H3 3B | ENSG00000132475 | NCBI 3021

Details for: H3 3B

Gene ID: 3021

Symbol: H3 3B

Ensembl ID: ENSG00000132475

Description: H3.3 histone B

Associated with

Activated pkn1 stimulates transcription of ar (androgen receptor) regulated genes klk2 and klk3
(R-HSA-5625886)
Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
Amyloid fiber formation
(R-HSA-977225)
Assembly of the orc complex at the origin of replication
(R-HSA-68616)
Assembly of the pre-replicative complex
(R-HSA-68867)
B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Chromatin modifications during the maternal to zygotic transition (mzt)
(R-HSA-9821002)
Chromosome maintenance
(R-HSA-73886)
Condensation of prophase chromosomes
(R-HSA-2299718)
Defective pyroptosis
(R-HSA-9710421)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
Dna methylation
(R-HSA-5334118)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Epigenetic regulation by wdr5-containing histone modifying complexes
(R-HSA-9917777)
Epigenetic regulation of adipogenesis genes by mll3 and mll4 complexes
(R-HSA-9851695)
Epigenetic regulation of gene expression
(R-HSA-212165)
Epigenetic regulation of gene expression by mll3 and mll4 complexes
(R-HSA-9818564)
Ercc6 (csb) and ehmt2 (g9a) positively regulate rrna expression
(R-HSA-427389)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Factors involved in megakaryocyte development and platelet production
(R-HSA-983231)
Formation of the beta-catenin:tcf transactivating complex
(R-HSA-201722)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Hemostasis
(R-HSA-109582)
Inhibition of dna recombination at telomere
(R-HSA-9670095)
Maternal to zygotic transition (mzt)
(R-HSA-9816359)
Meiosis
(R-HSA-1500620)
Meiotic recombination
(R-HSA-912446)
Metabolism of proteins
(R-HSA-392499)
Mitotic prophase
(R-HSA-68875)
Mll4 and mll3 complexes regulate expression of pparg target genes in adipogenesis and hepatic steatosis
(R-HSA-9841922)
M phase
(R-HSA-68886)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Norc negatively regulates rrna expression
(R-HSA-427413)
Oxidative stress induced senescence
(R-HSA-2559580)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Prc2 methylates histones and dna
(R-HSA-212300)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Regulation of endogenous retroelements
(R-HSA-9842860)
Regulation of endogenous retroelements by krab-zfp proteins
(R-HSA-9843940)
Regulation of endogenous retroelements by piwi-interacting rnas (pirnas)
(R-HSA-9845323)
Regulation of endogenous retroelements by the human silencing hub (hush) complex
(R-HSA-9843970)
Replacement of protamines by nucleosomes in the male pronucleus
(R-HSA-9821993)
Reproduction
(R-HSA-1474165)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate pkns
(R-HSA-5625740)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i promoter opening
(R-HSA-73728)
Rna polymerase i transcription
(R-HSA-73864)
Runx1 regulates genes involved in megakaryocyte differentiation and platelet function
(R-HSA-8936459)
Runx1 regulates transcription of genes involved in differentiation of hscs
(R-HSA-8939236)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by notch
(R-HSA-157118)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Sirt1 negatively regulates rrna expression
(R-HSA-427359)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Telomere maintenance
(R-HSA-157579)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Cell population proliferation
(GO:0008283)
Embryo implantation
(GO:0007566)
Male gonad development
(GO:0008584)
Multicellular organism growth
(GO:0035264)
Muscle cell differentiation
(GO:0042692)
Nucleosomal dna binding
(GO:0031492)
Nucleosome assembly
(GO:0006334)
Nucleus organization
(GO:0006997)
Oocyte maturation
(GO:0001556)
Osteoblast differentiation
(GO:0001649)
Pericentric heterochromatin formation
(GO:0031508)
Positive regulation of cell growth
(GO:0030307)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii core promoter sequence-specific dna binding
(GO:0000979)
Single fertilization
(GO:0007338)
Spermatid development
(GO:0007286)
Structural constituent of chromatin
(GO:0030527)
Subtelomeric heterochromatin formation
(GO:0031509)
Telomere organization
(GO:0032200)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 1492.7491
Cell Significance Index: -232.1900
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 879.7982
Cell Significance Index: -223.1600
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 668.3860
Cell Significance Index: -275.3400
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 613.8977
Cell Significance Index: -289.8400
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 566.4626
Cell Significance Index: -291.3800
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 433.6817
Cell Significance Index: -291.0100
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 208.8842
Cell Significance Index: -257.5500
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 71.0914
Cell Significance Index: -280.5300
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 56.3316
Cell Significance Index: -173.0200
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 36.8457
Cell Significance Index: -80.6400
Cell Name: theca cell (CL0000503)
Fold Change: 21.2799
Cell Significance Index: 125.0200
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 13.3364
Cell Significance Index: 700.2100
Cell Name: granulosa cell (CL0000501)
Fold Change: 11.1345
Cell Significance Index: 292.7800
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 9.9365
Cell Significance Index: 175.5900
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 9.7006
Cell Significance Index: 203.0500
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 9.3551
Cell Significance Index: 325.0900
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 8.4415
Cell Significance Index: 241.9800
Cell Name: odontoblast (CL0000060)
Fold Change: 8.2867
Cell Significance Index: 1062.3000
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 7.9453
Cell Significance Index: 146.8500
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 7.9127
Cell Significance Index: 60.9900
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 7.6468
Cell Significance Index: 1050.1200
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 7.0901
Cell Significance Index: 333.2300
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 7.0861
Cell Significance Index: 528.1200
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 7.0726
Cell Significance Index: 192.5100
Cell Name: early pro-B cell (CL0002046)
Fold Change: 6.7877
Cell Significance Index: 437.9100
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 6.2195
Cell Significance Index: 764.7500
Cell Name: lactocyte (CL0002325)
Fold Change: 6.2132
Cell Significance Index: 802.7000
Cell Name: cell in vitro (CL0001034)
Fold Change: 5.7090
Cell Significance Index: 3117.8400
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 5.7045
Cell Significance Index: 1028.3500
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 5.5259
Cell Significance Index: 2443.1400
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 5.0969
Cell Significance Index: 55.4100
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 4.8915
Cell Significance Index: 55.5700
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 4.7735
Cell Significance Index: 337.6000
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 4.4491
Cell Significance Index: 524.6900
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 4.2460
Cell Significance Index: 197.9700
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 4.1756
Cell Significance Index: 53.4800
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 3.1305
Cell Significance Index: 91.9400
Cell Name: colon goblet cell (CL0009039)
Fold Change: 3.0163
Cell Significance Index: 298.3800
Cell Name: peg cell (CL4033014)
Fold Change: 2.8875
Cell Significance Index: 66.7100
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 2.0120
Cell Significance Index: 104.5200
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 1.2052
Cell Significance Index: 138.0800
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.1957
Cell Significance Index: 237.3000
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 1.0479
Cell Significance Index: 1972.9800
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.8262
Cell Significance Index: 141.0700
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.7741
Cell Significance Index: 147.3200
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.7700
Cell Significance Index: 582.8100
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.2078
Cell Significance Index: 41.6800
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.1861
Cell Significance Index: 136.4200
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0629
Cell Significance Index: 39.9600
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0476
Cell Significance Index: 1.2700
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.0078
Cell Significance Index: 2.2300
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.0042
Cell Significance Index: 0.2100
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0185
Cell Significance Index: -0.3100
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0257
Cell Significance Index: -9.2200
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0867
Cell Significance Index: -8.8600
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.1241
Cell Significance Index: -191.0400
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.1287
Cell Significance Index: -237.3700
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1626
Cell Significance Index: -10.2500
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.1632
Cell Significance Index: -221.9000
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.1756
Cell Significance Index: -79.7100
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.2900
Cell Significance Index: -214.8500
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.3457
Cell Significance Index: -19.4000
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.4437
Cell Significance Index: -250.2300
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.5287
Cell Significance Index: -21.6600
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.5780
Cell Significance Index: -360.9500
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.8175
Cell Significance Index: -14.0100
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.9229
Cell Significance Index: -134.1500
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.9801
Cell Significance Index: -27.3900
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -1.0184
Cell Significance Index: -6.9000
Cell Name: kidney cell (CL1000497)
Fold Change: -1.1185
Cell Significance Index: -8.9300
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -1.3813
Cell Significance Index: -143.8300
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -1.5067
Cell Significance Index: -317.3600
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -1.9568
Cell Significance Index: -18.0200
Cell Name: pro-T cell (CL0000827)
Fold Change: -2.0601
Cell Significance Index: -52.6300
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -2.0899
Cell Significance Index: -60.2200
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -2.4082
Cell Significance Index: -190.7300
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -2.5095
Cell Significance Index: -192.5800
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -2.6819
Cell Significance Index: -121.5600
Cell Name: retinal rod cell (CL0000604)
Fold Change: -2.7377
Cell Significance Index: -32.6400
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: -2.7530
Cell Significance Index: -29.2500
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -2.8277
Cell Significance Index: -38.5800
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -3.6245
Cell Significance Index: -250.6600
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -3.8120
Cell Significance Index: -101.9700
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -3.9684
Cell Significance Index: -68.4100
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -4.6499
Cell Significance Index: -100.7400
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -4.6513
Cell Significance Index: -148.9800
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -4.6554
Cell Significance Index: -285.4200
Cell Name: Purkinje cell (CL0000121)
Fold Change: -4.9177
Cell Significance Index: -107.6800
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -5.2583
Cell Significance Index: -78.7900
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -5.2705
Cell Significance Index: -155.2400
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: -5.4077
Cell Significance Index: -33.2800
Cell Name: preadipocyte (CL0002334)
Fold Change: -5.5105
Cell Significance Index: -107.5500
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -5.7184
Cell Significance Index: -252.9400
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -5.7341
Cell Significance Index: -48.1700
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -6.1460
Cell Significance Index: -157.9800
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -6.3365
Cell Significance Index: -232.6100
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -6.6527
Cell Significance Index: -233.7700
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: -6.6706
Cell Significance Index: -57.3200
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -6.7433
Cell Significance Index: -255.3500
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -7.3372
Cell Significance Index: -257.0400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** 1. **Histone variant**: H3.3 is a variant of the histone H3 protein, which is a fundamental component of chromatin. 2. **DNA binding**: H3.3 has a high affinity for DNA, allowing it to interact with and regulate gene expression. 3. **Chromatin modifications**: H3.3 has been implicated in the regulation of chromatin modifications, including histone acetylation and methylation. 4. **Transcriptional regulation**: H3.3 plays a role in the regulation of transcriptional activity, particularly in the context of androgen receptor-regulated genes. 5. **Cellular expression**: H3.3 is significantly expressed in various cell types, including pancreatic A cells, follicular B cells, skeletal muscle satellite cells, and malignant cells. **Pathways and Functions** 1. **DNA replication**: H3.3 is involved in the assembly of the pre-replicative complex and the replication of DNA. 2. **Transcriptional regulation**: H3.3 regulates the expression of genes, particularly in the context of androgen receptor-regulated genes. 3. **Chromatin modifications**: H3.3 is involved in the regulation of chromatin modifications, including histone acetylation and methylation. 4. **Cellular responses to stimuli**: H3.3 plays a role in the regulation of cellular responses to stimuli, stress, and senescence. 5. **Gene silencing**: H3.3 has been implicated in the regulation of gene silencing by RNA. **Clinical Significance** 1. **Cancer**: H3.3 has been implicated in the regulation of gene expression in malignant cells, suggesting its potential role in cancer development and progression. 2. **Androgen receptor-regulated genes**: H3.3 plays a role in the regulation of androgen receptor-regulated genes, which are involved in various diseases, including prostate cancer and metabolic disorders. 3. **Chromatin modifications**: H3.3's involvement in chromatin modifications has implications for the treatment of diseases associated with chromatin dysfunction, such as cancer and neurodegenerative disorders. 4. **Cellular responses to stress**: H3.3's role in regulating cellular responses to stress and senescence has implications for the development of strategies to prevent or treat age-related diseases. 5. **Gene expression regulation**: H3.3's involvement in the regulation of gene expression has implications for the development of therapeutic strategies to modulate gene expression in various diseases. In conclusion, H3.3 histone B is a critical regulator of gene expression and chromatin modifications, with implications for various diseases, including cancer, metabolic disorders, and neurodegenerative disorders. Further research is needed to fully understand the role of H3.3 in these diseases and to develop therapeutic strategies to modulate its activity.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.