Details for: PCSK2

Gene ID: 5126

Symbol: PCSK2

Ensembl ID: ENSG00000125851

Description: proprotein convertase subtilisin/kexin type 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 104.3579
    Cell Significance Index: -42.9900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 4.6574
    Cell Significance Index: 101.9800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 3.9446
    Cell Significance Index: 174.4800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 3.5328
    Cell Significance Index: 133.7800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 3.5275
    Cell Significance Index: 237.1900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 3.4908
    Cell Significance Index: 214.0200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 3.3437
    Cell Significance Index: 95.4200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 3.0080
    Cell Significance Index: 603.4100
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 2.9903
    Cell Significance Index: 39.8900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.5027
    Cell Significance Index: 897.6800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.9145
    Cell Significance Index: -4.1900
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 1.7673
    Cell Significance Index: 18.4100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.7325
    Cell Significance Index: 37.5400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.6590
    Cell Significance Index: 101.9700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.3325
    Cell Significance Index: 60.4000
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 1.2353
    Cell Significance Index: 16.0200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.2011
    Cell Significance Index: 830.7300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.1283
    Cell Significance Index: 27.0600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9982
    Cell Significance Index: 189.9600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.8825
    Cell Significance Index: 22.0600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.7273
    Cell Significance Index: 40.8100
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.6910
    Cell Significance Index: 5.3000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.6635
    Cell Significance Index: 1249.3600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.5933
    Cell Significance Index: 67.7300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5185
    Cell Significance Index: 468.1700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4305
    Cell Significance Index: 42.5900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.4092
    Cell Significance Index: 5.0800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.4001
    Cell Significance Index: 12.8200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2731
    Cell Significance Index: 4.6800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.2548
    Cell Significance Index: 37.0400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2141
    Cell Significance Index: 34.8300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1148
    Cell Significance Index: 156.0500
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.1146
    Cell Significance Index: 1.0900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0644
    Cell Significance Index: 7.0000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.0538
    Cell Significance Index: 1.0800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0384
    Cell Significance Index: 7.6300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0315
    Cell Significance Index: 20.0300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.0275
    Cell Significance Index: 0.9000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0274
    Cell Significance Index: 0.7900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.0099
    Cell Significance Index: 2.0900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0083
    Cell Significance Index: 6.1300
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.0065
    Cell Significance Index: 0.0500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0062
    Cell Significance Index: 9.5900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0009
    Cell Significance Index: -0.0300
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.0082
    Cell Significance Index: -0.0900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0109
    Cell Significance Index: -20.1900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0115
    Cell Significance Index: -7.1900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0185
    Cell Significance Index: -0.6500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0216
    Cell Significance Index: -12.1800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0298
    Cell Significance Index: -0.3300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0361
    Cell Significance Index: -15.9700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0417
    Cell Significance Index: -31.5300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0553
    Cell Significance Index: -9.4400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0575
    Cell Significance Index: -42.1800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0691
    Cell Significance Index: -31.3400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0722
    Cell Significance Index: -0.9000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0726
    Cell Significance Index: -2.0300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0741
    Cell Significance Index: -40.4700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0914
    Cell Significance Index: -11.7200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1080
    Cell Significance Index: -31.0800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1613
    Cell Significance Index: -11.1600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1703
    Cell Significance Index: -8.9400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1909
    Cell Significance Index: -34.4200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2225
    Cell Significance Index: -4.4000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.2400
    Cell Significance Index: -14.4100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2431
    Cell Significance Index: -33.3800
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.2576
    Cell Significance Index: -3.0100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2869
    Cell Significance Index: -6.0900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2915
    Cell Significance Index: -35.8400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3018
    Cell Significance Index: -6.5200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3117
    Cell Significance Index: -35.7100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3539
    Cell Significance Index: -36.8500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3634
    Cell Significance Index: -42.3500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.3778
    Cell Significance Index: -2.5600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.3988
    Cell Significance Index: -3.7800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.4207
    Cell Significance Index: -42.9800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4229
    Cell Significance Index: -10.5500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4503
    Cell Significance Index: -28.3800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4844
    Cell Significance Index: -37.1700
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.4857
    Cell Significance Index: -9.5600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5344
    Cell Significance Index: -42.3300
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.5354
    Cell Significance Index: -4.8400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5421
    Cell Significance Index: -18.9900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.5523
    Cell Significance Index: -7.9100
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.5887
    Cell Significance Index: -7.4300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.6075
    Cell Significance Index: -31.5600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.6114
    Cell Significance Index: -12.7600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.6173
    Cell Significance Index: -7.7900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.6237
    Cell Significance Index: -29.0800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.7048
    Cell Significance Index: -36.7100
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.7559
    Cell Significance Index: -9.0400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.8435
    Cell Significance Index: -39.6500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.8450
    Cell Significance Index: -31.0200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.8638
    Cell Significance Index: -27.3200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.9342
    Cell Significance Index: -19.3800
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.9378
    Cell Significance Index: -18.7000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.9539
    Cell Significance Index: -20.3200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.9773
    Cell Significance Index: -25.1200
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -1.0024
    Cell Significance Index: -2.2600
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -1.0248
    Cell Significance Index: -13.6600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** PCSK2 is a 415-amino acid enzyme that belongs to the subtilisin/kexin family of proteases. It is a type II transmembrane protein, with the catalytic domain located in the extracellular loop. PCSK2 has a broad substrate specificity, cleaving a wide range of peptide hormones, neurotransmitters, and growth factors. The enzyme is activated by the removal of a prodomain, which is a characteristic feature of the subtilisin/kexin family. PCSK2 is also known to be involved in the processing of amyloid precursor protein (APP) and the regulation of insulin signaling. **Pathways and Functions** PCSK2 is involved in several key pathways, including: 1. **Enkephalin processing**: PCSK2 cleaves the enkephalin precursor, releasing the active neurotransmitter enkephalin, which plays a role in pain modulation and stress response. 2. **Insulin processing**: PCSK2 cleaves the proinsulin precursor, releasing insulin, a hormone involved in glucose regulation and metabolism. 3. **Peptide hormone metabolism**: PCSK2 processes a wide range of peptide hormones, including gastrin, secretin, and vasoactive intestinal peptide (VIP), which play roles in various physiological processes, including digestion, growth, and development. 4. **Neurotransmitter processing**: PCSK2 cleaves neurotransmitters, such as GABA and glutamate, which are involved in synaptic transmission and neuronal communication. **Clinical Significance** PCSK2 has been implicated in several neurological and endocrine disorders, including: 1. **Alzheimer's disease**: PCSK2 has been shown to be involved in the processing of APP, and its dysregulation has been linked to Alzheimer's disease. 2. **Diabetes**: PCSK2 has been implicated in the regulation of insulin signaling, and its dysregulation has been linked to type 2 diabetes. 3. **Pain modulation**: PCSK2 has been shown to be involved in the processing of enkephalins, and its dysregulation has been linked to chronic pain and inflammation. 4. **Neurodegenerative disorders**: PCSK2 has been implicated in the regulation of various neurotransmitters and hormones, and its dysregulation has been linked to neurodegenerative disorders, such as Parkinson's disease and Huntington's disease. In conclusion, PCSK2 is a multifunctional enzyme that plays a critical role in the processing and regulation of various peptide hormones, neurotransmitters, and growth factors. Its dysregulation has been linked to several neurological and endocrine disorders, highlighting the importance of PCSK2 in maintaining physiological homeostasis. Further research is needed to fully understand the mechanisms of PCSK2 and its role in human disease.

Genular Protein ID: 290697206

Symbol: NEC2_HUMAN

Name: Neuroendocrine convertase 2

UniProtKB Accession Codes:

P16519 B1ANH9 B4DFQ3 Q14927 Q5JYQ1 Q8IWA8 Q9NQG3 Q9NUG1 Q9UJC6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 2 EMBL 25 Ensembl 3 GO 17 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2154467

Title: Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2.

PubMed ID: 2154467

DOI: 10.1016/s0021-9258(19)39721-2

PubMed ID: 1594602

Title: Identification and analysis of the gene encoding human PC2, a prohormone convertase expressed in neuroendocrine tissues.

PubMed ID: 1594602

DOI: 10.1073/pnas.89.11.4977

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7983775

Title: Analysis of the gene encoding human PC2, a prohormone processing enzyme.

PubMed ID: 7983775

PubMed ID: 9287128

Title: Role of the prohormone convertase PC2 in the processing of proglucagon to glucagon.

PubMed ID: 9287128

DOI: 10.1016/s0014-5793(97)00892-2

PubMed ID: 28719828

Title: Functional analysis of PCSK2 coding variants: A founder effect in the Old Order Amish population.

PubMed ID: 28719828

DOI: 10.1016/j.diabres.2017.06.023

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 638
  • Mass: 70565
  • Checksum: 323623FBDA6086B2
  • Sequence:
    • MKGGCVSQWK AAAGFLFCVM VFASAERPVF TNHFLVELHK GGEDKARQVA AEHGFGVRKL 
PFAEGLYHFY HNGLAKAKRR RSLHHKQQLE RDPRVKMALQ QEGFDRKKRG YRDINEIDIN 
MNDPLFTKQW YLINTGQADG TPGLDLNVAE AWELGYTGKG VTIGIMDDGI DYLHPDLASN 
YNAEASYDFS SNDPYPYPRY TDDWFNSHGT RCAGEVSAAA NNNICGVGVA YNSKVAGIRM 
LDQPFMTDII EASSISHMPQ LIDIYSASWG PTDNGKTVDG PRELTLQAMA DGVNKGRGGK 
GSIYVWASGD GGSYDDCNCD GYASSMWTIS INSAINDGRT ALYDESCSST LASTFSNGRK 
RNPEAGVATT DLYGNCTLRH SGTSAAAPEA AGVFALALEA NLGLTWRDMQ HLTVLTSKRN 
QLHDEVHQWR RNGVGLEFNH LFGYGVLDAG AMVKMAKDWK TVPERFHCVG GSVQDPEKIP 
STGKLVLTLT TDACEGKENF VRYLEHVQAV ITVNATRRGD LNINMTSPMG TKSILLSRRP 
RDDDSKVGFD KWPFMTTHTW GEDARGTWTL ELGFVGSAPQ KGVLKEWTLM LHGTQSAPYI 
DQVVRDYQSK LAMSKKEELE EELDEAVERS LKSILNKN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.