Details for: H3 3B

Gene ID: 3021

Symbol: H3 3B

Ensembl ID: ENSG00000132475

Description: H3.3 histone B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 1492.7491
    Cell Significance Index: -232.1900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 879.7982
    Cell Significance Index: -223.1600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 668.3860
    Cell Significance Index: -275.3400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 613.8977
    Cell Significance Index: -289.8400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 566.4626
    Cell Significance Index: -291.3800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 433.6817
    Cell Significance Index: -291.0100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 208.8842
    Cell Significance Index: -257.5500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 71.0914
    Cell Significance Index: -280.5300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 56.3316
    Cell Significance Index: -173.0200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 36.8457
    Cell Significance Index: -80.6400
  • Cell Name: theca cell (CL0000503)
    Fold Change: 21.2799
    Cell Significance Index: 125.0200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 13.3364
    Cell Significance Index: 700.2100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 11.1345
    Cell Significance Index: 292.7800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 9.9365
    Cell Significance Index: 175.5900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 9.7006
    Cell Significance Index: 203.0500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 9.3551
    Cell Significance Index: 325.0900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 8.4415
    Cell Significance Index: 241.9800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 8.2867
    Cell Significance Index: 1062.3000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 7.9453
    Cell Significance Index: 146.8500
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 7.9127
    Cell Significance Index: 60.9900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 7.6468
    Cell Significance Index: 1050.1200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 7.0901
    Cell Significance Index: 333.2300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 7.0861
    Cell Significance Index: 528.1200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 7.0726
    Cell Significance Index: 192.5100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 6.7877
    Cell Significance Index: 437.9100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 6.2195
    Cell Significance Index: 764.7500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 6.2132
    Cell Significance Index: 802.7000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 5.7090
    Cell Significance Index: 3117.8400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 5.7045
    Cell Significance Index: 1028.3500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 5.5259
    Cell Significance Index: 2443.1400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 5.0969
    Cell Significance Index: 55.4100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 4.8915
    Cell Significance Index: 55.5700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 4.7735
    Cell Significance Index: 337.6000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 4.4491
    Cell Significance Index: 524.6900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.2460
    Cell Significance Index: 197.9700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 4.1756
    Cell Significance Index: 53.4800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 3.1305
    Cell Significance Index: 91.9400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 3.0163
    Cell Significance Index: 298.3800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.8875
    Cell Significance Index: 66.7100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.0120
    Cell Significance Index: 104.5200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.2052
    Cell Significance Index: 138.0800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1957
    Cell Significance Index: 237.3000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.0479
    Cell Significance Index: 1972.9800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.8262
    Cell Significance Index: 141.0700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7741
    Cell Significance Index: 147.3200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.7700
    Cell Significance Index: 582.8100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2078
    Cell Significance Index: 41.6800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1861
    Cell Significance Index: 136.4200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0629
    Cell Significance Index: 39.9600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0476
    Cell Significance Index: 1.2700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0078
    Cell Significance Index: 2.2300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0042
    Cell Significance Index: 0.2100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0185
    Cell Significance Index: -0.3100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0257
    Cell Significance Index: -9.2200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0867
    Cell Significance Index: -8.8600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1241
    Cell Significance Index: -191.0400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1287
    Cell Significance Index: -237.3700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1626
    Cell Significance Index: -10.2500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.1632
    Cell Significance Index: -221.9000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1756
    Cell Significance Index: -79.7100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.2900
    Cell Significance Index: -214.8500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3457
    Cell Significance Index: -19.4000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.4437
    Cell Significance Index: -250.2300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.5287
    Cell Significance Index: -21.6600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.5780
    Cell Significance Index: -360.9500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.8175
    Cell Significance Index: -14.0100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.9229
    Cell Significance Index: -134.1500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.9801
    Cell Significance Index: -27.3900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -1.0184
    Cell Significance Index: -6.9000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -1.1185
    Cell Significance Index: -8.9300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.3813
    Cell Significance Index: -143.8300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -1.5067
    Cell Significance Index: -317.3600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -1.9568
    Cell Significance Index: -18.0200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -2.0601
    Cell Significance Index: -52.6300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -2.0899
    Cell Significance Index: -60.2200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -2.4082
    Cell Significance Index: -190.7300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -2.5095
    Cell Significance Index: -192.5800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -2.6819
    Cell Significance Index: -121.5600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -2.7377
    Cell Significance Index: -32.6400
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -2.7530
    Cell Significance Index: -29.2500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -2.8277
    Cell Significance Index: -38.5800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -3.6245
    Cell Significance Index: -250.6600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -3.8120
    Cell Significance Index: -101.9700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -3.9684
    Cell Significance Index: -68.4100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -4.6499
    Cell Significance Index: -100.7400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -4.6513
    Cell Significance Index: -148.9800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -4.6554
    Cell Significance Index: -285.4200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -4.9177
    Cell Significance Index: -107.6800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -5.2583
    Cell Significance Index: -78.7900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -5.2705
    Cell Significance Index: -155.2400
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -5.4077
    Cell Significance Index: -33.2800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -5.5105
    Cell Significance Index: -107.5500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -5.7184
    Cell Significance Index: -252.9400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -5.7341
    Cell Significance Index: -48.1700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -6.1460
    Cell Significance Index: -157.9800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -6.3365
    Cell Significance Index: -232.6100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -6.6527
    Cell Significance Index: -233.7700
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -6.6706
    Cell Significance Index: -57.3200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -6.7433
    Cell Significance Index: -255.3500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -7.3372
    Cell Significance Index: -257.0400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Histone variant**: H3.3 is a variant of the histone H3 protein, which is a fundamental component of chromatin. 2. **DNA binding**: H3.3 has a high affinity for DNA, allowing it to interact with and regulate gene expression. 3. **Chromatin modifications**: H3.3 has been implicated in the regulation of chromatin modifications, including histone acetylation and methylation. 4. **Transcriptional regulation**: H3.3 plays a role in the regulation of transcriptional activity, particularly in the context of androgen receptor-regulated genes. 5. **Cellular expression**: H3.3 is significantly expressed in various cell types, including pancreatic A cells, follicular B cells, skeletal muscle satellite cells, and malignant cells. **Pathways and Functions** 1. **DNA replication**: H3.3 is involved in the assembly of the pre-replicative complex and the replication of DNA. 2. **Transcriptional regulation**: H3.3 regulates the expression of genes, particularly in the context of androgen receptor-regulated genes. 3. **Chromatin modifications**: H3.3 is involved in the regulation of chromatin modifications, including histone acetylation and methylation. 4. **Cellular responses to stimuli**: H3.3 plays a role in the regulation of cellular responses to stimuli, stress, and senescence. 5. **Gene silencing**: H3.3 has been implicated in the regulation of gene silencing by RNA. **Clinical Significance** 1. **Cancer**: H3.3 has been implicated in the regulation of gene expression in malignant cells, suggesting its potential role in cancer development and progression. 2. **Androgen receptor-regulated genes**: H3.3 plays a role in the regulation of androgen receptor-regulated genes, which are involved in various diseases, including prostate cancer and metabolic disorders. 3. **Chromatin modifications**: H3.3's involvement in chromatin modifications has implications for the treatment of diseases associated with chromatin dysfunction, such as cancer and neurodegenerative disorders. 4. **Cellular responses to stress**: H3.3's role in regulating cellular responses to stress and senescence has implications for the development of strategies to prevent or treat age-related diseases. 5. **Gene expression regulation**: H3.3's involvement in the regulation of gene expression has implications for the development of therapeutic strategies to modulate gene expression in various diseases. In conclusion, H3.3 histone B is a critical regulator of gene expression and chromatin modifications, with implications for various diseases, including cancer, metabolic disorders, and neurodegenerative disorders. Further research is needed to fully understand the role of H3.3 in these diseases and to develop therapeutic strategies to modulate its activity.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.