are associated with iron mishandling in a mutant ferritin causing neurodegeneration.
PubMed ID: 19923220
PubMed ID: 20159981
Title: Mutant ferritin L-chains that cause neurodegeneration act in a dominant-negative manner to reduce ferritin iron incorporation.
PubMed ID: 20159981
PubMed ID: 16116125
Title: Neuroferritinopathy: missense mutation in FTL causing early-onset bilateral pallidal involvement.
PubMed ID: 16116125
PubMed ID: 19176363
Title: A new missense mutation in the L ferritin coding sequence associated with elevated levels of glycosylated ferritin in serum and absence of iron overload.
PubMed ID: 19176363
Sequence Information:
- Length: 175
- Mass: 20020
- Checksum: 0DB98081FF976BC2
- Sequence:
MSSQIRQNYS TDVEAAVNSL VNLYLQASYT YLSLGFYFDR DDVALEGVSH FFRELAEEKR EGYERLLKMQ NQRGGRALFQ DIKKPAEDEW GKTPDAMKAA MALEKKLNQA LLDLHALGSA RTDPHLCDFL ETHFLDEEVK LIKKMGDHLT NLHRLGGPEA GLGEYLFERL TLKHD
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.