Details for: OPCML

Gene ID: 4978

Symbol: OPCML

Ensembl ID: ENSG00000183715

Description: opioid binding protein/cell adhesion molecule like

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 9.2606
    Cell Significance Index: 264.2700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.5437
    Cell Significance Index: -16.5100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 6.3334
    Cell Significance Index: 239.8300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 5.9308
    Cell Significance Index: 398.7900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 5.9094
    Cell Significance Index: 2119.6000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 5.8587
    Cell Significance Index: 128.2900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 5.7273
    Cell Significance Index: 253.3300
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 4.4007
    Cell Significance Index: 57.0700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 4.3998
    Cell Significance Index: 3043.0500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 4.1099
    Cell Significance Index: 824.4400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 3.5783
    Cell Significance Index: 219.9400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 3.3711
    Cell Significance Index: 5189.7100
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 3.1005
    Cell Significance Index: 41.3600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 2.4964
    Cell Significance Index: 59.8700
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 2.0640
    Cell Significance Index: 21.5000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 1.5825
    Cell Significance Index: 27.1200
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.3025
    Cell Significance Index: 9.9900
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.3641
    Cell Significance Index: 4.5400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1863
    Cell Significance Index: 253.3800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1089
    Cell Significance Index: 6.1100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0099
    Cell Significance Index: 18.3400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0147
    Cell Significance Index: -27.7700
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0620
    Cell Significance Index: -0.5900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0797
    Cell Significance Index: -1.5800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1102
    Cell Significance Index: -70.0000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1405
    Cell Significance Index: -104.1100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.1465
    Cell Significance Index: -107.4100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.2020
    Cell Significance Index: -126.1200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2047
    Cell Significance Index: -115.4300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.2254
    Cell Significance Index: -102.3100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2735
    Cell Significance Index: -7.0300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3340
    Cell Significance Index: -96.1000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.3341
    Cell Significance Index: -3.6400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.4354
    Cell Significance Index: -6.2400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4363
    Cell Significance Index: -9.2600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.4675
    Cell Significance Index: -20.3300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4838
    Cell Significance Index: -13.5200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.4997
    Cell Significance Index: -7.5900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.5124
    Cell Significance Index: -101.6800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.5183
    Cell Significance Index: -93.4400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.5762
    Cell Significance Index: -121.3700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.5770
    Cell Significance Index: -83.8800
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.5903
    Cell Significance Index: -7.4500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6173
    Cell Significance Index: -20.2100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6575
    Cell Significance Index: -20.9400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.6609
    Cell Significance Index: -112.8500
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.6856
    Cell Significance Index: -5.9300
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.6896
    Cell Significance Index: -8.0500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.7063
    Cell Significance Index: -14.1800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.7933
    Cell Significance Index: -97.5400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.8349
    Cell Significance Index: -114.6600
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.9660
    Cell Significance Index: -13.5400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -1.0089
    Cell Significance Index: -117.5800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.0165
    Cell Significance Index: -105.8400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -1.0640
    Cell Significance Index: -108.6900
  • Cell Name: neuron (CL0000540)
    Fold Change: -1.0919
    Cell Significance Index: -10.3500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -1.1007
    Cell Significance Index: -126.1000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -1.2307
    Cell Significance Index: -15.5300
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -1.3772
    Cell Significance Index: -16.4700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.4078
    Cell Significance Index: -111.5000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -1.4198
    Cell Significance Index: -9.6200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.4871
    Cell Significance Index: -114.1200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -1.7038
    Cell Significance Index: -42.5000
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -1.7883
    Cell Significance Index: -19.7300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.8497
    Cell Significance Index: -64.8000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -1.9407
    Cell Significance Index: -41.9300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.9858
    Cell Significance Index: -125.1600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -2.0265
    Cell Significance Index: -106.4000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -2.0351
    Cell Significance Index: -23.1200
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -2.1014
    Cell Significance Index: -16.7200
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: -2.1740
    Cell Significance Index: -17.0500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -2.2158
    Cell Significance Index: -104.1400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -2.3751
    Cell Significance Index: -49.5700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -2.4592
    Cell Significance Index: -114.6600
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -2.9691
    Cell Significance Index: -35.9900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -3.0976
    Cell Significance Index: -113.7100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -3.1669
    Cell Significance Index: -62.3300
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -3.1793
    Cell Significance Index: -42.3800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -3.2955
    Cell Significance Index: -56.9800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -3.3071
    Cell Significance Index: -114.9200
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -3.3924
    Cell Significance Index: -44.2800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -3.4048
    Cell Significance Index: -42.2300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -3.4147
    Cell Significance Index: -108.0000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -3.4466
    Cell Significance Index: -121.1100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -3.5224
    Cell Significance Index: -70.2400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -3.5773
    Cell Significance Index: -76.4700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -3.6631
    Cell Significance Index: -88.7300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -3.7236
    Cell Significance Index: -106.7400
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -3.8304
    Cell Significance Index: -77.9400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -3.8663
    Cell Significance Index: -113.8800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -4.0247
    Cell Significance Index: -115.9600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -4.1043
    Cell Significance Index: -111.7200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -4.1698
    Cell Significance Index: -111.3400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -4.1942
    Cell Significance Index: -104.5900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -4.3065
    Cell Significance Index: -107.5600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -4.3384
    Cell Significance Index: -116.0500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -4.3887
    Cell Significance Index: -115.4000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -4.3987
    Cell Significance Index: -112.0700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -4.5465
    Cell Significance Index: -121.8300
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -4.6056
    Cell Significance Index: -47.3500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cell-type specificity:** OPCM is significantly expressed in progenitor cells, type B pancreatic cells, Purkinje cells, GABAergic neurons, inhibitory interneurons, retinal ganglion cells, epithelial cells of alveoli in the lung, lens epithelial cells, pyramidal neurons, and cerebral cortex neurons. This cell-type specificity suggests that OPCM plays a critical role in the development, maintenance, and function of these cell types. 2. **Opioid-binding protein/cell adhesion molecule-like structure:** OPCM shares structural and functional similarities with opioid-binding proteins, which are involved in cell adhesion and recognition mechanisms. 3. **Post-translational modifications:** OPCM undergoes post-translational modifications, including GPI-anchored protein synthesis and post-translational protein modification, which are essential for its proper functioning and localization. 4. **Protein-protein interactions:** OPCM interacts with other proteins, including B7ZLQ0 and B2CZX3, which may modulate its functions and interactions. **Pathways and Functions:** 1. **Cell adhesion and recognition:** OPCM mediates cell adhesion and recognition through its interaction with other cell surface molecules, such as opioid-binding proteins. 2. **Neuron recognition:** OPCM plays a crucial role in neuron recognition and development, particularly in the formation of synaptic connections and neuronal networks. 3. **Protein metabolism:** OPCM is involved in the metabolism of proteins, including the synthesis of GPI-anchored proteins, which are essential for its proper functioning and localization. 4. **Post-translational modification:** OPCM undergoes post-translational modifications, including GPI-anchored protein synthesis and post-translational protein modification, which are essential for its proper functioning and localization. **Clinical Significance:** 1. **Neurological disorders:** OPCM's role in neuron recognition and development suggests that dysregulation of OPCM may contribute to neurological disorders, such as Alzheimer's disease, Parkinson's disease, and autism spectrum disorder. 2. **Immunological disorders:** OPCM's interaction with other proteins, such as B7ZLQ0 and B2CZX3, may modulate immune responses and contribute to immunological disorders, such as autoimmune diseases and cancer. 3. **Cancer development:** OPCM's expression in epithelial cells and its involvement in cell adhesion and recognition mechanisms suggest that dysregulation of OPCM may contribute to cancer development and progression. 4. **Regenerative medicine:** OPCM's role in tissue development and maintenance suggests that OPCM may be a valuable target for regenerative medicine applications, particularly in the development of therapies for tissue repair and regeneration. In conclusion, OPCML is a gene of diverse expression and function that plays a critical role in cell adhesion, recognition, and development. Its complex interplay with other proteins and pathways has far-reaching implications for our understanding of immunological and neurological disorders, and its dysregulation may contribute to various diseases. Further research is necessary to fully elucidate the functions and implications of OPCM in human health and disease.

Genular Protein ID: 2892474013

Symbol: OPCM_HUMAN

Name: Opioid-binding protein/cell adhesion molecule

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7721093

Title: Cloning, sequencing and localization to chromosome 11 of a cDNA encoding a human opioid-binding cell adhesion molecule (OBCAM).

PubMed ID: 7721093

DOI: 10.1016/0378-1119(94)00830-l

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12819783

Title: OPCML at 11q25 is epigenetically inactivated and has tumor-suppressor function in epithelial ovarian cancer.

PubMed ID: 12819783

DOI: 10.1038/ng1183

Sequence Information:

  • Length: 345
  • Mass: 38008
  • Checksum: E7AD17BEA1AA3FF4
  • Sequence:
  • MGVCGYLFLP WKCLVVVSLR LLFLVPTGVP VRSGDATFPK AMDNVTVRQG ESATLRCTID 
    DRVTRVAWLN RSTILYAGND KWSIDPRVII LVNTPTQYSI MIQNVDVYDE GPYTCSVQTD 
    NHPKTSRVHL IVQVPPQIMN ISSDITVNEG SSVTLLCLAI GRPEPTVTWR HLSVKEGQGF 
    VSEDEYLEIS DIKRDQSGEY ECSALNDVAA PDVRKVKITV NYPPYISKAK NTGVSVGQKG 
    ILSCEASAVP MAEFQWFKEE TRLATGLDGM RIENKGRMST LTFFNVSEKD YGNYTCVATN 
    KLGNTNASIT LYGPGAVIDG VNSASRALAC LWLSGTLLAH FFIKF

Genular Protein ID: 2202203873

Symbol: B2CZX3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 245
  • Mass: 26854
  • Checksum: 809253D1B3F5ED00
  • Sequence:
  • MIQNVDVYDE GPYTCSVQTD NHPKTSRVHL IVQVPPQIMN ISSDITVNEG SSVTLLCLAI 
    GRPEPTVTWR HLSVKEGQGF VSEDEYLEIS DIKRDQSGEY ECSALNDVAA PDVRKVKITV 
    NYPPYISKAK NTGVSVGQKG ILSCEASAVP MAEFQWFKEE TRLATGLDGM RIENKGRMST 
    LTFFNVSEKD YGNYTCVATN KLGNTNASIT LYGPGAVIDG VNSASRALAC LWLSGTLLAH 
    FFIKF

Genular Protein ID: 4278585065

Symbol: B7ZLQ0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 344
  • Mass: 37878
  • Checksum: 876E36747A7A5E9F
  • Sequence:
  • MGVCGYLFLP WKCLVVVSLR LLFLVPTGVP VRSGDATFPK AMDNVTVRQG ESATLRCTID 
    DRVTRVAWLN RSTILYAGND KWSIDPRVII LVNTPTQYSI MIQNVDVYDE GPYTCSVQTD 
    NHPKTSRVHL IVQVPPQIMN ISSDITVNEG SSVTLLCLAI GRPEPTVTWR HLSVKGQGFV 
    SEDEYLEISD IKRDQSGEYE CSALNDVAAP DVRKVKITVN YPPYISKAKN TGVSVGQKGI 
    LSCEASAVPM AEFQWFKEET RLATGLDGMR IENKGRMSTL TFFNVSEKDY GNYTCVATNK 
    LGNTNASITL YGPGAVIDGV NSASRALACL WLSGTLLAHF FIKF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.