Details for: MOBP

Gene ID: 4336

Symbol: MOBP

Ensembl ID: ENSG00000168314

Description: myelin associated oligodendrocyte basic protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 48.9890
    Cell Significance Index: -7.6200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 30.0028
    Cell Significance Index: -7.6100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 5.6972
    Cell Significance Index: 200.1900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.2738
    Cell Significance Index: -8.7700
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: 3.1016
    Cell Significance Index: 22.3200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 2.6873
    Cell Significance Index: 67.1800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.1916
    Cell Significance Index: 47.4800
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.8683
    Cell Significance Index: 6.6600
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.7794
    Cell Significance Index: 12.3700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6866
    Cell Significance Index: 130.6600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5262
    Cell Significance Index: 52.0600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4923
    Cell Significance Index: 10.4900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.4779
    Cell Significance Index: 10.2200
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.4305
    Cell Significance Index: 6.5500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3633
    Cell Significance Index: 328.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2941
    Cell Significance Index: 59.0000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.2923
    Cell Significance Index: 4.3800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2865
    Cell Significance Index: 46.6000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2684
    Cell Significance Index: 29.1900
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.2416
    Cell Significance Index: 2.5900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1896
    Cell Significance Index: 11.3800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1465
    Cell Significance Index: 6.6400
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.1330
    Cell Significance Index: 1.8600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1220
    Cell Significance Index: 8.4400
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.0660
    Cell Significance Index: 0.8800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0555
    Cell Significance Index: 3.5000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0421
    Cell Significance Index: 2.8300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0411
    Cell Significance Index: 14.7500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0017
    Cell Significance Index: -0.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0032
    Cell Significance Index: -6.0400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0043
    Cell Significance Index: -7.9900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0051
    Cell Significance Index: -7.8500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0054
    Cell Significance Index: -7.3500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0075
    Cell Significance Index: -0.3300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0090
    Cell Significance Index: -0.5500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0100
    Cell Significance Index: -7.5900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0108
    Cell Significance Index: -8.0100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0114
    Cell Significance Index: -6.2400
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0116
    Cell Significance Index: -0.1100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0130
    Cell Significance Index: -9.5200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0142
    Cell Significance Index: -9.0500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0145
    Cell Significance Index: -8.2000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0193
    Cell Significance Index: -8.7500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0236
    Cell Significance Index: -6.8000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0313
    Cell Significance Index: -5.6400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0331
    Cell Significance Index: -1.0600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0362
    Cell Significance Index: -7.1900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0371
    Cell Significance Index: -0.7700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0388
    Cell Significance Index: -8.1700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0389
    Cell Significance Index: -1.1100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0457
    Cell Significance Index: -6.6500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0462
    Cell Significance Index: -7.8900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0504
    Cell Significance Index: -1.9100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0533
    Cell Significance Index: -7.3200
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.0586
    Cell Significance Index: -0.7600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0662
    Cell Significance Index: -2.7100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0668
    Cell Significance Index: -8.2200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0681
    Cell Significance Index: -8.8000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0706
    Cell Significance Index: -8.0900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0734
    Cell Significance Index: -7.6400
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0870
    Cell Significance Index: -1.1600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0891
    Cell Significance Index: -5.4800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0917
    Cell Significance Index: -2.9200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0973
    Cell Significance Index: -2.1300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0994
    Cell Significance Index: -10.1500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1046
    Cell Significance Index: -8.0300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1071
    Cell Significance Index: -12.4800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1108
    Cell Significance Index: -2.1900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1108
    Cell Significance Index: -1.6700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1148
    Cell Significance Index: -4.9900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1185
    Cell Significance Index: -8.8300
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.1234
    Cell Significance Index: -1.4400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1376
    Cell Significance Index: -1.9700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1391
    Cell Significance Index: -3.4700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1426
    Cell Significance Index: -5.0000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1449
    Cell Significance Index: -3.8100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1517
    Cell Significance Index: -8.5100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1521
    Cell Significance Index: -7.9000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1552
    Cell Significance Index: -10.0100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1579
    Cell Significance Index: -5.1700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1630
    Cell Significance Index: -3.4600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1651
    Cell Significance Index: -7.7000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1659
    Cell Significance Index: -8.7100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1798
    Cell Significance Index: -8.4500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1916
    Cell Significance Index: -4.1400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2016
    Cell Significance Index: -2.7500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2021
    Cell Significance Index: -7.4200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2054
    Cell Significance Index: -4.9800
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.2080
    Cell Significance Index: -2.2800
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.2121
    Cell Significance Index: -2.3400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2197
    Cell Significance Index: -4.4100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2280
    Cell Significance Index: -7.2100
  • Cell Name: L5 intratelencephalic projecting glutamatergic neuron (CL4030064)
    Fold Change: -0.2288
    Cell Significance Index: -2.4700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2416
    Cell Significance Index: -4.1400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2523
    Cell Significance Index: -6.7600
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.2638
    Cell Significance Index: -3.6600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2684
    Cell Significance Index: -7.1800
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.2708
    Cell Significance Index: -5.5100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2745
    Cell Significance Index: -5.7300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2752
    Cell Significance Index: -6.6000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** MOBP is expressed in a variety of cell types, including oligodendrocytes, cardiac endothelial cells, granulocyte-monocyte progenitor cells, and intestinal epithelial cells. This widespread expression suggests a multifaceted role for MOBP in different tissues and cell types. 2. **Structural Function:** MOBP is a structural component of the myelin sheath, contributing to the formation and maintenance of this critical CNS structure. 3. **Gene Expression Regulation:** MOBP has been shown to regulate gene expression through transcriptional control, interacting with RNA polymerase II and other transcription factors. 4. **Protein Binding:** MOBP exhibits protein-binding capabilities, interacting with a range of proteins involved in various cellular processes. **Pathways and Functions:** 1. **Central Nervous System Myelin Formation:** MOBP plays a crucial role in the development and maintenance of the myelin sheath, facilitating the formation and repair of this critical CNS structure. 2. **Gene Expression (Transcription):** MOBP regulates gene expression through transcriptional control, influencing the expression of various genes involved in cellular processes. 3. **Generic Transcription Pathway:** MOBP participates in the generic transcription pathway, a fundamental process by which cells transcribe genetic information into RNA. 4. **Mitochondrial Function:** MOBP interacts with mitochondrial proteins, influencing mitochondrial function and energy metabolism. 5. **Nervous System Development:** MOBP is involved in the development and maturation of the CNS, including the formation of oligodendrocytes and the myelination of axons. **Clinical Significance:** 1. **Neurological Disorders:** Abnormalities in MOBP expression have been linked to various neurological disorders, including multiple sclerosis, Alzheimer's disease, and Parkinson's disease. 2. **Immunological Disorders:** MOBP has been implicated in immune-related disorders, including inflammatory bowel disease and autoimmune responses. 3. **Cancer:** MOBP expression has been observed in various types of cancer, including glioblastoma and melanoma, suggesting a potential role in tumorigenesis. 4. **Neurodegenerative Diseases:** MOBP has been implicated in neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and Huntington's disease. In conclusion, MOBP is a multifunctional protein with a range of roles in immune and neurological function. Further research is needed to fully elucidate the mechanisms by which MOBP regulates gene expression, interacts with proteins, and influences cellular processes. The clinical significance of MOBP in neurological and immunological disorders highlights the importance of continued investigation into this enigmatic protein.

Genular Protein ID: 677339108

Symbol: MOBP_HUMAN

Name: Myelin-associated oligodendrocyte basic protein

UniProtKB Accession Codes:

Q13875 A8K2C2 G5E945 Q13874 Q6DHZ6 Q8TBJ1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 Ensembl 12 ExpressionAtlas 1 GO 5 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 1 RefSeq 3 SMR 1 STRING 1 SignaLink 1 UCSC 1 VEuPathDB 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7989345

Title: Cloning and expression of myelin-associated oligodendrocytic basic protein. A novel basic protein constituting the central nervous system myelin.

PubMed ID: 7989345

DOI: 10.1016/s0021-9258(18)31756-3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 183
  • Mass: 20959
  • Checksum: 81831413BCC6A041
  • Sequence:
    • MSQKPAKEGP RLSKNQKYSE HFSIHCCPPF TFLNSKKEIV DRKYSICKSG CFYQKKEEDW 
ICCACQKTRT SRRAKSPQRP KQQPAAPPAV VRAPAKPRSP PRSERQPRSP PRSERQPRSP 
PRSERQPRSP PRSERQPRPR PEVRPPPAKQ RPPQKSKQQP RSSPLRGPGA SRGGSPVKAS 
RFW

Genular Protein ID: 1013040244

Symbol: A0A0S2Z3W1_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0S2Z3W1

Database IDs:

ARBA 2 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 ExpressionAtlas 1 GO 4 Gene3D 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 Pfam 2 RefSeq 1 SMR 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 81
  • Mass: 9614
  • Checksum: 741E059219155AAF
  • Sequence:
    • MSQKPAKEGP RLSKNQKYSE HFSIHCCPPF TFLNSKKEIV DRKYSICKSG CFYQKKEEDW 
ICCACQKTRL KRKIRPTPKK K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.