Gene H3 3B - ENSG00000132475 | NCBI Gene ID: 3021

Details for: H3 3B

Gene ID: 3021

Symbol: H3 3B

Ensembl ID: ENSG00000132475

Description: H3.3 histone B

Associated with

Activated pkn1 stimulates transcription of ar (androgen receptor) regulated genes klk2 and klk3
(R-HSA-5625886)
Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
Amyloid fiber formation
(R-HSA-977225)
Assembly of the orc complex at the origin of replication
(R-HSA-68616)
Assembly of the pre-replicative complex
(R-HSA-68867)
B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Chromatin modifications during the maternal to zygotic transition (mzt)
(R-HSA-9821002)
Chromosome maintenance
(R-HSA-73886)
Condensation of prophase chromosomes
(R-HSA-2299718)
Defective pyroptosis
(R-HSA-9710421)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
Dna methylation
(R-HSA-5334118)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Epigenetic regulation of gene expression
(R-HSA-212165)
Ercc6 (csb) and ehmt2 (g9a) positively regulate rrna expression
(R-HSA-427389)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Factors involved in megakaryocyte development and platelet production
(R-HSA-983231)
Formation of the beta-catenin:tcf transactivating complex
(R-HSA-201722)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Hemostasis
(R-HSA-109582)
Inhibition of dna recombination at telomere
(R-HSA-9670095)
Maternal to zygotic transition (mzt)
(R-HSA-9816359)
Meiosis
(R-HSA-1500620)
Meiotic recombination
(R-HSA-912446)
Metabolism of proteins
(R-HSA-392499)
Mitotic prophase
(R-HSA-68875)
M phase
(R-HSA-68886)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Norc negatively regulates rrna expression
(R-HSA-427413)
Oxidative stress induced senescence
(R-HSA-2559580)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Prc2 methylates histones and dna
(R-HSA-212300)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Replacement of protamines by nucleosomes in the male pronucleus
(R-HSA-9821993)
Reproduction
(R-HSA-1474165)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate pkns
(R-HSA-5625740)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i promoter opening
(R-HSA-73728)
Rna polymerase i transcription
(R-HSA-73864)
Runx1 regulates genes involved in megakaryocyte differentiation and platelet function
(R-HSA-8936459)
Runx1 regulates transcription of genes involved in differentiation of hscs
(R-HSA-8939236)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by notch
(R-HSA-157118)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Sirt1 negatively regulates rrna expression
(R-HSA-427359)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Telomere maintenance
(R-HSA-157579)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Chromosome, telomeric region
(GO:0000781)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Nucleoplasm
(GO:0005654)
Nucleosomal dna binding
(GO:0031492)
Nucleosome
(GO:0000786)
Nucleosome assembly
(GO:0006334)
Nucleus
(GO:0005634)
Positive regulation of cell growth
(GO:0030307)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii core promoter sequence-specific dna binding
(GO:0000979)
Structural constituent of chromatin
(GO:0030527)
Telomere organization
(GO:0032200)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: pancreatic A cell (CL0000171)
Fold Change: 7.51
Marker Score: 7350.5
Cell Name: follicular B cell (CL0000843)
Fold Change: 6.77
Marker Score: 7336
Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: 6.2
Marker Score: 4150.5
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 6.06
Marker Score: 12796
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 5.75
Marker Score: 4211.5
Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 5.35
Marker Score: 13601.5
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 5.3
Marker Score: 15456.5
Cell Name: malignant cell (CL0001064)
Fold Change: 5.24
Marker Score: 70347
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 5.22
Marker Score: 8042.5
Cell Name: early promyelocyte (CL0002154)
Fold Change: 5.21
Marker Score: 4170
Cell Name: radial glial cell (CL0000681)
Fold Change: 5.18
Marker Score: 1910
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 5.18
Marker Score: 10857
Cell Name: mature T cell (CL0002419)
Fold Change: 5.15
Marker Score: 50990
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 5.05
Marker Score: 3660
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 5.02
Marker Score: 2939
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 4.98
Marker Score: 169313
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 4.97
Marker Score: 2554
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 4.96
Marker Score: 6464
Cell Name: theca cell (CL0000503)
Fold Change: 4.95
Marker Score: 3546.5
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 4.9
Marker Score: 3710
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 4.9
Marker Score: 4172
Cell Name: T-helper 1 cell (CL0000545)
Fold Change: 4.9
Marker Score: 1910
Cell Name: secretory cell (CL0000151)
Fold Change: 4.89
Marker Score: 8931
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 4.87
Marker Score: 3239
Cell Name: cord blood hematopoietic stem cell (CL2000095)
Fold Change: 4.85
Marker Score: 3658
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 4.75
Marker Score: 15002
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 4.56
Marker Score: 5513
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 4.55
Marker Score: 240829
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 4.53
Marker Score: 1081
Cell Name: memory T cell (CL0000813)
Fold Change: 4.51
Marker Score: 1937
Cell Name: mesodermal cell (CL0000222)
Fold Change: 4.48
Marker Score: 59106.5
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 4.47
Marker Score: 249745
Cell Name: naive T cell (CL0000898)
Fold Change: 4.39
Marker Score: 2825.5
Cell Name: chondrocyte (CL0000138)
Fold Change: 4.38
Marker Score: 1969.5
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 4.35
Marker Score: 4100
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 4.32
Marker Score: 11925
Cell Name: epithelial cell of exocrine pancreas (CL1001433)
Fold Change: 4.3
Marker Score: 2425
Cell Name: blood cell (CL0000081)
Fold Change: 4.3
Marker Score: 49940
Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 4.28
Marker Score: 6199
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 4.28
Marker Score: 10446
Cell Name: myelocyte (CL0002193)
Fold Change: 4.24
Marker Score: 1834
Cell Name: neutrophil (CL0000775)
Fold Change: 4.23
Marker Score: 2579
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 4.2
Marker Score: 11777
Cell Name: Mueller cell (CL0000636)
Fold Change: 4.17
Marker Score: 5778
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 4.1
Marker Score: 2404
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 4.07
Marker Score: 3935.5
Cell Name: type I pneumocyte (CL0002062)
Fold Change: 4.06
Marker Score: 4890
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 4.05
Marker Score: 4997
Cell Name: supporting cell (CL0000630)
Fold Change: 4.04
Marker Score: 7595
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 4.04
Marker Score: 3442.5
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 4.01
Marker Score: 5902
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 4.01
Marker Score: 29824
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 4
Marker Score: 25509
Cell Name: germinal center B cell (CL0000844)
Fold Change: 4
Marker Score: 2431
Cell Name: type I NK T cell (CL0000921)
Fold Change: 3.99
Marker Score: 3132
Cell Name: endothelial cell (CL0000115)
Fold Change: 3.98
Marker Score: 3569
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 3.98
Marker Score: 4249
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 3.96
Marker Score: 907
Cell Name: intraepithelial lymphocyte (CL0002496)
Fold Change: 3.96
Marker Score: 4397
Cell Name: endothelial tip cell (CL0000704)
Fold Change: 3.96
Marker Score: 921
Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: 3.95
Marker Score: 2037.5
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 3.94
Marker Score: 3395
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 3.94
Marker Score: 2801
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 3.92
Marker Score: 4076
Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 3.92
Marker Score: 1033
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 3.91
Marker Score: 4201
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 3.89
Marker Score: 20441
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 3.88
Marker Score: 2640.5
Cell Name: fibroblast (CL0000057)
Fold Change: 3.85
Marker Score: 3721
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 3.85
Marker Score: 25081
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 3.84
Marker Score: 1988
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 3.83
Marker Score: 4169
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 3.83
Marker Score: 3775
Cell Name: reticular cell (CL0000432)
Fold Change: 3.8
Marker Score: 1388.5
Cell Name: granulocyte (CL0000094)
Fold Change: 3.79
Marker Score: 1698
Cell Name: muscle precursor cell (CL0000680)
Fold Change: 3.77
Marker Score: 978
Cell Name: ependymal cell (CL0000065)
Fold Change: 3.76
Marker Score: 1313
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 3.76
Marker Score: 50007
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 3.73
Marker Score: 3286.5
Cell Name: columnar/cuboidal epithelial cell (CL0000075)
Fold Change: 3.71
Marker Score: 983
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 3.7
Marker Score: 14334
Cell Name: retinal rod cell (CL0000604)
Fold Change: 3.7
Marker Score: 10553
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 3.69
Marker Score: 1053
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 3.69
Marker Score: 23999
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 3.68
Marker Score: 6028
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 3.67
Marker Score: 18032
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 3.66
Marker Score: 3270
Cell Name: club cell (CL0000158)
Fold Change: 3.66
Marker Score: 4273
Cell Name: Schwann cell precursor (CL0002375)
Fold Change: 3.66
Marker Score: 910
Cell Name: lung macrophage (CL1001603)
Fold Change: 3.65
Marker Score: 4174
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 3.65
Marker Score: 2400
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 3.64
Marker Score: 3065
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 3.64
Marker Score: 1482
Cell Name: pancreatic D cell (CL0000173)
Fold Change: 3.63
Marker Score: 1580
Cell Name: naive B cell (CL0000788)
Fold Change: 3.63
Marker Score: 3245
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 3.63
Marker Score: 1166.5
Cell Name: Sertoli cell (CL0000216)
Fold Change: 3.63
Marker Score: 21544.5
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 3.63
Marker Score: 962
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 3.63
Marker Score: 1251
Cell Name: endothelial cell of sinusoid (CL0002262)
Fold Change: 3.63
Marker Score: 880

Hover over a box to see details here...

Other Information

Description

**Key characteristics:** * H3.3 is a member of the histone family of proteins. * It is found in the nucleus of eukaryotic cells. * It is a highly conserved protein, with a similar sequence in humans, mice, and flies. * It is involved in the regulation of gene expression through its interaction with DNA-binding proteins. **Pathways and functions:** * H3.3 is involved in the activation of hox genes during differentiation. Hox genes are a family of genes that are responsible for the development of the body. H3.3 is a key regulator of hox gene expression, and its mutation can lead to a variety of developmental abnormalities. * It is also involved in the cell cycle, cell cycle, mitotic, and cellular responses to stimuli. H3.3 is a key regulator of cell cycle progression, and its mutation can lead to cell cycle abnormalities. * It is involved in developmental biology, disease, and meiosis. H3.3 is expressed in a variety of cell types during development, and its mutation can lead to a variety of developmental abnormalities. **Clinical significance:** * Mutations in H3.3 have been linked to a number of human diseases, including cancer and developmental disorders. * H3.3 is a potential target for cancer therapy. By targeting H3.3, it may be possible to inhibit cancer growth and metastasis.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.